• The research team investigated the regenerative significance of telomerase activity , particularly in terms of characteristic cell surface marker expression, multipotent differentiation capability, chromosomal stability, and safety of in vivo formation of tumors. (phys.org)
  • Yingai Shi et al, Differentiation Capacity of Human Urine-Derived Stem Cells to Retain Telomerase Activity, Frontiers in Cell and Developmental Biology (2022). (phys.org)
  • We've captured these phases of stem cell specialization, or differentiation, in a dish," says Zambidis. (sciencedaily.com)
  • Loss of asrij causes hyperproliferation of lymph gland lobes coupled with increased hemocyte differentiation, thereby depleting the pool of quiescent hemocyte precursors. (nih.gov)
  • Thus, conserved endocytic functions may control blood cell progenitor quiescence and differentiation. (nih.gov)
  • We discovered that interferon gamma (IFNγ) promotes hematopoietic stem cell (HSC) division and myeloid differentiation in a mouse model of Mycobacterium avium infection (Nature 2010). (bcm.edu)
  • During this time, neural precursor cells (NPCs) in the developing brain are undergoing proliferation, migration, and differentiation to form neurons and the normal cytoarchitecture of the brain. (rutgers.edu)
  • Therefore, to really understand ASD, we need to study developmental processes like proliferation, migration, and differentiation in human neural cells derived from individuals with idiopathic ASD. (rutgers.edu)
  • During the last several years, his lab has developed novel methods for multi-lineage differentiation of pluripotent stem cells for cell therapy in mice models of muscular dystrophies and injuries. (uh.edu)
  • These include generation of knock-in reporter stem cell lines to study myogenic differentiation, CRISPR/Cas9 gene targeting methods to correct mutated genes in muscular dystrophies, and using bioscaffolds, seeded with stem cells, to treat skeletal muscle injuries. (uh.edu)
  • 6- Differentiation of iPSCs into cardiomyocytes and endothelial cells for disease modeling and screening. (uh.edu)
  • Although we have known about induced pluripotent stem cells since 2006 , researchers still have plenty to learn about how cell differentiation in the human body can be mimicked artificially and safely in the lab for the purposes of delivering targeted medical treatment. (scitechdaily.com)
  • The variation among induced pluripotent stem cells (iPSCs) in their differentiation capacity to specific lineages is frequently attributed to somatic memory. (nih.gov)
  • In this study, we compared hematopoietic differentiation capacity of 35 human iPSC lines derived from four different tissues and four embryonic stem cell lines. (nih.gov)
  • Sequential rounds of division and differentiation give rise to an enormous amplification of cell numbers, necessary for the production of mature blood cells. (justia.com)
  • This process of division and differentiation is subject to regulation at many levels to control cell production. (justia.com)
  • The present invention relates to methods of inducing differentiation of stem cells. (justia.com)
  • In particular, the invention relates to methods of inducing differentiation of embryonic stem cells into muscle cells or vascular endothelial cells. (justia.com)
  • The process of differentiation in stem cells involves selective development of immature cells to committed and fully mature cells of various lineages. (justia.com)
  • Differentiation of stem cells is known be triggered by various growth factors and regulatory molecules. (justia.com)
  • During differentiation the expression of stem cell specific genes and markers are often lost and cells acquire gene expression profiles of somatic cells or their precursors. (justia.com)
  • Whilst differentiation of some lineage specific stem cells can be induced with a degree of certainty, a differentiation outcome of a population of pluripotent stem cells is less predictable. (justia.com)
  • Placing the cells under conditions which induce specific cell types has been one form of an attempt to regulate the differentiation outcome. (justia.com)
  • These conditions include growing the cells to high or low density, changing media, introducing or removing cytokines, hormones and growth factors, creating an environment which suits differentiation toward a specific cell type, such as providing a suitable substrate. (justia.com)
  • Methods of inducing differentiation in stem cells and muscle cells produced therefrom may be used for the study of cellular and molecular biology of tissue development, for the discovery of genes and proteins such as differentiation factors that play a role in tissue development and regeneration. (justia.com)
  • The induction of cardiomyocyte differentiation in stem cells is especially useful in developing therapeutic methods and products for heart disease and abnormal heart conditions. (justia.com)
  • However, the molecular pathways that lead to specification and terminal differentiation of specific cell types, such as myocytes, from embryonic stem cells during development are not entirely clear. (justia.com)
  • Therefore there remains a need for providing effective methods of inducing differentiation of stem cells into specific cell types, such as myocytes or endothelial cells. (justia.com)
  • culturing a stem cell in the presence of an embryonic cell and/or extracellular medium of an embryonic cell, under conditions that induce differentiation of the stem cell. (justia.com)
  • In the last decade, there has been an increased desire for the characterization of this precursor from differentiating hESCs using several methods, generally through three-dimensional embryoid body (EB) differentiation (Ditadi et?al. (bioskinrevive.com)
  • 2006). Moreover, in both these experimental strategies, the hemogenic potential of endothelium precursor people has been examined at differing times from the differentiation procedure, with or with out a prior purification stage of this people (Ditadi et?al. (bioskinrevive.com)
  • Following hemogenic potential of endothelium cell populations frequently during the period of hESC differentiation would address a few of these problems but to time this has hardly ever been reported. (bioskinrevive.com)
  • 2006). Using EB differentiation protocols, the onset of hematopoietic commitment was also defined from the manifestation of CD43, growing from a CD34+ endothelial precursor human population (Kennedy et?al. (bioskinrevive.com)
  • Pluripotent stem cells are found in the bone marrow and can give rise to different blood cell lineages including mast cells. (proprofs.com)
  • A diagnosis of MDS-MLD requires that dysplastic features be present in more than 10% of cells from two or more lineages. (medscape.com)
  • Acute leukemia affects immature cell lineages or blastic cells and, when not diagnosed and treated, results in rapid debility of the individual's general condition. (bvsalud.org)
  • Similarly, destruction of neonatally abundant pluripotent stem cells would likely have a more pervasive outcome than destruction of The value of incorporating immunologic appeared more severe and/or persistent when single lineages or differentiated cells that pre- data for the toxicologic assessment of drugs, the exposure occurred perinatally when com- dominate in adults. (cdc.gov)
  • Around 30% of patients with MDS progress to acute myeloid leukaemia, and the only treatment is hematopoietic stem cell transplantation. (wikipedia.org)
  • BACKGROUND: The Cord Blood Transplantation (COBLT) Study banking program was initiated in 1996. (emmes.com)
