Blood cells fetal blood stem cells. Medical search. Frequent questions

21 University Medical Center Hamburg-Eppendorf Center of Oncology, Department of Stem Cell Transplantation, Chairman of the CMWP EBMT, Hamburg, Germany. (nih.gov)
To determine whether umbilical cord blood transplantation (UCBT) is an alternative cure for myelofibrosis (MF), we evaluated 35 UCBTs reported to Eurocord. (nih.gov)
Umbilical cord blood transplantation. (nih.gov)
Immunotherapy has become an important part of hematopoietic stem cell (HSC) transplantation and cancer therapy. (nih.gov)
1 This includes human cells for transplantation such as haematopoietic stem cells from bone marrow, peripheral blood or cord blood. (who.int)
MacLaren and his collaborators showed using precursor cells that are already programmed to become photoreceptors but are not quite there yet was the key to successful transplantation. (fightaging.org)
BACKGROUND: The Cord Blood Transplantation (COBLT) Study banking program was initiated in 1996. (emmes.com)
The study goals were to develop standard operating procedures for cord blood (CB) donor recruitment and banking and to build an ethnically diverse unrelated CB bank to support a transplantation protocol. (emmes.com)
MSCs were obtained from the bone marrow (BM) cells remaining in the bag and filter used in the transplantation of hematopoietic stem cells. (springer.com)
Innovative therapies, such as progenitor and mesenchymal stem cell transplantation, targeting the specific altered pathway rather than the symptoms, are in the process of development. (smw.ch)
Bone marrow or stem cell transplantation, which can cure SCD. (medlineplus.gov)
Unmanipulated haploidentical hematopoietic stem cell transplantation (HCT) with post-transplantation cyclophosphamide as graft-versus-host disease (GVHD) prophylaxis (haplo-PTCY) and unrelated double-unit umbilical cord blood transplantation (dUCBT) are feasible options for treating patients with high-risk acute myelogenous leukemia (AML). (unisr.it)
This study compared outcomes after dUCBT and haplo-HCT using peripheral blood stem cells (PBSCs) in adult patients with AML in complete remission (CR) who underwent transplantation in European Society for Blood and Marrow Transplantation (EBMT)-affiliated centers. (unisr.it)
Experimental mice, i.e., wild-type, Col5a1 f/f and Kera-Cre/Col5a1 f/f ( Col5a1 ∆st/∆st , collagen V null in the corneal stroma) mice in a C57BL/6J genetic background, were subjected to a lamellar keratectomy, and treated with or without UMSC (10 4 cells/cornea) transplantation via an intrastromal injection or a fibrin plug. (molvis.org)
Hu G, Liu P, Feng J, Jin Y. Transplantation with Bone Marrow Stromal Cells Promotes Wound Healing Under Chemotherapy through Altering Phenotypes. (ijbs.com)
Stem cell transplantation is a promising strategy for delayed wound healing caused by chemotherapy. (ijbs.com)
Nevertheless, myelosuppression can be reversed by autologous stem cell transplantation (SCT), even without additional toxicity ( 4 , 5 ). (ijbs.com)
In order to eliminate the interference from the transplanted cells themselves, fetal stem cells were used for transplantation because the proliferation and differentiation potentials of fetal stem cells are superior to the adult ones ( 8 ). (ijbs.com)
Recent news of an impending clinical cell transplantation trial in Parkinson's disease using parthenogenetic stem cells as a source of donor tissue have raised hopes in the patient community and sparked discussion in the research community. (lu.se)
Based on discussions held by a global collaborative initiative on translation of stem cell therapy in Parkinson's disease, we have identified a set of key questions that we believe should be addressed ahead of every clinical stem cell-based transplantation trial in this disorder. (lu.se)
The specific medications administered depend on the choice of therapy and whether it is supportive care only, immunosuppressive therapy, or hematopoietic cell transplantation. (medscape.com)

