• For example, we observed increased platelet aggregation that plays a key role in the blood viscosity value in blood vessels with low shear rates. (annaly-nevrologii.com)
  • can enhance and improve brain oxygen supply, promote metabolism, enhance the erythrocyte deformability, reduce blood viscosity, inhibit platelet aggregation, improve cerebral metabolism. (eoextract.com)
  • Danshen can affect hemostasis in several ways, including inhibition of platelet aggregation, interference with the extrinsic blood coagulation, Antithrombin III (ATIII) - like activity, and promotion of fibrinolytic activity. (bfsumastore.com)
  • [18] In addition, pentoxifylline improves red blood cell deformability (known as a haemorrheologic effect), reduces blood viscosity and decreases the potential for platelet aggregation and blood clot formation. (mdwiki.org)
  • In patients with chronic peripheral arterial disease, this increases blood flow to the affected microcirculation and enhances tissue oxygenation. (drugs.com)
  • Clinical Hemorheology and Microcirculation , a peer-reviewed international scientific journal, serves as an aid to understanding the flow properties of blood and the relationship to normal and abnormal physiology. (iospress.com)
  • The endeavour of the Editors-in-Chief and publishers of Clinical Hemorheology and Microcirculation is to bring together contributions from those working in various fields related to blood flow all over the world. (iospress.com)
  • It also improves microcirculation and peripheral tissue oxygenation through better blood flow. (medicscientist.com)
  • Studies have suggested that these comorbidities also are related to erythrocyte factors linked to increased blood viscosity in microcirculation such as erythrocyte aggregation and erythrocyte deformability. (bvsalud.org)
  • Increased blood viscosity in microcirculation can lead to a decrease in oxygenation and nutrition of tissues. (bvsalud.org)
  • Cardiovascular diseases: VitaLAG helps normalize blood pressure, improves blood microcirculation and cerebral circulation, reduces the effects of hypoxia and ischemia. (ametis.ru)
  • Suspensions of healthy and pathological red blood cells (RBC) flowing in microfluidic devices are frequently used to perform in vitro blood experiments for a better understanding of human microcirculation hemodynamic phenomena. (aip.org)
  • The proposed particulate fluids provide a more realistic behavior of the flow properties of suspended RBCs when compared with existing non-particulate blood analogues, and consequently, they are advantageous for detailed investigations of microcirculation. (aip.org)
  • Pentoxifylline has been shown to increase leukocyte deformability and to inhibit neutrophil adhesion and activation. (drugs.com)
  • RESULTS: After taking Egb 761 orally for 3 months, the blood viscosity was significantly reduced at different shear rates, by 0.44 +/- 0.10 (gamma = 400), 0.52 +/- 0.09 (gamma = 150) and 2.88 +/- 0.57 (gamma = 5). (tmu.edu.tw)
  • During erythrocyte aggregation erythrocytes may get damaged and an erythrocyte coagulation factor may be developed, which could cause a rheological catastrophe. (rheology.biz)
  • Blood coagulation functions were evaluated according to activated partial thromboplastin time (APTT), prothrombin time (PT), thrombin time, and fibrinogen preoperatively and on postoperative days 1, 3, 7, and 14. (biomedcentral.com)
  • Hemorheology, also spelled haemorheology (from Greek 'αἷμα, haima 'blood' and rheology, from Greek ῥέω rhéō, 'flow' and -λoγία, -logia 'study of'), or blood rheology, is the study of flow properties of blood and its elements of plasma and cells. (wikipedia.org)
  • Contrarily, blood viscosity increases when shear rate goes down with increased vessel diameters or with low flow, such as downstream from an obstruction or in diastole. (wikipedia.org)
  • Blood viscosity is a measure of the resistance of blood to flow. (wikipedia.org)
  • Pentoxifylline and its metabolites improve the flow properties of blood by decreasing its viscosity. (drugs.com)
  • On average, ocular blood flow (OBF) is reduced in glaucoma patients in various tissues of the eye. (molvis.org)
  • The deformation and flow behavior of BLOOD and its elements i.e. (bvsalud.org)
  • These parameters included lipid peroxidation stress of erythrocytes, erythrocyte deformability, plasma and blood viscosity, blood viscoelasticity, and retinal capillary blood flow velocity. (tmu.edu.tw)
  • And lastly, retinal capillary blood flow rate was increased from 3.23 +/- 0.12 to 3.67 +/- 0.24 cm min(-1). (tmu.edu.tw)
