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  • HEMOGLOBIN
  • COMPOSITIONS FOR OXYGEN TRANSPORT COMPRISING A HIGH OXYGEN AFFINITY MODIFIED HEMOGLOBIN - The present invention relates to blood products, and more particularly to compositions comprising a modified oxygenated hemoglobin having a high affinity for oxygen and methods for making such compositions. (patentsencyclopedia.com)
  • LIPIDS
  • They prevent macromolecules from navigating the intercellular cleft and limit the lateral diffusion of intrinsic membrane proteins and lipids between the apical and basolateral cell surface domains. (wikipedia.org)
  • gene
  • Using deep sequencing techniques, Bergmeier's team found that Rasa3 was the only highly expressed GAP gene for Rap1 in platelets. (unchealthcare.org)
  • Kaptin is a protein that in humans is encoded by the KPTN gene. (wikipedia.org)
  • Docking protein 2 is a protein that in humans is encoded by the DOK2 gene. (wikipedia.org)
  • The protein encoded by this gene is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. (wikipedia.org)
  • Multimerin 1, also known as elastin microfibril interfacer 4 (EMILIN-4), is a protein that, in humans, is encoded by the MMRN1 gene. (wikipedia.org)
  • In humans, protein S is encoded by the PROS1 gene. (wikipedia.org)
  • biochemistry
  • We believe these findings could lead to improved strategies for treatment following a heart attack and a better understanding of why people respond differently to anti-platelet drugs, such as aspirin and Plavix," said Wolfgang Bergmeier, PhD, professor of biochemistry and biophysics, member of the McAllister Heart Institute at UNC, and senior author of the paper. (unchealthcare.org)
  • disorders
  • Oxidized low-density lipoprotein (oxLDL) promotes unregulated platelet activation in dyslipidemic disorders. (whiterose.ac.uk)
  • identification of the molecular defect in patients with blood coagulation disorders. (csuohio.edu)
  • Such diseases might include hemophilia, blood clots, other bleeding disorders and blood cancers such as leukemia, multiple myeloma, and lymphoma. (wikipedia.org)
  • Hematologists may specialize further or have special interests, for example, in: treating bleeding disorders such as hemophilia and idiopathic thrombocytopenic purpura treating hematological malignancies such as lymphoma and leukemia (cancers) treating hemoglobinopathies the science of blood transfusion and the work of a blood bank bone marrow and stem cell transplantation Starting hematologists complete a four-year medical degree followed by three or four more years in residency or internship programs. (wikipedia.org)
  • After completion, they further expand their knowledge by spending two or three more years learning how to experiment, diagnose, and treat blood disorders. (wikipedia.org)
  • When applying for this career, most job openings look for first-hand practical experience in a recognized training program that provides practice in the following: Cause of abnormalities in formation of blood and other disorders, diagnosis of numerous blood related conditions or cancers using experimentation, and the proper care and treatment of patients in the best manner. (wikipedia.org)
  • globulin
  • Instead, there is a large C-terminus domain that is homologous to plasma steroid hormone-binding proteins such as sex hormone-binding globulin and corticosteroid-binding globulin. (wikipedia.org)
  • arterial
  • Researchers at the UNC School of Medicine have found that the blood platelet protein Rasa3 is critical to the success of the common anti-platelet drug Plavix, which breaks up blood clots during heart attacks and other arterial diseases. (unchealthcare.org)
  • As venous and arterial cannulas are inserted, pharmaceuticals are administered to provide anticoagulation of the blood. (encyclopedia.com)
  • A centrifugal or roller head pump can be used in the arterial position for extracorporeal circulation of the blood. (encyclopedia.com)
  • The glomerulus receives its blood supply from an afferent arteriole of the renal arterial circulation. (wikipedia.org)
  • concentrate
  • For preparation of PRP, various protocols are used, with an underlying principle of concentrating platelets to 3-5 times physiological levels, then injecting this concentrate in the tissue where healing is desired. (wikipedia.org)
  • membrane
  • In fact, Protein S was first discovered in 1977 in this role and it is named after the membrane site that it occupies in the complex. (wikipedia.org)
  • mammalian
  • In one study, protein aggregates from yeast prions were released into a mammalian intercellular cleft and were taken up by the adjacent cell, as opposed to direct cell transfer. (wikipedia.org)
  • vascular
  • However, the drug's anti-platelet effect increases the risk of bleeding in patients and makes emergency surgery too risky because Plavix affects the ability of platelets to prevent blood loss after vascular injury. (unchealthcare.org)
  • diagnosis
  • Hematology, also spelled haematology, is the branch of medicine concerned with the study of the cause, diagnosis, treatment, and prevention of diseases related to blood. (wikipedia.org)
  • solutes
  • Its composition varies but generally includes water and the dissolved solutes of the main circulatory fluid such as blood. (wikipedia.org)
  • cell
  • identification of specific proteins involved in the control of cell proliferation. (csuohio.edu)
  • This method is especially useful in cell-to-cell propagation of infectious cytosolic protein aggregates. (wikipedia.org)
  • The bridging property of Protein S enhances the phagocytosis of the apoptotic cell, allowing it to be removed 'cleanly' without any symptoms of tissue damage such as inflammation occurring. (wikipedia.org)
  • Bone
  • Their routine work mainly includes the care and treatment of patients with hematological diseases, although some may also work at the hematology laboratory viewing blood films and bone marrow slides under the microscope, interpreting various hematological test results and blood clotting test results. (wikipedia.org)
  • found
  • Platelets from hyperlipidemic mice were also found to have a diminished sensitivity to cGMP when tested ex vivo, a phenotype that was corrected by infusion of gp91ds-tat into the mice. (whiterose.ac.uk)
  • function
  • They are instrumental in reducing blood pressure by regulating prostaglandin, a hormone which helps the kidneys function more effectively. (essortment.com)
  • Understanding the protein's role could also prove vital in the development of new compounds aimed at altering platelet function. (unchealthcare.org)
  • The rate at which blood is filtered through all of the glomeruli, and thus the measure of the overall renal function, is the glomerular filtration rate (GFR). (wikipedia.org)
  • When cardiopulmonary status is compromised (i.e. when the fluid or air has its repercussions on the function of heart and lungs), due to air (significant pneumothorax), fluid (pleural fluid) or blood (hemothorax) outside the lung, then this procedure is usually replaced with tube thoracostomy, the placement of a large tube in the pleural space. (wikipedia.org)
  • Multimerin is a factor V/Va-binding protein and may function as a carrier protein for platelet factor V. It may also have functions as an extracellular matrix or adhesive protein. (wikipedia.org)
  • capillary
  • The blood exiting the efferent arterioles of these nephrons enter the vasa recta, which are straight capillary branches that deliver blood to the renal medulla. (wikipedia.org)
  • Understanding
  • Understanding the routes of intercellular protein aggregate transfer, particularly routes involving clefts is imperative in understanding the progressive spreading of this infection8. (wikipedia.org)
  • urine
  • In dogs, the most common clinical signs are spontaneous bleeding from the gums or nose, blood in the urine or gastrointestinal tract, or excessive bleeding at the time of surgery. (dmoztools.net)
  • tissue
  • As a concentrated source of blood plasma and autologous conditioned plasma, PRP contains several different growth factors and other cytokines that can stimulate healing of soft tissue and joints. (wikipedia.org)