They showed that opposing gradients of bone morphogenetic protein (BMP) and Nodal, two transforming growth factor family members that act as morphogens, are sufficient to induce molecular and cellular mechanisms required to organize, in vivo or in vitro, uncommitted cells of the zebrafish blastula animal pole into a well-developed embryo. (wikipedia.org)
To test the hypothesis that fetal mesenchymal stem cells persist in maternal organs, we studied female bone marrow and ribs. (mendeley.com)
This process initially occurs in fetal liver cells and subsequently takes place in the bone marrow of children and adults. (medscape.com)
The scientists knew from previous work in this field that cells from fetuses normally begin circulating in their mothers' blood very early in pregnancy and can be found in the bone marrow and other tissues of these women for decades afterward. (livescience.com)
Though red and white blood cells may end up in different places in the body, after we are born production of blood cells starts in the bone marrow. (davidicke.com)
Bone marrow makes more than 220 billion new blood cells every day. (davidicke.com)
Instead, they multiply rapidly in the bone marrow and interfere with blood cell production. (davidicke.com)
In a 2020 Nature Biomedical Engineering study, researchers used a type of genetic therapy, known as RNA interference, and nanoparticles modified in such a way that they would accumulate in the cells found in the bone marrow, rather than in the liver. (davidicke.com)
Using this gene therapy technique with specialised nanoparticles, researchers from Penn Engineering and the Massachusetts Institute of Technology ("MIT") developed a way to turn off specific genes in cells of bone marrow. (davidicke.com)
If we could develop technologies that could control cellular activity in bone marrow and the hematopoietic stem cell niche, it could be transformative for disease applications," said Michael Mitchell, one of the study's lead authors. (davidicke.com)
Mitchell was already working on new nanotechnologies that target bone marrow and immune cells for treating other diseases, especially blood cancers such as multiple myeloma. (davidicke.com)
In a paper published last week, Italian researchers treated lymphoblast cells isolated from the bone marrow of a 53-year-old chronic myelogenous leukaemia patient with Pfizer's mRNA covid injection, at increasing concentrations. (davidicke.com)
Establish stromal cell layers and culture hematopoietic progenitors in "Dexter-type" long-term bone marrow cultures. (stemcell.com)
Chorionic and amniotic MSCs suppress T cell proliferation to the same extent as bone marrow derived MSCs. (parentsguidecordblood.org)
First, they removed stem cells - cells in the bone marrow programmed to become red blood cells - from the mice and used gene editing to modify part of the stem cells' DNA to switch on the healthy foetal haemoglobin gene. (eurekalert.org)
Their cells embed in our bone marrow and breasts. (smithsonianmag.com)
Bone is the basic unit of the human skeletal system and provides the framework for and bears the weight of the body, protects the vital organs, supports mechanical movement, hosts hematopoietic cells, and maintains iron homeostasis. (medscape.com)
Here, in the presence of KL+FL+megakaryocyte growth and development factor (MGDF), which recruits virtually all Lin(-)Sca-1(+)kit(+) bone marrow cells into proliferation and promotes their self-renewal under serum-free conditions, IL-3 and IL-11 revealed an indistinguishable ability to further enhance proliferation. (lu.se)
Self-renewal and differentiation are tightly controlled to maintain haematopoietic stem cell (HSC) homeostasis in the adult bone marrow 1,2 . (elsevierpure.com)
Herein we characterized human fetal bone marrow stromal cells (hBMSCs) during wound healing in mice treated with cyclophosphamide (CTX). (ijbs.com)
Treatment for this condition remains difficult and largely ineffective, because the growth of cells in the wound is inhibited ( 2 ) and chemotherapy usually leads to myelosuppression, the latter of which further compromises the migration of multipotent cells from the bone marrow ( 3 ). (ijbs.com)
Additionally, readers interested in an in depth review of Fanconi anemia and other IBMFSs are referred to an article by Shimamura and Alter in the journal Blood Reviews: "Pathophysiology of inherited bone marrow failure syndromes. (medscape.com)
The platelets arise from the fragmentation of the cytoplasm of megakaryocytes in the bone marrow and circulate in blood as disc-shaped anucleate particles for 7-10 days. (medscape.com)
Progenitor cell (stem cell) lines in the bone marrow produce new blood cells and stromal cells. (medscape.com)
Bone marrow consists of stem cells, which are large, "primitive," undifferentiated cells supported by fibrous tissue called stroma. (medscape.com)
There are 2 main types of stem cells and, therefore, the bone marrow consists of 2 types of cellular tissue. (medscape.com)
Both types of bone marrow are highly vascular, being enriched with numerous blood vessels and capillaries. (medscape.com)
Bone marrow first appears in the clavicle near the end of fetal life and becomes active about 3 weeks later. (medscape.com)
Bone marrow thus contains blood cells at varying stages of development. (medscape.com)
Illustration of the pelvis to show the site of bone marrow and blood cells derived from bone marrow. (medscape.com)
When the oxygen content of body tissues is low, if there is loss of blood or anemia, or if the number of red blood cells decreases, the kidneys produce and release erythropoietin, a hormone that stimulates the bone marrow to produce more red blood cells. (medscape.com)
Similarly, the bone marrow produces and releases more white blood cells in response to infections, and it produces and releases more platelets in response to bleeding. (medscape.com)
If a person experiences serious blood loss, yellow bone marrow can be activated and transformed into red bone marrow. (medscape.com)
As age progresses, more of the red bone marrow turns into yellow bone marrow and the production of new blood cells becomes more difficult. (medscape.com)
The bone marrow stroma contains mesenchymal stem cells. (medscape.com)
Low-power view of hematoxylin-eosin-stained bone marrow showing hypocellularity, with increased adipose tissue and decreased hematopoietic cells in the marrow space. (medscape.com)
The clinical presentation of patients with aplastic anemia includes signs and symptoms related to the decrease in bone marrow production of hematopoietic cells. (medscape.com)

Progenitors are obtained by so-called direct reprogramming or directed differentiation and are also called induced somatic stem cells. (wikipedia.org)
This meant that the cells can change their differentiation pathway. (wikipedia.org)
In Drosophila imaginal discs, cells have to choose from a limited number of standard discrete differentiation states. (wikipedia.org)
The fact that transdetermination (change of the path of differentiation) often occurs for a group of cells rather than single cells shows that it is induced rather than part of maturation. (wikipedia.org)
The anti-SARS-CoV-2 BNT162b2 vaccine suppresses mithramycin-induced erythroid differentiation and expression of embryo-foetal globin genes in human erythroleukemia K562 cells, bioRvix. (davidicke.com)
2016). Natural killer cell-based adoptive immunotherapy eradicates and drives differentiation of chemoresistant bladder cancer stem-like cells. (springer.com)
Here are their technical properties: AECs have multipotent differentiation potential and expression of pluripotent stem cell specific transcription factors including Oct4 and Nanog. (parentsguidecordblood.org)
They also established that at least some of the impact was mediated through several molecular pathways known to play a role in differentiation.In one of the pathways, the toxins dramatically increased the activity of a key gene that keeps embryonic stem cells in an undifferentiated state, suggesting that its disruption might be responsible for much of the delay seen in embryonic development. (ucsf.edu)
Finally, they assessed gene expression in three stem cell differentiation pathways, known as Notch, canonical Wnt and TGF-β. (ucsf.edu)
During fetal development, expansion of HSCs (self-renewal) and production of differentiated haematopoietic cells (differentiation) are both required to sustain the haematopoietic system for body growth 3,4 . (elsevierpure.com)
Moreover, proliferating cell nuclear antigen (PCNA) and CD31 showed co-localization with α-SMA, suggesting the differentiation of hBMSCs into epithelial cells and myofibroblasts/fibroblasts. (ijbs.com)
Temporal multimodal single-cell profiling of native hematopoiesis illuminates altered differentiation trajectories with age. (lu.se)

Researchers in America have discovered that vaccinating mice with embryonic stem cells prevented lung cancer in those animals that had had cancer cells transplanted into them after the vaccination or that had been exposed to cancer-causing chemicals. (fightaging.org)
The discovery could influence the American debate about embryonic stem cells because these extremely rare cells appear to migrate to diseased organs and help to heal them. (bioedge.org)
The UCSF-led team made its discovery by studying the impact of smoke on human embryonic stem cells as they differentiated, or specialized into various cell types, in the culture dish. (ucsf.edu)
Next, they exposed human embryonic stem cells in the culture dish either to tobacco smoke or nicotine at concentrations found in fetal blood. (ucsf.edu)
They discovered that both nicotine and non-nicotine components of tobacco smoke increased the activity of genes that hold embryonic stem cells in a pluripotent, or undifferentiated, state. (ucsf.edu)
They also highlight the power of human embryonic stem cells as a model of human development. (ucsf.edu)

