AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and ProcessesAnthropology, Education, Sociology and Social PhenomenaInformation ScienceNamed GroupsHealth Care
Peripheral Blood Stem Cell TransplantationHematopoietic Stem Cell TransplantationTransplantation, HomologousTransplantation, AutologousBone Marrow TransplantationBlood DonorsGraft vs Host DiseaseHematopoietic Stem Cell MobilizationTransplantation ConditioningStem Cell TransplantationHematologic NeoplasmsLeukapheresisGranulocyte Colony-Stimulating FactorMelphalanAntigens, CD34Blood Component RemovalCombined Modality TherapyGraft SurvivalCyclophosphamideTissue DonorsHematopoietic Stem CellsBusulfanMyeloablative AgonistsTreatment OutcomeMultiple MyelomaStem CellsAntineoplastic Combined Chemotherapy ProtocolsCord Blood Stem Cell TransplantationTransplantation ChimeraRecurrenceRemission InductionAntineoplastic Agents, AlkylatingLymphoma, Non-HodgkinEtoposideHistocompatibilityPOEMS SyndromeThiotepaWhole-Body IrradiationHistocompatibility TestingDisease-Free SurvivalInfectionTransplantation, IsogeneicImmunosuppressive AgentsRetrospective StudiesVidarabineAmyloidosisHematopoiesisLeukemiaSalvage TherapyIfosfamideSurvival RateSurvival AnalysisVincristineBlood CellsCarmustineGraft vs Leukemia EffectCytarabineTime FactorsHodgkin DiseaseLeukemia, Myeloid, AcutePlatelet CountCytomegalovirus InfectionsMyelodysplastic SyndromesAnemia, AplasticLiver TransplantationBlood Cell CountLymphomaCytophagocytosisLeukemia, Myelogenous, Chronic, BCR-ABL PositiveLymphocyte DepletionNeoplasmsFatal OutcomeFollow-Up StudiesFeasibility StudiesHistiocytosis, Non-Langerhans-CellLivedo ReticularisHLA AntigensOpportunistic InfectionsHematologic DiseasesCyclosporinePrecursor Cell Lymphoblastic Leukemia-LymphomaDoxorubicinImmunophenotypingBone MarrowImmunosuppressionProspective StudiesRecombinant ProteinsMesenchymal Stem Cell TransplantationLymphoma, T-CellPilot ProjectsBone Marrow PurgingPrednisoneKidney TransplantationCarboplatinBone Marrow DiseasesAntigens, CDDonor SelectionPrognosisBlood Group IncompatibilityTransplantation Immunology
HSCTUmbilicalTransplantTransplantsPBSCMarrowProgenitorMultiple MyelomaChemotherapyHuman leukocyAutologous transplantationCord bloodFollowed by allogeneicRecipientPatient underwent allogeneicOrganAcutePatient'sApheresisPatientsEngraftmentHaploidentical donorsRecipientsDonor'sImmuneMononuclear cellsOutcomeLymphomaClinicalSurvivalLymphocytesPlateletsProcedureInfusionHaematopoietic stemGraft2022OutcomesHematolChimerismRelapseCytokine2019ProliferationTumorsNervesLeukapheresisInfectionsAdultsDonationInfectiousLeukemia
HSCT32
  • Hematopoietic stem cell transplantation (HSCT) results in the alteration of several components of the immune system. (medscape.com)
  • Patients who undergo HSCT experience a sequential suppression of host defenses, resulting in varying infectious risk at different phases of the transplantation process. (medscape.com)
  • If the results show patients with low levels of lymphocytes, absence of granulocytes or absence of thymus then the patient may be suspected to have RD. RD can only be treated temporarily through hematopoietic stem cell transplantation (HSCT) and cytokine therapy. (wikipedia.org)
  • Hematopoietic stem cell transplantation (HSCT) involves intravenous infusion of stem cells to those who have either a damaged bone marrow or defective immune system. (wikipedia.org)
  • Thus, we studied the safety, efficacy, and feasibility of transfer of gene modified donor T-cells shortly after allo-HSCT in two clinical trials between 2002 and 2007 and here we compare the results to unmodified donor leukocyte infusion (DLI). (frontiersin.org)
  • The aim of these trials was to provide patients with the protection of T-cells after T-cell-depleted allo-HSCT in the matched or mismatched donor setting with an option to delete transduced T-cells, if severe aGvHD occurred within the trial period. (frontiersin.org)
  • Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is applied successfully to the treatment of many hematopoietic malignancies, but remains limited by severe acute graft-versus-host-disease (aGvHD). (frontiersin.org)
  • We performed a nationwide registry-based analysis to describe the clinical outcome of adult patients with Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL) who underwent an allogeneic hematopoietic stem cell transplantation (HSCT) after a tyrosine kinase inhibitor (TKI)-based treatment A total of 441 patients were included in the study. (uniba.it)
  • The most common adverse event following allogeneic hematopoietic stem cell transplantation (HSCT) is graft-versus-host disease (GVHD), which can increase morbidity and mortality in HSCT patients. (oncologynurseadvisor.com)
  • There is a paucity of data examining the tolerance and outcome of hematopoietic stem cell transplantation (HSCT) for relapse after tositumomab/iodine-131 tositumomab. (cancernetwork.com)
  • There is a paucity of data examining the tolerance andoutcome of hematopoietic stem cell transplantation (HSCT) for relapse aftertositumomab/iodine-131 tositumomab. (cancernetwork.com)
  • Five patients received autologous HSCT: threemarrow and two peripheral blood stem cells. (cancernetwork.com)
  • For the purposes of this document, HSCT is defined of the CDC, the Infectious Diseases Society of America, as any transplantation of blood or marrow-derived he- and the American Society of Blood and Marrow Trans- matopoietic stem cells, regardless of transplant type plantation," which was published in the Morbidity and (allogeneic or autologous) or cell source (bone marrow, Mortality Weekly Report [1]. (cdc.gov)
  • Opportunistic infections (OIs) are defined as any in- the infusion of hematopoietic stem cells from a donor fections that occur with increased frequency or severity into a patient who has received chemotherapy, which in HSCT patients. (cdc.gov)
  • are basically 3 phases of immune recovery for HSCT patients, The purposes of the guidelines are (1) to summarize the beginning at day 0, the day of transplantation. (cdc.gov)
  • This is a single arm pilot study using TCR alpha/beta+ T cell-depleted peripheral blood stem cells (PBSC) from closely matched unrelated donors or partially matched/haploidentical related donors for hematopoietic stem cell transplant (HSCT) in patients with acquired and inherited bone marrow failure (BMF) syndromes. (sparkcures.com)
