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Stem CellsPeripheral Blood Stem Cell TransplantationHematopoietic Stem Cell TransplantationHematopoietic Stem CellsStem Cell TransplantationHematopoietic Stem Cell MobilizationTransplantation, AutologousEmbryonic Stem CellsAdult Stem CellsBlood CellsPluripotent Stem CellsGranulocyte Colony-Stimulating FactorCord Blood Stem Cell TransplantationLeukapheresisTransplantation, HomologousStem Cell NicheAntigens, CD34Neural Stem CellsInduced Pluripotent Stem CellsCell DifferentiationBlood Component RemovalMultipotent Stem CellsStem Cell FactorTransplantation ConditioningMesenchymal Stem Cell TransplantationBlood Cell CountMesenchymal Stromal CellsHematologic NeoplasmsGraft vs Host DiseaseCell LineageErythrocytesHematopoiesisBone Marrow TransplantationMelphalanGraft SurvivalFetal BloodCombined Modality TherapyCyclophosphamideStem Cell ResearchBone Marrow CellsCells, CulturedPlant StemsFetal Stem CellsMultiple MyelomaCell SeparationBusulfanTreatment OutcomeAntineoplastic Combined Chemotherapy ProtocolsColony-Forming Units AssayCell ProliferationFlow CytometryNeoplastic Stem CellsCell Culture TechniquesTissue DonorsLeukocyte CountTransplantation ChimeraTime FactorsAntineoplastic Agents, AlkylatingWhole-Body IrradiationBone MarrowLymphoma, Non-HodgkinRecurrenceEtoposideRemission InductionRegenerationThiotepaMyeloablative AgonistsLeukemiaOctamer Transcription Factor-3HistocompatibilityMice, Inbred C57BLErythrocyte TransfusionAntigens, CDMice, SCIDPlatelet CountRegenerative MedicineHistocompatibility TestingTotipotent Stem CellsInfectionBlood DonorsRecombinant ProteinsBiological MarkersImmunophenotypingImmunomagnetic SeparationCell CountVidarabineDisease-Free SurvivalHematologic DiseasesLeukemia, Myeloid, AcuteNeoplasmsSignal TransductionEmbryo, MammalianRetrospective StudiesCytarabineBone Marrow PurgingReverse Transcriptase Polymerase Chain ReactionSurvival RateSalvage TherapySOXB1 Transcription FactorsIfosfamide
TransplantationTransplantDonorsPlateletsTransplantsRegenerative medicinePeripheral blood stem cellsBaby's cord bloodMarrowCancersChemotherapyProgenitor cellReplenishBiologyHSCsMesenchymal StemResearchersMononuclear cellsEngraftmentAdultLaboratoryRecipientPluripotentScientistsLund Stem Cell CenterEmbryonic developmentDonor stem cellsRegistryLymphocytesGenesDonor's bloodImmatureMyeloidLeukemiaMiceMakes blood stem cellsDiseasesProgenitorsPatientsGene2022DifferentiationCord blood banksLymphomaHumanEmbryosPlateletSource of stem cellsHematopoiesisResearchSubset
Transplantation36
  • Foundation for the Accreditation of Cellular Therapy (FACT) - A non-profit established by the International Society for Cell and Gene Therapy (ISCT) and the American Society for Transplantation and Cellular Therapy (ASTCT) to create and facilitate inspection and accreditation of quality standards for medical and laboratory practice for cellular therapies. (babycenter.com)
  • Successful stem cell transplantation for patients with severe combined immunodeficiency (SCID) from matched family donors without conditioning results in engraftment of T lymphocytes. (nih.gov)
  • In order to assess the incidence and analyze reasons which cause prolongation of hospital stay in patients engrafted after peripheral blood stem cell transplantation (PBSCT), we performed this retrospective analysis. (nature.com)
  • Peripheral blood stem cell and bone marrow transplantation for solid tumors and lymphomas: hematologic recovery and costs. (nature.com)
  • All patients received high-dose etoposide (60 mg/kg) and allogeneic stem cell transplantation following the TBI. (nature.com)
  • The product is intended for use in adults and pediatric patients 12 years and older with blood cancers planned for umbilical cord blood transplantation following a myeloablative conditioning regimen (treatment such as radiation or chemotherapy). (fda.gov)
  • Hastening the return of the body's white blood cells can reduce the possibility of serious or overwhelming infection associated with stem cell transplantation. (fda.gov)
  • Stem cell transplantation is a common treatment for blood cancers. (fda.gov)
  • The safety and effectiveness of Omisirge was supported by a randomized, multicenter study comparing transplantation of Omisirge to transplantation of umbilical cord blood, in subjects between the ages of 12 and 65 years. (fda.gov)
  • The efficacy of Omisirge was based on the amount of time needed for recovery of the subject's neutrophils (a type of white blood cell that helps protect the body from infections) and the incidence of infections following transplantation. (fda.gov)
  • Eighty-seven percent of subjects who were randomized to receive Omisirge achieved neutrophil recovery with a median of 12 days following treatment with the product, compared to 83% of subjects who were randomized to receive umbilical cord blood transplantation and who achieved neutrophil recovery with a median of 22 days. (fda.gov)
  • Bacterial or fungal infections by 100 days following transplantation were seen in 39% of subjects receiving Omisirge versus 60% of subjects in the control group who received umbilical cord blood. (fda.gov)
  • Bone marrow transplantation (BMT) is the oldest and most common form of stem cell-based therapy. (ca.gov)
  • We have brought together world experts in transplantation, protein development and clinical study design who have the shared objective of bringing the technology of antibody targeting stem cells to patients. (ca.gov)
  • Hematopoietic stem cell transplantation has become a major treatment option for patients with hematopoietic malignancies and immune deficiencies. (cdc.gov)
  • To the best of our knowledge, only the transmission of malarial parasites has been reported during stem cell transplantation ( 3 , 4 ). (cdc.gov)
  • Because of the patient's risk status, the physicians intended to perform allogeneic stem cell transplantation after induction and consolidation chemotherapy, which was scheduled to end in January 2013, and a conditioning chemotherapy regimen, which was planned to be given in March. (cdc.gov)
  • The findings support future studies of assessing the safety and efficacy of the novel drug-chemotherapy combination as a maintenance strategy following stem cell transplantation across a range of blood cancers, according to the study authors. (curetoday.com)
  • Maintenance treatment with eprenetapopt, a novel drug, plus the chemotherapy Vidaza (azacitidine) following allogeneic hematopoietic stem cell transplantation was associated with improved survival outcomes in a group of patients with TP53-mutant, high-risk acute myeloid leukemia and myelodysplastic syndromes, according to new study findings. (curetoday.com)
  • A total of 84 patients were screened to determine if they were eligible for an allogeneic hematopoietic stem cell transplantation. (curetoday.com)
  • Umbilical cord blood (UCB) is a valuable source of hematopoietic stem cells (HSCs) and potential alternative for bone marrow transplantation for patients who lack human leukocyte antigen (HLA)-matched donors. (wjgnet.com)
  • OBJECTIVES: I. Determine whether mixed or full donor chimerism can be safely established in older patients with acute myeloid leukemia (AML) treated with nonmyeloablative conditioning comprised of low dose total body irradiation, followed by allogeneic peripheral blood stem cell transplantation, followed by unrelated donor lymphocyte infusion (DLI). (knowcancer.com)
  • Major increases were observed in allogeneic, haploidentical HSCT and, to a lesser extent, in cord blood transplantation. (unisg.ch)
