MesylateDilationAlmotriptanRizatriptanMigrainesConstrict blood vesselsTriptansMedicationsArteriesDilateNarrow the blood vesselsWorks by narrowing bloTrudhesaSumatriptanMedicationDerivativeSerotonin receptorsVasoconstrictionCranialWorkload of the heartHeadachesPotentSpraysCoronaryBrainIntravenous infusionVeinsInflammationErgonovineCerebralHeart or bloodIschemicSymptomsCirculationNauseaDiseaseHoursAnginaMedicinesKidneyOccurPain
Mesylate10
- Each mL of injectable solution contains dihydroergotamine mesylate 1 mg. (medbroadcast.com)
- D.H.E. 45 (dihydroergotamine mesylate) is an ergot alkaloid used to treat a migraine or cluster headache attack. (rxlist.com)
- Our D.H.E. 45 (dihydroergotamine mesylate) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication. (rxlist.com)
- D.H.E. 45 (dihydroergotamine) ® is ergotamine hydrogenated in the 9, 10 position as the mesylate salt. (rxlist.com)
- D.H.E. 45® (dihydroergotamine mesylate) Injection, USP is indicated for the acute treatment of migraine headaches with or without aura and the acute treatment of cluster headache episodes. (rxlist.com)
- D.H.E. 45® (dihydroergotamine mesylate) Injection, USP should be administered in a dose of 1 mL intravenously, intramuscularly or subcutaneously. (rxlist.com)
- Available as a clear, colorless, sterile solution in single 1 mL sterile ampuls containing 1 mg of dihydroergotamine mesylate per mL, in packages of 10 (NDC 0078-0041-01). (rxlist.com)
- Serious cardiac events, including some that have been fatal, have occurred following use of D.H.E. 45® (dihydroergotamine mesylate) Injection, USP, but are extremely rare. (rxlist.com)
- Ergot alkaloids -- such as ergotamine tartrate ( Cafergot ) and dihydroergotamine mesylate (D.H.E. 45 Injection, Migranal Nasal Spray) -- are potent drugs that constrict blood vessels. (rxlist.com)
- Each mL of clear, colourless to faintly yellow solution contains dihydroergotamine mesylate USP 4 mg. (mediresource.com)
Dilation5
- This relieves the dilation (widening) of blood vessels, which is related to migraine headache pain. (medbroadcast.com)
- Migraine symptoms occur, in part, because of the dilation of blood vessels in the brain. (rxlist.com)
- While analgesics, NSAIDs, and narcotics relieve pain, they don't address the underlying physiology -- primarily the dilation of blood vessels in the brain. (rxlist.com)
- Dilation of blood vessels … Most cases of aplastic anemia are idiopathic, meaning the underlying cause is unknown. (kraneks.by)
- Dilation of blood vessels. (headacheaustralia.org.au)
Almotriptan1
- Are you taking any other migraine 5-HT 1 agonist medications such as sumatriptan succinate, naratriptan hydrochloride, rizatriptan benzoate, almotriptan malate or migraine medications containing ergotamine, dihydroergotamine, or methysergide? (pricepropharmacy.com)
Rizatriptan1
- Rizatriptan decreases this widening and returns the blood vessels to their normal size, helping to relieve the pain. (mydr.com.au)
Migraines3
- Ergots (ergotamine or dihydroergotamine preparations), like triptans, abort migraines by constricting of blood vessels. (tianmedical.com)
- Sumatriptan relieves migraines by stimulating serotonin receptors in the brain which cause the muscles surrounding the blood vessels in the brain to contract and narrow the blood vessels. (hdkino.org)
- A major cause of migraines is high blood pressure. (v-carepharmacy.com)
Constrict blood vessels1
- The main effect of ergotamine is to constrict blood vessels, sometimes so severely as to cause gangrene of fingers and toes. (britannica.com)
Triptans6
- But newer migraine drugs known as triptans cause constriction of blood vessels and also bring about a general interruption in the chain of chemical events that leads to a migraine. (rxlist.com)
- But unlike triptans, they don't narrow your blood vessels. (webmd.com)
- The biggest danger of triptans is heart attack or stroke in people with previously undiagnosed heart disease or risk factors like obesity and high blood pressure. (tianmedical.com)
- Ergots are not as targeted as triptans, however, and cause constriction of vessels throughout the body, not just in the brain. (tianmedical.com)
- Like triptans, they act by constricting the blood vessels. (healthvigil.com)
- However not like triptans, they don't slender your blood vessels. (ezesavers.com)
Medications8
- Dihydroergotamine belongs to a family of medications called ergot alkaloids . (medbroadcast.com)
- These medications work by constricting blood vessels in the head. (medbroadcast.com)
- D.H.E. 45 may interact with other migraine headache medicines, zileuton, cold or allergy medications, nicotine , diet pills, stimulants, medication to treat ADHD , antidepressants , antifungal medications, or heart or blood pressure medication. (rxlist.com)
- These include certain blood pressure medications as well as some antidepressants , anti- seizure drugs, and herbals. (rxlist.com)
- These medications have anti-inflammatory effects and are thought to narrow the blood vessels in your brain, helping to ease pain. (healthline.com)
- Ergotamine and its derivative, dihydroergotamine are the cheaper and older medications still being prescribed to treat migraine. (healthvigil.com)