  • The study goals were to develop standard operating procedures for cord blood (CB) donor recruitment and banking and to build an ethnically diverse unrelated CB bank to support a transplantation protocol. (emmes.com)
  • Assessment of the myogenic stem cell compartment following transplantation of pax3/pax7-induced embryonic stem cell-derived progenitors. (uh.edu)
  • This special cell is a blood stem cell and we now routinely use radiation and bone marrow transplantation to cure many blood cancers. (nhsbt.nhs.uk)
  • Stem cell transplantation is performed after high-dose chemotherapy (HDC) to restore a cancer patient's blood and immune cell production capacity. (bdbiosciences.com)
  • 30,000 patients with blood-related malignancies receive HDC, which, if the response is satisfactory, could subsequently be followed by hematopoietic stem cell transplantation (HSCT). (bdbiosciences.com)
  • 1 Improvements in transplantation techniques, including the wider use of cell selection, have contributed to a significant reduction in the morbidity and mortality associated with conventional transplantation. (bdbiosciences.com)
  • This pharmacologically induced egress of HSCs into peripheral blood, called mobilization, is utilized as the preferred strategy for generating HSCs for transplantation. (bdbiosciences.com)
  • 3 Autologous stem cell transplantation almost exclusively uses peripheral blood, while for allogeneic SCT, T-lymphocytes in the peripheral blood could pose some danger. (bdbiosciences.com)
  • The number of viable CD45+/CD34+ cells will determine the quality of the harvested specimen for transplantation. (bdbiosciences.com)
  • An accurate measurement of CD34 is critical for dose requirement protocols in stem cell transplantation. (bdbiosciences.com)
  • Therefore, hematopoietic stem cells mobilized into a subject's peripheral blood by the method of the invention is useful as a source of donor cells in bone marrow transplantation for the treatment of a variety of disorders, including cancer, anemia, autoimmunity and immunodeficiency. (justia.com)
  • Curative options for sickle cell disease: haploidentical stem cell transplantation or gene therapy? (nih.gov)
  • The induction of a specific differentiated cell type can be useful for transplantation or drug screening and drug discovery in vitro. (justia.com)
  • In particular, the induction of stem cells to differentiate into muscle cells (myocytes) is useful for muscle transplantation and therapeutic purposes, as well as providing potential human disease models in culture (e.g. for testing pharmaceuticals). (justia.com)
  • The only curative therapy is stem cell transplantation. (lu.se)
  • Comparable survival outcomes with haploidentical stem cell transplantation and unrelated bone marrow transplantation. (cdc.gov)
  • STUDY DESIGN AND METHODS: The hematopoietic progenitor cell (HPC) and lymphocyte subset (LS) content of approximately 8000 CB units were characterized, and these results were correlated with donor ethnicity, birth weight, gestational age, sex, and type of delivery. (emmes.com)
  • 2 Evaluation of harvest adequacy requires the use of reliable progenitor cell assays and this is usually achieved by CD34 cell counting using flow cytometry. (bdbiosciences.com)
  • Flow cytometric applications for CD34+ cell identification and enumeration provide a rapid, quantitative and reproducible method to evaluate the progenitor cell population. (bdbiosciences.com)
  • The present invention relates generally to improved methods and pharmaceutical compositions for mobilizing hematopoietic stem and progenitor cell from bone marrow into peripheral blood by administration of at least one inhibitor of a GTPase, such as Rac1 and/or Rac2 GTPase. (justia.com)
  • The various mature blood cell types are all ultimately derived from a single class of progenitor cell known as hematopoietic stem cells. (justia.com)
  • We know that innate immune cells are required for blastema progenitor cell formation, but are lacking an understanding of the immune cell processes and functions that are required for inducing and maintaining these progenitors cells. (lu.se)
  • We performed gain and loss of function studies for leukemia inhibitory factor (LIF) and showed a depletion of NSCs, a subset of multipotential neural precursors and immature oligodendrocytes in LIF null mice. (karger.com)
  • CD34, a transmembrane phosphoglycoprotein, is present on immature hematopoietic precursor cells and all hematopoietic colony-forming cells in bone marrow and blood, including unipotent and pluripotent progenitor cells. (bdbiosciences.com)
  • 107 immature T-cells per day competence. (lu.se)
  • More and more we're learning that the genes that turn on in the embryo to make blood stem cells are the same genes that go wrong in cancer," he says. (sciencedaily.com)
  • Zambidis and colleagues are currently using their model to study the next stage in blood cell development, which in a growing embryo involves blood cell precursors moving from the yolk sac into the liver, bone marrow and thymus. (sciencedaily.com)
  • Identification of VENT - ventrally emigrating neural tube - cells within the stomach and small intestine is another piece in Dr. Sohal's effort to fully define and describe the cells that he first found migrating out from the neural tube of a chick embryo. (scienceblog.com)
  • If Dr. Sohal's studies are on target, he's found the first source of new cells identified in the embryo since 1868 and what might be the precursor for adult stem cells. (scienceblog.com)
  • We will then use a sensitive technique to look at such cell-types directly in the embryo. (bath.ac.uk)
  • The thing that just wows me about this is that blood stem cells, when they form in the embryo, form in the wall of the main vessel called the aorta. (scitechdaily.com)
  • Embryonic stem (ES) cells are derived from the embryo and are pluripotent, thus possessing the capability of developing into any organ, cell type or tissue type. (justia.com)
  • … "embryo" means a human organism during the first 56 days of its development following fertilization or creation, excluding any time during which its development has been suspended, and includes any cell derived from such an organism that is used for the purpose of creating a human being. (hinxtongroup.org)
  • She makes use of mouse models, cell assays and gene transduction. (wikipedia.org)
  • People with a specific mutation (called Δ32) on the CCR5 gene develop defective receptors, so the HIV virus can't enter the cell. (forbes.com)
  • Along with a technique called TALENs, invented several years ago, and a slightly older predecessor based on molecules called zinc finger nucleases, CRISPR could make gene therapies more broadly applicable, providing remedies for simple genetic disorders like sickle-cell anemia and eventually even leading to cures for more complex diseases involving multiple genes. (technologyreview.com)
  • Most conventional gene therapies crudely place new genetic material at a random location in the cell and can only add a gene. (technologyreview.com)
  • A disease caused by a single mutation, in a single gene, that involves only a single cell type. (technologyreview.com)
  • After harvesting blood cell precursors called hematopoietic stem cells from the bone marrow of a sickle-cell patient, scientists would use CRISPR to correct the defective gene. (technologyreview.com)
  • Then the gene--corrected stem cells would be returned to the patient, producing healthy red blood cells to replace the sickle cells. (technologyreview.com)
  • Rat stem-cell leukemia gene expression increased during testis maturation. (nih.gov)