  • Jan. 25, 2012 - Scientists with the new Children's Research Institute at UT Southwestern Medical Center have identified the environment in which blood-forming stem cells survive and thrive within the body, an important step toward increasing the safety and effectiveness of bone-marrow transplantation. (utsw.edu)
  • Doing so will make it possible to expand blood-forming stem cells prior to transplantation into patients, thereby increasing the safety and effectiveness of this widely used clinical procedure. (utsw.edu)
  • Hastening the return of the body's white blood cells can reduce the possibility of serious or overwhelming infection associated with stem cell transplantation," Peter Marks, MD, PhD, director of the FDA's Center for Biologics Evaluation and Research, said in an agency press release . (medscape.com)
  • Adverse events are consistent with allogeneic hematopoietic stem cell transplantation . (medscape.com)
  • Hematopoietic stem cell transplantation (HSCT) involves the intravenous infusion of hematopoietic stem cells in order to reestablish blood cell production in patients whose bone marrow or immune system is damaged or defective. (medscape.com)
  • Worldwide, approximately 90,000 first HSCTs-53% autologous and 47% allogeneic-are performed every year, according to the World Wide Network of Blood and Marrow Transplantation. (medscape.com)
  • This, along with the development of unrelated cord blood transplantation and familial haploidentical transplantation methods, have improved the likelihood of finding an appropriate HSCT source in a timely manner. (medscape.com)
  • Hematopoietic stem cells (HSCs) sustain blood formation throughout life and are the functional units of bone marrow transplantation . (bvsalud.org)
  • We show that transient expression of six transcription factors Run1t1, Hlf, Lmo2, Prdm5, Pbx1, and Zfp37 imparts multilineage transplantation potential onto otherwise committed lymphoid and myeloid progenitors and myeloid effector cells . (bvsalud.org)
  • Stem cell transplantation is the removal of stem cells (undifferentiated cells) from a healthy person and their injection into someone who has a serious blood disorder. (msdmanuals.com)
  • Overview of Transplantation Transplantation is the removal of living, functioning cells, tissues, or organs from the body and then their transfer back into the same body or into a different body. (msdmanuals.com)
  • But researchers think that these stem cells have the most potential for producing different kinds of cells and for surviving after transplantation. (msdmanuals.com)
  • These stem cells are most often used for transplantation. (msdmanuals.com)
Transplant27
  • When patients undergo a stem cell transplant for these conditions, the stem cells effectively rebuild the blood and immune systems. (disabled-world.com)
  • Be The Match® connects patients with a matching donor for a life-saving blood stem cell transplant. (bethematch.org)
  • She hoped that this gift could one day save the life of a patient in need of a stem cell transplant. (blood.ca)
  • Or that the stem cells for his transplant would come from another parent's cord blood donation. (blood.ca)
  • Generally, before receiving this kind of transplant, the patient will undergo a course of treatments to remove their own stem cells and prepare the body for the new stem cells. (fda.gov)
  • The Mix & Match events bring together cancer survivors, current patients in search of a match, and donors who have saved lives with a stem cell or bone marrow transplant. (icla.org)
  • A blood stem cell transplant, from a genetically matched donor is his only hope for a cure. (icla.org)
  • Larisa Bothma's nine-month-old son Arend has chronic Granulomatous disease, which doesn't allow his blood cells to battle bacterial and fungal infections, and a bone cell transplant is the only known cure. (theprogress.com)
  • Disease relapse is the primary reason why allogeneic hematopoietic stem cell transplants fail, according to the study authors, who noted that novel strategies for stem cell transplant to reduce the risk for disease relapse are severely needed. (curetoday.com)
  • Of note, an allogeneic hematopoietic stem cell transplant is a procedure where a patient with cancer receives healthy blood-forming stem cells from a donor to replace their own stem cells that have been damaged by other cancer treatments such as radiation or chemotherapy. (curetoday.com)
  • Currently, maintenance strategies (which are used to reduce the risk for disease recurrence) are not standard of care in allogeneic (hematopoietic stem cell transplant) for (acute myeloid leukemia and myelodysplastic syndromes)," the study authors wrote. (curetoday.com)
  • Unlike the more traditional bone marrow transplant that is an invasive and painful procedure, collection of stem cellsis painless and safe and has no possibility of harming the baby. (cordblood-banking.org)
  • While the individual probability of your needing a cord blood transplant is low, the list of diseases that can be tackled with these methods is growing rapidly. (cordblood-banking.org)
  • They accept donations of cord blood from any mother and offer it to any sick person who will benefit from the transplant. (cordblood-banking.org)
  • Data on 68 146 hematopoietic stem cell transplants (HSCTs) (53% autologous and 47% allogeneic) gathered by 1566 teams from 77 countries and reported through their regional transplant organizations were analyzed by main indication, donor type and stem cell source for the year 2012. (unisg.ch)
  • Without an immediate transplant of stem cells, Krabbe infants rapidly begin to lose all cognitive and motor functions and die by the age of two, said the researchers. (dukehealth.org)
  • While the child's age and symptom severity at the time of transplant are crucial to determining outcome, the source of stem cells is also important, said Kurtzberg. (dukehealth.org)
  • The stem cell (or progenitor cell) collection is a portion of the bone marrow transplant process. (upstate.edu)
  • Your cells will be stored until the time of your transplant. (upstate.edu)
  • As president of Beef O'Brady's restaurants, he participated in a bone marrow registry drive held at one of his restaurants in support of a patron whose young son needed a compatible donor for a marrow/stem cell transplant. (tampabaynewswire.com)
  • He followed up with doctors who monitored his health and in 2015, was diagnosed with Myelofibrosis, a precursor to leukemia and was told he needed a stem cell transplant. (tampabaynewswire.com)
  • Luckily, an unrelated donor match who joined the registry during college was found and with her donation and the support of many OneBlood platelet and blood donors, Nick underwent his transplant at Moffitt Cancer Center in January 2017 and won his battle to live! (tampabaynewswire.com)
  • Abbey Jenkins, president and CEO of Gamida, called the approval "a major advancement in the treatment of patients with hematologic malignancies that we believe may increase access to stem cell transplant and help improve patient outcomes. (medscape.com)
  • People with life-threatening cancers, such as leukemia , lymphoma , and myeloma can be treated with a bone marrow transplant or, sometimes, a stem cell transplant. (medlineplus.gov)
  • If a donor's HLAs match well with a person who needs a transplant, the donor must give a new blood sample to confirm the match. (medlineplus.gov)