  • Allogeneic hematopoietic stem cell transplantation (HSCT) offers a curative treatment for acute myeloid leukemia patients. (oncotarget.com)
  • We performed absolute quantification of BAALC copy numbers in peripheral blood prior (median 7 days) to HSCT in complete remission (CR) or CR with incomplete peripheral recovery in 82 acute myeloid leukemia patients using digital droplet PCR (ddPCR) technology. (oncotarget.com)
  • Evaluation of pre-HSCT BAALC / ABL1 copy numbers in peripheral blood by ddPCR represents a feasible and rapid way to identify acute myeloid leukemia patients at high risk of early relapse after HSCT. (oncotarget.com)
  • Background It really is unfamiliar if the reduction in HIV-1 reservoirs observed following allogeneic hematopoietic stem cell transplantation (HSCT) with vulnerable donor cells is sufficient to achieve sustained HIV-1 remission. (palomid529.com)
  • Conclusions Allogeneic HSCT may lead to loss of detectable HIV-1 from blood and gut cells and variable periods of antiretroviral-free HIV-1 remission but viral rebound can occur despite a minimum 3-log10 reduction in reservoir size. (palomid529.com)
  • Continual HIV-1 remission for over 7 years continues to be demonstrated inside a chronically contaminated individual (the "Berlin individual") who underwent myeloablative allogeneic hematopoietic stem cell transplantation (HSCT) for severe myeloid leukemia using cells from a donor homozygous to get a 32-base set deletion in the gene encoding CCR5 (bloodstream and gut) had been Spry1 largely shielded from disease by Artwork. (palomid529.com)
  • Complete data on Artwork interruption pursuing allogeneic HSCT are limited by the record of a person who experienced a decrease in HIV-1 DNA soon after myeloablative HSCT and complete donor chimerism (34). (palomid529.com)
  • Long-lived cells reservoirs including sponsor macrophages that are changed more gradually than T-lymphocytes pursuing HSCT (12) may possess added to viral rebound. (palomid529.com)
  • Individuals going through allogeneic HSCT possess variable HIV-specific mobile immune reactions after transplantation. (palomid529.com)
  • Hematopoietic stem cell transplantation (HSCT) involves the intravenous infusion of hematopoietic stem cells in order to reestablish blood cell production in patients whose bone marrow or immune system is damaged or defective. (yashfiin.com)
  • Cells for HSCT may be obtained from the patient himself or herself (autologous transplant) or from another person, such as a sibling or unrelated donor (allogeneic transplant) or an identical twin (syngeneic transplant). (yashfiin.com)
  • The Hematopoietic stem cell transplantation (HSCT) is used in children as a definitive treatment for various oncological, immune deficiencies, hemoglobinopathy, and malignancies diseases that involve the hematological system, congenital metabolism disorders, among others. (bvsalud.org)
  • This is a quantitative, retrospective, observational, descriptive and analytical quantitative approach approaching the medical records of children and adolescents submitted to HSCT in a referral hospital service for this type of transplantation in the state of Rio Grande do Sul North (RN). (bvsalud.org)
  • The allogeneic HSCT was the most frequently performed (57.14%) and the most used source of Hematopoietic progenitor cells (HPC) was the peripheral blood (54.29%) and 5.71% of these patients developed the Graft versus Host Disease (GVHD), of which one was affected by acute GVHD and another by chronic GVHD. (bvsalud.org)
  • The profile of the clinical variables presented by the children and adolescents of this study shows that the most prevalent diagnosis was ALL, the most frequent toxicities were gastrointestinal, cardiac, respiratory and hematological, the most common HSCT was allogeneic peripheral blood and the greatest cause of mortality was sepsis. (bvsalud.org)
  • Hematopoietic stem cell transplantation not responded to other therapeutic modalities, with (HSCT) is used in children as a definitive treatment an increase in survival after transplantation, for different oncological, immune deficiencies, contributing to its use (YEILIPEK, 2014). (bvsalud.org)
Umbilical13
Transplant39
  • Risks of infection also vary with the type of transplant, the indication for transplantation, and other host factors. (medscape.com)
  • The transplant procedure requires the harvesting of hematopoietic stem cells from a donor. (medscape.com)
  • Determining the mechanisms of viral acceleration of chronic allograft rejection from latently infected donor, which is the most common cause of HCMV-associated disease in transplant patients associated with expression during the different stages of viremia associated with CMV including. (ohsu.edu)
  • Patients undergoing bone marrow transplant, specifically from a matched sibling, have a higher 5 year survival rate than those receiving a transplant from other donors. (wikipedia.org)
  • Similarly, in bone transplant, stem cells are able to find their way back through tracking mechanisms. (wikipedia.org)
  • Historical transplants used a matched donor's peripheral blood or bone marrow to transplant to a patient. (biologynews.net)
  • Zweidler-McKay also predicts this type of transplant could be used for adults who have already had a transplant or for those adult and pediatric patients who aren't candidates for other stem cell transplants due to blood counts or illness. (biologynews.net)
  • However, the donor was unable to postpone her trip, and the recipient was in urgent need of the transplant. (cdc.gov)
  • Late-occurring Venous Thromboembolism in Allogeneic Blood or Marrow Transplant Survivors - a BMTSS-HiGHS2 Risk Model. (stembook.org)
  • Transplant Cell Ther. (stembook.org)
  • Follistatin and Soluble Endoglin Predict 1-year Non-Relapse Mortality after Allogeneic Hematopoietic Cell Transplant. (stembook.org)
  • Biol Blood Marrow Transplant. (stembook.org)
  • After being informed about possible infection of the donor, the transplant physicians administered immunoglobulin to the recipient intravenously. (cdc.gov)
  • 1 Significant advances have been made by combining novel agents with autologous peripheral blood stem cell transplantation which allows for long-term disease-free survival in the majority of transplant-eligible patients. (haematologica.org)
