AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and ProcessesAnthropology, Education, Sociology and Social PhenomenaInformation ScienceNamed GroupsHealth Care
Bone Marrow TransplantationHematopoietic Stem Cell TransplantationPeripheral Blood Stem Cell TransplantationTransplantation, HomologousBone MarrowTransplantation, AutologousBone Marrow CellsStem Cell TransplantationGraft vs Host DiseaseTransplantation ConditioningHematologic NeoplasmsHematopoietic Stem CellsBone and BonesWhole-Body IrradiationGraft SurvivalStem CellsTransplantation ChimeraCord Blood Stem Cell TransplantationHematopoietic Stem Cell MobilizationBusulfanTissue DonorsCombined Modality TherapyLeukemiaCyclophosphamideLiver TransplantationTreatment OutcomeGranulocyte Colony-Stimulating FactorMelphalanHistocompatibility TestingAnemia, AplasticAntigens, CD34RecurrenceHistocompatibilityRemission InductionBone Marrow DiseasesMultiple MyelomaHematopoiesisBone Marrow PurgingLeukapheresisTransplantation, IsogeneicAntineoplastic Combined Chemotherapy ProtocolsImmunosuppressive AgentsLymphoma, Non-HodgkinLeukemia, Myeloid, AcuteKidney TransplantationMyeloablative AgonistsTime FactorsRetrospective StudiesLeukemia, Myelogenous, Chronic, BCR-ABL PositiveSurvival AnalysisDisease-Free SurvivalPrecursor Cell Lymphoblastic Leukemia-LymphomaMyelodysplastic SyndromesHematologic DiseasesBlood Component RemovalGraft vs Leukemia EffectBone Marrow ExaminationSurvival RateEtoposideMice, Inbred C57BLCell DifferentiationBone RemodelingMesenchymal Stem Cell TransplantationLymphocyte DepletionTransplantation ImmunologyInfectionHepatic Veno-Occlusive DiseaseImmunosuppressionBone Marrow NeoplasmsHLA AntigensCytarabineCell TransplantationGraft RejectionAntineoplastic Agents, AlkylatingAcute DiseaseColony-Forming Units AssayCarmustineHodgkin DiseaseSalvage TherapyFollow-Up StudiesHeart TransplantationCytomegalovirus InfectionsBlood CellsVidarabineT-LymphocytesThiotepaRadiation ChimeraLymphomaCyclosporineLeukemia, MyeloidFatal OutcomeLymphocyte TransfusionLung TransplantationGraft vs Tumor EffectFlow CytometryVincristineCells, CulturedNuclear FamilyBone DensityLeukocyte Count
Umbilical-cordKidney TransplantationChemotherapyGraft versusMultiple myelomaLeukemiaDonorsLymphomaAutologous hematopoietic stem cell transAcuteAplasticCancersTherapyHSCTAllogeneic hemaProgenitorGraftsDonor's bone marrow2000GVHDNormal bone marrowCalled an allogeneicCord Blood2022CancerDisordersCorneal TransplantationPatient'sTransfusionBiopsyHematologyHaploidenticalPediatricTransplants workSolid tumorsDiseases2021SickleHematopoietic stemLymphoidRetrospective analysisImmature2020Transplant ProgramCollected from a donorCurativeFluorescence in situ hybriAdultsTreatmentsMalignanciesTumorsOrganDonor stem cellsSurvivalUndergo
Umbilical-cord7
Kidney Transplantation3
Chemotherapy29
  • In addition to complications seen from exposure to chemotherapy and radiation, patients undergoing allogeneic transplantation can experience unique late effects secondary to graft versus host disease (GVHD) and autoimmunity. (medscape.com)
  • Stem cell transplantation is performed after high-dose chemotherapy (HDC) to restore a cancer patient's blood and immune cell production capacity. (bdbiosciences.com)
  • 3 Following exogenous stimulation, such as chemotherapy or using growth factors such as granulocyte colony stimulating factor (G-CSF) and filgrastim, the number of HSCs in the peripheral blood increases, either becoming on par or even exceeding the number in the bone marrow. (bdbiosciences.com)
  • For many hematopoietic malignancies, collection and infusion of CD34+ hematopoietic stem/progenitor cells following chemotherapy is critical. (bdbiosciences.com)
  • Other risk factors for survival were primary refractory disease, initial lymphoma stage, number of previous chemotherapy lines, and high amounts of blood product transfusions. (smw.ch)
  • Autologous bone marrow transplantation as compared with salvage chemotherapy in relapses of chemotherapy-sensitive non-Hodgkin's lymphoma. (smw.ch)
  • High-dose therapy and autologous bone marrow transplantation after failure of conventional chemotherapy in adults with intermediate-grade or high-grade non-Hodgkin's lymphoma. (smw.ch)
  • High-dose sequential chemotherapy followed by autologous stem cell transplantation in relapsed and refractory aggressive non-Hodgkin's lymphoma: results of a multicenter phase II study. (smw.ch)
  • High dose sequential chemotherapy and autologous stem cell transplantation in patients with relapsed/refractory lymphoma. (smw.ch)
  • The role of intensive therapy and autologous blood and marrow transplantation for chemotherapy-sensitive relapsed and primary refractory non-Hodgkin's lymphoma: identification of major prognostic groups. (smw.ch)
  • High-dose chemotherapy with autologous bone marrow transplantation: 11 years' experience in Zurich. (smw.ch)
  • Treatments for leukemia include chemotherapy, radiation therapy, and stem cell transplants. (medicalnewstoday.com)