  • This can be life-threatening in the weeks immediately following chemotherapy or a bone marrow transplant as it takes time for blood stem cells to replenish platelets to safe levels. (ox.ac.uk)
  • Cells for HSCT may be obtained from the patient himself or herself (autologous transplant) or from another person, such as a sibling or unrelated donor (allogeneic transplant) or an identical twin (syngeneic transplant). (medscape.com)
Donors7
  • Choose ready-to-use, ethically sourced, primary mononuclear cells from donors diagnosed with ulcerative colitis. (stemcell.com)
  • Cells from donors with ulcerative colitis can be used as representative intestinal model to study the interactions between intestinal and immune cells in triggering the pathological responses of the disorder. (stemcell.com)
  • We save lives by recruiting stem cell donors. (icla.org)
  • New discoveries about embryonic blood stem cell creation made independently by biomedical engineers and medical researchers at the University of New South Wales (UNSW) Sydney could one day eliminate the need for blood stem cell donors. (scitechdaily.com)
  • Kurtzberg pioneered the use of umbilical cord blood from unrelated donors in 1993 and her team has treated and saved more children with cancers and rare genetic diseases than any other center in the world - 147 children in all. (dukehealth.org)
  • Exclusion of prospective blood donors based on their acknowledged risk behaviors for human immunodeficiency virus (HIV) infection began in 1983 (1). (cdc.gov)
  • In 1985, when tests for HIV antibody became available, screening prospective donors of blood, organs, and other tissues also began (2,3). (cdc.gov)
Platelets14
  • Researchers at the Center for iPS Cell Research and Application at Kyoto University in Japan presented data at a meeting of the American Society of Hematology showing they were able to create the cells in the laboratory and confirm they had the same life span as normal human platelets when infused in mice. (ibtimes.com)
  • The limitation in using stem cells to produce platelets has been the ability to find a method that creates a large number of high-quality, functional platelets. (ibtimes.com)
  • The Japanese researchers set out to create an immortalized cell line with a large number of high-quality megakaryocytes -- precursor cells that develop into platelets -- from stem cells that can be grown indefinitely and differentiate into a variety of cell types in the body. (ibtimes.com)
  • They were able to produce a cell line that turned off certain genes to generate functional platelets. (ibtimes.com)
  • In normal clotting, platelets stick together and form a plug at the site of an injured blood vessel, allowing the injured site to heal. (ibtimes.com)
  • Platelets used for transfusions are derived from donated blood but they have a short shelf life since they must be stored at room temperature and cannot be frozen. (ibtimes.com)
  • Similar to all approved umbilical cord products , the label carries a Boxed Warning for infusion reactions, graft versus host disease (GvHD - a condition that occurs when donor bone marrow or stem cells attack the graft recipient), engraftment syndrome (characterized by a noninfectious fever and rash), and graft failure (occurs when new cells do not produce white blood cells, red blood cells and platelets). (fda.gov)
  • These systems promoted the development of precursor blood stem cells which can differentiate into various blood components - white blood cells, red blood cells, platelets, and others. (scitechdaily.com)
  • They can become red cells, white cells, or platelets once they mature. (upstate.edu)
  • A new type of bone marrow stem cell in mice that is primed to produce large numbers of vital blood-clotting platelets has been discovered. (ox.ac.uk)
  • These cells can copy themselves (self-renew) and give rise to all the different cell types that make up the blood system, including white and red blood cells, and platelets. (ox.ac.uk)
  • Platelets help the blood to clot by clumping together at the site of bleeding. (ox.ac.uk)
  • But here we've identified a new type of stem cell that is very driven, at a molecular and functional level, towards making platelets,' said Professor Sten Eirik Jacobsen of Oxford University's MRC Weatherall Institute of Molecular Medicine who led the research with Claus Nerlov. (ox.ac.uk)
  • Transplanting just one platelet-primed stem cell into mice that lacked their own bone marrow was enough to stably restore more than 10% of their platelets. (ox.ac.uk)
Transplants8
  • Unfortunately, the way the transplants are currently performed, with toxic treatments to prepare the children to accept the donor cells and the side effects caused by lymphocytes that contaminate standard blood cell grafts reduces the likelihood of successful cure. (ca.gov)
  • Bone marrow transplants have been used for decades to treat people with some diseases of the blood or immune system. (medicalxpress.com)
  • However, bone marrow transplants have significant limitations: Finding a compatible bone marrow donor is not always possible, the patient's immune system may reject the foreign cells, and the number of transplanted stem cells may not be enough to successfully treat the disease. (medicalxpress.com)
  • Stem cells in a baby's cord blood are still so immature that they are unable to react and cause the rejection that is otherwise so common with transplants. (cordblood-banking.org)
  • The research has implications for bone marrow and umbilical cord blood transplants, Dr. Morrison said. (utsw.edu)
  • The US Food and Drug Administration (FDA) approved omidubicel-onlv (Omisirge) for reducing infections and hastening neutrophil recovery for blood cancer patients aged 12 years and older who are undergoing allogeneic umbilical cord blood stem cell transplants. (medscape.com)
  • The FDA approval was based on phase 3 testing that pitted the use of omidubicel in 62 patients against standard unmanipulated cord blood transplants in 63 patients following myeloablative conditioning. (medscape.com)
  • Bone marrow transplants offer a way to cure leukemia, sickle cell disease, and a variety of other life-threatening blood disorders.There are two major problems, however: One is many patients don't have a well-matched donor to provide the marrow needed to reconstitute their blood with healthy cells. (nih.gov)
Regenerative medicine2
Peripheral blood stem cells3
  • Three days after donation of peripheral blood stem cells to a recipient with acute myeloblastic leukemia, dengue virus was detected in the donor, who had recently traveled to Sri Lanka. (cdc.gov)
  • OUTLINE: Conditioning: Patients undergo low dose total body irradiation followed by infusion of allogeneic peripheral blood stem cells (PBSC) on day 0. (knowcancer.com)
  • The National Marrow Donor Program (NMDP), founded in 1986, and the World Marrow Donor Association (WMDA), founded in 1988, were established to (1) locate and secure appropriate unrelated-donor HSCT sources for patients by promoting volunteer donation of bone marrow and peripheral blood stem cells in the community and (2) promote ethical practices of sharing stem cell sources by need, rather than by geographic location of the donor. (medscape.com)
Baby's cord blood5
  • Once you decide to preserve your newborn's stem cells by banking your baby's cord blood in a private bank, choosing a cord blood bank is your next important decision. (babycenter.com)
  • As your baby's cord blood sample is being tested, processed, and stored, we test maternal blood (mother's blood) samples as well. (alphacord.com)