  • A gene known for its ability to form blood vessels has been found to be a key player in a chromosomal abnormality that causes potentially devastating birth defects in the heart and throughout the body. (scienceblog.com)
  • A key experiment is to use a complementary technique to look at gene activity in thousands of neural crest cells, looking comprehensively at their cell-profiles so as to study the range of identifiable precursor states in the neural crest. (bath.ac.uk)
  • The analysis revealed that hematopoietic commitment capacity (PSCs to hematopoietic precursors) is correlated with the expression level of the IGF2 gene independent of the iPSC origins. (nih.gov)
  • The brain-like blobs can be kept alive for more than two years, maturing long enough to develop the cell types, activity patterns and gene-expression profiles of a typical human brain after birth. (spectrumnews.org)
  • Current Research and Scholarly Interests We have six main areas of current interest: 1) Cranial Suture Developmental Biology, 2) Distraction Osteogenesis, 3) Fibroblast heterogeneity and fibrosis repair, 4) Scarless Fetal Wound Healing, 5) Skeletal Stem Cells, 6) Novel Gene and Stem Cell Therapeutic Approaches. (stanford.edu)
  • In addition, strategies to correct the underlying mutation which causes sickle cell disease are being pursued utilizing newly developed gene editing tools, and work in the laboratory to develop methods for efficient editing of hematopoietic stem cells is underway. (nih.gov)
  • After extracting and isolating precursor CD34+ cells from patients, they use viral transduction to insert a correct copy of the β-globin gene before returning the cells to the patient's bone marrow. (nih.gov)
  • The laboratory has focused on optimizing the conditions for viral transduction, including selecting and modifying viral strains for study in animal models, optimizing growth conditions for transduced hematopoietic cells, and designing gene vectors to ensure appropriate placement and expression of the inserted gene. (nih.gov)
  • Clonal plasma cell proliferative diseases in which the Vl 6 gene is expressed are always associated with amyloid deposition. (medscape.com)
  • The APP gene provides instructions for making a protein called amyloid precursor protein. (medlineplus.gov)
  • The most common APP gene variant changes one of the protein building blocks (amino acids) in the amyloid precursor protein. (medlineplus.gov)
  • Hematopoietic stem cells (HSCs) are the precursors of all cells of the peripheral blood, and they usually reside in a quiescent state in the bone marrow. (bcm.edu)
  • These syndromes are characterized by ineffective hematopoiesis manifested in morphologic dysplasia of hematopoietic precursors, one or more peripheral blood cytopenias, and a propensity to progress to acute myeloid leukemia (AML). (medscape.com)
  • The 2016 update to the fourth edition of the World Health Organization (WHO) Classification of Tumors of the Hematopoietic and Lymphoid Tissues renamed the entity previously diagnosed as refractory cytopenia with multilineage dysplasia (RCMD) as MDS-MLD, in part because the presence of a specific cytopenia (eg, anemia) does not necessarily correlate with the degree or type of dysplasia seen in the bone marrow and peripheral blood. (medscape.com)
  • There are less than 1% blasts in the peripheral blood and less than 5% blasts in the bone marrow. (medscape.com)
  • Vulnerability to infection is extremely high in patients with agranulocytosis, which is the virtual absence of neutrophils in peripheral blood, with ANC typically lower than 100/μL. (medscape.com)
  • Concurrent anemia, thrombocytopenia, and/or an abnormal result on a peripheral blood smear from a patient with neutropenia suggest an underlying hematologic disorder. (medscape.com)
  • We used G-CSF-mobilized CD34 + HSPCs, FACS-sorted from healthy donor peripheral blood mononuclear cells (PBMCs). (hindawi.com)
  • 2 HSCs are primarily found in bone marrow niches, but a small fraction of HSCs can also be found in the peripheral blood. (bdbiosciences.com)
  • 3 Following exogenous stimulation, such as chemotherapy or using growth factors such as granulocyte colony stimulating factor (G-CSF) and filgrastim, the number of HSCs in the peripheral blood increases, either becoming on par or even exceeding the number in the bone marrow. (bdbiosciences.com)
  • Improved methods and pharmaceutical compositions are provided herein for mobilizing hematopoietic progenitor cells from bone marrow into peripheral blood, comprising the administration of an effective amount of an inhibitor of GTPases, such as Rac1 and Rac2 alone or in combination. (justia.com)
  • Specifically, methods are disclosed for mobilizing hematopoietic stem cells into a subject's peripheral blood. (justia.com)
  • In particular, embodiments of the method involve inhibition of both Rac1 and Rac2 GTPases to increase the numbers of hematopoietic stem cells into a subject's peripheral blood of a subject. (justia.com)
  • In such procedures, patients undergo successive treatments with cell mobilization agents to cause mobilization of hematopoietic progenitor cells from the bone marrow to the peripheral circulation for harvesting. (justia.com)
  • Diagnosis is usually based on a complete blood count and peripheral smear, which usually shows a macrocytic anemia with anisocytosis and poikilocytosis, large oval red blood cells (macro-ovalocytes), Howell-Jolly bodies (residual fragments of the nucleus), hypersegmented neutrophils, and reticulocytopenia. (msdmanuals.com)
  • We hope that in a few years - I honestly think it's going to be five years or more - that we can potentially derive blood cells to be used for transfusions, red blood cells, platelets or such, or for bone-marrow transplants. (badgerherald.com)
  • Researchers at the Center for iPS Cell Research and Application at Kyoto University in Japan presented data at a meeting of the American Society of Hematology showing they were able to create the cells in the laboratory and confirm they had the same life span as normal human platelets when infused in mice. (ibtimes.com)
  • The limitation in using stem cells to produce platelets has been the ability to find a method that creates a large number of high-quality, functional platelets. (ibtimes.com)
  • The Japanese researchers set out to create an immortalized cell line with a large number of high-quality megakaryocytes -- precursor cells that develop into platelets -- from stem cells that can be grown indefinitely and differentiate into a variety of cell types in the body. (ibtimes.com)
  • They were able to produce a cell line that turned off certain genes to generate functional platelets. (ibtimes.com)
  • In normal clotting, platelets stick together and form a plug at the site of an injured blood vessel, allowing the injured site to heal. (ibtimes.com)
  • Platelets used for transfusions are derived from donated blood but they have a short shelf life since they must be stored at room temperature and cannot be frozen. (ibtimes.com)
  • These systems promoted the development of precursor blood stem cells which can differentiate into various blood components - white blood cells, red blood cells, platelets, and others. (scitechdaily.com)
  • Mr Souradip Mookerjee is an MB/PhD student in Dr Cedric Ghevaert's Lab at the University of Cambridge, working on the translational research of making platelets from stem cells. (nhsbt.nhs.uk)
  • Radiation affects cells that divide quickly, especially blood - red cells only last about 120 days in circulation, and platelets only 5 days. (nhsbt.nhs.uk)