  • Chemotherapy, radiation therapy, targeted therapy, and stem cell or bone marrow transplant are common treatment options for leukemia. (medicalnewstoday.com)
  • Chemotherapy uses drugs to kill cancer cells and slow or stop their growth. (medicalnewstoday.com)
  • Some supportive therapies, such as anti-nausea medications or growth factors to boost blood cell production, may help manage side effects and improve quality of life during chemotherapy. (medicalnewstoday.com)
  • Autologous transplantation involves extracting a person's stem cells from the bone marrow or blood and freezing them before a person has chemotherapy or radiation therapy. (medicalnewstoday.com)
  • Doctors transplant the donor's stem cells into the individual after chemotherapy or radiation therapy to replace their diseased or damaged stem cells. (medicalnewstoday.com)
  • Once the process is complete, the NK cells can be transplanted to patients without prior chemotherapy. (biologynews.net)
  • Currently, recipients that undergo BMT are treated with toxic agents such as radiation and chemotherapy in order to in order to eliminate their own blood forming stem cells and permit the donor cells to take and develop. (ca.gov)
  • [ 2 ] Options for second-line therapy in patients with relapsed/refractory disease include chemotherapy-free regimens with biologic targeted agents such as covalent Bruton tyrosine kinase (BTK) inhibitors, lenalidomide,venetoclax, and chimeric antigen receptor (CAR) T-cell therapy. (medscape.com)
  • OUTLINE: Patients receive 2 courses of reinduction chemotherapy followed by bone marrow biopsy and aspirate prior to peripheral blood stem cell (PBSC) harvest. (knowcancer.com)
  • If marrow involvement is still present at harvest, then 2 additional courses of induction chemotherapy are given. (knowcancer.com)
  • T-prolymphocytic leukemia (T-PLL) is an aggressive mature T-cell neoplasm that responds poorly to conventional chemotherapy and has a dismal outcome. (haematologica.org)
  • The transplant of blood stem cells or bone marrow will be infused one to three days after the last chemotherapy or radiation dose. (ucsfhealth.org)
  • Consolidation chemotherapy can follow induction chemotherapy to treat any remaining leukemia cells that are not visible in the blood or bone marrow. (medicalnewstoday.com)
  • Research suggests that while treatments such as intensive chemotherapy and allogeneic stem cell transplantation may be curative for younger people, they are less likely to be effective in older individuals. (medicalnewstoday.com)
  • Hematopoietic stem cell transplantation is also sometimes used for solid tumors (eg, some germ cell tumors) that respond to chemotherapy. (msdmanuals.com)
  • AML (Acute Myeloid Leukemia) is a blood cancer (haematological malignancy), and the standard way of treating older AML patients is chemotherapy. (lu.se)
  • Because of the patient's risk status, the physicians intended to perform allogeneic stem cell transplantation after induction and consolidation chemotherapy, which was scheduled to end in January 2013, and a conditioning chemotherapy regimen, which was planned to be given in March. (cdc.gov)
Graft versus4
  • Cord blood is a promising source of natural killer cells because the NK cells have enhanced sensitivity to stimulation, decreased potential to cause graft-versus-host disease and are available from cord banks throughout the country and world," says Zweidler-McKay. (biologynews.net)
  • Graft-versus-host disease is a common side effect of patients receiving stem cell transplants, which results when the T cells in the transplanted blood react against the patient's own cells. (biologynews.net)
  • Peripheral Blood versus Bone Marrow from Unrelated Donors: Bone Marrow allografts have improved Long-term Overall and Graft-versus-Host Disease, Relapse-Free Survival. (stembook.org)
  • The allogeneic HSCT was the most frequently performed (57.14%) and the most used source of Hematopoietic progenitor cells (HPC) was the peripheral blood (54.29%) and 5.71% of these patients developed the Graft versus Host Disease (GVHD), of which one was affected by acute GVHD and another by chronic GVHD. (bvsalud.org)
Multiple myeloma7
Leukemia21
  • People with life-threatening cancers, such as leukemia , lymphoma , and myeloma can be treated with a bone marrow transplant or, sometimes, a stem cell transplant. (medlineplus.gov)
  • Create healthcare diagrams like this example called Leukemia - Stem Cell Transplantation in minutes with SmartDraw. (smartdraw.com)
  • The killing of leukemia cells is proportional to the radiation absorbed dose. (nature.com)
  • Stem cell transplantation, or bone marrow transplantation, is a treatment option for leukemia and other blood cancers. (medicalnewstoday.com)
  • Refractory ALL is a more challenging form of leukemia because the cancer cells have become resistant to standard treatments. (medicalnewstoday.com)
  • Patients with monoclonal gammopathy of unknown significance, smoldering MM, plasma cell leukemia and amyloidosis were excluded. (scielo.br)