  • We do this to check for any diseases or abnormalities that may affect your baby's cord blood sample. (alphacord.com)
  • Red blood cells and plasma actually do not carry the stem cells you're saving from your baby's cord blood. (alphacord.com)
  • We do some serious testing on your baby's cord blood to make sure it is viable and able to be used if the time ever comes. (alphacord.com)
Marrow31
Cancers15
  • A newborn's umbilical cord blood contains a unique population of stem cells that have been used for more than 20 years in medical practice to treat certain cancers, blood diseases and immune disorders. (disabled-world.com)
  • Learn more about the heart of our mission-delivering cures for blood cancers-in our latest Annual Report to the Community . (bethematch.org)
  • Become a potential life-saver to patients battling blood cancers or blood diseases in need of a donor. (bethematch.org)
  • Today's approval is an important advance in cell therapy treatment in patients with blood cancers," said Peter Marks, M.D., Ph.D., director of the FDA's Center for Biologics Evaluation and Research. (fda.gov)
  • Blood cancers are a form of cancer caused by uncontrolled growth of cells in the blood, disrupting the ability of blood cells to perform their normal functions. (fda.gov)
  • Blood cancers represent about 10% of all cases of cancer each year in the U.S. Blood cancers can be fatal, with varying survival rates based on multiple factors including the specific type of blood cancer diagnosed. (fda.gov)
  • All subjects in the study had confirmed blood cancers. (fda.gov)
  • Thousands of patients undergo BMT yearly to successfully cure cancers or disorders of blood formation. (ca.gov)
  • These diseases include, but are not limited to sickle cell and Fanconi's anemia, autoimmune diseases like diabetes and multiple sclerosis, and cancers that originate from the blood system such as leukemias and lymphomas. (ca.gov)
  • Multiplying blood stem cells in conditions outside the human body could greatly improve treatment options for blood cancers like leukemia and for many inherited blood diseases. (medicalxpress.com)
  • Moreover, results from prior studies have shown the combination to be safe and effective in patients with other forms of blood cancers. (curetoday.com)
  • Dr. Morrison's lab focuses on adult stem cell biology and cancers of the blood, nervous system and skin. (utsw.edu)
  • For the thousands of people diagnosed every year with life-threatening blood cancers like leukemia and lymphoma, a cure exists. (tampabaynewswire.com)
  • The FDA's "approval is an important advance in cell therapy treatment in patients with blood cancers. (medscape.com)
  • A team of researchers led by Dr. Cristian Bellodi recently discovered a hardwired genetic control mechanism modulating individual spliceosomal components, known as splicing factors, in cells harboring oncogenic lesions common in human cancers. (lu.se)
Chemotherapy3
  • Currently, recipients that undergo BMT are treated with toxic agents such as radiation and chemotherapy in order to in order to eliminate their own blood forming stem cells and permit the donor cells to take and develop. (ca.gov)
  • In the future, this knowledge could be used to help cancer patients, among others, who have undergone high doses of radio- and chemotherapy, to replenish their depleted blood stem cells. (scitechdaily.com)
  • The purpose is to deliver chemotherapy, immunotherapy, and/or radiation to eliminate malignancy, prevent rejection of new stem cells, and create space for the new cells. (medscape.com)
Progenitor cell3
  • Angiopoietin‑like protein 7 (Angptl7) is one of the main paracrine cytokines in cord blood stem cells, and is capable of stimulating human hematopoietic stem and progenitor cell expansion. (spandidos-publications.com)
  • Angptl7 has been shown to be one of the most abundant paracrine cytokines secreted by stem cells, which is capable of stimulating human hematopoietic stem and progenitor cell expansion ( 15 , 16 ). (spandidos-publications.com)
  • In our previous study, it was revealed that Angptl7 was capable of stimulating human hematopoietic stem and progenitor cell expansion, and increasing the repopulation activities of human hematopoietic progenitors ( 15 , 16 ). (spandidos-publications.com)
Replenish3
  • In addition, in many tissues they serve as a sort of internal repair system, dividing essentially without limit to replenish other cells as long as the person or animal is still alive. (disabled-world.com)
  • These platelet-primed cells are able to also replenish other stem cell types that mostly generate the vital blood cells of the immune system. (ox.ac.uk)
  • Hematopoietic stem cells can replenish all blood cell types (i.e., are multipotent) and self-renew. (wikipedia.org)
Biology6
  • Irving Weissman, MD discusses his pioneering work in stem cell biology with a focus on cells that make up the blood-forming and immune systems. (uctv.tv)
  • Although we've learned a lot about the biology of these cells over the years, one key challenge has remained: making human blood stem cells self-renew in the lab," she said. (medicalxpress.com)
  • If we think about the amount of blood stem cells needed to treat a patient, that's a significant number," said Mikkola, who is also a professor of molecular, cell and developmental biology in the UCLA College and a member of the UCLA Jonsson Comprehensive Cancer Center. (medicalxpress.com)
  • In another article, which was recently published in Nature Cell Biology , researchers from UNSW Medicine & Health revealed the identity of cells in mice embryos responsible for blood stem cell creation. (scitechdaily.com)
  • Taking a cell from an adult and converting it all the way back to the way it was when that person was a 6-day-old embryo creates a completely new biology toward our understanding of how cells age and what happens when things go wrong, as in cancer development," Zambidis says. (jhu.edu)
  • Under Dr. Morrison's leadership, the institute is focusing on research at the interface of stem cell biology, cancer, and metabolism that has the potential to reveal new strategies for treating disease. (utsw.edu)
HSCs11
  • In the second, researchers employed another approach to convert mature mouse endothelial cells, which line the inside of blood vessels, directly into self-renewing HSCs. (nih.gov)
  • When these HSCs were transplanted into mice, they fully reconstituted the animals' blood systems with healthy red and white blood cells. (nih.gov)
  • As reported in Nature , both teams took advantage of earlier evidence showing that HSCs are formed during embryonic development from budding endothelial cells in the aorta. (nih.gov)
  • However, the biochemical signals, or recipes, driving that natural conversion of endothelial cells into HSCs weren't known. (nih.gov)
  • To test them out, the researchers first used a previously defined protocol to convert human iPSCs into endothelial cells similar to those known to produce HSCs during development. (nih.gov)
  • Bypassing the pluripotent state, in which stem cells are still capable of producing several different cell types, the researchers showed that expression of only four transcription factors was sufficient to convert the adult endothelial cells into long-lasting HSCs. (nih.gov)
  • Both groups relied on external signals to encourage the immature HSCs or HSC-like cells to mature into self-renewing stem cells that no longer needed any assistance from the researchers to continue growing and producing various types of blood cells. (nih.gov)