  • Furthermore, it effectively improved retinal capillary blood flow rate in type 2 diabetic patients with retinopathy. (tmu.edu.tw)
  • Vinpocetine is a little mentioned nootropic that enhances cognitive function and learning via increasing blood flow to the brain. (priceplow.com)
  • Historically, vinpocetine has been used in Europe as a means to enhance cerebral blood flow in the treatment of epilepsy, stroke recovery, and cognitive decline. (priceplow.com)
  • The simple explanation of what vinpocetine does is that it increases blood flow to the brain . (priceplow.com)
  • With increased blood flow, you get more oxygen and nutrients delivered to the brain thereby increasing cognition, memory, and concentration. (priceplow.com)
  • Starting off with the most obvious benefit, and the reason for all the others to follow is the increased blood flow vinpocetine provides to the brain. (priceplow.com)
  • A study in Japan found that blood flow to the scalp of young men diagnosed with androgenetic alopecia (male pattern baldness) was 2.6 times lower than in the normal control group. (hairloss-research.org)
  • The discovery that increasing blood flow to the scalp helps stave off baldness may be old news to many barbers. (hairloss-research.org)
  • This method forces the blood cells in a small drop of blood to flow extremely rapidly through a narrow microfluidic channel while they are imaged by a fast camera. (elifesciences.org)
  • In the last decades, numerical simulations have been widely used to assess the blood flow behavior in stenotic arteries and, consequently, providing insights into the cardiovascular disease condition, its progression and therapeutic optimization. (openbiomedicalengineeringjournal.com)
  • The present work reviews state-of-the-art in vitro macro-scale arterial stenotic biomodels for flow measurements, summarizing the different fabrication methods, blood analogues and highlighting advantages and limitations of the most used techniques. (openbiomedicalengineeringjournal.com)
  • Laviocard+" helps to normalize the blood pressure, decrease it daily fluctuation range, improves vessels tone and cerebral blood flow. (ametis.ru)
  • For venous walls strengthening, venous blood flow improvement, prevention of thrombosis formation and edema reduction. (ametis.ru)
  • Red blood cells (RBCs) deformability can be defined as the ability of the cells to deform when subjected to certain flow conditions. (webmedcentral.com)
  • Here, we detail and model a blood separation principle which exploits discrete viscosity differences caused by blood particle sedimentation in a laminar flow. (researchgate.net)
  • The viscous component arises primarily through the viscosity of blood plasma, while the elastic component arises from deformation of the red blood cells. (wikipedia.org)
  • Calculations have shown that the maximum volume percentage of red blood cells without deformation is 58% which is in the range of normally occurring levels. (wikipedia.org)
  • The role of membrane organization is prominently reflected in red blood cell deformation and aggregation. (frontiersin.org)
  • Hence, the main objective of the present paper is to measure RBCs deformability index (DI) in a hyperbolic microchannel and examine the effect of both diamide and glutaraldehyde on the cell deformation of human and ovine RBC. (webmedcentral.com)
  • CONCLUSION: In this preliminary clinical study, 3 months of oral administration of Egb 761 significantly reduced MDA levels of erythrocytes membranes, decreased fibrinogen levels, promoted erythrocytes deformability, and improved blood viscosity and viscoelasticity, which may facilitate blood perfusion. (tmu.edu.tw)
  • The rapidly expanding science of hemorheology concerns blood, its components and the blood vessels with which blood interacts. (iospress.com)
  • A few scientific studies have suggested that people with hair loss may have fewer blood vessels. (hairloss-research.org)
  • But prior to the MGH study, no one had actually measured how closely blood vessel growth is correlated with hair growth, or what might cause scalp vessels to grow in the first place. (hairloss-research.org)
  • Blood vessels located in the skin surrounding the pumped-up hair follicles were 40 percent larger in diameter than those found in normal mice, suggesting that the VEGF-mediated angiogenesis was causing the hair to grow faster and thicker. (hairloss-research.org)
  • As for how the VEGF-inspired blood vessels are plumping up the hair shafts, the researchers believe they may be delivering an extra supply of growth factors, in addition to oxygen and nutrients. (hairloss-research.org)