  • [ 1 ] First described in 1848, MM is part of a spectrum of diseases ranging from monoclonal gammopathy of unknown significance ( MGUS ) to plasma cell leukemia. (medscape.com)
  • The Leukemia & Lymphoma Society® (LLS) is a global leader in the fight against blood cancer. (lls.org)
  • Patrick Zweidler-McKay, M.D., Ph.D., assistant professor of pediatrics from the Children's Cancer Hospital at M. D. Anderson, has shown an effective method for expanding the number of NK cells from a single cord blood unit while retaining the cells' anti-leukemia effects, as presented at the American Society of Pediatric Hematology/Oncology annual conference on May 16. (biologynews.net)
  • However, Zweidler-McKay and co-senior investigator Elizabeth Shpall, M.D., professor in M. D. Anderson's Department of Stem Cell Transplantation and Cellular Therapy, have found a novel process to increase NK cells in cord blood more than 30-fold, generating more than 150 million NK cells from one cord blood unit while maintaining their activation to find and kill acute leukemia cells. (biologynews.net)
  • When given to mice with aggressive human leukemias, these NK cells reduced the circulating human acute lymphocytic leukemia (ALL) and acute myelogenous leukemia (AML) cells by 60 to 85 percent. (biologynews.net)
  • These NK cells demonstrate significant cytotoxic activity against human AML and ALL cell lines and patient leukemia blasts. (biologynews.net)
  • Adult stem cell treatments have been used clinically to successfully treat leukemia and related bone/blood cancers using bone marrow transplantation. (kumc.edu)
  • 1 T-PLL cells commonly demonstrate rearrangements involving T-cell leukemia/lymphoma 1 (TCL1) family genes TCL1A, MTCP1 (mature T-cell proliferation), or TCL1B as molecular hallmarks. (haematologica.org)
  • The second patient underwent allogeneic bone marrow transplantation for acute myelogeneous leukemia from his sister. (koreamed.org)
  • Retrospective analysis by the Center for International Blood and Marrow Transplant Research (CIBMTR): Prompt complete remission plus consolidation therapy yields improved survival after allogeneic hematopoietic cell transplantation (allo-HCT) for patients with acute myeloid leukemia (AML) receiving a myeloablative conditioning regimen and not a reduced-intensity conditioning regimen. (ascopost.com)
  • Leukemia is an umbrella term for cancers affecting the blood-forming cells in the body. (medicalnewstoday.com)
  • Acute myelogenous leukemia (AML) is a type of cancer that involves the bone marrow. (medicalnewstoday.com)
  • It is different than other forms of leukemia because it has eight distinct subtypes, which develop from different types of cells. (medicalnewstoday.com)
  • AML is the most common type of acute leukemia in adults, and it happens when the bone marrow begins making myeloblasts, also called blasts. (medicalnewstoday.com)
  • Doctors use this treatment regimen to eliminate leukemia cells and bring blood counts back to normal. (medicalnewstoday.com)
Donors9
  • high-risk patients included male subjects, recipients of stem cells from female donors, patients younger than 10 years, those with nonidentical donors, and those who received radiation therapy in the transplant preparative regimen. (medscape.com)
  • Successful stem cell transplantation for patients with severe combined immunodeficiency (SCID) from matched family donors without conditioning results in engraftment of T lymphocytes. (nih.gov)
  • These substances include, for instance, granulocyte- colony-stimulating factor (G-CSF), which is added so that the donors own bone marrow will make and produce more stem cells that will end up in the bloodstream. (differencebetween.net)
  • Organ Transplantation.2 These Guiding Principles - whose emphases include voluntary donation, noncommercialization, genetic relation of recipients to donors and a preference for cadavers over living donors as sources - have considerably influenced professional codes, national, state and provincial legislation, and the policies of intergovernmental organizations. (who.int)
  • Infections following Transplantation of Bone Marrow or Peripheral-Blood Stem Cells from Unrelated Donors. (stembook.org)
  • Neither vitiligo nor evidences of autoimmune diseases were found in their stem cell donors. (koreamed.org)
  • Allogeneic hematopoietic stem cell transplantation is limited mainly by lack of histocompatible donors. (msdmanuals.com)
  • Exclusion of prospective blood donors based on their acknowledged risk behaviors for human immunodeficiency virus (HIV) infection began in 1983 (1). (cdc.gov)
  • In 1985, when tests for HIV antibody became available, screening prospective donors of blood, organs, and other tissues also began (2,3). (cdc.gov)
Lymphoma9
  • OBJECTIVE: To assess the prognostic value of various parameters including positron emission tomography / computed tomography (PET/CT) and identify risk factors for survival of patients with non-Hodgkin's lymphoma (NHL) and Hodgkin's lymphoma (HL) treated with autologous stem cell transplantation (ASCT). (smw.ch)