  • Lis and Rafii instead grew the emerging mouse HSCs on a layer of endothelial cells in a dish, where they acquired the attributes of fully functional HSCs, and later were transplanted into mice. (nih.gov)
  • Hematopoietic stem cells (HSCs) are the stem cells that give rise to other blood cells. (wikipedia.org)
  • The reprogrammed cells , designated induced-HSCs (iHSCs), possess clonal multilineage differentiation potential, reconstitute stem /progenitor compartments, and are serially transplantable. (bvsalud.org)
  • Single-cell analysis revealed that iHSCs derived under optimal conditions exhibit a gene expression profile that is highly similar to endogenous HSCs. (bvsalud.org)
Mesenchymal Stem3
  • Mesenchymal stem cells (MSC) are multipotent cells which can be obtained from several adult and fetal tissues including human umbilical cord units. (escholarship.org)
  • Umbilical cord-derived mesenchymal stem cells reversed the suppressive deficiency of T regulatory cells from peripheral blood of patients with multiple. (oncotarget.com)
  • The immunoregulatory function of T regulatory cells (Tregs) is impaired in multiple sclerosis (MS). Recent studies have shown that umbilical cord-derived mesenchymal stem cells (UC-MSCs) exert regulatory effect on the functions of immune cells. (oncotarget.com)
Researchers17
  • It's exciting to partner with thought-leading medical researchers and clinicians, like Dr. Chez, who are pursuing a scientifically sound approach in evaluating new therapeutic uses for cord blood stem cells for conditions that currently have no cures," said Heather Brown, vice president of scientific & medical affairs at CBR. (disabled-world.com)
  • Researchers at the Leibniz Institute on Aging - Fritz Lipmann Institute (FLI) have now found a gene mechanism that is responsible for the aging of hematopoietic stem cells. (idw-online.de)
  • Researchers at the Leibniz Institute on Aging - Fritz Lipmann Institute (FLI) in Jena have been able to demonstrate that in mice, the growth factor Igf2bp2 controls hematopoietic stem cell function in young adulthood by activating stem cell metabolism and growth. (idw-online.de)
  • To uncover what makes blood stem cells self-renew in a lab, the researchers analyzed the genes that turn off as human blood stem cells lose their ability to self-renew, noting which genes turned off when blood stem cells differentiate into specific blood cells such as white or red cells. (medicalxpress.com)
  • The researchers wondered if maintaining the level of the MLLT3 protein in blood stem cells in lab dishes would be sufficient to improve their self-renewing abilities. (medicalxpress.com)
  • Although we have known about induced pluripotent stem cells since 2006 , researchers still have plenty to learn about how cell differentiation in the human body can be mimicked artificially and safely in the lab for the purposes of delivering targeted medical treatment. (scitechdaily.com)
  • UNSW researchers have recently completed two studies in this area that shine new light on not only how the precursors to blood stem cells occur in animals and humans, but how they may be induced artificially. (scitechdaily.com)
  • In the study detailed in Cell Reports , lead author Dr. Jingjing Li and fellow researchers described how a 3cm x 3cm (1.2″ x 1.2″) microfluidic system pumped blood stem cells produced from an embryonic stem cell line to mimic an embryo's beating heart and conditions of blood circulation. (scitechdaily.com)
  • Researchers from Inserm, CNRS and Université d'Aix-Marseille at the Center of Immunology Marseille-Luminy have now discovered a new role played by these cells in immune response. (inserm.fr)
  • The researchers succeeded in describing the mechanisms at work during the encounter between the blood stem cell and a specific pathogen: the Brucella bacterium, which is a mandatory reportable microorganism/toxin (MOT) [2] . (inserm.fr)
  • Two new studies by NIH-funded research teams bring us closer to achieving this feat. In the first study, researchers developed a biochemical "recipe" to produce HSC-like cells from human induced pluripotent stem cells (iPSCs), which were derived from mature skin cells. (nih.gov)
  • The researchers found that different subtypes of blood stem cell are organised into a hierarchy, with platelet-primed cells at the top. (ox.ac.uk)
  • Lund University researchers find that individual blood stem cells (depicted as snowflakes in this image) express stress-related transcripts when subjected to experimental procedures involving cell incubation at elevated temperatures. (lu.se)
  • According to a recent study by researchers from the Lund Stem Cell Center at Lund University, published in Nature Aging, the genetic changes previously observed in aging blood stem cells could be linked to cell extraction stress rather than the aging process itself. (lu.se)
  • Researchers at Lund Stem Cell Center are particularly interested in studying hematopoietic stem cells, their changes with age, and the factors contributing to this decline. (lu.se)
  • Researchers hope to use stem cells to repair or replace cells or tissues damaged or destroyed by such disorders as Parkinson disease, diabetes, and spinal injuries. (msdmanuals.com)
  • By triggering certain genes, researchers may be able to cause the stem cells to specialize and become the cells that need to be replaced. (msdmanuals.com)
Mononuclear cells2
  • Notably, autologous cord blood mononuclear cells (ACBMNCs) can substantially prevent severe BPD and decrease the inflammatory response in surviving very preterm neonates. (spandidos-publications.com)
  • Our previous study demonstrated that autologous cord blood mononuclear cells (ACBMNCs), which are rich in stem cells, could substantially prevent moderate or severe BPD in surviving very preterm neonates, and that the immunomodulatory effect of MNCs contributed in mitigating the severity of BPD ( 13 ). (spandidos-publications.com)
Engraftment3
  • In contrast to the expected mixed chimerism that usually occurs in the absence of conditioning, we found in our patients 100% donor cell engraftment based on fluorescence in situ hybridization (FISH) and microsatellite techniques. (nih.gov)
  • In the two cases with ABO incompatibility, erythroid engraftment was evidenced by blood group conversion from recipient to donor type. (nih.gov)
  • If the antibody treatment results a stronger blood system originating from a donor in SCID patients, this result would prove that the antibody could be used to optimize engraftment of gene-therapy modified cells and could be applied to the treatment the many other diseases that need a BMT. (ca.gov)
Adult5
  • Reuters) - Scientists have for the first time created blood platelet cells by reprogramming stem cells derived from adult cells, offering the potential for a renewable supply of the fragile blood component. (ibtimes.com)
  • This is where stem cells are reverse engineered from adult tissue cells rather than using live human or animal embryos. (scitechdaily.com)
  • Chapter One,' Zambidis says, was work described last spring in PLoS One in which Zambidis and colleagues recounted the use of this successful method of safely transforming adult blood cells into heart cells. (thepaytons.org)
  • In the latest experiments, he and his colleagues now describe methods for coaxing adult blood cells to become so-called induced-pluripotent stem cells (iPS) - adult cells reprogrammed to an embryonic like state, and with unprecedented efficiencies. (thepaytons.org)