  • BK polyomavirus (BKPyV) is a member of the Polyomaviridae family, and it was first identified in 1971 by electron microscopy of the urine and uroepithelial cells of a renal transplant recipient [ 1 ]. (biomedcentral.com)
  • Allogeneic transplants involve grafts from a genetically nonidentical donor of the same species and are the transplant type most often used in children. (oncologynurseadvisor.com)
  • RATIONALE: Giving an infusion of natural killer cells from a donor after a donor stem cell transplant may help kill any remaining cancer cells after the transplant. (bioseek.eu)
  • PURPOSE: This phase I/II trial is studying the side effects and best dose of donor natural killer cells when given after a donor stem cell transplant in treating patients with advanced cancer. (bioseek.eu)
  • Related transplant donors must be proven not to have Fanconi anemia in order for a transplantation to succeed. (medscape.com)
  • This site provides information about bone marrow or cord blood transplant process for patients, their families, and health care providers. (myeloma.org)
  • This site provides information, referrals, and support by trained peer volunteers who are transplant survivors, caregivers, and donors. (myeloma.org)
  • Hopefully, following the recommendations made in the guidelines will reduce morbidity and mortality from opportunistic infections in hematopoietic stem cell transplant recipients. (cdc.gov)
  • A stem cell transplant is when cells are taken out of the blood for use in a transplant. (differencebetween.net)
  • A bone marrow transplant is when stem cells are removed from the bone marrow for transplant. (differencebetween.net)
  • What is Stem Cell Transplant? (differencebetween.net)
  • Stem cell transplant can be used to treat conditions such as multiple myeloma, and other cancers such as certain kinds of lymphoma and leukemia. (differencebetween.net)
  • A bone marrow transplant is when stem cells are removed from a donor's bone marrow for transplant into a patient. (differencebetween.net)
  • A bone marrow transplant is when stem cells are harvested directly from the bone marrow. (differencebetween.net)
  • In the case of a stem cell transplant, granulocyte- colony-stimulating factor has to be given to the donor a few days before the procedure. (differencebetween.net)
  • Retrospective analysis by the Center for International Blood and Marrow Transplant Research (CIBMTR): Prompt complete remission plus consolidation therapy yields improved survival after allogeneic hematopoietic cell transplantation (allo-HCT) for patients with acute myeloid leukemia (AML) receiving a myeloablative conditioning regimen and not a reduced-intensity conditioning regimen. (ascopost.com)
  • Building off experience in hematopoietic stem cell transplant and exploiting advances in genetic engineering, genome editing, immunology, immunotherapy, stem cell biology, understanding disease mechanisms and cell therapy manufacturing, considerable progress has been made with hundreds of clinical trials underway. (bdbiosciences.com)
  • The research team is working to reduce treatment toxicity and improve patient outcomes using leading-edge research to advance hematopoietic stem cell transplant methods. (lovesorghum.com)
  • It's possible that residual pre-transplant receiver lymphoid cells persisted despite an extremely high amount of donor bloodstream AUY922 chimerism or that donor cells AUY922 inaccessible to peripheral bloodstream and cells sampling got become contaminated. (palomid529.com)
  • This is a prospective, multi-center, Phase II study of hematopoietic cell transplantation (HCT) using human leukocyte antigen (HLA)-mismatched unrelated donors (MMUD) for peripheral blood stem cell transplant in adults and bone marrow stem cell transplant in children. (uchicagomedicine.org)
  • People with life-threatening cancers, such as leukemia , lymphoma , and myeloma can be treated with a bone marrow transplant or, sometimes, a stem cell transplant. (medlineplus.gov)
  • But only about 30% of people who need a bone marrow transplant can find a matching donor in their own family. (medlineplus.gov)
  • Doctors can then use the registry to find a matching donor for a person who needs a bone marrow transplant. (medlineplus.gov)
  • If a donor's HLAs match well with a person who needs a transplant, the donor must give a new blood sample to confirm the match. (medlineplus.gov)
  • Thus, a comprehensive understanding of lung transplantation-related pathology is necessary for both tertiary care pathologists dealing with highly specialized lung transplantation teams and a much larger spectrum of healthcare providers who may be involved in the care of lung transplant recipients or candidates for lung transplantation. (medscape.com)
Transplants14
  • Donors for allogeneic transplants may be related or unrelated to the recipient. (medscape.com)
  • In syngeneic transplants, the donor is the identical twin of the recipient. (medscape.com)
  • Allogeneic transplants are further categorized by the degree of human leukocyte antigen (HLA) match between the donor and recipient. (medscape.com)
  • Transplants from HLA-matched siblings are associated with a lower risk of GVHD and faster recovery of the recipient's immune system following transplantation. (medscape.com)
  • Graft-versus-host disease is a common side effect of patients receiving stem cell transplants, which results when the T cells in the transplanted blood react against the patient's own cells. (biologynews.net)
  • In immunocompromised populations, such as patients with AIDS and recipients of solid organ and hematopoietic stem cell transplants, BK polyomavirus (BKPyV) can reactivate and cause several diseases, which can lead to death in their severe forms. (biomedcentral.com)
  • The number of human tissue transplants is increasing in both developed and developing countries, but global data on this form of transplantation are less complete. (who.int)
  • Access to transplantation is limited in low- and many medium-income countries, where the rate of transplants remains far below that of richer nations. (who.int)
  • Among seven allogeneic transplants,three received matched related peripheral blood stem cells and four receivedmatched unrelated marrow (n = 3) or peripheral blood (n = 1) stem cells.Allogeneic recipients received tacrolimus and methotrexate for graft-vs-hostdisease prophylaxis. (cancernetwork.com)