- If a moderate to severe migraine attack is underway, however, triptan or dihydroergotamine (DHE) medications are recommended. (chemist2u.com.au)
- Blood pressure-lowering medications help prevent the blood vessels from dilating , which also helps reduce the frequency of attacks. (seattlecrc.com)
Arteries5
- It results from relaxation of smooth muscle cells within the vessel walls, in particular in the large veins, large arteries, and smaller arterioles.The process is the opposite of vasoconstriction, which is the narrowing of blood vessels. (kraneks.by)
- The vessels that carry blood away from the heart are called arteries. (kraneks.by)
- High blood pressure adds to the workload of the heart and arteries. (apollopharmacy.in)
- Hypertension or high blood pressure is a long-term force of the blood against the arteries that may lead to various heart diseases. (apollopharmacy.in)
- It can damage the blood vessels (arteries) of the brain, heart, and kidneys if it continues for a long time, resulting in a stroke, heart failure or kidney failure. (apollopharmacy.in)
Dilate3
- Later, the blood vessels dilate or enlarge, leading to increased blood flow and a severe headache. (mountsinai.org)
- Various theories have been put forward to explain why these vessels tend to dilate. (abdel-gadir.com)
- During a migraine attack, blood vessels in the brain dilate, or widen, resulting in a throbbing pain. (mydr.com.au)
Narrow the blood vessels1
- They narrow the blood vessels in the brain, reducing the symptoms. (chemist2u.com.au)
Works by narrowing blo1
- It works by narrowing blood vessels around the brain, stopping pain signals from being sent to the brain, and blocking the release of natural substances that cause pain, nausea, and other symptoms of migraine. (medlineplus.gov)
Trudhesa1
- Serious or potentially life-threatening reductions in blood flow to the brain or extremities due to interactions between dihydroergotamine (the active ingredient in Trudhesa) and strong CYP3A4 inhibitors (such as protease inhibitors and macrolide antibiotics) have been reported rarely. (trudhesa.com)
Sumatriptan5
- Sumatriptan relieves migraine headaches by constricting these blood vessels. (medbroadcast.com)
- Sumatriptan has caused serious side effects in some people, especially people who have heart or blood vessel disease. (mayoclinic.org)
- Sumatriptan may elevate blood pressure in individuals with or without a history of high blood pressure. (hdkino.org)
- Individuals with uncontrolled high blood pressure should not use sumatriptan. (hdkino.org)
- Monoamine oxidase inhibitors or MAOIs , for example, isocarboxazid (Marplan), phenelzine (Nardil), tranylcypromine (Parnate), and procarbazine ( Matulane ), may reduce the breakdown of sumatriptan in the liver , leading to increased blood levels and side effects of sumatriptan. (hdkino.org)
Medication2
- Verapamil (Calan, generic), a drug for high blood pressure, is typically the first choice of medication used for long-term prevention. (adam.com)
- One of the classic ways of tackling a migraine is through a medication called Dihydroergotamine, or DHE for short. (encoredocs.com)
Derivative1
- Dihydroergotamine, a derivative, can be used in treating migraine. (britannica.com)
Serotonin receptors2
- work by attaching to serotonin receptors on the blood vessels and nerves in the brain. (tianmedical.com)
- Their main action is on the serotonin receptors, which are present in the nerve endings as well as the blood vessels. (healthvigil.com)
Vasoconstriction2
- This causes vasoconstriction (narrowing of blood vessels). (healthline.com)
- Ergotamine and its derivatives work by activating the 5-HT1D receptors, causing vasoconstriction of intracranial blood vessels and inhibiting the release of inflammatory neuropeptides. (pharmacytimes.com)
Cranial2
- Action Constricts peripheral and cranial blood vessels, depresses central vasomotor centers, and reduces extracranial blood flow. (medicscientist.com)
- Tumour size, cavernous sinus invasion, traction or displacement of intracranial pain-sensitive structures such as blood vessels, cranial nerves and dura mater, and hormonal hypersecretion are implicated causes. (medscape.com)
Workload of the heart1
- These drugs relax the muscle walls in the blood vessels so that the workload of the heart is reduced. (zeepedia.com)
Headaches3
- The pain of migraine headaches is thought to be caused by dilated blood vessels inside the head. (medbroadcast.com)
- Ergomar works by targeting the blood vessels around the brain that affects the blood flow patterns associated with headaches. (optionrx.com)
- Migraine headaches are believed to result from dilatation of blood vessels in the brain. (hdkino.org)
Potent2
- Serious and/or life-threatening peripheral ischemia has been associated with the coadministration of DIHYDROERGOTAMINE with potent CYP 3A4 inhibitors including protease inhibitors and macrolide antibiotics. (rxlist.com)
- Ergotamine and dihydroergotamine, two notable members of this category, are potent vasoconstrictors that alleviate migraine symptoms by narrowing blood vessels in the brain. (pharmaoffer.com)
Sprays2
- The recommended dose of dihydroergotamine is one spray in each nostril (total of 2 sprays) at the first sign or symptom of a migraine headache, or as early as possible after the onset of migraine headache pain. (medbroadcast.com)
