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  • vascular
  • St. Croix and his colleagues focused on endothelial cells, which line the inner surface of blood vessels and are critical for new vascular growth. (nih.gov)
  • The word vascular , meaning relating to the blood vessels, is derived from the Latin vas , meaning vessel. (wikipedia.org)
  • When blood vessels connect to form a region of diffuse vascular supply it is called an anastomosis . (wikipedia.org)
  • Scientists have discovered new ways in which the body regulates blood clots, in a discovery which could one day lead to the development of better treatments that could help prevent and treat conditions including heart diseases, stroke and vascular dementia. (news-medical.net)
  • These blood vessels (pictured) - also called tissue-engineered vascular grafts - are made ahead of time and stored, so surgeons can grab them off the shelf whenever they need them. (zdnet.com)
  • Their results confirmed a connection previously suggested by other studies - that blood flow regulates the expression of CXCR4, a gene important to vascular development. (yaledailynews.com)
  • According to the researchers, this silencing is a form of "down" regulation, which is what is seen in the crosstalk between blood flow patterns and the expression of the important CXCR4 gene, which governs many elements of vascular development. (yaledailynews.com)
  • Engineered blood vessels could one day be transplanted into tissues such as the kidneys, liver, heart or any other organs that require large amounts of vascular tissue, which moves nutrients, gases and waste to and from cells. (innovations-report.com)
  • Vasoconstriction is the constriction of blood vessels (narrowing, becoming smaller in cross-sectional area) by contracting the vascular smooth muscle in the vessel walls. (wikipedia.org)
  • In hemodialysis, vascular access is used to remove the patient's blood so that it can be filtered through the dialyzer. (wikipedia.org)
  • Vascular permeability, often in the form of capillary permeability or microvascular permeability, characterizes the capacity of a blood vessel wall to allow for the flow of small molecules (drugs, nutrients, water, ions) or even whole cells (lymphocytes on their way to the site of inflammation) in and out of the vessel. (wikipedia.org)
  • Innervated by barometric nerve terminals, the aortic arch is responsible for sensing changes in the dilation of the vascular walls, inducing changes in heart rate to compensate for changes in blood pressure. (wikipedia.org)
  • tissue
  • In many diseases, including most forms of cancer, this carefully regulated process becomes imbalanced, and normal blood vessel growth is redirected toward supplying nutrients and oxygen to feed diseased tissue, destroy normal tissues, and in the case of cancer, allow tumor cells to escape and travel to distant sites in the body. (nih.gov)
  • However, blocking angiogenesis requires a delicate balance between tumor and normal cells as most angiogenesis-related molecules are also critical for normal blood vessel growth in the body - for example, during menstruation, pregnancy, or tissue repair. (nih.gov)
  • Research published this week describes how lab-grown blood vessels were transformed into living tissue when grafted into dialysis patients needing replacement blood vessels. (news-medical.net)
  • Prof. Wasserman and his colleagues note that the "ability of insulin to stimulate glucose uptake" in muscle cells "depends on the rate at which insulin gets through the endothelium," which is the thin layer of tissue that lines the blood vessels and controls movement of substances in and out of the bloodstream. (medicalnewstoday.com)
  • The intravascular module should be equipped with an opto-acoustical imaging sensor which can provide an internal image of the tissue of the coronary blood vessels up to a depth of 1 mm. (innovations-report.com)
  • To achieve this, a guided laser impulse from an illuminating fiber is first absorbed by the blood vessel tissue. (innovations-report.com)
  • Nearly every epithelium rests on a layer of areolar tissue, whose blood vessels provide the epithelium with nutrition, waste removal, and a ready supply of infection-fighting leukocytes in times of need. (wikipedia.org)
  • vein
  • Large collecting vessels, such as the subclavian vein , the jugular vein , the renal vein and the iliac vein . (wikipedia.org)
  • The term "arterial blood" is nevertheless used to indicate blood high in oxygen , although the pulmonary artery carries "venous blood" and blood flowing in the pulmonary vein is rich in oxygen. (wikipedia.org)
  • Two carry blood to it - the hepatic artery and the portal vein - while the third, the hepatic vein, returns the blood which has circulated through the gland to the posterior vena cava, which it joins just before that vessel perforates the diaphragm to discharge its blood into the right auricle of the heart. (chestofbooks.com)
  • The portal vein is a large trunk that contains the blood returning from the stomach and intestines, and from the spleen and pancreas . (chestofbooks.com)
  • Vein , in human physiology, any of the vessels that, with four exceptions, carry oxygen-depleted blood to the right upper chamber (atrium) of the heart . (britannica.com)
  • To avoid complications, surgeons prefer to use vessels taken from a patient's own body - harvesting a portion of vein from the leg, for example. (zdnet.com)
  • Large blue vessel (vena cava) _(includes the superior and inferior vena cava) - _Large vein that empties blood into the right atrium of the heart. (clevelandclinic.org)
  • Catheter access, sometimes called a CVC (central venous catheter), consists of a plastic catheter with two lumens (or occasionally two separate catheters) which is inserted into a large vein (usually the vena cava, via the internal jugular vein or the femoral vein) to allow large flows of blood to be withdrawn from one lumen, to enter the dialysis circuit, and to be returned via the other lumen. (wikipedia.org)
  • During treatment, two needles are inserted into the vein, one to draw blood and one to return it. (wikipedia.org)
  • aorta
  • This is so-called because it is a narrowing (isthmus) of the aorta as a result of decreased blood flow when in foetal life. (wikipedia.org)
