• Bisphosphonates (BPs) should be considered in all patients with MM receiving first-line antimyeloma therapy, regardless of presence of osteolytic bone lesions on conventional radiography. (elsevier.com)
  • Aneurysmal bone cysts are rare lesions which even more rarely involve the bones of the hand. (elsevier.com)
  • Although rare, aneurysmal bone cysts should be included in the differential diagnosis and ruled out prior to embarking on a course of treatment. (elsevier.com)
  • Insights stemming from molecular and cellular events are applied to the clinical setting, providing a deeper understanding of bone development complications for the practicing clinician, whilst informing bone scientists of the advancements in their field and the wider applications of their research. (springer.com)
  • Bone marrow transplantation can be used to treat certain blood disorders such as leukemia or immunodeficiency, but can also have serious complications such as graft-versus-host disease. (nature.com)
  • Bone marrow transplantation is the transference of bone marrow from one human or animal to another for a variety of purposes. (nature.com)
  • Targeting GM-CSF in allogeneic bone marrow transplantation could prevent graft-versus-host disease while maintaining graft-versus-leukaemia responses. (nature.com)
  • On Saturday, after batting .367 over his previous 20 games to raise his season average to .254, Hollandsworth was put on the 15-day disabled list because of a broken bone near his right elbow, which probably will sideline him for two to four weeks. (latimes.com)
  • For them, the only symptom of OI might be an occasional broken bone. (kidshealth.org)
  • If osteoporosis leads to a broken bone and you don't do anything about it, you may get another fracture. (usatoday.com)
  • It is never easy as a parent to see your child go through the pain and disappointment that can come with a broken bone during summer break. (prweb.com)
  • Allogeneic bone marrow transplant -- The term allo means other. (medlineplus.gov)
  • The bone used in a sinus lift may come from your own body (autogenous bone), from a cadaver (allogeneic bone) or bone morphogenic protein (BMP) . (google.com)
  • After menopause, bone resorption (breakdown) overtakes the building of new bone. (clevelandclinic.org)
  • These are the cells responsible for the resorption of bone. (wikipedia.org)
  • Conditions that result in a decrease in bone mass, can either be caused by an increase in resorption, or a decrease in ossification. (wikipedia.org)
  • During childhood, bone formation exceeds resorption. (wikipedia.org)
  • Bone resorption rates are much higher in post-menopausal older women due to estrogen deficiency related with menopause. (wikipedia.org)
  • Light weight bearing exercise tends to eliminate the negative effects of bone resorption. (wikipedia.org)
  • Recent research indicates that calcitriol leads to a reduction in osteoclast formation, and bone resorption. (wikipedia.org)
  • It follows that an increase in vitamin D3 intake should lead to a decrease in bone resorption - it has been shown that oral administration of vitamin D does not linearly correlate to increased serum levels of calcifediol, the precursor to calcitriol. (wikipedia.org)
  • In some cases where bone resorption outpaces ossification, the bone is broken down much faster than it can be renewed. (wikipedia.org)
  • Some people who experience increased bone resorption and decreased bone formation are astronauts. (wikipedia.org)
  • Ossification decreases due to a lack of stress, while resorption increases, leading to a net decrease in bone density. (wikipedia.org)
  • Bone is not uniformly solid, but consists of a flexible matrix (about 30%) and bound minerals (about 70%) which are intricately woven and endlessly remodeled by a group of specialized bone cells. (wikipedia.org)
  • Osteoarthritis (OA) also known as degenerativearthritis or degenerative joint disease or osteoarthrosis, is a group of mechanical abnormalities involving degradation of joints,including articular cartilage and subchondral bone. (amazonaws.com)
  • Bone spurs, also called osteophytes, are bony growths that usually form along the joints. (buzzle.com)
  • A bone spur is a bone projection, which is formed along the joints or on the edges if the joint. (buzzle.com)
  • Nutrients like hyaluronic acid, glycosamine, collagen and gelatin, are also present in quantities that help support and regenerate joints adding strength to the cushion between our own bones. (selfgrowth.com)
  • Signs of Paget's disease of bone include: pain associated with bones and joints, headaches, hearing loss, enlargement or bowing of bones, tingling or numbness. (rheumatology.org)
  • The Latin word for bone is os, hence the many terms that use it as a prefix - such as osseous and osteopathy. (wikipedia.org)
  • Some diseases with symptoms of decreased bone density are osteoporosis, and rickets. (wikipedia.org)
  • Based on your doctor's referral, the Bone Density Center performs one of several tests to determine the causes of your symptoms and provide your primary care physician or specialist with information to help develop a treatment plan. (massgeneral.org)
  • High-resolution magnetic resonance imaging of the tibia or radius shows promise for allowing a "virtual biopsy" of the bone and can non-invasively follow bone structural changes, but this is also currently a research tool. (washington.edu)