Regenerative and reparative properties of somatic cell-based therapies hold tremendous promise for repairing injured tissue, preventing and reversing damage to organs, and restoring balance to compromised immune systems. (nih.gov)
After injury, mature terminally differentiated kidney cells dedifferentiate into more primordial versions of themselves and then differentiate into the cell types needing replacement in the damaged tissue Macrophages can self-renew by local proliferation of mature differentiated cells. (wikipedia.org)
In newts, muscle tissue is regenerated from specialized muscle cells that dedifferentiate and forget the type of cell they had been. (wikipedia.org)
The use of gametes, embryonic and fetal tissue as well as blood and blood products raises additional questions that need to be separately addressed. (who.int)
The Precision Link Biobank for Health Discovery , a library of blood, tissue, and cells donated by thousands of patients and their families at Boston Children's Hospital to advance knowledge of health and disease. (childrenshospital.org)
Vangsness and his colleagues injected the stem cell solution into the knees of 55 patients with a torn meniscus, cartilage-like tissue in the knee. (fightaging.org)
If we can prove these are stem cells, and harvest them from the blood or tissue of a woman who's been pregnant, they could have therapeutic potential for that woman, her children, and perhaps even unrelated individuals," says Dr Diana Bianchi. (bioedge.org)
A more realistic service is offered by a few cord blood banks that preserve the stem cells from placental blood and placental tissue. (parentsguidecordblood.org)
The MSCs represent less than 1% of the cells present in the placenta, while the average yield of MSCs from chorions and amnions is between 1 to 10 million per gram of tissue. (parentsguidecordblood.org)
First, they extended the analysis of gene activity in umbilical cord stem cells previously examined by their University of Connecticut co-authors, determining that tobacco smoke increased the activity of genes that delay the development of mesoderm - the layer of tissue that gives rise to blood, musculoskeletal and cardiovascular systems - as well endoderm and ectoderm, the two other layers of embryonic cells that give rise to the tissues of the body. (ucsf.edu)
Projects carried out using human biological materials such as cells, blood, embryos, foetuses, foetal tissue, human reproductive material or human stem cells. (etsmtl.ca)
Adult heart tissue doesn't rally easily, but new mothers may somehow be able to regrow heart cells the way salamanders sprout new tails. (smithsonianmag.com)
Fluorescence in-situ hybridization (FISH) assays on fresh (including Amniotic fluid, chorionic villi sampling, peripheral blood, product of conception, tumour tissue) and FFPE tissues. (kkh.com.sg)
In these studies, cells are either removed and edited in tissue culture and then readministered to the patient (ex vivo), or genome editors are packaged within viral vectors or lipid nanoparticles and given intravenously to home to specific tissues (in vivo). (cdc.gov)

Angiopoietin‑like protein 7 (Angptl7) is one of the main paracrine cytokines in cord blood stem cells, and is capable of stimulating human hematopoietic stem and progenitor cell expansion. (spandidos-publications.com)
Angptl7 has been shown to be one of the most abundant paracrine cytokines secreted by stem cells, which is capable of stimulating human hematopoietic stem and progenitor cell expansion ( 15 , 16 ). (spandidos-publications.com)
In our previous study, it was revealed that Angptl7 was capable of stimulating human hematopoietic stem and progenitor cell expansion, and increasing the repopulation activities of human hematopoietic progenitors ( 15 , 16 ). (spandidos-publications.com)
We compared five strategies in CD34+ hematopoietic stem and progenitor cells, using either Cas9 nuclease or adenine base editors. (cdc.gov)

This disease is caused by a mutation in a gene that makes haemoglobin, the protein that carries oxygen in red blood cells, with the damaged haemoglobin distorting the shape of red blood cells, causing painful and potentially life-threatening blockages in blood vessels. (eurekalert.org)
During pregnancy the fetal mouse cells cross the placenta into the mother's body, joyriding through her blood vessels until cardiac damage happens, at which point they sense inflammation and make a beeline for her wounded heart. (smithsonianmag.com)
Normal red blood cells are disc-shaped and flexible enough to move smoothly through the blood vessels. (acsh.org)
These misshapen red blood cells are inflexible and get stuck in blood vessels, and the resulting impaired blood flow can lead to a variety of complications, including stroke , infection, episodes of pain called "pain crises," and arthritis from hemorrhaging into joints. (acsh.org)
But in a slice of the population, these cells are misshapen, contorted by a genetic mutation into sharp-edged scythes that snag in blood vessels. (pharmavoice.com)
Many of them burst apart as they move through your blood vessels. (medlineplus.gov)
The sickle-shaped cells also tend to stick to each other, causing blockages in small blood vessels. (sscb-stembiotech.com)
Sickle cell patients are chronically fatigued from lack of adequate oxygen, and they have crises of pain and swelling from blocked blood vessels. (sscb-stembiotech.com)
The hemostatic system consists of platelets, coagulation factors, and the endothelial cells lining the blood vessels. (medscape.com)

Differentiated airway epithelial cells can revert into stable and functional stem cells in vivo. (wikipedia.org)
Amnion Epithelial Cells (AECs) are a stem-like cell that can be isolated in large numbers (150 to 200 million per gram) from full-term placentae. (parentsguidecordblood.org)