  • There have been no major advances to improve the storage of platelets beyond 7 days, compared with 35-40 days for red blood cells, making these a comparatively perishable blood product. (nhsbt.nhs.uk)
  • Our laboratory is interested in genetic disorders of bleeding and thrombosis, focusing on blood platelets as the tools to understand the molecular basis of these disorders in humans. (ny.gov)
  • Blood platelets are generated from bone marrow stem cells, serving not only to control normal bleeding, but involved also in excessive clotting that may predispose to pathological disorders such as heart attacks and stroke. (ny.gov)
  • For our NYSTEM proposal, we have developed novel means of infecting bone marrow stem cells to specifically target the deficient protein (factor VIII) in bone marrow stem cells that are the precursors for circulating blood platelets. (ny.gov)
  • Multiplexed genetic profiling of human blood platelets using fluorescent microspheres. (ny.gov)
  • In one channel, the scientists seed endothelial cells, which line blood vessels in natural tissues. (mpg.de)
  • When this has happened, the scientists deliver a growth factor cocktail of molecules that drive blood vessel growth in natural tissues through the second channel, whereupon the endothelial cells migrate into the hydrogel. (mpg.de)
  • iPSCs are stem cells reprogrammed from mature somatic tissues (like white blood cells) that have the capability of forming almost any cell in the body including neurons. (rutgers.edu)
  • Stem cells are precursor cells that develop into specific kinds of tissues, replenishing blood, skin, and other kinds of cells in the body. (harvard.edu)
  • This paved the way for the idea that given the right factors, our own differentiated cells can have their internal clocks turned back, to turn them back into a stem cell just like the one that makes all of those trillion cells that make us who we are, and one day we might be able to use them to grow tissues for transplant. (nhsbt.nhs.uk)
  • The subject's blood can be processed and used to repopulate the destroyed lymphohematopoietic system of a recipient and may in the future be utilized to repair a variety of non-hematopoietic tissues. (justia.com)
  • Dr. Tisdale has an active research program in trying to characterize tolerance and create conditions in which patients will more easily tolerate donor cells and tissues without the need for destroying the immune system or perpetual use of immunosuppressant drugs. (nih.gov)
  • Inspired from developmental processes, human mesenchymal cell lines can be programmed to form cartilage, bone and bone marrow tissues in vitro and in vivo. (lu.se)
  • It is essential to have sensitive and reproducible methods of either quantifying or isolating these stem cells and progenitors to understand their intrinsic properties and how extrinsic signals regulate their development. (karger.com)
  • However, stem cells are difficult to distinguish from multipotential progenitors, which may look and act like them. (karger.com)
  • Here we define a 4-color flow cytometry panel using CD133, LeX, CD140a, NG2 to define a neural stem cell (NSC) as well as 4 classes of multipotential progenitors and 3 classes of bipotential progenitors, several of which have not been described previously. (karger.com)
  • Wu J, Matthias N, Lo J, Ortiz-Vitali JL, Shieh AW, Wang SH, Darabi R . A Myogenic Double-Reporter Human Pluripotent Stem Cell Line Allows Prospective Isolation of Skeletal Muscle Progenitors. (uh.edu)
  • In our study, we worked on cells derived from the CD34 + hematopoietic stem and progenitor cells, enriched with CD133 + population, and used culture media promoting growth of hematopoietic progenitors. (hindawi.com)
  • 2012). At later EB stage, most CD43+ cells upregulated the manifestation of CD41a and CD235a, and were enriched for megakaryocyte and erythroid progenitors, respectively (Klimchenko et?al. (bioskinrevive.com)
  • DN1 stage) T-cell progenitors. (lu.se)
  • Proliferation-linked shifts in eligibility of T-cell progenitors, population dynamics, DN1 cells to undergo specification thus control kinetics of T-cell generation. (lu.se)
  • thymus from marrow-derived progenitors circulating in the blood. (lu.se)
  • In detail, thymus-settling progenitors enter the thymus and generate early T-cell progeni- tors (ETP/DN1 stage), which in turn give rise to DN2, DN3 and DN4 cells. (lu.se)
  • The bone marrow contains various populations of skeletal stem cells (SSCs) in the stromal compartment, which are important regulators of bone formation. (nature.com)
  • Basically, given the difference of telomere and telomerase activity in human and mouse cells, the telomere and telomerase status in stem cell populations is different between humans and mice ( Harrington, 2004 ). (nature.com)
  • The BD ® Stem Cell Enumeration (SCE) Kit provides simultaneous enumeration of viable dual-positive CD45+/CD34+ hematopoietic stem cell populations in CD34+ absolute counts (cells/µL) as well as the percentage of the total viable leucocyte count that is CD34+ (%CD34). (bdbiosciences.com)
  • This roadmap allowed us to generate enriched populations of human liver, bone, heart and blood vessel precursors in a Petri dish from embryonic stem cells. (stanford.edu)
  • A synthetic hydrogel in which endothelial cells (pink cell nuclei) form new blood vessels that grow from a parent blood vessel (upright on the left). (mpg.de)
  • The endothelial cells form contacts with each other and attach to their synthetic tissue environment in the channel, thus forming a parent blood vessel after about a day," explains Britta Trappmann. (mpg.de)
  • The scientists then wanted to find out which properties of the hydrogel determine whether the migrating endothelial cells actually form new blood vessels. (mpg.de)
  • The researchers first enriched the hydrogel tissue framework with varying amounts of peptides that activate a certain type of adhesion molecule found in the membrane of endothelial cells called integrins. (mpg.de)
  • The higher the concentration of peptides, the more the endothelial cells migrated together through the hydrogel. (mpg.de)
  • Conditioned media from such cells were then used to stimulate human aortic endothelial cells (HAoECs) to enhance tube-like structure formation in a Matrigel assay. (hindawi.com)
  • Neither AT alone in control media nor conditioned media nor AT-stimulated cells affected numbers of endothelial cells in the plug or plug's vascularization. (hindawi.com)
  • The process of neovascularization can be influenced not only by the residual endothelial cells but also by the circulating cells. (hindawi.com)
  • These 2 members mediate leukocyte adhesions to endothelial cells but they also serve as receptors for iC3b (inactivated C3b). (medscape.com)
  • This disease is a defect in fucose metabolism (lack of fucosylation of the carbohydrate selectin ligands) that results in failure to express the ligand for E and P selectin, sialyl Lewis-X (CD15s) expressed on leukocytes and endothelial cells. (medscape.com)
  • A critical length of telomere repeats is required to ensure proper telomere function and avoid the activation of DNA damage pathways that result in replicative senescence or cell death. (nature.com)
  • Several signaling pathways control blood cell (hemocyte) development in the Drosophila lymph gland. (nih.gov)
  • Therefore, the goals of my studies were to assess neurite outgrowth, migration, and signaling pathways in neural precursor cells derived from 6 individuals with ASD. (rutgers.edu)
  • Lipids, amino acids, and nucleotides necessary for the biosynthesis of the daughter cells are mostly provided by intermediate metabolites of these pathways. (hindawi.com)