  • In the human body at birth, there are over 270 bones, but many of these fuse together during development, leaving a total of 206 separate bones in the adult, not counting numerous small sesamoid bones . (wikipedia.org)
  • In the human anatomy , sesamoid bones are usually small, round and flat. (everything2.com)
  • Few individuals have sesamoid bones at every possibly location, but everyone has sesamoid patellae . (everything2.com)
  • Leukapheresis -- First, the donor is given several days of shots to help stem cells move from the bone marrow into the blood. (medlineplus.gov)
  • If you're getting bone marrow from someone else, your donor goes through the same process. (webmd.com)
  • Tokyo, July 23, 2012 - (JCN Newswire) - Traditionally, bone grafts require material to be transplanted from either another bone of the patient or from a donor. (redorbit.com)
  • Each day a bone marrow donor recruitment clinic will be held, where you will have the opportunity to join the bone marrow register. (warwick.ac.uk)
  • Bone disease affects women and men of all ethnicities, although the risk of bone disease is highest among women. (news-medical.net)
  • After age 35, bone breakdown overtakes bone buildup, which causes a gradual loss of bone mass. (clevelandclinic.org)
  • Once this loss of bone reaches a certain point, a person has osteoporosis. (clevelandclinic.org)
  • Early menopause (before age 45) and any long phases in which the woman has low hormone levels and no or infrequent menstrual periods can cause loss of bone mass. (clevelandclinic.org)
  • Tooth loss often leads to more loss of bone. (google.com)
  • Tooth loss may have led to a loss of bone as well. (google.com)
  • The majority of current medications - including Fosamax and Boniva - are bisphosphonates that slow or prevent the loss of bone density but don't rebuild bone. (aarp.org)
  • It compares your bone density, or mass, to that of a healthy person who is the same age and sex as you are. (medlineplus.gov)
  • This also kills all healthy bone marrow that remains, and allows new stem cells to grow in the bone marrow. (medlineplus.gov)
  • To keep your bones strong and healthy over time, you need to eat well, get exercise, and make other good health choices. (healthline.com)
  • The idea is simple: Replace damaged bone marrow cells with healthy ones. (webmd.com)
  • If the healthy cells come from your own bone marrow, it's an autologous transplant. (webmd.com)
  • A bone health campaign for girls ages 9 to 12 that teaches how to get and keep strong, healthy bones for life. (kidshealth.org)
  • Left, shows a histological image of healthy mouse bone. (eurekalert.org)
  • You will also receive an information pack with evidence-based nutrition, exercise and lifestyle advice to enable you to safeguard yourself against osteoporosis, greatly enhancing your chances of having strong and healthy bones for life. (ox.ac.uk)
  • When food is flavorful it is consumed and bone broth is an ingredient with many healthy benefits. (selfgrowth.com)
  • Healthy and strong bones are essential for keeping active, especially as people grow older. (arrt.org)
  • Other bone diseases include Paget's disease and osteogenesis imperfecta. (news-medical.net)
  • Osteoporosis and other bone diseases, such as Paget's disease and osteogenesis imperfecta, can lead to a downward spiral in physical health and quality of life including losing the ability to walk, stand, and dress. (news-medical.net)
  • For those with Paget's disease, however, this process of rebuilding the involved bones takes place at a faster rate. (rheumatology.org)
  • Paget's disease often causes an arthritic condition and can be diagnosed and treated by your rheumatologist as well as medical care practitioners who focus on bone disorders. (rheumatology.org)
  • People with OI might have bones that break easily, which is why the condition is commonly called brittle bone disease . (kidshealth.org)
  • More than 2 million incidents a year in the USA are linked to osteoporosis, a chronic illness in which bones become brittle. (usatoday.com)
  • The trapezium bone is one of the eight small carpal bones in the wrist that are firmly bound in two rows of four bones each. (innerbody.com)
  • A bone marrow transplant replaces bone marrow that is either not working properly or has been destroyed (ablated) by chemotherapy or radiation. (medlineplus.gov)
  • Not only does it wipe out your bone marrow, but chemo and radiation also can be tough on your body. (webmd.com)
  • When the bone marrow has been destroyed by disease, chemotherapy or radiation, the stem cells may be transplanted and restored. (news-medical.net)
  • In these patients high doses of chemotherapy or radiation therapy is a good therapy option but cannot be given due to its potential to cause bone marrow suppression. (news-medical.net)
  • Bone scans aren't usually performed on pregnant women or nursing mothers because of concerns about radiation exposure to the baby. (mayoclinic.org)
  • An x-ray source is capable of producing an intensity of radiation about 1000 times greater than conventional radioisotopic sources used for bone density measurements. (freepatentsonline.com)