Notably, autologous cord blood mononuclear cells (ACBMNCs) can substantially prevent severe BPD and decrease the inflammatory response in surviving very preterm neonates. (spandidos-publications.com)
Subsequently, the association between cord blood Angptl7 levels and BPD incidence in a cohort of very preterm neonates was assessed (cohort 2). (spandidos-publications.com)
In cohort 2, the cord blood Angptl7 levels were significantly lower in infants who later developed BPD. (spandidos-publications.com)
In conclusion, the anti‑inflammatory and proangiogenic effects of Angptl7 derived from cord blood stem cells may ameliorate BPD severity. (spandidos-publications.com)
Our previous study demonstrated that autologous cord blood mononuclear cells (ACBMNCs), which are rich in stem cells, could substantially prevent moderate or severe BPD in surviving very preterm neonates, and that the immunomodulatory effect of MNCs contributed in mitigating the severity of BPD ( 13 ). (spandidos-publications.com)
A BC-based team of TFRI-funded researchers has discovered that CD33, a protein from the sialic acid-binding receptor family that was previously believed to be unique to normal maturing white blood cell precursors and acute myeloid leukemias (AML), is also present on human cord blood stem cells with the highest regenerative ability. (tfri.ca)
The medical potential that lies in cord blood is clear and the cord blood banking industry is booming, but have you ever considered the remaining perinatal tissues that are routinely discarded as medical waste? (parentsguidecordblood.org)
In summary, the placenta and other perinatal tissues are a rich source of stem cells and stem-like cells, which can potentially be banked in a similar manner to cord blood. (parentsguidecordblood.org)
Cord blood mononuclear cells prevent neuronal apoptosis in response to perinatal asphyxia in the newborn lamb. (umassmed.edu)
Effects of umbilical cord blood cells, and subtypes, to reduce neuroinflammation following perinatal hypoxic-ischemic brain injury. (umassmed.edu)
Umbilical cord blood versus mesenchymal stem cells for inflammation-induced preterm brain injury in fetal sheep. (umassmed.edu)
Neurovascular effects of umbilical cord blood-derived stem cells in growth-restricted newborn lambs : UCBCs for perinatal brain injury. (umassmed.edu)
Multiple doses of umbilical cord blood cells improve long-term brain injury in the neonatal rat. (umassmed.edu)
She gave birth to a second son in 2018 and stored his cord blood with Cordlife Sciences India, a cord blood bank that is part of the Cordlife Group and located near Kolkata. (sscb-stembiotech.com)
Then in January of 2020, Kamsiyochukwu underwent chemotherapy at Indraprastha Apollo Hospital in Delhi and next received a transplant of his baby brother's cord blood stem cells. (sscb-stembiotech.com)
The infant was admitted for observation, and infection during the epidemic of Zika in Colombia cord blood samples were sent to the Instituto Nacio- and data on the neurodevelopmental outcome at 18 nal de Salud (INS) for additional testing by reverse months of age (corrected). (cdc.gov)
The purpose of this study is to examine the therapeutic efficacy of human umbilical cord mesenchymal stem/stromal cells (UMSCs) in treating congenital and acquired corneal opacity associated with the loss of collagen V. (molvis.org)
Safety of umbilical cord blood derived cells (UCBC) administration as determined by absence of any adverse events (AE) necessitating cessation of cell infusion (e.g. anaphylaxis or major change in cardio-respiratory status), or any AE attributable to cell administration within first 48 hours of infusion (e.g. bacterial infection). (who.int)

A series of scientific sessions and speakers highlighted key aspects of the latest scientific, clinical and technologic developments in cell therapy, involving a unique set of cell products with a special emphasis on converging concepts in these fields. (nih.gov)
Notably, stem cell-based paracrine cytokine treatment, with its anti-inflammatory and immunoregulatory ability ( 9 , 10 ) has been regarded as a promising therapy for BPD in preclinical models and clinical studies ( 10 - 12 ). (spandidos-publications.com)
Gene therapy for sickle cell disease , severe immunodeficiency (SCID-X), adrenoleukodystrophy , relapsed acute lymphoblastic leukemia , Wiskott-Aldrich syndrome , and a growing list of other conditions. (childrenshospital.org)
Stem cell therapy - a technique that relies on the idea that stem cells can be prompted to turn into cartilage cells that will grow and repair damage - is another possible avenue for future treatment. (fightaging.org)
Vangsness and his colleagues are testing a stem cell therapy developed by Osiris Therapeutics. (fightaging.org)
Fleischmann calls that concept "pie in the sky" but says that years from now doctors might have injectable stem cell therapy or some other technique that could hold the line on osteoporosis. (fightaging.org)
RNA interference is a gene therapy that could potentially be used to "treat a variety of diseases" by delivering short strands of RNA that block specific genes from being turned on in a cell. (davidicke.com)
We believe that engineering nanoparticles to deliver RNA to different types of cells and organs in the body is key to reaching the broadest potential of genetic therapy. (davidicke.com)
Understanding of molecular mechanisms in natural killer cell therapy. (springer.com)
2014). Human NK cells: From surface receptors to the therapy of leukemias and solid tumors. (springer.com)
Before a new treatment can be tested on people, scientists test them on laboratory animals, so Weiss and colleagues tried their new gene therapy in two types of mice that carry the symptoms of sickle cell disease: so-called 'Berkeley' and 'Townes' mice. (eurekalert.org)
Surprisingly, 70% of the Berkeley mice died from the therapy and it only activated production of the healing foetal haemoglobin gene in 3.1% of mouse's stem cells. (eurekalert.org)
Acceptability of neural stem cell therapy for cerebral palsy: survey of the Australian cerebral palsy community. (umassmed.edu)
Today, fetal therapy is recognized as one of the most promising fields in pediatric medicine, and prenatal surgery (surgery before birth) is becoming an option for a growing number of babies with birth defects. (chop.edu)
The therapy is bespoke, created from an individual's own stem cells via a laborious and expensive process. (pharmavoice.com)
An investigational gene therapy for Sickle Cell Disease (SCD) and β-thalassaemia, known as ARU-1801 , has been given Orphan Drug Designation an orphan drug by the U.S. Food and Drug Administration (FDA), a status that helps to advance and support its development. (thalassaemia.org.cy)
The therapy is expected to increase functioning red blood cells through proprietary technology that inserts a modified fetal haemoglobin gene into autologous stem cells via a lentiviral vector. (thalassaemia.org.cy)
For patients suffering from sickle cell disease, we believe the ultimate promise of gene therapy is a one-time cure without the side effect profile of high intensity myeloablative conditioning. (thalassaemia.org.cy)
Data from two pivotal trials suggest that a single infusion of the CRISPR-based gene therapy exagamglogene autotemcel (exa-cel) can provide a 'functional cure' for patients with transfusion-dependent beta-thalassemia or severe sickle cell disease. (cdc.gov)
In this article, we first provide a short history of cell therapy in Parkinson's disease and briefly describe the current state-of-art regarding human stem cell-derived dopamine neurons for use in any patient trial. (lu.se)
The PI, Gesine Paul, is also an active clinical investigator in clinical cell therapy and growth factor trials. (lu.se)

Patients find themselves on a life-long regimen of blood transfusions, drugs to alter the shape of blood cells, and pain killers. (sscb-stembiotech.com)
Blood transfusions -are the main treatment for people with severe alpha thalassemia. (stjude.org)

Normal erythropoiesis begins with multipotent hematopoietic stem cells, which differentiate into erythroid progenitors, eventually to develop into the mature red blood cells. (medscape.com)
In my research, I utilise a variety of technologies, including single-cell RNA sequencing, whole genome sequencing and cell-culture assays, to characterise foetal blood progenitors and to understand how stem cells colonise the different organs during development. (cam.ac.uk)
In this assay hematopoietic cells are cultured in MyeloCult™ medium with supportive human or mouse stromal cell layers and tested for their ability to generate myeloid clonogenic progenitors for several weeks as assayed by replating the cells in a colony-forming unit (CFU) assay using MethoCult™ medium. (stemcell.com)
Through kinetic study, we observed the simultaneous formation of HSCs and defined progenitors-previously regarded as descendants of HSCs 5 -from the HLF + precursor population, followed by prompt formation of the hierarchical haematopoietic population structure in the fetal liver in an HSC-independent manner. (elsevierpure.com)
These data suggest that fetal HSCs minimally contribute to the generation of progenitors and functional blood cells before birth. (elsevierpure.com)

