Embryo LossGenes, LethalFetal DeathEmbryo, MammalianGene TargetingEmbryonic DevelopmentMice, KnockoutGene Expression Regulation, DevelopmentalHomozygoteHeterozygoteEmbryonic and Fetal DevelopmentMice, Mutant StrainsBlastocystPhenotypeMutationMice, TransgenicMice, Inbred C57BLGene DeletionBone Morphogenetic ProteinsIntegrasesCrosses, GeneticAllelesPregnancyMesodermSignal TransductionApoptosisNuclear ProteinsEmbryonic Stem CellsGenotypeTranscription FactorsDNA-Binding ProteinsCarrier ProteinsIn Situ HybridizationTumor Suppressor ProteinsBase SequenceStem CellsCell DifferentiationFibroblastsExonsCell Cycle ProteinsCells, CulturedRNA, MessengerMolecular Sequence DataCell ProliferationCell LineBone Morphogenetic Protein 7Reverse Transcriptase Polymerase Chain ReactionBone Morphogenetic Protein 4MammalsBone Morphogenetic Protein 2Amino Acid SequenceCell SurvivalTumor Suppressor Protein p53Time FactorsEmbryo, NonmammalianCell DivisionBone Morphogenetic Protein ReceptorsCardiovascular AbnormalitiesBone Morphogenetic Protein Receptors, Type ICaenorhabditis elegans ProteinsYolk SacNeural Tube DefectsCaenorhabditis elegansBone Morphogenetic Protein 6Sequence Homology, Amino AcidAnimals, Genetically ModifiedDNA PrimersProteinsMorphogenesisBody PatterningMembrane ProteinsPlacentaRNA InterferenceTransforming Growth Factor betaChimeraHomeodomain ProteinsProtein-Serine-Threonine KinasesTransgenesBlood VesselsGene ExpressionNervous SystemHeartGene Knockout TechniquesMutagenesisSmad1 ProteinFetal ViabilityGene Expression RegulationTrans-ActivatorsRecombination, GeneticBone Morphogenetic Protein Receptors, Type IIDrosophilaBlotting, WesternCloning, MolecularProtein BindingImmunohistochemistryModels, BiologicalRepressor ProteinsZebrafish ProteinsDrosophila melanogasterProtein Structure, Tertiary