Methods A next-generation sequencing (NGS) panel was created for the human TRPV1 gene and in addition, for the leukotriene receptors BLT1 and BLT2 recently described to modulate TRPV1 mediated sensitisation processes rendering the coding genes LTB4R and LTB4R2 important co-players in pharmacogenetic approaches involving TRPV1. (researchgate.net)
The arachidonic acid, released by phospholipase A2, is an important substrate for the production of a group of lipid mediators known as leukotrienes, which induce proinflammatory signaling through the activation of specific BLT and CysLT receptors. (hindawi.com)
Two receptors for LTB 4 have been molecularly identified: BLT1 and BLT2. (hindawi.com)
55. Biochemical and pathophysiological roles of two types of leukotoriene B4 receptors (BLT1 and BLT2). (ncgmlipidsp.jp)
2000). "A second leukotriene B(4) receptor, BLT2. (wikipedia.org)
2010 ) Structure of a GPCR ligand in its receptor-bound state: leukotriene B4 adopts a highly constrained conformation when associated to human BLT2. (ibpc.fr)
The ubiquitous expression and the broader ligand specificity suggest that BLT2 may mediate distinct biological and pathophysiological roles from BLT1. (hindawi.com)
LTB46
Leukotriene B4 (LTB4) is a potent lipid mediator of allergic and inflammatory reactions, as well as a modulator of immune responses. (multispaninc.com)
The high-affinity human leukocyte LTB4 receptor, BLT1 (or LTB4R) mediates aggregation, chemotaxis, chemokinesis, and increased adherence to surfaces, whereas the low-affinity receptor mediates degranulation and increased oxidative metabolism. (multispaninc.com)
Studies in mice with disrupted BLT1 gene indicate a major role for BLT1 in acute inflammation and immediate hypersensitivity, as well as in leukocyte functions such as chemotaxis and firm adhesion to endothelium in response to LTB4. (multispaninc.com)
The LTB4 receptor, BLT1, mediates LTB4 induced firm adhesion of effector and memory CD8+ T cells in inflamed cremaster muscle venules. (sagispodiatry.com)
The direct effects of LTB4 on human airway smooth muscle (ASM) have also been studied and suggested a role for a LTB4-BLT1 signaling in ASM responses contributing to the pathogenesis of airway remodeling in asthma. (cmdm.tw)
Chronic neutrophilic airway inflammation is a key symptom of cystic fibrosis (CF). Noninvasive inflammatory markers may be useful in monitoring CF. Leukotriene B4 (LTB4) is a noninvasive inflammatory biomarker that may be elevated in EBC levels of CF patients during exacerbation. (cmdm.tw)
Mediates1
2000) BLTR mediates leukotriene B4-induced chemotaxis and adhesion and plays a dominant role in eosinophil accumulation in a murine model of peritonitis. (multispaninc.com)
Tissue injury, allergens or microbes activate formation and release of arachidonic acid-derived lipid mediators, such as prostaglandins and leukotrienes, which regulate early events in the inflammatory response. (biomedcentral.com)
The term "eicosanoids" includes prostaglandins (PGs), tromboxanes (TX), leukotrienes (LTs), and hydroxyl-eicosatetraenoic acid made by polyunsaturated 20-carbon fatty acids (PUFA), including the most abundant and biological precursor AA [ 21 ]. (hindawi.com)
Human monocytes1
Pro- and anti-inflammatory substances modulate expression of the leukotriene B4 receptor, BLT1, in human monocytes. (lu.se)
Synthesis inhibitors1
For these, reasons both leukotriene synthesis inhibitors and leukotriene receptor antagonists have been suggested for inducing beneficial effects at different stages of the atherosclerosis process and may represent a new therapeutic target in the treatment of atherosclerotic vessel diseases, in particular in acute coronary syndrome. (hindawi.com)
Lipid3
Leukotrienes (LTs) are lipid mediators derived from the 5-lipoxygenase pathway of arachidonic acid metabolism. (springer.com)
Lungs and AM were analysed for pro- and anti-inflammatory lipid mediators, namely leukotriene B 4 (LTB 4 ), prostaglandin E 2 (PGE 2 ), 15(S)-hydroxy-eicosatetraenoic acid (15(S)-HETE), lipoxin A 4 (LXA 4 ) and oxidative stress marker 8-isoprostane by enzyme immunoassays and immunohistochemistry. (biomedcentral.com)
Cysteinyl leukotrienes (Cys-LTs) are potent inflammatory lipid mediators derived from the 5-lypoxygenase (5-LO) pathway of arachidonic acid (AA) metabolism [ 1 ], initially identified to have important effects on pathogenetic aspects of allergic rhinitis and bronchial asthma and approved in the late 1990s for the relief of perennial and seasonal allergic rhinitis symptoms, and the treatment of mild persistent bronchial asthma [ 2 - 5 ]. (hindawi.com)
LTB4R1
Leukotriene B4 receptor 1 is a protein that in humans is encoded by the LTB4R gene. (wikipedia.org)
Pathway2
They play important roles in the pain pathway where in concert with proinflammatory factors such as leukotrienes they mediate sensitization and hyperalgesia. (researchgate.net)
For these reasons, the leukotriene pathway may represent an alternative therapeutic target in the treatment of atherosclerotic vessel diseases [ 6 , 13 , 14 ]. (hindawi.com)
Asthmatic2
GC-MS can be used to accurately quantify and measured EBC of leukotrienes in asthmatic adults and children. (cmdm.tw)
Higher concentrations of leukotriene B4 in EBC of asthmatic patients in comparison with healthy control subjects increase asthma severity in adults. (cmdm.tw)
Localization1
LifeSpan has used multiple antibodies to study the localization profile of the Leukotriene B4 Receptor / BLT1 protein across an extensive panel of normal and diseased human tissue types. (kxcdn.com)
Studies1
Many studies regarding myocardial ischemia and reperfusion show that leukotriene signaling may be involved in the development of ischemic injury. (hindawi.com)
Inflammation2
2. Tumour necrosis factor-alpha and leukotriene B(4) mediate the neutrophil migration in immune inflammation. (nih.gov)
7. Effects of the second-generation leukotriene B(4) receptor antagonist, LY293111Na, on leukocyte infiltration and collagen-induced arthritis in mice. (nih.gov)
Human BLT1 (extracellular) Blocking Peptide (#BLP-LR001) is the original antigen used for immunization during Anti-Human BLT1 (extracellular) Antibody (#ALR-001) generation. (alomone.com)
The blocking peptide binds and 'blocks' Anti-Human BLT1 (extracellular) primary antibody, this makes it a good negative reagent control to help confirm antibody specificity in western blot and immunohistochemistry applications. (alomone.com)
Anti-Human BLT1 (extracellular) Antibody , preincubated with Human BLT1 (extracellular) Blocking Peptide (#BLP-LR001). (alomone.com)
Anti-Human BLT1 (extracellular) Antibody (#ALR-001) is a highly specific antibody directed against an extracellular epitope of the human Leukotriene B4 receptor 1. (alomone.com)
Role1
1. Hikiji H, Ishii S, Yokomizo T, Takato T, Shimizu T. (2009) A distinctive role of the leukotriene B4 receptor BLT1 in osteoclastic activity during bone loss. (guidetopharmacology.org)