  • Of the NHL patients, 59 (44%) had diffuse large B-cell lymphoma (DLBCL). (smw.ch)
  • Mantle cell lymphoma (MCL) is a lymphoproliferative disorder derived from a subset of naive pregerminal center cells localized in primary follicles or in the mantle region of secondary follicles. (medscape.com)
  • Mantle cell lymphoma (MCL) is recognized in the Revised European-American Lymphoma and World Health Organization classifications as a distinct clinicopathologic entity. (medscape.com)
  • it was frequently categorized as diffuse small-cleaved cell lymphoma (by the International Working Formulation) or centrocytic lymphoma (by the Kiel classification). (medscape.com)
  • Cancer Care provides free, professional support services for people affected by cutaneous T-cell lymphoma, as well as cutaneous T-cell lymphoma treatment information and additional resources. (cancercare.org)
  • Oncology social workers help you cope with the emotional and practical challenges of cutaneous t-cell lymphoma. (cancercare.org)
  • Estimate the failure-free survival rate in a cohort of relapsed Hodgkin's lymphoma and non-Hodgkin's lymphoma patients after retrieval therapy which includes peripheral blood stem cell transplantation (PBSCT) in patients who achieve a complete remission or partial remission. (knowcancer.com)
  • Hodgkin lymphoma is distinguished from other diseases classified as lymphoma primarily because of the presence of Reed-Sternberg cells, which are large, cancerous cells found in Hodgkin lymphoma tissues. (rxwiki.com)
Autologous hematopoietic stem cell trans4
Acute3
  • Patients who benefit most from the transfusion of RBCs include those with chronic anemia resulting from kidney failure or gastrointestinal bleeding, and those with acute blood loss resulting from surgery or trauma. (utmb.edu)
  • These results support the evaluation of cord blood-derived NK cells as a potential immuno-therapeutic approach in acute leukemias. (biologynews.net)
  • and translational and basic science researchers from the Pediatric Acute Lung Injury and Sepsis Investigators Network, the EBMT, the Pediatric Blood and Marrow Transplant Consortia, and several other institutions with extensive experience in sinusoidal obstructive syndrome. (uni-regensburg.de)
Aplastic3
Cancers10
  • Distinctive patterns of genes turned off -- or left on -- in healthy versus cancerous cells could enable early screening for many common cancers and maybe help avoid them scientists say. (sciencedaily.com)
  • DNA methylation inhibitors already are under study at MCG and other centers for a variety of cancers and blood disorders. (sciencedaily.com)
  • Because tumor cells that result from aberrant changes shed their DNA into bodily fluids, non-invasive screening for a wide range of cancers could result be another result of this initiative, Dr. Bhalla says. (sciencedaily.com)
  • Dr. Robertson, who also works in breast cancer and brain tumors as well as colon cancer, is finding patterns of genes that regulate healthy cell differentiation are shut off in cancers. (sciencedaily.com)
  • p>A blood and bone marrow transplant takes unhealthy stem cells out of the bone marrow and replaces them with healthy stem cells, with the intent to treat childhood cancers and nonmalignant blood and bone marrow diseases. (nemours.org)
  • p>In addition to childhood cancers and blood disorders, Nemours treats nonmalignant bone marrow disorders, immune system deficiencies and some metabolic disorders with allogeneic blood and bone marrow transplantation. (nemours.org)
  • Thousands of patients undergo BMT yearly to successfully cure cancers or disorders of blood formation. (ca.gov)
  • These diseases include, but are not limited to sickle cell and Fanconi's anemia, autoimmune diseases like diabetes and multiple sclerosis, and cancers that originate from the blood system such as leukemias and lymphomas. (ca.gov)
  • Older adults with cancers of the blood often have different needs from younger adults, for example, a higher risk for heart disease, diabetes, or kidney problems, which may limit treatment options. (dana-farber.org)
  • In general, cancers result from mutations in cells. (medicalnewstoday.com)
Therapy19
  • The place of high-dose BEAM therapy and autologous bone marrow transplantation in poor-risk Hodgkin's disease. (smw.ch)
  • Other treatment options for patients with enzyme or protein deficiencies include substrate reduction therapy, gene therapy, and bone-marrow derived stem cell transplantation. (wikipedia.org)
  • Patients undergoing fludarabine therapy (purine analog) , bone marrow transplantation or peripheral blood stem cell transplantation. (utmb.edu)
  • Radiation therapy is a cancer treatment that uses high-energy radiation to destroy cancer cells. (medicalnewstoday.com)
  • External radiation therapy involves delivering radiation to the cancer cells from outside the body using a linear accelerator. (medicalnewstoday.com)