  • To prevent aberrant cell proliferation, these pathways are tightly regulated. (hindawi.com)
  • In order to mimic the natural environment of cells, many additional biomolecules and cells would have to be integrated into the model system in later steps - these may be signaling proteins, immune cells or cells to stabilize the blood vessels. (mpg.de)
  • Cytokines are small proteins that play a crucial role in cell signaling and communication. (proprofs.com)
  • They are proteins that cut other proteins, enabling a wide range of essential functions such as wound healing, blood clotting and formation of muscle and nerve cells. (scienceblog.com)
  • The roles of clonal hematopoiesis, RNA-binding proteins, and alterations in metabolism and cell signaling (e.g. (cshlpress.com)
  • All stem from dysfunctional N -glycosylation of proteins. (medscape.com)
  • The most common light chain-type amyloidosis precursor proteins are L chains of the lambda (l) class. (medscape.com)
  • Researchers speculate that it may bind to other proteins on the surface of cells or help cells attach to one another. (medlineplus.gov)
  • Although the aetiology of these disorders remains unknown, in this review we analyse the pathogenic mechanisms by cell of interest (fibroblast, fibrocyte, myofibroblast, endothelial and alveolar epithelial cells and immune competent cells). (ersjournals.com)
  • Myeloid angiogenic cells (MAC) derive from hematopoietic stem/progenitor cells (HSPCs) that are mobilized from the bone marrow. (hindawi.com)
  • Our study is aimed at investigating whether precursors of myeloid angiogenic cells (PACs) treated with known pharmaceuticals would produce media with better proangiogenic activity in vitro and if such media can be used to stimulate blood vessel growth in vivo . (hindawi.com)
  • Then, we used atorvastatin-stimulated cells or conditioned media from them in the Matrigel plug in vivo angiogenic assay. (hindawi.com)
  • Concluding, high concentrations of atorvastatin stabilize tubes and enhance the paracrine angiogenic activity of human PAC cells in vitro . (hindawi.com)
  • Such myeloid angiogenic cells (MAC) [ 1 ] of bone marrow origin were known as endothelial progenitor cells (EPCs). (hindawi.com)
  • Cells previously known as endothelial progenitor cells are considered now to be rather myeloid angiogenic cells than endothelial precursors [ 4 ]. (hindawi.com)
  • Therefore, the cells we used should be considered as hematopoietic precursors of myeloid angiogenic cells and are referred as PACs. (hindawi.com)
  • A winner of the World Economic Forum Technology Pioneer Award, the Company has developed, patented, and is scaling a patient's blood-based stem cell therapeutics platform that includes angiogenic cell precursors, neuronal cell precursor and cardiomyocyte cell precursors. (menafn.com)
  • The Johns Hopkins researchers' system involves the study of existing embryonic stem cell lines derived from in vitro fertilization methods, and so doesn't require generation of embryos through cloning, a technique recently reported by South Korean scientists. (sciencedaily.com)
  • Bisulfite converted genomic DNA lysates from induced pluripotent stem cell and embryonic stem cell lines were hybridized to Illumina HumanMethylation450 BeadChip. (nih.gov)
  • She identified that altered HOXA1 genes impact the ability of haematopoietic stem cells. (wikipedia.org)
  • Yet scientists have until recently remained largely ham-fisted when they've tried to directly modify genes in a living cell. (technologyreview.com)
  • Generally, when a stem cell culture is induced to differentiate, the differentiated population is analysed for particular cell types by expression of genes, markers or phenotypic analysis. (justia.com)
  • In fact, low levels of telomerase activity have been found in human adult stem cells including haematopoietic and non-haematopoietic stem cells such as neuronal, skin, intestinal crypt, mammary epithelial, pancreas, adrenal cortex, kidney, and mesenchymal stem cells (MSCs) ( Table 1 ). (nature.com)
  • The transplants are also risky, with common complications being infection (often pneumonia), sepsis, bleeding, organ failure, and chronic graft vs. host disease, which happens when the donor cells attack the recipient's tissue. (forbes.com)
  • The researchers believe that egg stem cells in the donor bone marrow established themselves in the sterile mice and began producing egg cells, also called oocytes. (harvard.edu)
  • She said that in the last few decades, biomedical engineers have been trying to make blood stem cells in laboratory dishes to solve the problem of donor blood stem cell shortages. (scitechdaily.com)
  • A team headed by biomedical engineer Dr Britta Trappmann from the Max Planck Institute for Molecular Biomedicine in Münster, Germany, has developed a cell culture system in which, for the first time, a functional blood vessel system is able to grow within a framework made of synthetic materials. (mpg.de)
  • The scientists, working in a special hydrogel with properties they can change in a controlled manner, first grew a parent blood vessel from human blood vessel lining cells. (mpg.de)
  • The biggest challenge is to make an ideal product for transplant, which would be either a mixture of heart muscle- and blood vessel-forming cells or a pure population of some sort of precursor that could give rise to both muscle and blood vessel cells. (scienceblog.com)
  • and they don't yet have any of the full characteristics of heart muscle or blood vessel cells such as producing cardiac myosin - an important protein in heart muscle cells. (scienceblog.com)
  • Altogether our FACS (fluorescence-activated cell sorter) analyses reveal that the neonatal subventricular zone is far more heterogeneous than previously suspected and our studies provide new insights into the signals and mechanisms that regulate their self-renewal and proliferation. (karger.com)
  • The TAL1/SCL transcription factor regulates cell cycle progression and proliferation in differentiating murine bone marrow monocyte precursors. (nih.gov)
  • Cell proliferation involves the replication of all cellular contents with the required energy for this to happen. (hindawi.com)
  • This activation is necessary for both cell proliferation as well as glucose uptake and use. (hindawi.com)
  • WFIRM's Yuanyuan Zhang, Ph.D, lead author of the paper published by Frontiers in Cell and Developmental Biology , said that human urine-derived stem cells can be easily isolated from urine samples which offers clear advantages over stem cells from other sources, like bone marrow or fat tissue which often require a surgical procedure for collection. (phys.org)
  • One of the objectives for decades in biology is an understanding of how we can start from a single cell to a complex organism with over 200 cell types," said Tim Mulcahy, UW associate dean of biological sciences. (badgerherald.com)
  • The research team leader, Associate Professor of Obstetrics, Gynecology, and Reproductive Biology Jonathan Tilly, characterized criticism of the current paper as more severe than that directed at last year's work, a fact he attributed to the findings that the bone marrow, rather than the ovaries, are the ultimate site of egg cell generation. (harvard.edu)
  • A major problem in developmental biology is to understand how these flexible precursors make a specific choice of cell-type to adopt. (bath.ac.uk)
  • Increasingly, stem cell biology is being explored using a mathematical modelling approach which has often given key insights into how they function. (bath.ac.uk)