  • Strengthens blood vessels and capillary walls, increasing their strength and elasticity. (ametis.ru)
  • Inhibits the activity of gualuronidase, the enzyme that damages blood vessels. (ametis.ru)
  • Pentoxifylline administration has been shown to produce dose-related hemorrheologic effects, lowering blood viscosity, and improving erythrocyte flexibility. (drugs.com)
  • Following oral administration of aqueous solutions containing 100 to 400 mg of pentoxifylline, the pharmacokinetics of the parent compound and Metabolite l are dose-related and not proportional (non-linear), with half-life and area under the blood-level time curve (AUC) increasing with dose. (drugs.com)
  • Plasma's viscosity is determined by water-content and macromolecular components, so these factors that affect blood viscosity are the plasma protein concentration and types of proteins in the plasma. (wikipedia.org)
  • Furthermore, elevation of plasma viscosity correlates to the progression of coronary and peripheral artery diseases. (wikipedia.org)
  • Inflammation and mortality risk markers were previously detected in COVID-19 plasma and red blood cells (RBCs) metabolic and proteomic profiles. (bvsalud.org)
  • Cobalt bioaccumulation in mouse blood plasma and liver. (bsb-bg.eu)
  • Acute exposure causes marked depletion of antioxidants in plasma 13 , 14 , intracellular GSH in erythrocytes 15 and GSH in ELF 10 , 12 . (ersjournals.com)
  • Taking "Laviocard+" together with course of medical treatment the concentration of cholesterol and its atherogenic fractions is reduced as well as the coefficient of atherogeneity of blood plasma, the level of triglyceride goes lower in blood, that favours the reduction of atherosclerosis development. (ametis.ru)
  • The red blood cells (RBCs) are the major component of the blood and contain a lot of physiological and clinical information. (webmedcentral.com)
  • The pathological RBCs were obtained by an incubation of healthy RBCs at a high concentration of glucose, representing the pathological stage of hyperglycaemia in diabetic complications, and analyses of their deformability and aggregation were carried out. (aip.org)
  • Hemorheological parameters determine blood rheological properties. (rheology.biz)
  • Patients in the acute phase of ischemic stroke had pronounced changes in the hemorheological indicators that could be characterized as high blood viscosity syndrome. (annaly-nevrologii.com)
  • This biophysical property makes it a critical determinant of friction against the vessel walls, the rate of venous return, the work required for the heart to pump blood, and how much oxygen is transported to tissues and organs. (wikipedia.org)
  • Deformability is a critical determinant of RBC function, because of the extensive change in cell shape required for efficient passage through the capillaries and the spleen. (frontiersin.org)
  • Hyperlipidemia, characterized by the abnormal blood lipid profiles, is one of the dominant factors of many chronic diseases such as diabetes, obesity, and cardiovascular diseases (CVD). (hindawi.com)
  • In 2013, the American Heart Association reported that proportions of American adults aged 20 or above had abnormal blood lipid serum profile (details are shown in Table 1 ) [ 4 ]. (hindawi.com)
  • Average percentage of abnormal blood lipid levels among Americans at age 20 or above [ 4 ]. (hindawi.com)
  • Nevertheless, it has little effect on the cytoplasmic or lipid membrane viscosity. (webmedcentral.com)
  • For the case of glutaraldehyde, this chemical is a non-specific fixative that promotes the cross-link of the membrane skeletal proteins, phospholipids in the membrane and cytoplasm and consequently it promotes the increase of the shear modulus and viscosity of the entire cell, including the cytoplasm and lipid membrane [11]. (webmedcentral.com)
  • Cartwright I. J., A. G. Pockley, J. H. Galloway, M. Greaves, F. E. Preston (1985) The effects of dietary ω-3 polyunsaturated fatty acids on erythrocyte membrane phospholipids, erythrocyte deformability and blood viscosity in healthy volunteers. (edu.pl)
  • The molecular organization of the membrane of the red blood cell controls cell morphology and function and is thereby a main determinant of red blood cell homeostasis in the circulation. (frontiersin.org)
  • Also, we found that most of these correlations were absent in misshapen red blood cells that have an inborn defect in the interaction between the membrane and the cytoskeleton. (frontiersin.org)