  • Successful stem cell therapy requires the exchange of diseased or non-functional stem cells with healthy ones. (ca.gov)
  • These healthy stem cells can come from either a donor or can be stem cells that are modified by gene therapy techniques. (ca.gov)
  • Bone marrow transplantation (BMT) is the oldest and most common form of stem cell-based therapy. (ca.gov)
  • If the antibody treatment results a stronger blood system originating from a donor in SCID patients, this result would prove that the antibody could be used to optimize engraftment of gene-therapy modified cells and could be applied to the treatment the many other diseases that need a BMT. (ca.gov)
  • Partner and collaborate with the blood and marrow transplant center of Kansas to foster a regional network of physicians trained in adult, cord blood and related stem cell therapy applications. (kumc.edu)
  • Create education modules to train and educate physicians and research scientists about peer-reviewed adult, cord blood and related stem cell therapy applications for patients. (kumc.edu)
  • In July 2013, the Midwest Stem Cell Therapy Center (MSCTC) was created by Kansas Legislature to facilitate existing research and therapy on a global level and establish a frontier for other research and therapies for patients suffering from diseases. (kumc.edu)
  • With the MSCTC goal of providing adult stem cell therapy to Kansas and the surrounding region and establishing its FDA registered GMP facility, the Center acts as a hub to facilitate a systematic mechanism for the translation of basic stem cell research into clinical applications. (kumc.edu)
  • As adult stem cell therapy is becoming more effective, many patients will benefit. (kumc.edu)
  • This radiation therapy is intended to destroy remaining cancer cells and further suppress the immune system. (ucsfhealth.org)
  • Methods Center for International Blood and Marrow Transplant Research data from 184 adults who completed the Functional Assessment of Cancer Therapy-Bone Marrow Transplant (FACT-BMT) before undergoing alloHCT and at day 100 were used. (cdc.gov)
  • At post transplantation day plus 3, antibiotic drug therapy was switched from piperacillin/tazobactam to meropenem. (cdc.gov)
  • If it weren't for the hematopoietic stem cells, this transplant would only be a transient therapy meaning its effects would only last a short time. (lu.se)
  • It is because of these stem cells and their capacity to regenerate and rebuild the entire hematopoietic (blood) system that makes transplantation a promising therapy. (lu.se)
HSCT8
  • Likewise, many children are now surviving hematopoietic stem-cell transplantation (HSCT) (see related histology slide below) and require structured long-term follow-up care. (medscape.com)
  • 30,000 patients with blood-related malignancies receive HDC, which, if the response is satisfactory, could subsequently be followed by hematopoietic stem cell transplantation (HSCT). (bdbiosciences.com)
  • For pre-symptomatic infants and older individuals with mild symptoms, hematopoietic stem cell transplantation (HSCT) with cord blood is beneficial over symptomatic treatment only. (disabled-world.com)
  • Sinusoidal obstructive syndrome, also known as hepatic veno-occlusive disease, is a potentially life-threatening complication that occurs in children undergoing haemopoietic stem-cell transplantation (HSCT). (uni-regensburg.de)
  • The Hematopoietic stem cell transplantation (HSCT) is used in children as a definitive treatment for various oncological, immune deficiencies, hemoglobinopathy, and malignancies diseases that involve the hematological system, congenital metabolism disorders, among others. (bvsalud.org)
  • This is a quantitative, retrospective, observational, descriptive and analytical quantitative approach approaching the medical records of children and adolescents submitted to HSCT in a referral hospital service for this type of transplantation in the state of Rio Grande do Sul North (RN). (bvsalud.org)
  • The profile of the clinical variables presented by the children and adolescents of this study shows that the most prevalent diagnosis was ALL, the most frequent toxicities were gastrointestinal, cardiac, respiratory and hematological, the most common HSCT was allogeneic peripheral blood and the greatest cause of mortality was sepsis. (bvsalud.org)
  • Hematopoietic stem cell transplantation not responded to other therapeutic modalities, with (HSCT) is used in children as a definitive treatment an increase in survival after transplantation, for different oncological, immune deficiencies, contributing to its use (YEILIPEK, 2014). (bvsalud.org)
Allogeneic hema4
Progenitor6
  • 2 Evaluation of harvest adequacy requires the use of reliable progenitor cell assays and this is usually achieved by CD34 cell counting using flow cytometry. (bdbiosciences.com)
  • CD34, a transmembrane phosphoglycoprotein, is present on immature hematopoietic precursor cells and all hematopoietic colony-forming cells in bone marrow and blood, including unipotent and pluripotent progenitor cells. (bdbiosciences.com)