  • In parallel we will explore the mathematical basis for the three models, developing current models to describe PFR, and applying novel theoretical insights to stem cell biology to investigate the plausibility of both DFR and our novel Cyclical model. (bath.ac.uk)
  • Together, these studies will test a revolutionary view of neural crest stem cell biology. (bath.ac.uk)
  • In another article, which was recently published in Nature Cell Biology , researchers from UNSW Medicine & Health revealed the identity of cells in mice embryos responsible for blood stem cell creation. (scitechdaily.com)
  • His undergraduate research, conducted under the mentorship of Dr. Yibin Kang, centered around cancer metastasis and cancer stem cell biology. (stanford.edu)
  • In addition to our interests in developmental and stem cell biology, we also interested in discovering the entry receptors and target cells of deadly biosafety level 4 viruses, together with our collaborators. (stanford.edu)
  • He then continued as a Siebel Investigator, and later, as an Assistant Professor and The Anthony DiGenova Endowed Faculty Scholar at Stanford, where he is jointly appointed in the Department of Developmental Biology and Institute for Stem Cell Biology & Regenerative Medicine. (stanford.edu)
  • In 2011, I started my own laboratory at WEHI with a consistently innovative research program focused on the biology of blood production and function. (edu.au)
  • In brief, my research team uses cutting edge imaging, clonal tracking (cellular barcoding), genomics technologies, and functional assays (in vivo and in vitro) to tackle long-standing questions about the biology of blood production. (edu.au)
  • Yet, until the discovery of induced pluripotent stem cell (iPSC) technology such studies were impossible. (rutgers.edu)
  • Wu J, Hunt SD, Matthias N, Servián-Morilla E, Lo J, Jafar-Nejad H, Paradas C, Darabi R . Generation of an induced pluripotent stem cell line (CSCRMi001-A) from a patient with a new type of limb-girdle muscular dystrophy (LGMD) due to a missense mutation in POGLUT1 (Rumi). (uh.edu)
  • Induced pluripotent stem cells are a type of pluripotent stem cell that can be generated directly from a somatic cell. (scitechdaily.com)
  • Knowing the steps by which stem cells develop into blood cells are likely to help medical researchers figure out how to treat cancers of the blood, such as leukemia and lymphoma, Zambidis notes. (sciencedaily.com)
  • Stem cell transplants are typically used for patients with leukemia or specific cancers. (forbes.com)
  • Leukemia and lymphoma are cancers that affect white blood cells. (cshlpress.com)
  • Problems start when leukemia cells become more numerous than normal cells and erythrocyte precursor cells5. (bvsalud.org)
  • The diagnosis of leukemia is established, through a myelogram, by the presence of more than 25% of leukemic cells on a bone marrow aspirative on puncture 6 . (bvsalud.org)
  • RUNX1-positive leukemia cells in preclinical models. (lu.se)
  • The third project is focused on identifying targets affecting leukemia stem cells and on providing in vivo proof of concept data for targeted therapies with a focus on antibody-based strategies. (lu.se)
  • To achieve our objectives, we use start of the art next-generation sequencing technologies, in vitro and in vivo models of acute leukemia, cell sorting, single-cell sequencing and advanced bioinformatics. (lu.se)
  • Several possible mechanisms were considered for the induction of human leukemia, such as clastogenic damage to circulatory stem cells. (who.int)
  • These precursors are multipotent, having the flexibility to develop into any one of many types of working cells (e.g. neurons, blood or skin cells). (bath.ac.uk)
  • The scale of the problem is illustrated by the fact that for one key exemplar, neural crest stem cells, there is still uncertainty about how the process works even after four decades of research - do fully multipotent cells 'jump' straight to a specific chosen fate, or do they go through a series of steps in which their options become more and more limited, until eventually they choose a single cell-type? (bath.ac.uk)
  • We see evidence for only some very broadly multipotent precursors, leading us to propose our novel Cyclical Fate Restriction model. (bath.ac.uk)
  • 1983) and the multipotent progenitor cells from fetal disease (Bjorklund and Lindvall, 2000). (lu.se)
  • 2011 National Health and Medical Research Council Senior Research Fellowship[citation needed] 2016 SVI Foundation Award 2019 University of Melbourne Professorial Fellow[citation needed] 2022 International Society for Experimental Hematology McCulloch & Till Award 2022 Chair, ASH Scientific Committee on Stem Cells and Regenerative Medicine. (wikipedia.org)
  • The Wake Forest Institute for Regenerative Medicine (WFIRM) researchers, who were the first to identify that stem cells in human urine have potential for tissue regenerative effects, continue their investigation into the power of these cells. (phys.org)
  • These achievements are part of a move in regenerative medicine towards the use of 'induced pluripotent stem cells' to treat disease. (scitechdaily.com)
  • Each of these tissue precursors could regenerate their cognate tissue upon injection into respective mouse models, with relevance to regenerative medicine. (stanford.edu)
  • Additionally, characterization of the tumor microenvironment such as interactions with immune cells remain largely unknown. (springer.com)
  • Wu J, Hunt SD, Xue H, Liu Y, Darabi R . Generation and Characterization of a MYF5 Reporter Human iPS Cell Line Using CRISPR/Cas9 Mediated Homologous Recombination. (uh.edu)
  • In somatic cells, the activity of telomerase, a reverse transcriptase that can elongate telomeric repeats, is usually diminished after birth so that the telomere length is gradually shortened with cell divisions, and triggers cellular senescence. (nature.com)
  • Thus, even in stem cells, except for embryonal stem cells and cancer stem cells, telomere shortening occurs during replicative ageing, possibly at a slower rate than that in normal somatic cells. (nature.com)
  • Telomeric DNA consists of short guanine-rich repeat sequences in all eukaryotes with linear chromosomes, and its length in human somatic cells is remarkably heterogeneous among individuals ranging from 5 to 20 kb, according to age, organ, and the proliferative history of each cell ( Wright and Shay, 2005 ). (nature.com)
  • In most human somatic cells except for stem cells and lymphocytes, telomerase activity is diminished after birth so that telomere length shortens with each cell division. (nature.com)
  • The disease is characterized by lack or very reduced levels of B and T cells , thrombocytes involved in blood clotting, and granulocytes that form the majority of blood leukocytes , due to the failed maturation of not only lymphoid but also of myeloid precursor cells. (lu.se)
  • Virtually all of the neurons and glia that populate the mature brain arise from neural precursors (NPs) that reside immediately adjacent to the lateral ventricles. (karger.com)
  • they contain both neurons (green) and support cells called glia (purple). (spectrumnews.org)
  • Studies suggest that in the brain, it helps direct the movement (migration) of nerve cells (neurons) during early development. (medlineplus.gov)
  • A fundamental requirement for functional tissue is that blood vessels must be able to grow in them and connect to the organism's vascular system, so that the tissue is properly supplied with oxygen and nutrients. (mpg.de)
  • Their findings provide a novel perspective to evaluate the capacity of telomerase-positive human urine -derived stem cells to become a wide variety of other cell types, and to be used as an optimal cell source for stem cell therapy or cell-based tissue regeneration. (phys.org)