  • Visit this information page on stem cell transplants for multiple myeloma. (myeloma.org)
  • BMT InfoNet provides emotional support and information about bone marrow and peripheral blood stem cell transplants to patients and their loved ones. (myeloma.org)
  • This site provides information about stem cell transplants provided by the American Society of Clinical Oncology (ASCO). (myeloma.org)
  • Bone marrow transplants involve cells that are taken out of the bone marrow. (differencebetween.net)
  • Bone marrow transplants work best if the HLAs from the donor and the patient are a close match. (medlineplus.gov)
PBSC4
  • Allogeneic peripheral blood stem cell (PBSC) transplantation: Patients undergo allogeneic PBSC transplantation on day 0. (knowcancer.com)
  • The Effect of Aging and Pre-Donation Comorbidities on the Related PBSC Donor Experience: A Report from the Related Donor Safety Study (RDSafe). (stembook.org)
  • The NMDP performs thistask by maintaining a registry of morethan 4.9 million volunteer donors ofmarrow and peripheral blood stemcells (PBSC) and 12 cord blood bankscontaining more than 25,000 units ofumbilical cord blood. (cancernetwork.com)
  • This is the procedure used for a Peripheral Blood Stem Cell (PBSC) Donation. (bonemarrowtest.com)
Marrow50
Progenitor4
  • A single injection of 12 mg pegfilgrastim was used to mobilize peripheral blood progenitor cells (PBPCs) from healthy donors in some studies. (bvsalud.org)
  • Globally, it is estimated that 120 000 corneal transplantations and 18 000 transplantations of allogeneic haematopoietic progenitor cells took place in the year 2000. (who.int)
  • This article contains highlights of "Guidelines for Pre- allogeneic or autologous, depending on the source of venting Opportunistic Infections among Hematopoi- the transplanted hematopoietic progenitor cells. (cdc.gov)
  • Independent origins of fetal liver haematopoietic stem and progenitor cells. (u-tokyo-hemat.com)
Multiple Myeloma3
Chemotherapy7
  • Once the process is complete, the NK cells can be transplanted to patients without prior chemotherapy. (biologynews.net)
  • Because of the patient's risk status, the physicians intended to perform allogeneic stem cell transplantation after induction and consolidation chemotherapy, which was scheduled to end in January 2013, and a conditioning chemotherapy regimen, which was planned to be given in March. (cdc.gov)
  • Chemotherapy, radiation, or both are initiated prior to transplantation to enable engraftment of the transplanted cells, decrease tumor size, and reduce immunoreactivity of the recipient. (oncologynurseadvisor.com)
  • An environment for GVHD is formed when antigen-presenting cells are activated by the patient's disease and the pretreatment destruction of cells caused by chemotherapy and radiotherapy. (oncologynurseadvisor.com)
  • Chemotherapy: It involves the administration of anti-cancer drugs into the body via injection or through a pill to target cancerous cells and destroy them. (ndtv.com)
  • This procedure starts with the patient receiving intensive chemotherapy with or without total body irradiation in an attempt to kill all cancerous cells. (lovesorghum.com)
  • Hematopoietic stem cell transplantation is also sometimes used for solid tumors (eg, some germ cell tumors) that respond to chemotherapy. (msdmanuals.com)
Human leukocy1
  • A human leukocyte antigen (HLA)-identical sibling donor is ideal, followed by an HLA-matched sibling donor. (msdmanuals.com)
Autologous transplantation2
Cord blood13
  • Patrick Zweidler-McKay, M.D., Ph.D., assistant professor of pediatrics from the Children's Cancer Hospital at M. D. Anderson, has shown an effective method for expanding the number of NK cells from a single cord blood unit while retaining the cells' anti-leukemia effects, as presented at the American Society of Pediatric Hematology/Oncology annual conference on May 16. (biologynews.net)
  • Previous efforts to expand cord blood have resulted in ineffective NK cells. (biologynews.net)
  • However, Zweidler-McKay and co-senior investigator Elizabeth Shpall, M.D., professor in M. D. Anderson's Department of Stem Cell Transplantation and Cellular Therapy, have found a novel process to increase NK cells in cord blood more than 30-fold, generating more than 150 million NK cells from one cord blood unit while maintaining their activation to find and kill acute leukemia cells. (biologynews.net)
  • Cord blood is a promising source of natural killer cells because the NK cells have enhanced sensitivity to stimulation, decreased potential to cause graft-versus-host disease and are available from cord banks throughout the country and world," says Zweidler-McKay. (biologynews.net)
  • However, in 1988, researchers found cord blood to be another source for stem cell transplantation. (biologynews.net)
  • Zweidler-McKay's study involves selecting out NK cells from cord blood. (biologynews.net)
  • As the cord blood is expanded to multiply in number, the NK cells are given a cytokine, interleukin-2, and a target cell, K562, which keep the NK cells active throughout the three week expansion. (biologynews.net)
  • These results support the evaluation of cord blood-derived NK cells as a potential immuno-therapeutic approach in acute leukemias. (biologynews.net)
  • The positive result came too late to save cord blood. (sunjournal.com)
  • During delivery of the placenta together with cord blood is usually disposable. (klb.lt)
  • Today more and more people decide to collect and store cord blood stem cells, because they could be used for treatment of the newborn in the future. (klb.lt)
  • Because cord blood contains immature stem cells, HLA matching appears less crucial than for the other types of hematopoietic stem cell transplantation. (msdmanuals.com)
  • One concern about the procedure is that immune cells in cord blood do not have experience with the viruses responsible for latent infections, leading to a higher percentage of naive T cells and thus increased vulnerability to reactivation of cytomegalovirus or Epstein-Barr virus infection. (msdmanuals.com)
Followed by allogeneic1
Recipient14
  • The median yielded CD34+ cell in the pegfilgrastim group was higher than those in the G-CSF group, at 5.06 × 106/kg recipient weight. (bvsalud.org)
  • When the donor is someone other than the recipient, the procedure is described as allogeneic transplantation. (medscape.com)
