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  • patients
  • Dr. Travis Ye, Beike Biotech's CEO, commented, 'This groundbreaking research is consistent with the safety record we have compiled after providing stem cells for the treatment of more than 8,000 patients. (news-medical.net)
  • mice
  • What's more, all the groups showed that a batch of the stem cells implanted into mice developed into the three main types of progenitor cells found in human embryos. (wired.com)
  • Mice treated with a combination of G-CSF and meloxicam mobilized significantly more cells than those treated with either drug separately. (nih.gov)
  • These findings, in mice, suggest that mitochondrial respiration is required for normal blood stem cell function. (nih.gov)
  • For this study, Gao and his colleagues used mouse precancerous stem cells grown in the laboratory and transplanted into immune-deficient mice. (innovations-report.com)
  • (nih.gov)
  • In the study, the engineered blood stem cells were placed into human thymus tissue that had been implanted in the mice, allowing Zack and his team to study the human immune system reaction to melanoma in a living organism. (scienceblog.com)
  • The mice were then implanted with two types of melanoma tumors, one that expressed the antigen complex that attracts the engineered T-cells and one that did not. (scienceblog.com)
  • Suppression of nitric oxide production in mice, by either genetic or chemical means, similarly reduced the number of functional Runx1-expressing blood stem cells. (scienceblog.com)
  • Blood stem cells from mutant mice could more easily squeeze through narrow pores. (eurekalert.org)
  • In addition, they showed that treating normal mice with blebbistatin, which interferes with parts of a cell's internal skeleton, also results in mobilization of stem cells into the blood. (eurekalert.org)
  • In the mice with chronic kidney disease, Gli1 cells end up resembling osteoblasts, secreting bone in the vessel wall. (medindia.net)
  • Li's team zeroed in on Gtl2 by studying hematopoietic stem cells in mice with support from Stowers core centers including cytometry, bioinformatics, histology and electron microscopy, molecular biology, and tissue culture. (innovations-report.com)
  • bone
  • The first part of the infographic explains what exactly stem cells are: cells which have the potential to develop into various different cell types within the body including blood, bone, tissue and organ. (news-medical.net)
  • The stem cells develop into osteoblasts that are essentially bone cells. (medindia.net)
  • These stem cells have the ability to differentiate into a number of connective tissue like fat, bone and smooth muscle. (medindia.net)
  • In chronic kidney disease, this mechanism is disrupted with changes in signaling pattern resulting in these stem cells being converted into osteoblasts, which are a type of bone cells that increase the deposition of calcium in the arteries. (medindia.net)
  • Dr Humphreys adds, "We expect to find osteoblasts in bone, not blood vessels. (medindia.net)
  • tissues
  • In embryos, these progenitor cells give rise to different tissues. (wired.com)
  • The association is the first to join together public and private banks toward a common mission to advocate for cord blood use in order to expand its potentials in cell therapies and regenerative medicine, and to also jointly advocate for global regulations that will allow use of cord blood and cord tissues in medical applications. (prweb.com)
  • As cells and tissues develop in the embryo, the process by which they take on specific characteristics involves cellular proteins called transcription factors, which regulate whether genes are turned on or off. (nih.gov)
  • Biologists have long wondered why the embryonic heart begins beating so early, before the tissues actually need to be infused with blood. (scienceblog.com)
  • laboratory
  • Roger Dodd, vice president of research and development at the American Red Cross' Holland Laboratory in Rockville, Md., said producing blood in the lab could cost thousands of dollars per unit - far too expensive to replace the 14 million pints of red blood cells that are transfused every year. (spokesman.com)
  • When examining human and mouse blood stem cells with and without Tie2, they found that those with Tie2 have superior ability to grow and repeatedly give rise to new daughter stem cells over longer periods of time in the laboratory, creating many generations of blood stem cells. (nih.gov)
  • 1 Molecular Genetics of Stem Cells Laboratory, Institute of Research in Immunology and Cancer, University of Montreal, Montreal, QC H3C 3J7, Canada. (sciencemag.org)
  • potentially
  • For example, lab experiments with cells from these collections might be used to study why motor neurons from people with amyotrophic lateral sclerosis die, or how healthy liver cells respond to a promising but potentially toxic drug. (wired.com)
  • These cells could be screened for pathogenic organisms and even potentially be genetically engineered to treat specific patients or to combat specific diseases. (sun-sentinel.com)
  • In the case of blood cells, they could potentially be used to treat illnesses such as leukemia and anemia. (sun-sentinel.com)
  • donor eligibility
  • Learn about how to donate stem cells, donor eligibility, important registration information, registration forms (available in multiple languages), knowledge testing and more. (blood.ca)