  • As a safe cell source, telomerase-positive human urine-derived stem cells have a robust regenerative potential, which might induce better tissue repair," said Zhang. (phys.org)
  • Without any chemical manipulation or stimulation, the clusters of human stem cells first became colonies of cells that can produce endothelium, or the tissue that makes up the circulatory system. (sciencedaily.com)
  • If Thomson and other stem-cell scientists are right in their findings, heart tissue could be recreated to cure heart-attack victims and insulin could be created for diabetes patients. (badgerherald.com)
  • A cell type with the potential for making the four major types of human tissue has been found in the stomach and small intestine by a Medical College of Georgia researcher. (scienceblog.com)
  • This is where stem cells are reverse engineered from adult tissue cells rather than using live human or animal embryos. (scitechdaily.com)
  • Study co-author Associate Professor Robert Nordon said he was amazed that not only did the device create blood stem cell precursors that went on to produce differentiated blood cells, but it also created the tissue cells of the embryonic heart environment that is crucial to this process. (scitechdaily.com)
  • Development of new blood vessels is necessary for the effective tissue regeneration. (hindawi.com)
  • Typically, rapidly proliferating tumor cells have glycolytic rates up to 200 times higher than those of their normal tissue of origin, even in the presence of oxygen [ 3 ]. (hindawi.com)
  • XI - embryonic stem cells: embryonic cells that are capable of modifying the cells of any organism tissue. (hinxtongroup.org)
  • and salivary enzymes may lyse the blood clot before the growth of granulation tissue 2 . (bvsalud.org)
  • While responses to inflammation may be necessary to maintain normal and emergency hematopoiesis, it may be deleterious over the long term, with prolonged inflammation leading to stem cell exhaustion (Cell Reports, 2016). (bcm.edu)
  • Blood 2016:128:2683-2693. (lu.se)
  • These colonies can then also form the precursors of blood cells, in a structure similar to the yolk sac of human embryos. (sciencedaily.com)
  • Basophils, lymphoid cells, and megakaryocytes are not direct precursors of mast cells. (proprofs.com)
  • As iPSCs retain the genetic signature of the individuals from whom they are derived, we can for the first time, study the development and function of neural cells of people with genetically complex neuropsychiatric disorders. (rutgers.edu)
  • Johns Hopkins scientists have developed a way to study the earliest steps of human blood development using human embryonic stem cells grown in a lab dish instead of the embryos themselves. (sciencedaily.com)
  • In their report on the work in the June issue of the journal Blood, the Johns Hopkins team demonstrated a clear similarity between how human embryonic stem cells specialize into blood cells and how blood cells develop in human embryos. (sciencedaily.com)
  • Historically, scientists have worked on mouse and zebrafish models of embryological blood cell development, but ethical and technical barriers have stood in the way of an in-depth study of blood formation in human embryos. (sciencedaily.com)
  • Most importantly, Zambidis says, the stages of blood cell development he and his team found in the stem cell lines correlate with what is already known about early stages of human blood cell development in embryos in the womb. (sciencedaily.com)
  • The cells, taken from fertilized embryos less than a week old, are important because they have not yet specialized into one of the 220 different cell types. (badgerherald.com)
  • As a result of work done on an ongoing BBSRC grant studying neural crest stem cells in zebrafish embryos, we are proposing a revolutionary new view, which we believe reconciles these conflicts. (bath.ac.uk)
  • Finally, some of the cells in the colonies form blood cells similar to those found in the liver and bone marrow of a developing fetus, making it simple for the researchers to pick out the blood cells for further investigation. (sciencedaily.com)
  • It is likely to be at least several years before such efforts can be developed into human therapeutics, but a growing number of academic researchers have seen some preliminary success with experiments involving sickle-cell anemia, HIV, and cystic fibrosis (see table below). (technologyreview.com)
  • In an article published Tuesday, Dan Kaufman, hematology fellow at the UW Medical School, announced he and a team of researchers have taken an undifferentiated stem cell and coaxed it into a specialized blood cell. (badgerherald.com)
  • Kaufman said creating the blood cell means a lot for transplant researchers and patients in the future. (badgerherald.com)
  • Harvard researchers have found new evidence that female mammals can produce egg cells throughout life and have traced their production out of the ovary and into the bone marrow in findings that could both reshape science's understanding of female reproduction and provide new avenues for treatment of infertility. (harvard.edu)
  • New discoveries about embryonic blood stem cell creation made independently by biomedical engineers and medical researchers at the University of New South Wales (UNSW) Sydney could one day eliminate the need for blood stem cell donors. (scitechdaily.com)
  • UNSW researchers have recently completed two studies in this area that shine new light on not only how the precursors to blood stem cells occur in animals and humans, but how they may be induced artificially. (scitechdaily.com)
  • In the study detailed in Cell Reports , lead author Dr. Jingjing Li and fellow researchers described how a 3cm x 3cm (1.2″ x 1.2″) microfluidic system pumped blood stem cells produced from an embryonic stem cell line to mimic an embryo's beating heart and conditions of blood circulation. (scitechdaily.com)
  • The researchers use a multi-step process: They coax stem cells to become brain-cell precursors in a standard way. (spectrumnews.org)
  • The researchers discovered that they could boost the proportion of stem cells that mature into brain cells if they started transforming the cells earlier - after letting stem cell colonies divide just once instead of 20 times over four to five months. (spectrumnews.org)
  • The efficiency was good enough that, despite having a smaller pool of cells, the researchers were able to coax enough of them to become brain cells to make an organoid. (spectrumnews.org)
  • The study demonstrates that human primary urinary stem cells with positive telomerase activity act as a distinct subpopulation with potential regeneration capacity in both cell growth and its capacity to become other cells, Zhang said. (phys.org)
  • Better understanding of alterations in this cell subpopulation throughout the human lifespan, and how they translate into, aging, kidney damage, or cancer, among others will be beneficial overall. (phys.org)
  • Recently, the importance of telomere maintenance in human stem cells has been highlighted by studies on dyskeratosis congenital, which is a genetic disorder in the human telomerase component. (nature.com)
  • The regulation of telomere length and telomerase activity is a complex and dynamic process that is tightly linked to cell cycle regulation in human stem cells. (nature.com)
  • Here we review the role of telomeres and telomerase in the function and capacity of the human stem cells. (nature.com)
  • Our findings provide an unparalleled opportunity to study the basic questions of human development, like 'Where does blood come from? (sciencedaily.com)