  • The observations suggest that deformability and aggregation share at least one common, membrane-related molecular mechanism. (frontiersin.org)
  • Together with data obtained after treatment with various agents known to affect membrane organization in vitro , our findings suggest that a phosphorylation-controlled interaction between the cytoskeleton and the integral membrane protein band 3 is part of the membrane-centered mechanism that plays a role in deformability as well as aggregation. (frontiersin.org)
  • Studies of inborn errors of metabolism and membrane protein composition, in combination with the structural and functional changes that occur during RBC aging, have led to a membrane-centered molecular understanding of red blood cell function and survival, and of the role of membrane molecules in cell morphology and membrane organization. (frontiersin.org)
  • Previous studies have shown that diamide increases the shear modulus and viscosity of the RBC membrane skeleton by creating disulphide bonds preferentially on the spectrin proteins. (webmedcentral.com)
  • Influence of cobalt chloride on biochemical parameters in blood sera. (bsb-bg.eu)
  • As a first step, we correlated a number of deformability and aggregation parameters in red blood cells from healthy donors, which we obtained in the course of our studies on red blood cell homeostasis in health and disease. (frontiersin.org)
  • Red blood cells have unique mechanical behavior, which can be discussed under the terms erythrocyte deformability and erythrocyte aggregation. (wikipedia.org)
  • This elastic property is the largest contributing factor to the viscoelastic behavior of blood. (wikipedia.org)
  • Tissue oxygenation depends on hemoglobin as much as on red blood cell (RBC) characteristics such as metabolism, communication with the immune system, deformability and aggregation behavior. (frontiersin.org)
  • Laviocard+" promotes improvement rheological blood properties as well as the condition of erythrocytes, improves its deformability and hemodynamic characteristics. (ametis.ru)
  • The presence of circulating tumor cells (CTCs) in peripheral blood can serve as a "liquid biopsy" approach and has thus emerged lately as one of the hottest fields in cancer research. (shengsci.com)
  • Influence of cobalt chloride on mouse peripheral blood cells. (bsb-bg.eu)
  • Role of RBC deformability and morphology. (bsb-bg.eu)
  • Role of RBC Deformability and Morphology, IFMBE Proceedings Series, vol.31, pp. 330-333, 2010, C.T. Lim and J.C.H. Goh (Eds. (bsb-bg.eu)
  • This approach takes previous results of mechanical studies on specifically isolated blood cells to the level of application directly in blood and adds a functional dimension to conventional blood analysis. (elifesciences.org)
  • Notably, it has been recently shown that the coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is underlined by changes in the mechanical properties of blood cells, including decreased erythrocyte deformability and decreased lymphocyte and neutrophil stiffness as compared to blood cells from SARS-CoV-2-naïve individuals 6 . (jove.com)
  • Additionally, biophysical properties, such as deformability, were found to be changed during the infection. (bvsalud.org)
  • Blood is a viscoelastic fluid, meaning that it possesses both viscous and fluid characteristics. (wikipedia.org)
  • a small part of the energy is dissipated by the viscosity of the suspension, another part is stored as elastic energy in the red blood cells, and the remaining energy is used to drive blood circulation and is thus converted to kinetic energy. (wikipedia.org)
  • In a drop of blood we can identify all major blood cells and characterize their pathological changes in several disease conditions in vitro and in patient samples. (elifesciences.org)
  • The red blood cells occupy about half of the volume of blood and possess elastic properties. (wikipedia.org)
  • What determines blood rheological properties? (rheology.biz)
  • show that this approach can detect characteristic changes that affect blood cells as a result of malaria, spherocytosis, bacterial and viral infections, and leukemia. (elifesciences.org)
  • Based on this phenomenon, we developed a portable capillary-driven microfluidic device that separates blood microsamples collected from finger-pricks and delivers 2 µL of metered serum for bench-top analysis. (researchgate.net)
  • Additionally, the neuronal type of nAChRs can also be found in non-neuronal tissues such as lymphocytes, platelets, macrophages, myelo- and erythrocyte progenitors, as well as mature erythrocytes [2][3]. (dysona.org)