They form characteristic cell clusters in suspension culture that express a set of genes associated with pluripotency and can differentiate into endodermal, ectodermal and mesodermal cells both in vitro and in vivo. (wikipedia.org)
In vivo hematopoietic stem cell modification by mRNA delivery. (davidicke.com)
Shaping of natural killer cell antitumor activity by ex vivo cultivation. (springer.com)
Foetal stem cells have a higher regenerative potential than their adult counterparts and studying them could provide important insights on how we can mimic these properties in the production of blood stem cells ex-vivo for regenerative medicine purposes. (cam.ac.uk)
Although long-term repopulating hematopoietic stem cells (HSC) can self-renew and expand extensively in vivo, most efforts at expanding HSC in vitro have proved unsuccessful and have frequently resulted in compromised rather than improved HSC grafts. (lu.se)
In striking contrast, the ex vivo expansion of murine HSC in fetal calf serum-containing medium resulted in extensive loss of reconstituting activity, an effect further facilitated by the presence of IL-3. (lu.se)
article{ff9b980d-2e89-453c-b22b-428d2e903c6f, abstract = {{Although long-term repopulating hematopoietic stem cells (HSC) can self-renew and expand extensively in vivo, most efforts at expanding HSC in vitro have proved unsuccessful and have frequently resulted in compromised rather than improved HSC grafts. (lu.se)
Patients receiving in vivo antithymocyte globulin, Campath, or ex vivo T cell depletion were excluded. (unisr.it)
Ex vivo therapies have focused on blood disorders, including at least 6 trials aiming to cure sickle cell disease (SCD) or transfusion-dependent ß-thalassemia (TDT). (cdc.gov)

Fetal cells enter maternal blood during pregnancy and persist in women with autoimmune disease. (mendeley.com)
We conclude that fetal stem cells transferred into maternal blood engraft in marrow, where they remain throughout life. (mendeley.com)
This must be balanced against the proposed benefits of fetal cells for long-term maternal health. (livescience.com)
this interaction takes place at the maternal-fetal interface and is necessary for a healthy pregnancy. (parentsguidecordblood.org)
The switch in a mother's immune system during pregnancy is largely mediated by regulatory T cells in the maternal bloodstream. (parentsguidecordblood.org)
They are responsible for triggering cellular events such as activating the maternal regulatory T cells that maintain tolerance and promoting their proliferation, while concurrently inducing the death of activated T cells that could compromise the pregnancy. (parentsguidecordblood.org)
The HLA-G molecule plays a major role in immune tolerance during pregnancy, particularly at the maternal-fetal interface, where HLA-G inhibits the migration and proliferation of maternal immune cells. (parentsguidecordblood.org)
Multiplying in maternal chests, the fetal stem cells transform into blood vessel-like tubes and, more significant, cells that resemble full-fledged heart muscle cells, which cardiologists have struggled for decades to recreate in a lab. (smithsonianmag.com)

Kamsiyochukwu and his family are from Nigeria, but they were living in India when he was diagnosed with Sickle Cell Anaemia at the age of two years old in 2013. (sscb-stembiotech.com)
Hydroxyurea (hydroxycarbamide) is approved for treating both children and adults with sickle cell anaemia (SCA). (cdc.gov)

Globally, it is estimated that 120 000 corneal transplantations and 18 000 transplantations of allogeneic haematopoietic progenitor cells took place in the year 2000. (who.int)
In fact, low levels of telomerase activity have been found in human adult stem cells including haematopoietic and non-haematopoietic stem cells such as neuronal, skin, intestinal crypt, mammary epithelial, pancreas, adrenal cortex, kidney, and mesenchymal stem cells (MSCs) ( Table 1 ). (nature.com)
haematopoietic) is the medical term used to describe the process by which our blood cells are formed, develop and mature into their final "adult" types. (davidicke.com)
The process begins with a haematopoietic stem cell ("HSC"), which then goes through a series of steps to arrive at the final product - a mature blood cell. (davidicke.com)

They are classified as either totipotent (iTC), pluripotent (iPSC) or progenitor (multipotent - iMSC, also called an induced multipotent progenitor cell - iMPC) or unipotent - (iUSC) according to their developmental potential and degree of dedifferentiation. (wikipedia.org)
STUDY DESIGN AND METHODS: The hematopoietic progenitor cell (HPC) and lymphocyte subset (LS) content of approximately 8000 CB units were characterized, and these results were correlated with donor ethnicity, birth weight, gestational age, sex, and type of delivery. (emmes.com)

They determined that sentinel genes in each pathway were over expressed, but one most prominently: Expression of the Nodal gene was 50- to 75-fold higher in nicotine and tobacco smoke-exposed cells, respectively, than in untreated cells. (ucsf.edu)
In their current Disease Models & Mechanisms article , Mitchell Weiss and colleagues from St. Jude Children's Research Hospital, Memphis, USA, investigated a promising new treatment that is being developed in Weiss' lab and works by editing genes to switch on the production of this healthy, foetal haemoglobin in adult red blood cells. (eurekalert.org)
Therefore, the team sequenced the haemoglobin genes and surrounding DNA of the Berkeley mice and discovered that instead of having a single copy of the mutated human gene, the mice had 22 randomly arranged, broken-up copies of the mutated human sickle cell disease gene and 27 copies of the human foetal haemoglobin that the team had hoped to activate to cure the mice of the disease. (eurekalert.org)
Exa-cel, a new CRISPR-based treatment, modifies the genes of the patient's stem cells to induce them to produce fetal hemoglobin. (acsh.org)
People with the disease are born with two sickle cell genes, one from each parent. (medlineplus.gov)
They have discovered novel genes that control blood forming stem cells and uncovered new cell populations that produce platelets. (childrenshospital.org)
This study aimed to establish afatinib-resistant cell lines from which afatinib resistance-associated genes are identified and the underlying mechanisms of multiple-TKI resistance in NSCLC can be further investigated. (bvsalud.org)
We established afatinib-resistant lung cancer cell lines and here report genes associated with afatinib resistance in human NSCLC. (bvsalud.org)
These cell lines and the identified genes serve as useful investigational tools, prognostic biomarkers of TKI therapies, and promising molecule targets for development of human NSCLC therapeutics. (bvsalud.org)
However, prior to commitment, it has been cells, it is evident that GATA-1 and PU.1 are able to specify observed that many genes are expressed at intermediate or basal erythroid and myeloid cell fates (see [16] and references therein). (lu.se)