  • In the parallel study, Raphael Lis and Shahin Rafii from Weill Cornell Medicine, New York, began with readily accessible endothelial cells taken from the organs of adult mice. (nih.gov)
Laboratory10
  • In a study published today in the journal Nature , the team reports that activating the protein causes blood stem cells to self-renew at least twelvefold in laboratory conditions. (medicalxpress.com)
  • Mikkola's goal, making blood stem cells self-renew in controlled laboratory conditions, would open up a host of new possibilities for treating many blood disorders-among them safer genetic engineering of patients' own blood stem cells. (medicalxpress.com)
  • They then put the blood stem cells into laboratory dishes and observed which genes shut down. (medicalxpress.com)
  • Other recent studies have identified small molecules-organic compounds that are often used to create pharmaceutical drugs-that help to multiply human blood stem cells in the laboratory. (medicalxpress.com)
  • She said that in the last few decades, biomedical engineers have been trying to make blood stem cells in laboratory dishes to solve the problem of donor blood stem cell shortages. (scitechdaily.com)
  • The First and Only Cord Blood Stem Cell Laboratory in Miami, Florida. (biotechblog.com)
  • Zambidis says his team has managed to develop a 'super efficient, virus-free' way to make iPS cells, overcoming a persistent difficulty for scientists working with these cells in the laboratory. (thepaytons.org)
  • In the first breakthrough from the Children's Research Institute, Dr. Morrison's laboratory addressed this issue by systematically determining which cells are the sources of stem cell factor, a protein required for the maintenance of blood-forming stem cells. (utsw.edu)
  • If scientists can identify the remaining signals by which perivascular cells promote the expansion of blood-forming stem cells, then they may be able to replicate these signals in the laboratory. (utsw.edu)
  • Scientists from the University of Michigan and Cold Spring Harbor Laboratory also contributed to the study, which was supported by the HHMI and the National Heart, Lung and Blood Institute. (utsw.edu)
Recipient4
  • These stem cells are the only cells that can permanently generate new blood for the life of a recipient. (ca.gov)
  • Here, we report transmission of DENV to a peripheral blood stem cell recipient by a donor who had recently traveled to an area to which the virus is endemic. (cdc.gov)
  • The part of white blood cells that contains stem cells is then separated in a machine and removed to be later given to the recipient. (medlineplus.gov)
  • Now that we know these cells exist, we can start thinking about devising new strategies to enhance platelet output - either by generating and transplanting more of this type of cell into a recipient, or by somehow stimulating their own pool of stem cells to restore platelet levels more quickly. (ox.ac.uk)
Pluripotent5
Scientists8
  • Using this expertise, the scientists were able to identify a new subset of hematopoietic stem cells that exhibit particularly strong activity of Igf2bp2-dependent metabolism and growth in adolescent mice. (idw-online.de)
  • UCLA scientists have discovered a link between a protein and the ability of human blood stem cells to self-renew. (medicalxpress.com)
  • One study was published on September 13, 2022, in the journal Cell Reports by scientists from the UNSW School of Biomedical Engineering. (scitechdaily.com)
  • Johns Hopkins scientists have developed a reliable method to turn back the clock on blood cells , restoring them to a primitive stem cell state from which they can then develop into any other type of cell in the body. (jhu.edu)
  • The scientists then showed that this "handshake" leads to a rapid response by the stem cells, whereby they begin to produce more white blood cells. (inserm.fr)
  • Although scientists have searched for decades to identify the stem cell home, this is the first study to reveal the cells that are functionally responsible for the maintenance of blood-forming stem cells in the body," said Dr. Morrison, director of the new institute and senior author of the study available Jan. 26 in Nature . (utsw.edu)
  • Scientists already have determined how to make large quantities of stem cells and how to change these cells into those of the nervous system, skin and other tissues. (utsw.edu)
  • Scientists are developing ways of enabling (inducing) other cells (such as a blood or skin cell) to act as stem cells. (msdmanuals.com)
Lund Stem Cell Center2
  • Anna Konturek-Ciesla, a researcher at Lund Stem Cell Center and the lead author of the study explains, "In our research, which focuses on hematopoiesis, or blood cell formation, many studies have attempted to analyze the changes associated with aging in blood stem cells using gene expression profiling. (lu.se)
  • When we looked at our data, we noticed a pattern of stress-induced changes in gene activity, especially in cells exposed to higher temperatures during isolation," explains David Bryder, Professor of Molecular Hematology at Lund University, and research group leader at Lund Stem Cell Center. (lu.se)
Embryonic development3
  • Whether the metabolic and dividing activity of hematopoietic stem cells during embryonic development or in adolescence already predetermines later aging of the cells had not been previously been reported and was therefore the subject of the current study. (idw-online.de)
  • Part of the problem is that we still don't fully understand all the processes going on in the microenvironment during embryonic development that leads to the creation of blood stem cells at about day 32 in the embryonic development," Dr. Li said. (scitechdaily.com)
  • The very first hematopoietic stem cells during (mouse and human) embryonic development are found in aorta-gonad-mesonephros region and the vitelline and umbilical arteries. (wikipedia.org)
Donor stem cells3
Registry6
  • Sutter Neuroscience Institute, a recognized Center of Excellence, and CBR (Cord Blood Registry), the world's largest stem cell bank, are launching the first U.S. FDA approved clinical trial to assess the use of a child's own cord blood stem cells to treat select patients with autism. (disabled-world.com)
  • This will be our second time using Cord Blood Registry. (babycenter.com)
  • Whatever the family decides, Bothma is still advocating for people to register for Canadian Blood Services' stem cell registry. (theprogress.com)
  • In the U.S., most of the market share is with the three major companies such as Cryo-Cell, Cord Blood Registry (CBR), and ViaCord. (maximizemarketresearch.com)
  • The Cord Blood Registry (CBR) has been traded twice, once in 2015 to AMAG Pharmaceuticals for US$ 700 Mn. (maximizemarketresearch.com)
  • In Sept 2021, Cord Blood Registry also bought Natera's Evercord Cord Blood Banking business. (maximizemarketresearch.com)
Lymphocytes3
  • Subset analysis of the engrafted cells using a multiparametric system enabling a combined analysis of morphology, immunophenotyping and FISH showed that both T and B lymphocytes and myeloid cells were of donor origin in two patients, while T lymphocytes and myeloid cells were of donor origin in the third. (nih.gov)
  • In shape, hematopoietic stem cells resemble lymphocytes. (wikipedia.org)