  • The greater the mismatch between donor and recipient, the higher the risk of graft versus host disease (GVHD). (medscape.com)
  • In GVHD, the donated stem cells view the recipient cells as foreign and attack recipient cells. (medscape.com)
  • The harvested stem cells are processed before infusion into the recipient. (medscape.com)
  • Three days after donation of peripheral blood stem cells to a recipient with acute myeloblastic leukemia, dengue virus was detected in the donor, who had recently traveled to Sri Lanka. (cdc.gov)
  • Here, we report transmission of DENV to a peripheral blood stem cell recipient by a donor who had recently traveled to an area to which the virus is endemic. (cdc.gov)
  • In the two cases with ABO incompatibility, erythroid engraftment was evidenced by blood group conversion from recipient to donor type. (nih.gov)
  • Single-cell RNA-sequence analyses demonstrate the homogenous distribution of the gene expression profile in individual cytomegalovirus-specific cytotoxic T-cells within each recipient. (nature.com)
  • Cytotoxic T cells mount a response on the body and target recipient cells are lysed. (oncologynurseadvisor.com)
  • During cell therapy healthy and new cells are transplanted into a recipient and the failed functions are restored, together with damaged tissues and organs. (klb.lt)
  • In the second part of our study, combining in-situ-hybridization and immunohistochemical methods, we were able to show that there is a migration of donor cells into the central nervous system of the recipient after peripheral blood stem cell transplantation as well as a differentiation of these cells into other cell types. (uni-goettingen.de)
  • The part of white blood cells that contains stem cells is then separated in a machine and removed to be later given to the recipient. (medlineplus.gov)
  • The transplantation of a "foreign" organ, despite meticulous matching for donor-recipient compatibility, leads to a complex adaptive and innate immune system-mediated injury. (medscape.com)
Patient underwent allogeneic1
Organ6
  • Determining the mechanisms of CMV-accelerated vascular disease in both mouse models of atherosclerosis and rat organ transplantation models using a DNA microarray approach. (ohsu.edu)
  • A 1991 investigation determined that several recipients had been infected with HIV by an organ/tissue donor who had tested negative for HIV antibody at the time of donation (4). (cdc.gov)
  • Organ Transplantation.2 These Guiding Principles - whose emphases include voluntary donation, noncommercialization, genetic relation of recipients to donors and a preference for cadavers over living donors as sources - have considerably influenced professional codes, national, state and provincial legislation, and the policies of intergovernmental organizations. (who.int)
  • Principles, such as reliance on living organ donors and payments for organs, have increased in some places over the past dozen years. (who.int)
  • Transference of a tissue or organ from either an alive or deceased donor, within an individual, between individuals of the same species, or between individuals of different species. (jefferson.edu)
  • Stem cells are used in cardiac therapy, gene therapy, organ repair and for some solid tumors as breast cancer, Ewing's sarcoma and Renal cell carcinoma. (klb.lt)
Acute4
  • When given to mice with aggressive human leukemias, these NK cells reduced the circulating human acute lymphocytic leukemia (ALL) and acute myelogenous leukemia (AML) cells by 60 to 85 percent. (biologynews.net)
  • Thus, prophylactic transfusion of donor T-cells has been included in many protocols, despite the increased risk for acute GvHD ( Kolb, 2008 ). (frontiersin.org)
  • CAR-T cells, which incorporate an antibody-derived extracellular receptor and T cell derived intracellular signaling domains, have shown convincing outcomes in certain types of leukemia and lymphoma, including commercial licensure of CD19 CAR-Ts for the treatment of relapsed/ refractory large B cell lymphoma and acute lymphoblastic leukemia. (bdbiosciences.com)
  • Lung transplantation-related pathology encompasses a spectrum of disorders that include, but are not limited to, indications for lung transplantation (seen in explanted lungs), surgical complications (airway anastomotic and vascular complications), ischemia-reperfusion injury, rejection (acute and chronic), infections, and posttransplantation lymphoproliferative disorders (PTLDs). (medscape.com)
Patient's3
  • Successful transplantation of organs and living tissues depends on continued medical follow-up and the patient's compliance with a regimen of immunosuppressive drugs. (who.int)
  • A simple, painless process in which blood is drawn from a patient's or donor's arm and circulated through a filter which removes stem cells from the blood. (bonemarrowtest.com)
  • Hematopoietic stem cell transplantation may be autologous (using the patient's own cells) or allogeneic (using cells from a donor). (msdmanuals.com)
Apheresis5
  • The 73.3% of donors mobilized with pegfilgrastim yielded >4 × 106 cells /kg CD34+ cells in a single apheresis procedure when compared to the 33.3% of donors mobilized with G-CSF (P (bvsalud.org)
  • T cell preparation: Patients and donors undergo apheresis to obtain peripheral blood mononuclear cells (PBMCs), which are expanded in culture. (knowcancer.com)
  • Before apheresis, the donor's blood count showed mild thrombocytopenia after G-CSF mobilization. (cdc.gov)
  • Apheresis produces no side effects or discomfort for the blood stem cell donor. (bonemarrowtest.com)
  • The stem cells are then separated from the other blood cells by the process of apheresis, and then they are given to the patient through a catheter placed into a vein. (differencebetween.net)
Patients45
  • Patients with RD have a genetic defect that affects the T cells and at least one other type of immune cell. (wikipedia.org)
  • Patients who suffer from RD will now have more stem cells that can differentiate into immune cells. (wikipedia.org)
  • These immature stem cells were easier to match to patients, especially those from non-Caucasian ethnicities, and could be stored for use as needed. (biologynews.net)
  • Determine the safety of LMB-2 immunotoxin-treated, selectively-depleted donor T cells, administered after allogeneic PBSCT, in these patients. (knowcancer.com)
  • Patients' PBMCs are irradiated and mixed with donor PBMCs. (knowcancer.com)