- One bottle of dihydroergotamine nasal spray contains 4 sprays. (medbroadcast.com)
Coronary1
- Obstruction of blood flow in a coronary artery by a blood clot (thrombus). (kraneks.by)
Brain5
- Researchers are not sure what causes a migraine, but they know it involves changes in the blood flow to the brain. (mountsinai.org)
- Midodrine does not cross the blood-brain barrier and is not associated with CNS effects. (scireproject.com)
- It is known that estrogen is able to cross the blood-brain-barrier freely. (sunshinentc.com)
- When stimulated, the nerve may release substances that cause painful inflammation in the blood vessels of the brain (cerebral blood vessels) and the layers of tissues that cover the brain (meninges). (msdmanuals.com)
- ZOMIG is a headache medicine that narrows blood vessels around the brain. (pricepropharmacy.com)
Intravenous infusion1
- Prostaglandin E 1 also dilates blood vessels, and it is sometimes administered by intravenous infusion to treat peripheral vascular disease . (britannica.com)
Veins3
- On the other hand, excessive local production of oestrogens could lead to dilatation and stasis of blood in the pelvic veins leading to pelvic pain in women with abnormal ovarian function [Kroon and Reginald, 2005]. (abdel-gadir.com)
- Veins are vessels that return blood to the heart. (kraneks.by)
- This increased or decreased blood pressure causes the veins & valves to contract and expand accordingly putting pressure on the blood vessels and the heart. (kraneks.by)
Inflammation2
- By blocking these receptors, inflammation is reduced and the vessels are able to constrict. (tianmedical.com)
- They act by constricting the blood vessels and reducing inflammation, thus giving relief from pain. (healthvigil.com)
Ergonovine1
- Ergonovine has much less effect on blood vessels but a stronger effect on the uterus. (britannica.com)
Cerebral1
- Because CYP 3A4 inhibition elevates the serum levels of DIHYDROERGOTAMINE, the risk for vasospasm leading to cerebral ischemia and/or ischemia of the extremities is increased. (rxlist.com)
Heart or blood1
- Have you ever had heart or blood vessel disease? (pricepropharmacy.com)
Ischemic1
- Tell your doctor if you have heart disease or blood circulation problems, including heart rhythm problems, ischemic bowel disease, peripheral vascular disease, or a history of heart attack, angina (chest pain), stroke, or transient ischemic attack (TIA). (limamemorial.org)
Symptoms3
- At first, blood vessels narrow or constrict, reducing blood flow and leading to visual disturbances, difficulty speaking, weakness, numbness, or tingling sensation in one area of the body, or other similar symptoms. (mountsinai.org)
- Symptoms are attributed to ischaemia of the tissues and blood vessels themselves subsequent to slow blood drainage and stasis especially following increased intra-abdominal pressure. (abdel-gadir.com)
- Betamerit-XL 50 Tablet 15's belongs to a group of medicines called "Antihypertensive" used alone or together with other drugs to treat high blood pressure (hypertension), symptoms caused by an overactive thyroid gland, heart-related chest pain (angina), heart rhythm disorder (arrhythmia). (apollopharmacy.in)
Circulation2
- In case of circulatory collapse (poor blood circulation). (zeepedia.com)
- Ergotamine should not be taken by patients with liver or kidney disease, heart disease, circulation problems, high blood pressure, or an infection of the blood. (optionrx.com)
Nausea1
- Nausea is a common side effect but Dihydroergotamine has fewer side effects than its parent ergotamine and is more effective. (healthvigil.com)
Disease1
- Tosymra is not for people with risk factors for heart disease (high blood pressure or cholesterol, smoking, overweight, diabetes, family history of heart disease) unless a heart exam is done and shows no problem. (tosymra.com)
Hours1
- However, the primary metabolite reaches peak blood concentrations about 1 to 2 hours after a dose of Midodrine and has a half-life of about 3 to 4 hours. (scireproject.com)
Angina1
- Lowering blood pressure reduces the risk of stroke, heart attack and heart-related chest pain (angina). (apollopharmacy.in)
Medicines1
- HA719 trade name] is used in combination with other HIV medicines to reduce the amount of virus in your blood and keep it at a low level. (who.int)
Kidney2
- This lowers your blood pressure and reduces the risk of having a stroke, a heart attack, other heart problems or kidney problems in the future. (apollopharmacy.in)
- This, in turn, lowers your overall body's blood pressure and helps in reducing the risk of having a stroke, heart problems, or kidney problems in the future. (apollopharmacy.in)
Occur2
- Dihydroergotamine is most effective if used at the first sign of a migraine headache with or without aura (warning signs that occur prior to the onset of a migraine headache). (medbroadcast.com)
- Orthostatic hypotension (sudden lowering of blood pressure n standing) might occur so patients using Betamerit-XL 50 Tablet 15's should get up with caution. (apollopharmacy.in)
Pain1
- Dilated blood vessels contribute towards the pain of a migraine attack. (headacheaustralia.org.au)