  • Learn about how to donate cord blood, donor eligibility, important registration information, registration and consent forms (available in multiple languages), where to donate, how your baby's cord blood may be used, safety standards and more. (blood.ca)
  • Learn about stem cell and cord blood donor eligibility, how to register, who can register, the stem cells knowledge test, registration events, accessing registration forms in other languages, donating cord blood for research and more. (blood.ca)
  • Be sure to review our donor eligibility and stem cell registration information below. (blood.ca)
  • research
  • It's an exciting time in this area of research to take stem cells that can become anything and get them to specifically become blood cells,' Stanley was quoted. (medindia.net)
  • The ASCC has narrowed its research focus for the past year and a half, putting half of its resources into trying to manufacture red blood cells. (medindia.net)
  • The dominant thinking is that regime change, whether Republican or Democratic, will move the ball forward in terms of the federal funds embargo on human embryonic stem cell research," says Geoffrey Crouse, vice president of a life science unit. (medindia.net)
  • Some experts opine Washington brings about bad science when it limits federal funds to non-embryonic stem cell research. (medindia.net)
  • Written before the discovery of human embryonic stem cells, the ban on federal funding for stem-cell research bars the use of federal money for creation of human embryos for research and for research in which human embryos are destroyed. (medindia.net)
  • Three research groups used similar methods to prod certain immune cells in human blood to become induced pluripotent stem cells. (wired.com)
  • More research is needed to determine whether these cells can be further coaxed to form fully functional tissue, says Rudolf Jaenisch of MIT and the Whitehead Institute for Biomedical Research in Cambridge, Massachusetts, who led one of the studies. (wired.com)
  • The project represents a major technical breakthrough in the controversial area of stem cell research. (newser.com)
  • The research team outlined a four-step process for turning embryonic stem cells into red blood cells capable of carrying as much oxygen as normal blood. (spokesman.com)
  • Lanza said the research team is conducting additional experiments to see whether the stem cells will produce more adult globin if given more time to mature in the lab. (spokesman.com)
  • With this partnership, SCTM will launch a new journal section dedicated to cord blood research. (prweb.com)
  • By bridging stem cell research and helping speed translations of emerging lab discoveries into clinical trials, SCTM will help move applications of these critical investigations closer to accepted best practices and ultimately improve outcomes. (prweb.com)
  • By bridging stem cell research and clinical trials, SCTM will help move applications of these critical investigations closer to accepted best practices. (prweb.com)
  • About AlphaMed Press: Established in 1983, AlphaMed Press with offices in Durham, NC, San Francisco, CA, and Belfast, Northern Ireland, publishes two other internationally renowned peer-reviewed journals: STEM CELLS® ( http://www.StemCells.com ), celebrating its 35th year, is the world's first journal devoted to this fast paced field of research. (prweb.com)
  • Breakthrough studies led by Drs. Colleen Delaney and Irv Bernstein in the Clinical Research Division demonstrated that cord blood stem and progenitor cells could be expanded by treating cells with specific cytokines and inducing Notch signaling (Delaney et al . (fredhutch.org)
  • The achievement comes as Congress is about to begin examining President Bush's controversial new policy on federal funding of stem cell research. (sun-sentinel.com)
  • The results from animal research were published on March 14 in the journal Cell Stem Cell . (eurekalert.org)
  • While hematopoietic stem cells have gained attention in research, it remains largely unknown how cell metabolic states are controlled. (innovations-report.com)
  • tissue
  • Blood drawn with a simple needle stick can be coaxed into producing stem cells that may have the ability to form any type of tissue in the body, three independent papers report in the July 2 Cell Stem Cell . (wired.com)
  • The concern is that if these cells retain traces of memory from their previous lives as blood cells, they may not be good at forming other tissue types. (wired.com)
  • Endometrial regenerative cells are stem cells taken from menstrual blood that are capable of forming into at least nine different tissue types, including heart, liver and lung. (upi.com)
  • The Cord Blood Association is excited and honored to partner with Stem Cells Translational Medicine to showcase the newest and highest quality translational and clinical applications of cord blood and cord tissue based therapies," said Dr. Kurtzberg. (prweb.com)
  • The mission and goals of both parties are aligned to maximize sharing of advances in these novel cell and tissue based therapies. (prweb.com)
  • With the information in a graphic and easy-to-read format, they hope to reach more potential customers in order to broaden their understanding about what collection of cord blood and cord tissue at birth can offer them and to dispel any myths around it. (news-medical.net)
  • One worry many people have is that collection of cord blood or cord tissue may be painful or distressing to the mother or infant. (news-medical.net)