  • Flow cytometric enumeration of CD34+ HSCs and progenitor cells is an established method for the evaluation of bone marrow and stem cell grafts. (bdbiosciences.com)
  • Flow cytometric applications for CD34+ cell identification and enumeration provide a rapid, quantitative and reproducible method to evaluate the progenitor cell population. (bdbiosciences.com)
  • Globally, it is estimated that 120 000 corneal transplantations and 18 000 transplantations of allogeneic haematopoietic progenitor cells took place in the year 2000. (who.int)
  • In addition to bone marrow, alternative sources of haemopoietic progenitor cells such as mobilized peripheral blood donations or cord blood are being used increasingly. (rlbuht.nhs.uk)
Grafts2
  • Unfortunately, the way the transplants are currently performed, with toxic treatments to prepare the children to accept the donor cells and the side effects caused by lymphocytes that contaminate standard blood cell grafts reduces the likelihood of successful cure. (ca.gov)
  • eg, bone, bone marrow, and skin grafts) Genetically identical (syngeneic [between monozygotic twins]) donor tissue (isografts) Genetically. (msdmanuals.com)
Donor's bone marrow2
20002
GVHD1
  • GVHD is a common problem after a transplant using donor cells. (bmtinfonet.org)
Normal bone marrow1
Called an allogeneic1
  • Stem cells from a donor (also called an allogeneic transplant). (cdc.gov)
Cord Blood16
  • Cord blood and haploidentical (half-matched) transplants are used to treat an increasing number of patients. (bmtinfonet.org)
  • An overview of bone marrow, peripheral blood stem cell and cord blood transplantation. (bmtinfonet.org)
  • Previous efforts to expand cord blood have resulted in ineffective NK cells. (biologynews.net)
  • However, in 1988, researchers found cord blood to be another source for stem cell transplantation. (biologynews.net)
  • Zweidler-McKay's study involves selecting out NK cells from cord blood. (biologynews.net)
  • As the cord blood is expanded to multiply in number, the NK cells are given a cytokine, interleukin-2, and a target cell, K562, which keep the NK cells active throughout the three week expansion. (biologynews.net)
  • Focus on activities that advance adult, cord blood and related stem cell and non-embryonic stem cell research and therapies for patient treatment. (kumc.edu)
  • Serve as a core facility to produce clinical-grade stem cells from adult tissues, cord blood and related materials for use in clinical trials and therapies. (kumc.edu)
  • Facilitate the delivery of adult, cord blood and related stem cell therapies to Kansas City and Midwest region hospitals where appropriate. (kumc.edu)
  • Initiate clinical trials with adult, cord blood and related stem cells. (kumc.edu)
  • Distribute information to Kansas physicians about methods for successful treatments with adult, cord blood and related stem cells through basic and clinical research. (kumc.edu)
  • Inform the public on available adult, cord blood and related stem cell therapeutic options. (kumc.edu)
  • 1 This includes human cells for transplantation such as haematopoietic stem cells from bone marrow, peripheral blood or cord blood. (who.int)
  • Some research indicates possible benefits associated with using bone marrow transplantation or cord blood transfusion as treatments for Krabbe disease. (disabled-world.com)
  • Because cord blood contains immature stem cells, HLA matching appears less crucial than for the other types of hematopoietic stem cell transplantation. (msdmanuals.com)
  • One concern about the procedure is that immune cells in cord blood do not have experience with the viruses responsible for latent infections, leading to a higher percentage of naive T cells and thus increased vulnerability to reactivation of cytomegalovirus or Epstein-Barr virus infection. (msdmanuals.com)
20221
Cancer27
  • In a study from the United States, long-term survivors of pediatric bone marrow transplantation followed in the Bone Marrow Transplant Survivors Study were compared with survivors of childhood cancer treated without bone marrow transplant from the Childhood Cancer Survivor Study. (medscape.com)
  • Gassas A , Grant R , Richardson S , Dupuis LL , Doyle J , Allen U , Predictors of viridans streptococcal shock syndrome in bacteremic children with cancer and stem-cell transplant recipients. (cdc.gov)
  • Wisplinghoff H , Reinert RR , Cornely O , Seifert H . Molecular relationships and antimicrobial susceptibilities of viridans group streptococci isolated from blood of neutropenic cancer patients. (cdc.gov)
  • Our scientists pursue every aspect of cancer research-from exploring the biology of genes and cells, to developing immune-based treatments, uncovering the causes of metastasis, and more. (mskcc.org)
  • MSK radiation oncologist Kathryn Beal explains how brachytherapy, a form of internal radiation, can be used to destroy lingering cancer cells after surgery. (mskcc.org)