  • cancers
  • They found that the CD276 protein was overexpressed in tumor-associated blood vessels from colon, lung, breast, esophageal and bladder cancers. (nih.gov)
  • These studies demonstrate that CD276 is overexpressed in the blood vessels of a variety of human cancers," says St. Croix. (nih.gov)
  • Tumor markers, chemicals sometimes found in the blood of people with cancer, can be helpful in diagnosing and monitoring the course of liver cancers. (wikipedia.org)
  • 2019
  • A minimally invasive surgery combining the use of a clot-busting drug and a catheter to drain blood from the brain of hemorrhagic stroke patients reduced swelling and improved patients' prognoses, according to preliminary research to be presented in Honolulu at the American Stroke Association's International Stroke Conference 2019, a world premier meeting for researchers and clinicians dedicated to the science and treatment of cerebrovascular disease. (news-medical.net)
  • findings
  • The findings on tumor vessel size, for example, "would require us to re-examine our understanding of tumor blood flow and associated tumor metabolism, drug delivery, and tumor host interaction," Dr. Zhang said. (cancer.gov)
  • tumours
  • Cerebral aneurysms can also occur from force traumas to the skull, high blood pressure, infection, tumours, and drug use, especially frequent and repeated use of cocaine. (ehow.co.uk)
  • inhibitors
  • One pervading difference was that inhibitors of COMT enhanced the effect of isoprenaline at β-adrenoceptors (and the ensuing blood vessel relaxation) but not the effect of noradrenaline at α-adrenoceptors (and the ensuing blood vessel contraction). (wikipedia.org)
  • causes
  • The U.S. Food and Drug Administration today approved Cablivi (caplacizumab-yhdp) injection, the first therapy specifically indicated, in combination with plasma exchange and immunosuppressive therapy, for the treatment of adult patients with acquired thrombotic thrombocytopenic purpura (aTTP), a rare and life-threatening disorder that causes blood clotting. (news-medical.net)
  • brain
  • In a report in The American Journal of Pathology investigators describe the generation of a successful novel transgenic rat model that accumulates amyloid specifically in brain blood vessels and strongly mimics many of the associated detrimental changes that are observed in humans - a condition known as cerebral amyloid angiopathy, which is also commonly observed in Alzheimer disease. (news-medical.net)
  • Could our blood hold the molecular secrets to a fountain of youth, preventing age-related brain disorders? (news-medical.net)
  • The Stentrode™ is a device that is placed inside a blood vessel of the brain located in an area that controls movement (motor cortex). (news-medical.net)
  • Cocaine can cause blood vessels in the brain to spasm or rupture, a finding that could explain why many users of the drug suffer high blood pressure, brain hemorrhages and stroke, a New York researcher reports.In a study on rats, researcher Burton M. Altura reports he was able to produce these symptoms using ''minute'' doses of cocaine -- doses ''even lower than what you would get in a user of cocaine. (orlandosentinel.com)
  • Vascul Pharmacol 39, 225-237 (2002) Patlak, C. S., Blasberg, R. G. & Fenstermacher, J. D. Graphical evaluation of blood-to-brain transfer constants from multiple-time uptake data. (wikipedia.org)
  • fibers
  • A thin membrane of elastic fibers in the tunica intima run parallel to the vessel. (wikipedia.org)
  • It exhibits interlacing, loosely organized fibers,[citation needed] abundant blood vessels, and significant empty space filled with interstitial fluid. (wikipedia.org)
  • organs
  • This changes the blood flow to downstream organs, and is determined by the autonomic nervous system. (wikipedia.org)
  • dialysis
  • This sequence prevents partial recycling of the same blood through the dialysis machine, which would lead to less effective treatment. (wikipedia.org)
  • pathology
  • The researchers also found that all of the visualized tumor blood vessels were much larger in diameter than would have been anticipated based on animal studies or from pathology, Dr. Skitzki said. (cancer.gov)
  • glucose
  • But new research from UBC's Okanagan campus says that just one 75-gram dose of glucose--the equivalent a large bottle of soda or a plate of fries--while on a high fat, low carbohydrate diet can lead to damaged blood vessels. (news-medical.net)
  • Diabetes: Can gene therapy normalize blood glucose levels? (medicalnewstoday.com)
  • Acetohexamide A pill taken to lower the level of glucose (sugar) in the blood. (wikipedia.org)
  • Scientists
  • According to the new study , scientists could use cell banks to make as many as 37 large or 74 smaller blood vessels per donor, and cell banks put together from multiple donors could hold even more. (zdnet.com)
  • readily
  • The level of permeability is such as to allow small and medium-sized proteins such as albumin to readily enter and leave the blood stream. (wikipedia.org)
  • drugs
  • These genes, and the proteins they encode, are important new potential targets for novel drugs that could selectively cut off a tumor's blood supply without affecting the blood vessels of healthy tissues, overcoming one of the major concerns of current anticancer therapies targeted at blood vessel growth. (nih.gov)
  • Researchers have tried to stop disease-related angiogenesis by identifying the molecules that stimulate blood vessel and developing new drugs to block their action. (nih.gov)
  • Therefore, it may be an important target for the development of new drugs that can selectively home in on blood vessels associated with disease. (nih.gov)
  • Drugs that inhibit a hormone that constricts blood vessels also help improve sodium excretion in blacks who hold onto too much sodium in the face of stress, investigators report. (news-medical.net)
  • Blood vessel diameter can potentially affect treatment in several ways, including impeding drug delivery and the efficacy of immunotherapy drugs. (cancer.gov)
  • supply
  • But, until recently, the method had not been used in humans due to several technical challenges, including how to illuminate the tumor without interfering with surgery or disrupting the blood supply to the tumor. (cancer.gov)