  • LMB-2 immunotoxin-treated, selectively-depleted donor T cells: Patients receive LMB-2 immunotoxin-treated, selectively-depleted donor T cells IV over 30-60 minutes on approximately day 28. (knowcancer.com)
  • Cohorts of 3-6 patients receive escalating dose of LMB-2 immunotoxin-treated, selectively-depleted donor T cells until the maximum tolerated dose (MTD) is determined. (knowcancer.com)
  • After completion of study treatment, patients are followed weekly for 100 days post-transplantation and then periodically for survival. (knowcancer.com)
  • Hematopoietic stem cell transplantation has become a major treatment option for patients with hematopoietic malignancies and immune deficiencies. (cdc.gov)
  • CD16xCD33 bispecific killer cell engager (BiKE) activates NK cells from MDS patients against primary MDS and MDSC CD33+ targets. (stembook.org)
  • Role of Reduced-Intensity Conditioning Allogeneic Hematopoietic Stem-Cell Transplantation in Older Patients With De Novo Myelodysplastic Syndromes: An International Collaborative Decision Analysis. (stembook.org)
  • Results Natural killer cells from healthy donors and myeloma patients expanded a median of 804- and 351-fold, respectively, without significant T-cell expansion. (haematologica.org)
  • Successful stem cell transplantation for patients with severe combined immunodeficiency (SCID) from matched family donors without conditioning results in engraftment of T lymphocytes. (nih.gov)
  • We studied three SCID patients who were transplanted with unmodified mobilized peripheral blood from HLA-identical family sex-mismatched members. (nih.gov)
  • In contrast to the expected mixed chimerism that usually occurs in the absence of conditioning, we found in our patients 100% donor cell engraftment based on fluorescence in situ hybridization (FISH) and microsatellite techniques. (nih.gov)
  • Subset analysis of the engrafted cells using a multiparametric system enabling a combined analysis of morphology, immunophenotyping and FISH showed that both T and B lymphocytes and myeloid cells were of donor origin in two patients, while T lymphocytes and myeloid cells were of donor origin in the third. (nih.gov)
  • Multilineage donor engraftment is possible in SCID patients even without conditioning. (nih.gov)
  • Donor chimerism was stabilized after transfusion of the transduced cells in all patients treated. (frontiersin.org)
  • To date, six patients have relapsed and died, two after a second hematopoietic stem cell transplantation without T-cell depletion or administration of unmodified T-cells. (frontiersin.org)
  • On the other hand, bulk RNA-sequence analyses reveal that gene expression profiles among patients are different according to the cytomegalovirus reactivation pattern, and are associated with cytokine production or cell division. (nature.com)
  • Both patients had consistent infectious pneumonia and graft-versus-host disease after stem cell transplantation. (biomedcentral.com)
  • The donor was unrelated in 46% of patients. (uniba.it)
  • The persistent and widening gap between patients' need for organs and the number available for transplantation has become a major concern to many Member States. (who.int)
  • Even between countries which have similar levels of health resources, patients' access to transplantation also varies. (who.int)
  • Moreover, for patients who have kidney failure, access to transplantation is reduced when funds are spent on other forms of treatment that are less cost-effective. (who.int)
  • Patients and potential donors alike share their experiences obtaining reliable, responsive, affordable HLA test results through BoneMarrowTest.com. (bonemarrowtest.com)
  • Four patients were alive withno evidence of disease (three matched unrelated donor and one matched relateddonor). (cancernetwork.com)
  • The safety profile of venetoclax following allogeneic hematopoietic stem cell transplantation in patients with chronic lymphocytic leukemia appears to be comparable with other reports in clinical trials. (cancernetwork.com)
  • To assess the safety of donor natural killer (NK) cell infusion after HLA-mismatched/haploidentical allogeneic hematopoietic stem cell transplantation from a familial donor in patients with advanced malignant disorders. (bioseek.eu)
  • To determine the maximum number of donor NK cells that can be safely given to these patients. (bioseek.eu)
  • To assess the clinical efficacy donor NK cell infusion, in terms of tumor response, response duration, and survival, in patients with progressive or recurrent malignant disorders. (bioseek.eu)
  • Phase I: Patients receive an infusion of donor natural killer (NK) cells on days 18 and 21. (bioseek.eu)
  • Phase II: Patients receive an infusion of donor NK cells on days 14 and 21. (bioseek.eu)
  • Supportive care for patients with symptomatic Fanconi anemia includes transfusions of packed RBCs that have been leukodepleted (and are not from family members, to avoid sensitization in case of a future transplantation). (medscape.com)
  • A study by MacMillan et al reported that alternative donor hematopoietic cell transplantation had a high success rate in patients with Fanconi anemia who did not have a history of opportunistic infections or transfusions and who underwent conditioning with single fraction total body irradiation 300 cGy, cyclophosphamide, fludarabine, and antithymocyte globulin. (medscape.com)
  • The study, which involved 130 patients, also found that adding fludarabine to conditioning caused three-fold enhancement of hematopoietic cell engraftment. (medscape.com)
  • Although the only therapy that can cure the pancytopenia is stem cell transplantation, androgens, to which approximately 50-75% of patients respond, are used for those in whom transplantation is not an option. (medscape.com)
  • Physicians and scientists work side by side to set standards for stem cell transplantation and improve long-term outcomes for both pediatric and adult patients. (lovesorghum.com)
  • We examined histopathological changes in the central nervous system of 19 patients who underwent autopsy studies following peripheral blood stem cell transplantation. (uni-goettingen.de)
  • The histological features of patients having received a stem cell transplantation were compared to patients who had not received any such treatment. (uni-goettingen.de)