  • The radiation given off by this source damages the DNA of nearby cancer cells. (mskcc.org)
  • http://www.cancer.gov/about-cancer/treatment/types/stem-cell-transplant/stem-cell-fact-sheet. (mayoclinic.org)
  • DNA methylation is a piece of a relatively new research field called epigenetics that looks more globally at which genes are turned off and on with an eye on early identification of some of the aberrant adjustments that enable cancer cells to thrive. (sciencedaily.com)
  • A lot of methylated genes we found in cancer are not naturally expressed in normal cells. (sciencedaily.com)
  • A lot of people think of cancer cells turning genes on, like oncogenes, that allow them to grow faster, evade immune surveillance, that sort of thing," Dr. Robertson says. (sciencedaily.com)
  • Hematologists are trained to treat a wide variety of disease conditions ranging from anemia to blood cancer. (apollohospitals.com)
  • They aim to eliminate cancer cells from the blood. (medicalnewstoday.com)
  • Doctors can deliver radiation externally or internally, depending on the location of the cancer cells. (medicalnewstoday.com)
  • However, it does not mean a complete cure, as some cancer cells may remain in the body and can cause the disease to return. (medicalnewstoday.com)
  • The procedure can also be used to replace bone marrow which has been somewhat depleted because of some types of cancer treatments. (differencebetween.net)
  • It can also be used to help patients whose own bone marrow has been destroyed because of cancer treatments. (differencebetween.net)
  • National Comprehensive Cancer Network (NCCN) Clinical Practice Guidelines also recommend the use of serum free light chain assay and plasma cell fluorescence in situ hybridization (FISH) on bone marrow: del 13, del 17p13, t(4;14), t(11;14), t(14;16), t(14;20), 1q21 amplification, 1p deletion as part of the initial diagnostic workup. (medscape.com)
  • Dr. Arnold is a Pediatric Hematologist/Oncologist at the Aflac Cancer and Blood Disorders Center of Children's Healthcare of Atlanta and Associate Professor of Pediatrics at Emory University School of Medicine. (choa.org)
  • These education programs cover topics related to childhood blood cancer. (lls.org)
  • LLS funds lifesaving blood cancer research around the world, provides free information and support services, and is the voice for all blood cancer patients seeking access to quality, affordable, coordinated care. (lls.org)
  • Orthopedists (bone specialists) and orthopedic surgeons at Nemours Center for Cancer and Blood Disorders make our pediatric orthopedics programs among the largest and most respected in the world. (nemours.org)
  • To make sure your care is as seamless as possible, a dedicated team of clinicians, who are highly specialized experts in your type of blood cancer, will care for you throughout the treatment process, from diagnosis though long-term follow-up. (dana-farber.org)
  • Learn about the advances in blood cancer care and research presented by Dana-Farber physicians and scientists at the Annual Meeting of the American Society of Hematology (ASH). (dana-farber.org)
  • Blood and Marrow Transplantation is where we replace parts of the body called stem cells as a way to cure difficult diseases and cancer. (rlbuht.nhs.uk)
  • Advances in the treatment of cancer and improvements in supportive care over the past 10 years have improved the results and tolerability of blood and marrow transplants (BMT). (ucsfhealth.org)
  • A biopsy of an enlarged lymph node or bone marrow will be taken and examined to figure out the specific type of cancer based on several tissue biological markers as well as cell structure. (rxwiki.com)
  • Additionally, blood tests, CT scans of the body, and PET scans may be done to see if the cancer has metastasized. (rxwiki.com)
Disorders3
  • Low-dose filgrastim significantly enhances neutrophil recovery following autologous peripheral-blood stem-cell transplantation in patients with lymphoproliferative disorders: evidence for clinical and economic benefit. (smw.ch)
  • Hematology (from the Greek word 'haima', meaning blood) is the branch of internal medicine that deals with the physiology, pathology, etiology, diagnosis, treatment, prognosis and prevention of blood-related disorders. (apollohospitals.com)
  • 1) Antibody deficiency disorders are defects in immunoglobulin-producing B cells . (lu.se)
Corneal Transplantation1
Patient's3
Transfusion5
  • Blood transfusion. (apollohospitals.com)
  • The high numbers of leukocytes remaining in a unit of pRBCs during the storage process can fragment, deteriorate, and release cytokines, and they have been implicated as a cause of reactions to a current and subsequent blood transfusions in some transfusion recipients. (utmb.edu)
  • The transplant procedure is similar to a simple blood transfusion and will be done in your hospital room. (ucsfhealth.org)
  • The blood stem cells will be infused through your central venous catheter just like a regular blood transfusion. (ucsfhealth.org)