  • In the new work, Hopkins scientists and colleagues from the University of Pittsburgh School of Medicine used laboratory-grown dishes of human stem cells, in clumps called human embryoid bodies, and observed three distinct steps taken by stem cells on their way to becoming blood cells. (sciencedaily.com)
  • Because embryonic stem cells are capable of becoming virtually every type of cell in the human body, understanding how they do so might provide the chance to harness that process to make a limitless supply of specific cells for therapeutic purposes. (sciencedaily.com)
  • One is Gang Bao, a bioengineering researcher at the Georgia Institute of Technology, who has already used CRISPR to correct the sickle-cell mutation in human cells grown in a dish. (technologyreview.com)
  • The human embryonic stem cell, discovered in 1998 by UW developmental biologist James Thomson, is at the heart of recent hype about the future of biotechnology. (badgerherald.com)
  • Induced pluripotent stem cells, or iPS cells, are produced by manipulating ordinary human skin or blood cells back to a state in which they are able to differentiate into a number of different cell types. (ibtimes.com)
  • Wu J, Hunt SD, Xue H, Liu Y, Darabi R . Generation and Validation of PAX7 Reporter Lines from Human iPS Cells Using CRISPR/Cas9 Technology. (uh.edu)
  • Derivation of Skeletal Myogenic Precursors from Human Pluripotent Stem Cells Using Conditional Expression of PAX7. (uh.edu)
  • Skoglund G, Lainé J, Darabi R , Fournier E, Perlingeiro R, Tabti N. Physiological and ultrastructural features of human induced pluripotent and embryonic stem cell-derived skeletal myocytes in vitro. (uh.edu)
  • Biologists have shown for the first time in the laboratory that they can convert some adult human neural stem cells to brain cells that can produce dopamine, the brain chemical missing in Parkinson's disease. (scienceblog.com)
  • Although the notion that malaria has helped shape the human genome is well- accepted, the lack of a nucleus in human erythrocytes has hindered our ability to study genetic interactions between these unusual host cells and P. falciparum parasites. (stanford.edu)
  • It's also notable that of these three cell types, it's only heart-derived cells that are in current human clinical trials for this sort of treatment. (scienceblog.com)
  • They first developed the method in mice and although the identifying markers are quite different in human cells, they have been able to successfully map their knowledge from mice onto humans. (scienceblog.com)
  • They demonstrated how a simulation of an embryo's beating heart using a microfluidic device in the lab led to the development of human blood stem cell 'precursors', which are stem cells on the verge of becoming blood stem cells. (scitechdaily.com)
  • He is currently an MD-PhD candidate in the lab of Dr. Irving Weissman, where he researches human neural stem cells and primary brain malignancies. (stanford.edu)
  • Bio How the richly varied cell-types in the human body arise from one embryonic cell is a biological marvel and mystery. (stanford.edu)
  • We have mapped how human embryonic stem cells develop into over twenty different human cell-types. (stanford.edu)
  • Expression of protease activated receptor 3 (PAR3) is upregulated by induction of megakaryocyte phenotype in human erythroleukemia (HEL) cells. (ny.gov)
  • derivation of this specialized endothelium Ezetimibe enzyme inhibitor from human being embryonic stem cells (hESCs) provides an priceless platform to study and dissect blood specification and the emergence of hematopoietic stem and progenitor cells. (bioskinrevive.com)
  • To date, a great deal of data describing the emergence of blood cells from human being HE have been acquired using stromal co-culture protocols Ezetimibe enzyme inhibitor (Choi et?al. (bioskinrevive.com)
  • 2005). Notch1 and syndecan-1 potent human embryonic stem (ES) cells. (lu.se)
  • CD133+), but are rarely codetected with the neural stem dents, very few human-specific NSC markers have been cell (NSC) marker CD15. (lu.se)
  • Blood cancer journal 2023 9 13 (1): 149. (cdc.gov)
  • A second patient appears to have been "cured" of HIV following a stem cell transplant procedure, which replaces unhealthy, infected cells, with healthy blood cell precursors. (forbes.com)
  • The first successful stem cell transplant occurred in the "Berlin patient," Timothy Ray Brown, in 2008 and, ten years later, he is still free of HIV. (forbes.com)
  • Professor Schneider's team have discovered a way to identify heart stem cells so as to purify them for transplant. (scienceblog.com)
  • Dr. Tisdale and his colleagues recently completed a modified bone marrow transplant strategy for the first time in adult patients with sickle cell disease. (nih.gov)
  • In a recent study, they demonstrated that they could transplant bone marrow cells from HLA-matched sibling donors without needing to completely destroy the patient's immune system. (nih.gov)
  • Hemostemix is an autologous stem cell therapy company, founded in 2003. (menafn.com)
  • She returned to America in 2004, where she studied cells in the bone marrow microenvironment and how they could regulate myeloproliferative-like disorders. (wikipedia.org)
  • Pemphigus vulgaris (PV) is a life-threate- disorders and to shed a light on the role of ning blistering skin disease in which pa- mast cells in autoimmune diseases [ 7 ]. (who.int)
  • For instance, stem cells directed down the path of blood cell development might be useful to help treat leukemias or other blood disorders. (sciencedaily.com)
  • Matthias N, Hunt SD, Wu J, Darabi R . Skeletal muscle perfusion and stem cell delivery in muscle disorders using intra-femoral artery canulation in mice. (uh.edu)
  • Hemoglobinopathies, thalassemias, ovalocytosis, and G6PD deficiency are all examples of red cell disorders that appear to provide protection against severe malaria. (stanford.edu)
  • These monoclonal plasma cell disorders can be categorized according to the total body burden of monoclonal plasma cells. (medscape.com)
  • The relationship among light chain-type amyloidosis (AL), the other monoclonal plasma cell disorders, and the other amyloidoses. (medscape.com)
  • This is a tool to help students find the right project for their Bachelor's and Master's thesis at Lund Stem Cell Center. (lu.se)
  • Telomerase can add telomeric repeats onto the chromosome ends, and prevents the replication-dependent loss of telomere and cellular senescence in highly proliferative cells of the germline and in the majority of cancers ( Blasco, 2005 ). (nature.com)
  • Mammalian Asrij (Ociad1) is expressed in stem cells of the blood vascular system and is implicated in several cancers. (nih.gov)
  • Bone marrow transplants from healthy donors are used successfully to treat certain blood cancers for which the course of the disease is so severe that the destruction of the patient's own immune system through high-dose chemotherapy and radiation seems an effective compromise. (nih.gov)
  • This project will delve into innate immune cell function, establishing in vitro and in vivo systems test innate immune cell function in regeneration. (lu.se)
  • U2AF1 pathogenic variants in myeloid neoplasms and precursor states: distribution of co-mutations and prognostic heterogeneity. (cdc.gov)
  • These VENT cells have been found in addition to the three sources of cells typically associated with gastrointestinal development, says Dr. Paul Sohal, MCG developmental biologist, who first identified these cells nearly a decade ago. (scienceblog.com)