  • If an x-ray source were successfully incorporated in a bone densitometer, an improvement in measurement time, resolution, accuracy, precision, and minimization of radiation dose might be effected. (freepatentsonline.com)
  • The purpose of this book is to provide students, young investigators as well as established researchers and clinicians with comprehensive reviews on fundamental and applied aspects of regeneration of bone and to offer insights into future developments. (worldcat.org)
  • Fortunately, bones can regenerate, and orthopedic surgeons can enhance this regeneration with a process called distraction osteogenesis. (bu.edu)
  • The problem, Morgan decided, was that there were no measurements of the loading microenvironment and therefore no way of relating this microenvironment to how much bone regeneration occurred. (bu.edu)
  • 4MATRIX's unique and novel engineering process produces a composite graft material with rapid bone regeneration and optimal space maintaining properties. (prweb.com)
  • Conditions that cause increased bone breakdown and regeneration over an extended period of time increase the risk of tumor development. (empowher.com)
  • The human body is in a constant state of bone remodeling. (wikipedia.org)
  • The blood-forming cells of the bone marrow are among the most radiosensitive cells in the body. (britannica.com)
  • The herbs found in Tiger Bone help to establish a superior body balance by working through the glands, and they are uniquely qualified to help combat disorders associated with sexual function. (angelfire.com)
  • Bones support and protect the various organs of the body, produce red and white blood cells , store minerals , provide structure and support for the body, and enable mobility . (wikipedia.org)
  • The largest bone in the body is the femur or thigh-bone, and the smallest is the stapes in the middle ear . (wikipedia.org)
  • Bones are a critically important part of your body. (healthline.com)
  • Osteogenesis imperfecta (OI) is a genetic disorder that prevents the body from building strong bones. (kidshealth.org)
  • Once the bone marrow is suppressed the frozen cells are thawed and replaced back within the body. (news-medical.net)
  • The bones in the body serve several purposes. (healthcentral.com)
  • Muscles pull against the bones to make the body move. (healthcentral.com)
  • It is found most often in the arms and legs, but it can occur in any bone in the body. (healthcentral.com)
  • On the other hand, it is not unusual for cancers to spread to the bones from other parts of the body. (healthcentral.com)
  • Swimming and bicycling, because they do not require the body to work against gravity, are not good bone-builders, Vicente-Rodriguez noted. (reuters.com)
  • The replacement of human bone in a living body with artificial or synthetic material has long been the subject of anatomical and chemical research. (google.co.uk)
  • Sterilized animal and human bone has not been very satisfactory due to immunological reactions prompting rejection of the implant by the human body. (google.co.uk)
  • We need to strenghten Ho in bones of whole body as well as in bony parts of knee as both erosion and Osteophytes are strongly HE in nature. (amazonaws.com)
  • If you've ever suffered from a bone spur on your body, then you'll know how annoying and painful it can get. (buzzle.com)
  • Bone spurs are also known as osteophytes, and refer to the abnormal growth of any bone in your body. (buzzle.com)
  • To better see some bones in your body, your doctor might order additional imaging called single-photon emission computerized tomography (SPECT). (mayoclinic.org)
  • When someone comes down with cold or flu or even recovering from surgery or chemotherapy, plain true chicken broth or beef bone broth is often the only nourishment a body feels up to eating. (selfgrowth.com)
  • Other foods can be difficult for an ailing body to break down and digest but real bone broth provides high nutrition in a form that's easy to swallow, soothing to the digestive system and more easily assimilated into the body. (selfgrowth.com)
  • Once teeth are gone, bone begins to be resorbed (absorbed back into the body). (google.com)
  • If your own bone will be used in the sinus lift, it will be taken from other areas of your mouth or body. (google.com)
  • When the standard methods of identifying a body are useless (when the remains are so badly decomposed, burned or destroyed), law enforcement calls on Brennan for her uncanny ability to read clues left behind in the victim's bones. (apple.com)
  • For we are members of his body, of his flesh, and of his bones. (wikiquote.org)
  • A bone tumor is an abnormal growth of cells within the bone that may be noncancerous (benign) or cancerous (malignant). (slideshare.net)
  • A fatigue fracture is caused by the prolonged cyclical application of abnormal mechanical stresses to a bone that has normal elastic resistance. (amazonaws.com)
  • In a study carried out at the University of Eastern Finland, bone histomorphometry and infrared spectroscopy revealed abnormal bone properties in children with vertebral. (scienceblog.com)
  • As a result, the rebuilt bone has an abnormal structure. (rheumatology.org)
  • Women lose 2% to 3% of bone during the first five years after menopause and then at a rate of about 1% per year. (usatoday.com)
  • Some things are good for your bones and help to strengthen them, while others speed up the natural weakening of your bones. (healthline.com)