  • Additionally, the red blood cell-acetylcholinesterase activity was regulated in all patients within the pre-set therapeutic target of 25-35 U/g Hb. (dysona.org)
  • Alongside malaria infection inside the human red blood cells, parasites consume host hemoglobin generating the hemozoin crystal as a by-product. (bvsalud.org)
  • CTCs can be isolated from blood in a non-invasive approach, and can be used to follow patients over time since these cells can provide significant information for a better understanding of tumor biology and tumor cell dissemination. (shengsci.com)
  • A first routine measure to narrow down diagnosis in clinical practice is the differential blood count, determining the frequency of all major blood cells. (elifesciences.org)
  • To address this need, we introduce the continuous, cell-by-cell morpho-rheological (MORE) analysis of diluted whole blood, without labeling, enrichment or separation, at rates of 1000 cells/sec. (elifesciences.org)
  • One of the first steps is to obtain a blood sample and to count how many of the different blood cells are present in it. (elifesciences.org)
  • A large number of certain white blood cells, for example, can show that the body is fighting an infection. (elifesciences.org)
  • But there might be several reasons why the number of white blood cells has increased, so this information alone is often not enough for a specific diagnosis. (elifesciences.org)
  • Can we get more decisive information from the initial blood test by measuring other properties of the blood cells? (elifesciences.org)
  • A computer algorithm can then analyze the size and stiffness of the blood cells in real-time. (elifesciences.org)
  • Rodrigues RO, Faustino V, Pinto E, Pinho D, Lima R. Red Blood Cells deformability index assessment in a hyperbolic microchannel: the diamide and glutaraldehyde effect. (webmedcentral.com)
  • This recognizes the significant body of work available for the structurally similar material, ethylene glycol butyl ether, which has been shown to exert toxicity in rodents primarily through hemolysis of red blood cells with effects secondary to this in the liver, kidney and spleen. (europa.eu)
  • Resistance in Red Blood Cells from Humans with Potential Susceptibility. (europa.eu)
  • Blood viscosity also increases with increases in red cell aggregability. (wikipedia.org)
  • Red blood cell distribution width: A simple parameter with multiple clinical applications. (shengsci.com)
  • The red blood cell distribution width (RDW) is a simple and inexpensive parameter, which reflects the degree of heterogeneity of erythrocyte volume (conventionally known as anisocytosis), and is traditionally used in laboratory hematology for differential diagnosis of anemias. (shengsci.com)
  • Pyridostigmine bromide and huperzine A are pharmacological agents that function as inhibitors of red blood cell-acetylcholinesterase. (dysona.org)
  • Six MG patients were monitored for subjective enhancements in MG symptoms and quality of life as well as red blood cell-acetylcholinesterase activity and acetylcholine receptor antibody binding reduction before and four weeks after the initiation of the treatment protocol. (dysona.org)
  • [4] It is a xanthine derivative and is believed to work by increasing red blood cell flexibility. (mdwiki.org)
  • The proteases of the drug, by binding to transport proteins of the blood (α-2-macroglobulin and α-1-antitrypsin), form a reversible protease-antiprotease complex, in which the antigenic determinants of exogenous proteases of the drug are masked, which prevents allergic reactions. (pillbuys.com)
  • Anemia can reduce blood viscosity, which may lead to heart failure. (wikipedia.org)
  • The proteases of the drug reduce the level of pro-inflammatory cytokines (IL-1β, IL-6, IL-8, INF-γ, TNF-α) and help increase the production of anti-inflammatory cytokines (including IL-4, IL-10), regulate the level Ig and blood antibodies. (pillbuys.com)
  • MGH researchers have succeeded in growing hair faster and thicker in mice, thanks to a protein that promotes blood vessel growth in their skin. (hairloss-research.org)
  • To explore these questions, Kiichiro Yano, a research associate in MGH Dermatology, and his colleagues compared two groups of mice, one normal and one genetically programmed to produce an abundance of VEGF, a protein known to trigger blood vessel growth. (hairloss-research.org)
  • l Trilinolein, isolated from the traditional Chinese herb Sanchi (Panax notoginseng), has been shown to have various beneficial effects including reducing thrombogenicity, erythrocyte deformability and arrhythmias. (bfsumastore.com)