  • The goal is to support you with red blood cell and platelet transfusion until you are producing cells again. (ucsfhealth.org)
Biopsy1
  • After birth, a physical exam of the child, evaluation of signs and symptoms, and diagnostic testing including blood, skin (biopsy) samples, lumbar puncture (spinal tap), MRI and CT scans, nerve conduction studies, eye exam, genetic testing may be done to confirm the diagnosis. (disabled-world.com)
Hematology3
  • 8 The BD ® Stem Cell Enumeration Kit incorporates BD Trucountâ„¢ tubes to determine the absolute cell count, thereby eliminating variability associated with hematology-derived absolute counts. (bdbiosciences.com)
  • The Malignant Hematology Laboratory's primary focus is the diagnosis of hematologic malignancies from blood and bone marrow samples, utilizing microscopy and special stains. (hamiltonhealthsciences.ca)
  • To complement The ASCO Post 's continued comprehensive coverage of the 2021 American Society of Hematology (ASH) Annual Meeting & Exposition, here are several abstracts selected from the meeting proceedings focusing on allogeneic transplantation for hematologic neoplasms in adults. (ascopost.com)
Haploidentical1
Pediatric2
  • To stimulate and facilitate further research, the NCI and NHLBI held the First International Consensus Conference on Late Effects after Pediatric Hematopoietic Cell Transplantation on April 28 and 29, 2011. (medscape.com)
  • Zweidler-McKay also predicts this type of transplant could be used for adults who have already had a transplant or for those adult and pediatric patients who aren't candidates for other stem cell transplants due to blood counts or illness. (biologynews.net)
Transplants work1
  • Bone marrow transplants work best if the HLAs from the donor and the patient are a close match. (medlineplus.gov)
Solid tumors1
Diseases3
  • The state has the opportunity to focus on the development of specific areas of adult stem cell research and patient treatment, with the potential to become a world leader in patient therapies for specific diseases or conditions. (kumc.edu)
  • Non-Hodgkin lymphomas (NHL) represent a varied group of diseases distinguished by the features of the cancerous cells with each disease type. (rxwiki.com)
  • As in many of the lysosomal storage diseases, the functional deficiency of lysosomal enzymes results in abnormal cell architecture. (medscape.com)
20211
Sickle1
Hematopoietic stem4
Lymphoid1
  • They can affect multiple parts of the the lymphoid tissue, including the lymph nodes, spleen, and the bone marrow and are further classified into fast-growing or slow-growing. (rxwiki.com)
Retrospective analysis2
Immature2
20201
Transplant Program2
  • Learn more about research in the Bone Marrow Transplant Program . (mayoclinic.org)
  • The Fox Chase-Temple University Hospital Bone Marrow Transplant Program offers patients in the Philadelphia region access to some of the most experienced stem cell transplant specialists. (templehealth.org)
Collected from a donor1
Curative1
Fluorescence in situ hybri1
  • In contrast to the expected mixed chimerism that usually occurs in the absence of conditioning, we found in our patients 100% donor cell engraftment based on fluorescence in situ hybridization (FISH) and microsatellite techniques. (nih.gov)
Adults1
Treatments3
  • Become the leader in providing adult stem cell treatments and information to physicians and patients around the world. (kumc.edu)
  • Additionally, many new treatments called monoclonal antibodies have been successfully used ( rituximab ( Rituxan ) for B-cell lymphomas, ofatumumab (Arzerra) for NHL, Ocrelizumab is in clinical trials). (rxwiki.com)
  • This type of transplantation, also known as a bone marrow transplant, is one of the common treatments used to treat several blood malignancies. (lu.se)
Malignancies1
Tumors1
  • p>Our combined expertise allows us to diagnose and treat common, rare and complex bone tumors in children. (nemours.org)
Organ4
  • http://www.researchandmarkets.com/research/f7thqr/organ_and_tissue ) has announced the addition of the "Organ and Tissue Transplantation - Global Strategic Business Report" report to their offering. (prnewswire.com)
  • This report analyzes the worldwide markets for Organ and Tissue Transplantation in Number of Procedures. (prnewswire.com)
  • The global and regional markets (except the US) for 'Organ and Tissue Transplantation' in this report are analyzed by the following Product Segments - Organ Tranplantation (Heart, Kidneys, Liver, Pancreas, and Lungs). (prnewswire.com)
  • In addition to bone marrow transplantation, additional therapies with adult stem cells - including organ repair - have been the focus of intense attention in the scientific community in recent years. (kumc.edu)
Donor stem cells2
Survival1
  • Access to transplantation entails more than the surgery itself, because success is measured by longer survival of the patient and a long-term improvement in the quality of life. (who.int)
Undergo1