  • The findings suggest that before they reach puberty, girls should take up activities that put some stress on the bones in order to strengthen them, the study authors report in the International Journal of Sports Medicine. (reuters.com)
  • A bone plate includes one or more locking devices which rotate to inhibit or prevent bone screws from backing out of the plate when installed on a patient. (google.co.uk)
  • Bone morphogenetic proteins. (nih.gov)
  • Bone morphogenetic proteins (BMPs) are multi-functional growth factors that belong to the transforming growth factor beta (TGFbeta) superfamily. (nih.gov)
  • 1995) "Cloning and characterization of a human type II receptor for bone morphogenetic proteins", Proc. (nih.gov)
  • The bone marrow produces blood cells. (medlineplus.gov)
  • A disease that affects the production of bone marrow cells, such as aplastic anemia , congenital neutropenia , severe immune system illnesses, sickle cell anemia , or thalassemia . (medlineplus.gov)
  • In humans the red bone marrow forms all of the blood cells with the exception of the lymphocytes , which are produced in the marrow and reach their mature form in the lymphoid organs. (britannica.com)
  • Red bone marrow also contributes, along with the liver and spleen , to the destruction of old red blood cells. (britannica.com)
  • The new blood cells are released into the sinusoids, large thin-walled vessels that drain into the veins of the bone. (britannica.com)
  • Because the white blood cells produced in the bone marrow are involved in the body's immune defenses, marrow transplants have been used to treat certain types of immune deficiency and hematological disorders, especially leukemia . (britannica.com)
  • The necessity for a bone marrow aspiration is ordinarily based on previous blood studies and is particularly useful in providing information on various stages of immature blood cells. (britannica.com)
  • Modified (flattened) osteoblasts become the lining cells that form a protective layer on the bone surface. (wikipedia.org)
  • Bone is actively constructed and remodeled throughout life by special bone cells known as osteoblasts and osteoclasts. (wikipedia.org)
  • The columns are metabolically active, and as bone is reabsorbed and created the nature and location of the cells within the osteon will change. (wikipedia.org)
  • Bone is composed of protein , minerals and cells. (slideshare.net)
  • Bones support and protect internal organs , act as levers and braces for muscles to produce movement, and produce and store blood cells in the bone marrow. (everything2.com)
  • Artificial grafts offer an easier and less risky process, providing an artificial scaffold on which bone cells can grow. (redorbit.com)
  • Writing in the current issue of Science and Technology of Advanced Materials, they describe how the scaffold also allows efficient growth of bone cells on its surface, thereby meeting the criteria of both strength and biocompatibility needed to be used in patients. (redorbit.com)
  • To test how the cells grow on the scaffold itself, the team incubated cultured bone cells on its surface for different lengths of time. (redorbit.com)
  • This regenerative capacity is something that bone cells share with liver cells. (bu.edu)
  • A graft from your own bone transplants bone cells or a block of bone that fuses to the jaw. (google.com)
  • Bone is formed by the hardening of this matrix around entrapped cells. (wikipedia.org)
  • People break bones, go to the emergency room, get the fracture fixed and are sent home,'' says Ethel Siris, director of the Toni Stabile Osteoporosis Center at Columbia University Medical Center in New York. (usatoday.com)
  • Despite your best efforts, children break bones. (prweb.com)
  • Wozney, J.M. (1992) "The bone morphogenetic protein family and osteogenesis", Mol. (nih.gov)
  • Yellow bone marrow serves primarily as a storehouse for fats but may be converted to red marrow under certain conditions, such as severe blood loss or fever. (britannica.com)
  • Examination of the bone marrow is helpful in diagnosing certain diseases, especially those related to blood and blood-forming organs, because it provides information on iron stores and blood production. (britannica.com)
  • To understand what a bone marrow transplant is really like, it might help to think of it like a blood transfusion. (webmd.com)
  • and on section during life every part of the bone exudes blood from the minute vessels which ramify in it. (theodora.com)
  • The radioactive tracer usually takes 2-3 hours to circulate in the blood and get absorbed in the bone. (buzzle.com)
  • Following an X-ray of both ankles he noticed some bone calcification on the previously injured ankle and has now suggested she have blood tests. (netdoctor.co.uk)
  • Blood tests taken most often will indicate an increase in serum alkaline phosphatase (SAP), which is reflective of the rapid new bone turnover. (rheumatology.org)
  • Primary bone cancers are called often called sarcomas. (healthcentral.com)
  • Cancers that begin in the bone are quite rare. (healthcentral.com)
  • The target audience is clearly an elite group of clinicians and scientists who are focused on understanding future innovations in the treatment of bone related cancers. (springer.com)