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  • erythroid differentiation
  • In the blood myeloid lineages, Epo (erythropoietin) controls erythroid differentiation, Tpo (thrombopoietin) controls megakaryocytic differentiation, whereas G-CSF (granulocyte colony-stimulating factor) regulates granulocyte formation. (biochemsoctrans.org)
  • patients
  • Arm I: Patients receive romiplostim subcutaneously once weekly for 8 weeks in the absence of disease progression or unacceptable toxicity. (clinicaltrials.gov)
  • rare
  • Metastasis from bladder cancer to the testis is extremely rare, occurs with advanced and metastatic disease, and is usually a finding at autopsy. (jove.com)
  • Budd-Chiari syndrome is a rare liver disease which involves clotting of blood in the hepatic veins, thereby producing mild to severe liver damage. (dp.ua)
  • Mice
  • see the Perspective by Johnson ) show that reducing the activity of the isoprenylcysteine carboxyl methyltransferase (ICMT) mislocalizes prelamin A, triggers prelamin A-dependent AKT-mTOR signaling, and eliminates disease phenotypes in 30-week-old progeria model mice. (sciencemag.org)
  • Interfering with farnesylation with an FTase inhibitor (FTI) reduces the frequency of misshapen nuclei in Zmpste24 -deficient fibroblasts and HGPS fibroblasts and ameliorates disease phenotypes in Zmpste24 -deficient mice and other models of HGPS, although the benefits are modest ( 2 , 5 - 10 ). (sciencemag.org)
  • vessels
  • BP in simple terms is the force that the heart exacts as it pushes blood round the vessels of the body. (dp.ua)
  • congenital
  • Associated features include short stature, chest deformity, undescended testes, muscle hypotonia, frequent learning difficulties, and congenital heart disease most commonly valvular pulmonary stenosis. (springer.com)
  • lineages
  • An increasing body of work suggests that differentiation of HSCs and progenitors into various blood lineages is controlled by multiple extrinsic and intrinsic factors. (bloodjournal.org)
  • symptoms
  • Some children with refractory cytopenia need only to be monitored with blood tests and may occasionally need blood transfusions to relieve symptoms, but their disease can remain stable for months or years. (leukaemia.org.au)
  • type
  • These tests provide more information about the exact type of disease your child has, the likely course of the disease and the best way to treat it. (leukaemia.org.au)
  • severe
  • Ante-natal testing to identify those at risk of severe genetic disease is carried out and referral made for counselling as appropriate. (stgeorges.nhs.uk)