Although the anemia is often normocytic, mild macrocytosis can also be observed in association with stress erythropoiesis and elevated fetal hemoglobin levels. (medscape.com)

The researchers were able to identify the minimal conditions and factors that would be sufficient for starting the cascade of molecular and cellular processes to instruct pluripotent cells to organize the embryo. (wikipedia.org)

NEW YORK - Diagnostics firm DiamiR Biosciences is preparing a clinical study of its microRNA-based Alzheimer's risk assessment blood test CogniMir, with the aim of making it available for pharma research clients in late 2023 or early 2024. (genomeweb.com)

The act of giving birth can lead blood from the fetus to mingle with that of the mother, especially in the case of cesarean sections, where more blood crosses the placenta into the woman. (livescience.com)
We now know that some of the stem cells and stem-like cells of the placenta and fetal membranes have a vital role to play in this immunological switch. (parentsguidecordblood.org)

NK cells were obtained from peripheral blood (PB) of healthy volunteers. (springer.com)

Recently, the importance of telomere maintenance in human stem cells has been highlighted by studies on dyskeratosis congenital, which is a genetic disorder in the human telomerase component. (nature.com)
Chromosomal abnormalities account for a significant proportion of patients with fetal malformations, congenital abnormalities, intellectual/developmental disorders, early pregnancy loss, stillbirths, recurrent miscarriage and infertility. (kkh.com.sg)

Some types of mature, specialized adult cells can naturally revert to stem cells. (wikipedia.org)
Researchers can create so-called induced pluripotent stem (iPS) cells by reprogramming adult cells from skin, blood or hair. (spectrumnews.org)

This first research isn't quite stem cell science, but it's both worthy of attention and something we're probably going to see much more of as scientists get better at this - the use of somewhat differentiated precursor cells. (fightaging.org)

Basically, given the difference of telomere and telomerase activity in human and mouse cells, the telomere and telomerase status in stem cell populations is different between humans and mice ( Harrington, 2004 ). (nature.com)
When testing the treatment in mice, the researchers found that even though the lab mice had the symptoms of sickle cell disease, the foetal haemoglobin gene and surrounding DNA were not properly configured, making the revolutionary stem-cell treatment ineffective or even harmful in the animals and raising concerns for future research testing new gene-based therapies in these laboratory mice. (eurekalert.org)
The scientists then put these reprogrammed stem cells back into the mice and monitored the animals for 18 weeks to find out how the treatment affected them. (eurekalert.org)
In contrast, the experimental treatment activated the foetal haemoglobin gene in 57% of red blood cells in the Townes mice and did not affect the animals' survival. (eurekalert.org)
However, the levels of foetal haemoglobin produced in the red blood cells of Townes mice were 7- to 10-times lower than seen when this approach is used in human cells grown in the laboratory and not high enough to reduce clinical signs of sickle cell disease. (eurekalert.org)
Weiss and colleagues then wanted to find out why this new treatment was not successful in the Berkeley mice, which have been used for decades to test treatments for sickle cell disease. (eurekalert.org)
In contrast, the Townes mice only had single copies of the mutated human haemoglobin gene and the gene that makes human foetal haemoglobin. (eurekalert.org)
However, these mice likely lacked crucial pieces of DNA that normally regulate the production of the foetal haemoglobin gene in humans. (eurekalert.org)
Dr Weiss commented, "Our findings will help scientists using the Berkeley and Townes mice decide which to use to address their specific research question relating to sickle cell disease or haemoglobin. (eurekalert.org)
In tests involving lab mice, which were surgically operated on to simulate a heart attack, she and her research team discovered something astonishing: heart cells with DNA that doesn't match the mother's own. (smithsonianmag.com)
The mystery cells belong to unborn mice. (smithsonianmag.com)
The lab has even found that these cells, harvested from mouse placentas, will travel to the damaged hearts of male mice after being artificially implanted in their tails. (smithsonianmag.com)

The treatment involves gene editing of the patient's blood-forming stem cells to induce them to produce high levels of fetal hemoglobin (HbF, or hemoglobin F) in red blood cells. (acsh.org)
In early 2021, Tsogbe received an experimental transplant of his own stem cells, which had been collected and edited in a laboratory using CRISPR gene editing, biomedicine's most cutting-edge tool. (pharmavoice.com)
Exa-cel also comes with the theoretical risk that wayward gene edits in the transplanted cells may one day lead to other problems, like cancer. (pharmavoice.com)
The cause of SCD is a defective gene, called a sickle cell gene. (medlineplus.gov)
If you are born with one sickle cell gene, it's called sickle cell trait. (medlineplus.gov)
People with sickle cell trait are generally healthy, but they can pass the defective gene on to their children. (medlineplus.gov)
Gene therapies to treat SCD in people who are 12 years and older and have had repeated sickle cell crises. (medlineplus.gov)
After two and a half months in culture, the cells show patterns of gene expression characteristic of neurons about 19 to 24 weeks after conception. (spectrumnews.org)
CRISPR gene editing holds great promise to modify DNA sequences in somatic cells to treat disease. (cdc.gov)

For the first time ever, a team of TFRI-funded researchers has created synthetic cancer cells that are indistinguishable from T-cell acute lymphoblast. (tfri.ca)
Cells from babies live on in their mothers for her lifetime and could even prolong it, US researchers at Tufts-New England Medical Center have found. (bioedge.org)
As to the unexpected finding of a lowered risk of autoimmune disease after abortion, the researchers conjectured that early loss of a fetus may allow more stem or similarly potent cells to enter the blood of these women, cell types more likely to prove beneficial than ones from later in fetal development. (livescience.com)
FINDINGSUCLA researchers have found that a Chinese herbal regimen called TSY-1 (Tianshengyuan-1) increased telomerase activity in normal blood cells but decreased it in cancer cells. (medworm.com)
Researchers at Duke University have now mapped out another system, a cell-to-cell connection between the gut and the nervous system, that may be more direct than the release of hormones in the blood. (fabresearch.org)
A new cell culture method allows researchers to easily transform skin cells into spheres of firing neurons. (spectrumnews.org)
For almost a decade, researchers have been growing neurons derived from iPS cells. (spectrumnews.org)
So far, the researchers have made spheroids from seven iPS cell lines derived from five individuals. (spectrumnews.org)
If comprehensive whole-organism family trees could be assembled, researchers would learn a lot about human fetal development, genetic diseases and more. (childrenshospital.org)