  • Cutaneous T-cell lymphoma (CTCL) (see the image below) is a heterogeneous group of lymphoproliferative disorders characterized by localization of neoplastic T lymphocytes to the skin, with no evidence of extracutaneous disease at the time of diagnosis. (medscape.com)
Genes5
  • The research group specializes in the study of genes at the single-cell level. (idw-online.de)
  • Genes related to systems development, osteogenesis and immune system were expressed at higher levels in UCB, whereas genes related to cell adhesion, morphogenesis, secretion, angiogenesis and neurogenesis were more expressed in UC cells. (escholarship.org)
  • Suspecting that experimental procedures used during gene expression analysis might be influencing the results, they examined how stress-related genes behaved in cells collected under different conditions. (lu.se)
  • However, prior to commitment, it has been cells, it is evident that GATA-1 and PU.1 are able to specify observed that many genes are expressed at intermediate or basal erythroid and myeloid cell fates (see [16] and references therein). (lu.se)
  • One way to induce these cells is to inject them with material that affects their genes, a process called reprogramming. (msdmanuals.com)
Donor's blood1
  • Before apheresis, the donor's blood count showed mild thrombocytopenia after G-CSF mobilization. (cdc.gov)
Immature2
  • Stem cells, also known as Hematopoetic Progenitor Cells (HPCs) are immature blood cells. (upstate.edu)
  • They ultimately narrowed down the recipe to a combination of seven transcription factors that were sufficient to convert the iPSC-derived endothelial cells to immature HSC-like cells. (nih.gov)
Myeloid3
Leukemia5
  • Every 3-4 minutes, someone in the U.S. is diagnosed with a blood cancer like leukemia or lymphoma. (bethematch.org)
  • The killing of leukemia cells is proportional to the radiation absorbed dose. (nature.com)
  • A stem cell donor is the only cure to life-threatening diseases like leukemia, lymphoma, and sickle cell. (icla.org)
  • Many parents know or sincerely believe that the future may bring exciting new discoveries in cord blood research that may totally change the outcomes of major diseases like leukemia, cancer and heart disease. (cordblood-banking.org)
  • Splicing factor mutations are particularly prevalent in MDS, a group of heterogeneous hematological disorders characterized by defective blood stem cells and a high risk of leukemia development. (lu.se)
Mice4
  • Surprisingly, mice in which the gene is mutated show a reduction in the age-associated loss of function of the blood stem cells in late life, even though the gene is no longer active. (idw-online.de)
  • The experimental findings of the current study suggest that the activation of growth and metabolism in juvenile mice preprograms the subsequent loss of function of hematopoietic stem cells and inscribes this into the cell's memory. (idw-online.de)
  • When used in mice, this antibody resulted in excellent donor stem cell take and cured mice that had a condition equivalent to human SCID. (ca.gov)
  • When Mikkola's team used the small molecules, they observed that blood stem cell self-renewal improved in general, but the cells could not maintain proper MLLT3 levels, and they also did not function as well when transplanted into mice. (medicalxpress.com)
Makes blood stem cells1
Diseases9
  • This is the start of a new age of research in stem cell therapies for chronic diseases such as autism, and a natural step to determine whether patients receive some benefit from an infusion of their own cord blood stem cells. (disabled-world.com)
  • This is the start of a new age of research in stem cell therapies for chronic diseases such as autism, and a natural step to determine whether patients receive some benefit from an infusion of their own cord blood stem cells," said Michael Chez, M.D., director of Pediatric Neurology with the Sutter Neuroscience and principal study investigator. (disabled-world.com)
  • Many amongst us are already aware that cord blood offers a near magical cure for a number of life threatening diseases and conditions. (cordblood-banking.org)
  • Stem cell technology has evolved to a point where a number of diseases can already be cured. (cordblood-banking.org)
  • Umbilical cord blood is a rich basis of hematopoietic stem cells capable of treating over 80 genetic diseases. (maximizemarketresearch.com)
  • Stem cells can also fight long-lasting illnesses like cancer, diabetes, blood disorders and immune diseases. (maximizemarketresearch.com)
  • The global market for stem cell umbilical cord blood is expected to gain market growth from 2019 to 2029 because of the growing prevalence of chronic diseases coupled with the developing field of regenerative medicines globally. (maximizemarketresearch.com)
  • Moreover, the findings add to the growing body of evidence showing that cord blood can save children with other fatal "lysosomal storage diseases," each of which stems from a specific enzyme deficiency. (dukehealth.org)
  • The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
Progenitors1
  • The hematopoietic tissue contains cells with long-term and short-term regeneration capacities and committed multipotent, oligopotent, and unipotent progenitors. (wikipedia.org)
Patients15
  • First FDA approved clinical trial to evaluate use of child's own cord blood stem cells to treat patients with autism. (disabled-world.com)
  • Cord blood stem cells may offer ways to modulate or repair the immune systems of these patients which would also improve language and some behavior in children who have no obvious reason to have become autistic. (disabled-world.com)
  • We studied three SCID patients who were transplanted with unmodified mobilized peripheral blood from HLA-identical family sex-mismatched members. (nih.gov)
  • We're calling on people across Canada to make three different kinds of contributions to Canadian Blood Services to support patients. (blood.ca)
  • On September 17, 2018, the Texas Department of State Health Services received notification of Enterobacter cloacae and Citrobacter freundii bloodstream infections in three patients who had received injections or infusions of non-FDA-approved umbilical cord blood-derived stem cell products processed by Genetech, Inc., and distributed by Liveyon, LLC, for other than hematopoietic or immunologic reconstitution at an outpatient clinic on September 12. (cdc.gov)
  • The six vials from Texas had the same cord-blood donor and processing date as those that had been administered to the patients with infections. (cdc.gov)
  • Regardless of when contamination occurred, this investigation highlights the serious potential risks to patients of stem cell therapies administered for unapproved and unproven uses other than hematopoietic or immunologic reconstitution ( 5 ). (cdc.gov)
  • This is because of well-developed healthcare sectors, the presence of leading medical diagnostics companies, and the rising number of patients suffering from blood disorders and cancer. (maximizemarketresearch.com)
  • "In addition to improving knowledge about how the immune response works, our study ultimately allows us to envisage the development of a targeted therapy capable of preventing the interactions between Brucella and the blood stem cell, preventing the spread of the bacteria in the body and helping patients with brucellosis," concludes Gorvel. (inserm.fr)
  • Cells from the donor "engrafted" or took hold in all of the patients. (dukehealth.org)