  • The discovery adds to the growing excitement about the enormous potential of stem cells -- very early cells capable of transforming into any kind of cell or tissue in the body. (sun-sentinel.com)
  • breakthrough
  • According to them, this breakthrough could be a lifesaver as well help fight AIDS and other blood-borne diseases. (medindia.net)
  • And after 5 years I've formulated a proprietary stem cell breakthrough - one that targets the ROOT CAUSE of blood sugar concerns. (elijahlist.com)
  • disorders
  • Qu is professor of pediatrics at Emory University School of Medicine, Winship Cancer Institute and Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta. (eurekalert.org)
  • This helps us better understand the pathogenesis of blood disorders associated with loss of stem cell quiescence. (eurekalert.org)
  • Lam is a clinical hematologist-bioengineer at the Aflac Cancer and Blood Disorders Center of Children's Healthcare of Atlanta, associate professor of pediatrics at Emory University School of Medicine and a faculty member in the Wallace H. Coulter Department of Biomedical Engineering at Georgia Tech and Emory. (eurekalert.org)
  • mitochondrial
  • The investigators found that deficiency in a protein component of the mitochondrial respiration process, called RISP, resulted in a mouse fetus that developed fewer red blood cells than normal and subsequently died. (nih.gov)
  • Another set of experiments confirmed that intact mitochondrial respiration is also essential for adult mouse blood stem cell functions. (nih.gov)
  • Ito K, Turcotte R, Cui J,…Ito K. Self-renewal of a purified Tie2+ hematopoietic stem cell population relies on mitochondrial clearance . (nih.gov)
  • These are MicroRNA clusters expressed from imprinted Gtl2 locus maintain adult hematopoietic stem cells through suppression of mitochondrial biogenesis and metabolic activity. (innovations-report.com)
  • Mechanistically, Gtl2's "megacluster" of microRNA, the largest cluster of microRNA in the mammalian genome, suppresses the mTOR signaling pathway and downstream mitochondrial biogenesis and metabolism, thus blocking mitochondrial-associated byproducts called reactive oxygen species (ROS) that can damage adult stem cells. (innovations-report.com)
  • ROS are unavoidable derivatives of the mitochondrial metabolic process and need to be managed by the cell," he explains. (innovations-report.com)
  • In subsequent experiments, deleting the locus from the maternally inherited allele in hematopoietic stem cells increased mitochondrial biogenesis and subsequent metabolic activity as well as increased ROS levels, with the latter inducing cell death. (innovations-report.com)
  • study's senior author
  • Up to 65 percent of the resulting cells matured to the point where they shed their nucleus, which allows them to take on the distinctive doughnut shape of circulating red blood cells, said Dr. Robert Lanza, chief scientific officer at Advanced Cell Technology Inc. and the study's senior author. (spokesman.com)
  • leukemia
  • These high doses, although more effective at killing leukemia cells, also kill healthy cells-a consequence that can be associated with severe and life-threatening side effects. (cancerconnect.com)
  • Some studies have also shown that peripheral-blood stem cells are associated with a decreased rate of relapse and improved survival among recipients with high-risk leukemia. (nih.gov)
  • found
  • Meanwhile, Elefanty claims his team had found a 'particular protein' that only red blood cells make. (medindia.net)
  • They found they could make cells lacking Ptpn21 stiff again by interfering with the function of another protein, Septin1. (eurekalert.org)
  • The calcification of blood vessels is a serious effect in chronic kidney disease patients and they are found to have two to five times more risk for coronary artery calcification than healthy controls. (medindia.net)
  • The study by Dr. Benjamin Humphreys and colleagues has found that these stem cells are responsible for the mineral deposits that clog the arteries. (medindia.net)
  • Over the three-year study, investigators used transcriptome profiling to analyze 17 hematopoietic cell types and found that non-coding RNAs expressed from the Gtl2 locus are predominantly located in a subset of the cell types, including adult "long-term" hematopoietic stem cells which have long-term self-renewal capacity. (innovations-report.com)
  • findings
  • The findings "represent a huge and important progression in the field," stem cell biologist Shinya Yamanaka of Kyoto University in Japan and the Gladstone Institute of Cardiovascular Disease in San Francisco, writes in a commentary appearing in the same issue of the journal. (wired.com)
  • These findings suggest that tumor blood vessels are derived mainly from tumor cells, with a smaller number coming from normal blood-vessel cells," says principal investigator Jian-Xin Gao, assistant professor of pathology. (innovations-report.com)
  • Our findings suggest that screening of these agents should include precancerous stem cells. (innovations-report.com)
  • These findings demonstrate that biomechanical forces promote blood formation. (scienceblog.com)
  • Our findings are that normal blood-forming stem cells are stiffer and less deformable than differentiated blood cells," Qu says. (eurekalert.org)
  • In addition, our findings suggest that cell biomechanics can be leveraged to improve current mobilization regimens for stem cell-based therapy. (eurekalert.org)