These findings could be a major aid to the development of better protocols for expanding human blood stem cells in the laboratory, and therefore contribute to an improved availability of donor cells useful for clinical transplants. (tfri.ca)
These particles could be tailored to help treat heart disease or to boost the yield of stem cells in patients who need stem cell transplants, Penn Engineering Today wrote. (davidicke.com)

Blood production during foetal development involves separate waves of migration of rare stem cells among different organs, including aorta, liver and bones. (cam.ac.uk)
That regimen is so arduous that older people and those with organs damaged by sickle cell may not be healthy enough to receive it. (pharmavoice.com)
The liver is one of the few organs in the body where differentiated adult stem cells can divide to regenerate after an injury. (childrenshospital.org)

In 1924 Hans Spemann and Hilde Mangold demonstrated the key importance of cell-cell inductions during animal development. (wikipedia.org)
Red cell development, or erythropoiesis, is a carefully ordered sequence of events. (medscape.com)
Uncovering the dynamics of blood production in foetal development has both biological and translational implications. (cam.ac.uk)
We hope the findings will be a launching pad for further investigations on the impact on fetal development at the cellular level. (ucsf.edu)
Improved fetal imaging and diagnostic tools have allowed us to identify more precisely when conditions worsen during fetal development. (chop.edu)
HbF is the form of the oxygen-carrying hemoglobin that is naturally present during fetal development, but the body switches to the adult form of hemoglobin after birth. (acsh.org)
Stem cell-independent pathways during development thus offer a rational strategy for the rapid and simultaneous growth of tissues and stem cell pools. (elsevierpure.com)
Studying the Hippo pathway can help scientists develop treatments which encourage a liver to heal itself, allow scientists to grow liver cells in the lab (a therapeutic approach not yet available) or study the development of liver cancer. (childrenshospital.org)
Until recently, it was impossible to look deep into development and record this lineage tree information at a single cell resolution. (childrenshospital.org)
They have applied this technology to generate family trees of blood development and blood regeneration. (childrenshospital.org)

This meeting report summarizes a workshop sponsored by the National Heart, Lung and Blood Institute (NHLBI) and Production Assistance for Cellular Therapies (PACT), held on 23-24 April 2009 at the National Institutes of Health (NIH, USA). (nih.gov)
The findings, published in Nature Cell Biology (June 2018), could significantly affect the design of targeted AML therapies, according to Dr. David Knapp (BC Cancer/UBC) and Colin Hammond (PhD candidate, UBC), the study's two co-first authors. (tfri.ca)
This new discovery provides a possible explanation of why some trials that have used CD33 as a potential target for AML therapies have shown specific toxicities expected from a loss of normal stem cells, according to the Eaves' group. (tfri.ca)
These new therapies involve taking some of your blood stem cells and either adding new DNA to them or changing their existing DNA. (medlineplus.gov)
Are Stem Cell-Based Therapies for Parkinson's Disease Ready for the Clinic in 2016? (lu.se)
Stem cell-based therapies for Parkinson's dis- ogy company International Stem Cell Corporation ease (PD) are rapidly moving towards clinical trials. (lu.se)

NK cell proliferation, phenotypic expression and cytotoxic activity were evaluated. (springer.com)

Several academic and industry efforts are well under owned subsidiary Cyto Therapeutics, it had received way to produce dopaminergic neurons from stem approval by the Australian government to conduct a cells under conditions compliant with use in patients. (lu.se)
Without this, the patient cells lost in PD could be replaced by grafted community is left trying to interpret complex scien- immature human dopaminergic neurons [3, 5]. (lu.se)
As a translational neurologist, Gesine Paul is also working on the implementation of novel preclinical findings by performing phase 1 clinical trials (e.g. growth factors, fetal cells, dopaminergic stem cells) in individuals with Parkinson's disease. (lu.se)

Male cells were identified by XY fluorescence in-situ hybridisation in marrow-derived mesenchymal stem cells and in rib sections from all women with male pregnancies, but not in controls (9/9 vs 0/5, p=0·0005). (mendeley.com)
However, the yellow marrow can revert to red if there is increased demand for red blood cells, such as in instances of blood loss. (medscape.com)
Normally, only mature cells are released from the marrow into the bloodstream. (medscape.com)
These stem cells divide to eventually give rise to red blood cells, platelets, and most white blood cells in the red marrow. (medscape.com)
The theoretical basis for marrow failure includes primary defects in or damage to the stem cell or the marrow microenvironment. (medscape.com)
External insults (eg, infections, radiation, drugs) may disrupt stem cell homeostasis in marrow environment, leading to altered growth. (medscape.com)

Roberto Rodriquez Jr. was the first-ever fetal surgery patient at CHOP, undergoing a prenatal procedure to remove a lung lesion in 1995. (chop.edu)
Clinicians and families share what makes the Wood Center for Fetal Diagnosis and Treatment the best place for prenatal diagnosis, fetal care and fetal surgery. (chop.edu)

The common stem cell produces 2 other stem cells, the myeloid stem cell and the lymphoid stem cell. (medscape.com)

When functioning normally, the Hippo pathway is important to cell growth, but when malfunctioning, the Hippo pathway can also play a role in diseases such as liver cancer and liver fibrosis. (childrenshospital.org)

ST. LOUIS Missouri voters have narrowly approved a state constitutional amendment that protects stem cell research, even involving the use of human embryos. (fightaging.org)

For instance, multilineage-differentiating stress-enduring (Muse) cells are stress-tolerant adult human stem cells that can self-renew. (wikipedia.org)
The regulation of telomere length and telomerase activity is a complex and dynamic process that is tightly linked to cell cycle regulation in human stem cells. (nature.com)
Here we review the role of telomeres and telomerase in the function and capacity of the human stem cells. (nature.com)

The study also sets the ground work for identifying shared features that could be critical to the high regenerative ability unique to these rare cells. (tfri.ca)