  • For certain patients treated by allogeneic hematopoietic stem cell transplantation (25% of patients), whose peripheral blood cells come from the graft and are therefore of the donor type, a skin biopsy is proposed for culture and freezing of the fibroblasts. (plateforme-lea.fr)
  • This is a single arm, open-label, multi-center, Phase 1 study to determine the safety and tolerability of an experimental therapy called NKX019 (allogeneic CAR NK cells targeting CD19) in patients with relapsed/refractory non-Hodgkin lymphoma (NHL), chronic lymphocytic. (uchicagomedicine.org)
  • Because only one fourth of patients have such a sibling donor, mismatched related or matched unrelated donors (identified through international registries) are often used. (msdmanuals.com)
  • Their stem cells are more likely to help patients than stem cells from older people. (medlineplus.gov)
  • This explains why researchers are now focusing attention on developing stem cell therapies using postnatal stem cells donated by the patients themselves or their close relatives. (bvsalud.org)
Engraftment1
  • We also analyse the engraftment of donor stem cells into non-conditioned and conditioned hosts, quantifying the impact of different treatment scenarios. (uzh.ch)
Haploidentical donors1
  • Transduced cells were transfused either after day +60 (matched donors) or on day +42 (haploidentical donors). (frontiersin.org)
Recipients3
  • In preparation for receipt of the stem cells, recipients undergo myeloablation to eliminate their own myeloid cells. (medscape.com)
  • Although previous recommendations for preventing transmission of human immunodeficiency virus (HIV) through transplantation of human tissue and organs have markedly reduced the risk for this type of transmission, a case of HIV transmission from a screened, antibody-negative donor to several recipients raised questions about the need for additional federal oversight of transplantation of organs and tissues. (cdc.gov)
  • Here we show the features of repertoire diversity and the gene expression profile of HLA-A24 cytomegalovirus-specific cytotoxic T-cells in actual recipients according to the cytomegalovirus reactivation pattern. (nature.com)
Donor's1
  • The donor first has to be treated with G-CSF, and then the stem cells can only be harvested a couple of days after the donor since time is needed for the donor's body to form more stem cells and transport these cells into the bloodstream. (differencebetween.net)
Immune10
  • The immune system consists of specialized cells that work together to fight off bacteria, fungi and viruses. (wikipedia.org)
  • These cells include T lymphocytes (T cells), that primarily mediate the immune system, B lymphocytes (B cells) and Natural Killer cells. (wikipedia.org)
  • Since more than one type of immune cell is affected, this disease is classified as a severe combined immunodeficiency disease (SCID). (wikipedia.org)
  • Cytomegalovirus reactivation is still a critical concern following allogeneic hematopoietic cell transplantation, and cellular immune reconstitution of cytomegalovirus-specific cytotoxic T-cells is necessary for the long-term control of cytomegalovirus reactivation after allogeneic hematopoietic cell transplantation. (nature.com)
  • These methods and results can help us to better understand immune reconstitution following hematopoietic cell transplantation, leading to future studies on the clinical application of adoptive T-cell therapies. (nature.com)
  • However, cellular immune reconstitution of CMV-specific cytotoxic T-cells (CMV-CTL) is generally considered to be necessary for the long-term control of CMV reactivation after allo-HCT. (nature.com)
  • A better and deeper understanding of immune reconstitution following allo-HCT is required for further clinical application of these adoptive T-cell therapies. (nature.com)
  • 5 however, it has been used to treat many pediatric hematologic conditions, including chronic immune thrombocytopenic purpura, posttransplant lymphoproliferative disease, juvenile rheumatoid arthritis, and other blood dyscrasias. (oncologynurseadvisor.com)
  • Immunotherapy: In this treatment option, the immune system is activated to kill only specific cancer cells. (ndtv.com)
  • The etiology of lung transplantation-related pathology is almost always immune-mediated. (medscape.com)
Mononuclear cells1
Outcome2
Lymphoma8
  • No HLA-matched (10/10 or 9/10) sibling donor or unrelated donor available NOTE: A new classification scheme for adult non-Hodgkin's lymphoma has been adopted by PDQ. (knowcancer.com)
  • The versatile drug is now also approved for the treatment of B-cell Hodgkin lymphoma, non-Hodgkin lymphoma, chronic lymphocytic leukemia, and rheumatoid arthritis in the adult population. (oncologynurseadvisor.com)
  • Investigators will assess LP-284 as a treatment for those with B-cell non-Hodgkin lymphoma in a phase 1 trial. (cancernetwork.com)
  • There are primarily three types of blood cancer including lymphoma, leukaemia and myeloma and are characterised by the specific components of blood that it affects. (ndtv.com)
  • Clinically, Hodgkin's lymphoma is the most common and affects more than 50% of adults diagnosed with blood cancer. (ndtv.com)
  • The image below shows pre-B-cell lymphoblastic leukemia/lymphoma (B-ALL). (medscape.com)
  • Discordant lymphomas of classic Hodgkin lymphoma and peripheral T-cell lymphoma following dupilumab treatment for atopic dermatitis. (u-tokyo-hemat.com)
  • This is a Phase I dose-finding study of FT596 as monotherapy and in combination with Rituximab or Obinutuzumab in subjects with relapsed/refractory B-cell Lymphoma or Chronic Lymphocytic Leukemia. (uchicagomedicine.org)
Clinical5
  • Established to conduct large multi-institutional clinical trials in hematopoietic stem cell transplantation. (myeloma.org)
  • T cell-targeted immunomodulators such as monoclonal antibodies against PD-1 or CTLA4 may be used in combination with CAR-T cells in clinical trials. (bdbiosciences.com)
  • Clinical features of lung transplantation-related pathology can range from an absence of symptoms to signs and symptoms of respiratory distress and/or infection and are not detailed in this article. (medscape.com)
  • The Registry of the International Society for Heart and Lung Transplantation (ISHLT) monitors and reports statistics on clinical lung transplantation. (medscape.com)