  • OneBlood is a not-for-profit 501(c)(3) community asset responsible for providing safe, available and affordable blood to more than 200 hospital partners and their patients throughout most of Florida, parts of Georgia, Alabama and South Carolina. (tampabaynewswire.com)
  • Background: Stem cell (SC) administration is a potential therapeutic strategy to improve blood supply in patients with peripheral artery disease (PAD). (edu.au)
  • Cite this: FDA OKs Stem Cell Therapy to Reduce Infection Risk in Blood Cancer Patients - Medscape - Apr 18, 2023. (medscape.com)
  • Their stem cells are more likely to help patients than stem cells from older people. (medlineplus.gov)
  • Une étude transversale comportant des entretiens a montré que 68,8 % des 1051 patients interrogés en consultation externe dans un hôpital de Riyad montraient une attitude positive au sujet de la recherche biomédicale. (who.int)
Gene13
  • The gene Igf2bp2 is important in youth for the full function of these cells, as it activates their growth and metabolism. (idw-online.de)
  • When the gene is missing, however, the aging-associated loss of function of the stem cells is surprisingly diminished. (idw-online.de)
  • The eventual aging of hematopoietic stem cells is apparently already preprogrammed by their gene-driven growth in youth. (idw-online.de)
  • After that, the gene is silenced and loses its function, it shows hardly any activity in the stem cells in advanced age," explains Prof. K. Lenhard Rudolph, research group leader at the FLI and professor of molecular medicine at FSU Jena. (idw-online.de)
  • This suggests that Igf2bp2 gene function in early life leads to the aging of the stem cells. (idw-online.de)
  • The Igf2bp2-gene drives growth and metabolic activity at a young age but these activities contribute to the age-associated loss of hematopoietic stem cell function in later life. (idw-online.de)
  • These healthy stem cells can come from either a donor or can be stem cells that are modified by gene therapy techniques. (ca.gov)
  • They found that the expression of a gene called MLLT3 was closely correlated with blood stem cells' potential to self-renew and that the protein generated by the MLLT3 gene provides blood stem cells with the instructions necessary to maintain its ability to self-renew. (medicalxpress.com)
  • Using a viral vector-a specially modified virus that can carry genetic information to a cell's nucleus without causing a disease-the team inserted an active MLLT3 gene into blood stem cells and observed that functional blood stem cells were able to multiply in number at least twelvefold in lab dishes. (medicalxpress.com)
  • His team swapped out the mouse gene responsible for stem cell factor with a gene from jellyfish that encodes green fluorescent protein. (utsw.edu)
  • Studying gene expression is essential for understanding how cells function and respond to different stimuli. (lu.se)
  • Today, performing gene expression analysis on young and aged hematopoietic stem cells is a common practice, used to understand the changes associated with aging. (lu.se)
  • These findings demonstrate that expression of a set of defined factors is sufficient to activate the gene networks governing HSC functional identity in committed blood cells . (bvsalud.org)
20221
  • According to a series of 2022 BabyCenter Surveys, which asked parents and parents to be which banks they had used or expected to use, banking parents most often chose CBR to save their newborn's stem cells. (babycenter.com)
Differentiation2
  • Since each ubiquitin ligase can recognize its target proteins through a specific degron, we are interested in delineating ubiquitin ligase-target protein interactions that are triggered by differentiation stimulus in stem cells. (lu.se)
  • This will provide key insights on how ubiquitin signaling plays a vital role in stem cell differentiation and how perturbations in these networks can lead to disorders such as cancer. (lu.se)
Cord blood banks8
Lymphoma4
  • Early patch-stage cutaneous T-cell lymphoma. (medscape.com)
  • Related articles include Cutaneous B-Cell Lymphoma and Cutaneous Pseudolymphoma . (medscape.com)
  • Among the changes to CTCL classification were the addition of primary cutaneous acral CD8 + T-cell lymphoma as a new provisional entity. (medscape.com)
  • Also, the term "primary cutaneous CD4 + small/medium T-cell lymphoma" was changed to "primary cutaneous CD4 + small/medium T-cell lymphoproliferative disorder" because of its indolent clinical behavior and uncertain malignant potential. (medscape.com)
Human10
  • Stem cells are distinguished from other human body cell types by two important characteristics. (disabled-world.com)
  • Omisirge, administered as a single intravenous dose, is composed of human allogeneic stem cells from umbilical cord blood that are processed and cultured with nicotinamide (a form of vitamin B3). (fda.gov)
  • Our objective is to test the antibody that targets human CD117 to safely prepare children with SCID to accept blood forming stem cells from a donor. (ca.gov)
  • They demonstrated how a simulation of an embryo's beating heart using a microfluidic device in the lab led to the development of human blood stem cell 'precursors', which are stem cells on the verge of becoming blood stem cells. (scitechdaily.com)
  • If we control the power in stem cells wisely, we will eventually get to a stage where the human body can be repaired after any damage, injury and possible even aging could be arrested. (cordblood-banking.org)
  • They also note that, while their new findings were in animals, they already have some evidence from a previous study to suggest a similar approach might work in human cells [3]. (nih.gov)
  • The cells or blood is then tested for special proteins, called human leukocytes antigens (HLAs). (medlineplus.gov)
  • But first we need to see whether we can find the same cells in human tissue and understand more about how they are regulated. (ox.ac.uk)
  • Changes occur in all cells of the human body as we age. (lu.se)
  • Because the embryos then lose the ability to grow into a complete human being, the use of stem cells from embryos is controversial. (msdmanuals.com)
Embryos1
  • Stem cells can be obtained from the embryos that are not used. (msdmanuals.com)
Platelet1
  • This has the potential of marching us forward to a day when we might to able to eliminate blood platelet shortages," said Dr. Charles Abrams, ASH secretary and associate chief of hematology/oncology at the University of Pennsylvania in Philadelphia. (ibtimes.com)
Source of stem cells1
  • Today we know that the blood in the umbilical cord - the umbilical cord blood - is the richest source of stem cells that we can possibly get. (cordblood-banking.org)
Hematopoiesis2
Research3
  • The idea that embryonic stem cells are a must-have for research is a myth. (thepaytons.org)
  • Cord blood research is producing new breakthroughs nearly everyday and has already changed the lives of thousands of those who have benefited from these techniques. (cordblood-banking.org)
  • Logistic regression analysis found that predictors for a positive attitude to biomedical research and to use of tissue in research were: female sex, higher level of education, previous experience of blood testing and previous participation in health-related research. (who.int)
Subset1
  • Today, the U.S. Food and Drug Administration approved Omisirge (omidubicel-onlv), a substantially modified allogeneic (donor) cord blood-based cell therapy to quicken the recovery of neutrophils (a subset of white blood cells) in the body and reduce the risk of infection. (fda.gov)