The present study had aimed to evaluate the effect of a feeder layer of irradiated MSCs in the in vitro expansion of NK cells. (springer.com)
NK expansion and activation were stimulated by culture with artificial antigen-presenting cells (aAPCs) and IL-2, in the presence or absence of BM-MSCs. (springer.com)
Mesenchymal Stem Cells (MSCs) have been successfully isolated from first-, second-, and third-trimester placental compartments, including the amnion, chorion, decidua parietalis and decidua basalis. (parentsguidecordblood.org)
Regardless of their source, MSCs have potent immunosuppressive properties and MSCs obtained from the fetal membranes are no exception. (parentsguidecordblood.org)
Unlike MSCs, which are all plastic adherent, primary AECs have three subpopulations of cells that are adherent, loosely adherent, and free-floating. (parentsguidecordblood.org)

The frequency of subsequent fetomaternal microchimerism in healthy women and its cell type is unknown. (mendeley.com)
The phenomenon is called "fetal microchimerism"-"micro," because these are typically teeny numbers of cells, only a handful per millimeter of blood in pregnant women, and fewer in moms later in life. (smithsonianmag.com)

Fetal surgery is a highly complex surgical intervention to repair birth defects in the womb that requires the most expert care for both mother and unborn baby. (chop.edu)

Induced stem cells (iSC) are stem cells derived from somatic, reproductive, pluripotent or other cell types by deliberate epigenetic reprogramming. (wikipedia.org)
Induced totipotent cells can be obtained by reprogramming somatic cells with somatic-cell nuclear transfer (SCNT). (wikipedia.org)
The process involves sucking out the nucleus of a somatic (body) cell and injecting it into an oocyte that has had its nucleus removed Using an approach based on the protocol outlined by Tachibana et al. (wikipedia.org)
In somatic cells, the activity of telomerase, a reverse transcriptase that can elongate telomeric repeats, is usually diminished after birth so that the telomere length is gradually shortened with cell divisions, and triggers cellular senescence. (nature.com)
Thus, even in stem cells, except for embryonal stem cells and cancer stem cells, telomere shortening occurs during replicative ageing, possibly at a slower rate than that in normal somatic cells. (nature.com)
Telomeric DNA consists of short guanine-rich repeat sequences in all eukaryotes with linear chromosomes, and its length in human somatic cells is remarkably heterogeneous among individuals ranging from 5 to 20 kb, according to age, organ, and the proliferative history of each cell ( Wright and Shay, 2005 ). (nature.com)
In most human somatic cells except for stem cells and lymphocytes, telomerase activity is diminished after birth so that telomere length shortens with each cell division. (nature.com)
Ongoing clinical trials use CRISPR for somatic cell genome editing to treat hereditary diseases or cancer. (cdc.gov)

The fetal membranes - amnion and chorion - also contain stem cells and stem cell-like cells that can be isolated and banked for clinical use. (parentsguidecordblood.org)
In the pivotal clinical study , 29 of 30 evaluable patients (96.7%) achieved the primary endpoint of the absence of severe blood vessel blockage (known as vaso-occlusive crises, or VOCs) for at least 12 consecutive months. (acsh.org)
A phase 1/2 clinical study in 10 individuals with sickle cell disease is currently examining the efficacy and safety of ARU-1801. (thalassaemia.org.cy)
This review describes current considerations in the use of hydroxyurea for the management of sickle cell disease in the context of clinical severity. (cdc.gov)
With this background information as a foundation, we then discuss each of the key questions in relation to the upcoming therapeutic trial and critically assess if the time is ripe for clinical translation of parthenogenetic stem cell technology in Parkinson's disease. (lu.se)
A second press release [2] has indicated stem cell source, resulting in widespread excitement that the program is planning to move forward very rapidly, with all of the patients being enrolled in the Correspondence to: Roger A. Barker, John van Geest Centre first quarter of 2016 and interim results being shared for Brain Repair, Department of Clinical Neurosciences, Univer- in October 2016. (lu.se)

It is still unclear how human foetal blood stem cells arise, expand and differentiate in the more than ten cell types that carry out vital body functions such as carrying oxygen, clotting and fighting infections. (cam.ac.uk)
As needed, the stem cells differentiate to become a particular kind of cell-a white blood cell, red blood cell, or platelet. (medscape.com)
T lymphocytes originate via lymphoid stem cells that migrate to the thymus and differentiate under the influence of the thymic hormones thymopoietin and thymosin. (medscape.com)

MyeloCult™ media have been developed for the long-term culture of hematopoietic progenitor cells in association with adherent stromal cells. (stemcell.com)
Stromal cell feeder layers (e.g. (stemcell.com)
Intranasal Delivery of Mesenchymal Stromal Cells Protects against Neonatal Hypoxic?Ischemic Brain Injury. (umassmed.edu)
One type of stem cell is involved in producing blood cells and the other is involved in producing stromal cells, which are responsible for the supporting stroma. (medscape.com)

What are the treatments for sickle cell disease (SCD)? (medlineplus.gov)

Going deeper: Neurons cultured in three dimensions mimic the layers (superficial, deep and ventricular zone, or VZ) of cells in the brain's outer rind, the cerebral cortex. (spectrumnews.org)
The approach, described 25 May in Nature Methods , yields networks of mature neurons that mimic those of the fetal brain at a stage pivotal to the understanding of autism 1 . (spectrumnews.org)
Within days, the cells develop into nerve-cell precursors and then neurons. (spectrumnews.org)
Star-shaped cells called astrocytes are scattered among the neurons. (spectrumnews.org)
In the brain, these cells help neurons form synapses. (spectrumnews.org)

Anatomy35

Organisms6

Diseases47

Chemicals and Drugs45

Analytical, Diagnostic and Therapeutic Techniques and Equipment82

Psychiatry and Psychology2

Phenomena and Processes40

Disciplines and Occupations3

Anthropology, Education, Sociology and Social Phenomena2

Technology, Industry, Agriculture1

Information Science3

Named Groups5

Health Care13

Transplantation21

Bone37

Differentiation12

Embryonic stem6

Tissue14

Hematopoietic stem and progenitor4

Vessels9

Epithelial cells2

Cord18

Therapy21

Transfusions2

Progenitors5

Vivo9

Maternal8

Sickle Cell An2

Haematopoietic4

Progenitor cell2

Genes10

Hemoglobin levels1

Pluripotent cells1

20231

Placenta2

Peripheral blood1

Congenital2

Adult cells2

Precursor cells1

Mice12

Gene9

Researchers9

Transplants2

Organs3

Development10

Therapies6

Proliferation1

Dopaminergic3

Marrow6

Prenatal2

Myeloid1

Liver1

Embryos1

Human stem cells3

Regenerative1

MSCs5

Microchimerism2

Unborn1

Somatic8

Clinical6

Differentiate3

Stromal4

Treatments for sickle cell di1

Neurons5