  • Literature review: This review summarizes current knowledge, barriers, and challenges in the clinical use of adult stem cells, scaffolds, and growth factors for the development and evaluation of regenerative endodontic therapies. (bvsalud.org)
Survival5
  • For example, in developing and developed countries alike, kidney transplantation not only yields survival rates and quality-of-life that are far superior to those obtained with other treatments for end-stage renal disease, such as haemodialysis, but is also less costly in the long run. (who.int)
  • Access to transplantation entails more than the surgery itself, because success is measured by longer survival of the patient and a long-term improvement in the quality of life. (who.int)
  • The survival rate after transplantation from alternative donors is improving, depending on the completeness of the HLA-matching. (medscape.com)
  • Recent advances in small bowel transplantation and nontransplant surgical techniques now offer hope of sustained survival in the future without parenteral nutrition. (optumhealtheducation.com)
  • However, long-term disease-free survival rates may be lower than those with HLA-identical sibling donors. (msdmanuals.com)
Lymphocytes1
Platelets1
  • single-donor platelets are preferred to reduce the frequency of antibody formation. (medscape.com)
Procedure3
Infusion2
  • Quality control testing is essential to ensure the CAR-T cell product meets established specifications for manufacturing release and patient infusion. (bdbiosciences.com)
  • CPP infusion was given amount of blood components and blood at 15 mL/kg body weight for 2 days and products given are shown in Table 1. (who.int)
Haematopoietic stem1
  • CCDC88C-FLT3 gene fusion in CD34-positive haematopoietic stem and multilineage cells in myeloid/lymphoid neoplasm with eosinophilia. (u-tokyo-hemat.com)
Graft6
  • However, T-cell depletion is associated with higher rates of graft rejection and increased vulnerability to viral and fungal infections while the T-cell population is diminished. (medscape.com)
  • Especially during and after steroid pulse therapy or immunosuppressive therapy for graft versus host diseases, BKPyV load in blood/urine needs to be regularly measured, and the immunosuppressive intensity should be adjusted properly after the BKPyV reactivation diagnosis. (biomedcentral.com)
  • Peripheral host T cells survive hematopoietic stem cell transplantation and promote graft-versus-host disease. (intec.edu.do)
  • Solid tumors, autoimmune diseases, graft versus host disease (GvHD), genetic diseases and neurodegenerative diseases are investigated using many types of autologous and allogeneic cells with rapidly evolving cell engineering and editing approaches. (bdbiosciences.com)
  • The team focuses its research on donor types, treatment complications (such as graft-vs-host disease), cytomegalovirus vaccination and regimens designed to reduce the risk of relapse. (lovesorghum.com)
  • That individual developed quality III graft-versus-host disease of your skin and gastrointestinal system and experienced fast viral rebound within 16 times of stopping Artwork 4 weeks after transplantation (34). (palomid529.com)
20222
Outcomes2
Hematol1
Chimerism1
  • We predict the time taken for mutant clones to expand within a host, as well as chimerism levels that can be expected following transplantation therapy, and the probability that a preconditioned host is reconstituted by donor cells. (uzh.ch)
Relapse1
  • CD34-selection of stem cells reduces the risk of aGvHD, but also leads to increased infectious complications and relapse. (frontiersin.org)
Cytokine1
  • These experimental cytokine-producing CAR-Ts, called T cells redirected for universal cytokine killing (TRUCKs), can deliver a variety of cytokines, such as IL-12, IL-15, IL-18 or IL-21. (bdbiosciences.com)
20191
Proliferation3
  • Differentiation and proliferation of hematopoietic stem cells require a lot of energy and this energy is supplied by the mitochondria. (wikipedia.org)
  • WAT is characterised by its capacity to adapt and expand in response to surplus energy through processes of adipocyte hypertrophy and/or recruitment and proliferation of precursor cells in combination with vascular and extracellular matrix remodelling. (springer.com)
  • Chronic myelogenous leukemia (CML), also known as chronic myeloid leukemia, is a myeloproliferative disorder characterized by increased proliferation of the granulocytic cell line without the loss of their capacity to differentiate. (medscape.com)
Tumors1
  • Adoptive transfer of expanded natural killer cells inhibited the growth of established OPM2 and high-risk primary myeloma tumors grown in the murine model. (haematologica.org)
Nerves2
  • The Department of Neurology deals with various diseases that affect the central nervous system (e.g., the cerebrum, cerebellum, brainstem, and spinal cord), peripheral nerves, and muscles. (keio.ac.jp)
  • we provide comprehensive medical care for a variety of neurological disorders affecting the central nervous system, peripheral nerves, and muscles. (keio.ac.jp)
Leukapheresis2
Infections4
  • After transplantation, the patient tested positive for recurrent blood cytomegalovirus (CMV) and Epstein-Barr virus (EBV) infections, and on March 31, 2020, he underwent lung lavage because of bilateral pneumonia. (biomedcentral.com)
  • Leukaemia on the other hand is a type of cancer that affects all white blood cells and prevents them from carrying out their main function-fighting off infections. (ndtv.com)
  • Myeloma is a type of cancer affecting the plasma, which is also a type of white blood cells that produce antibodies to ward off infections. (ndtv.com)
  • Although rare, pulmonary embolism, infections, or neoplasms in the allograft may be diagnosed in this manner, which would affect the decision to use the donor lung. (medscape.com)
Adults2
Donation1
  • and recall of stored tissues from donors found after donation to have been infected. (cdc.gov)
Infectious2
  • This processing consists primarily of testing for infectious agents and determination of cell count but may include additional modifications or evaluations. (medscape.com)
  • Reducing viral risks through nents and products originated from several expansion of donor history screening, im- hundred donors, she did not contract any provements in testing for infectious disease transfusion-transmitted disease. (who.int)
Leukemia2