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  • Efficacy
  • Dr. Wanzhang Yang, who led the study at Nanshan Affiliated Hospital of Guangdong Medical College commented, 'This important study, which is the largest of its kind, demonstrates the safety and efficacy of using cord-blood-derived stem cells to treat a variety of neurological conditions. (news-medical.net)
  • assays
  • This ties in with the resurgence of phenotypic screening and is a response to the perceived poor translation of the traditional simple cell-based assays, often developed to study just single protein targets. (news-medical.net)
  • sickle cell a
  • Have treated a total of 28 patients With following disease: aplastic anemia, sickle cell anemia, Thalassaemia,, diabetes type one, two spinal cord injury cases, one muscular dystrophy and very recently one ALS case. (futurepundit.com)
  • Their studies, published online by the journals Cell and Nature , respectively, on May 13, together offer clues that may help in treating blood diseases such as leukemia, immune deficiency and sickle cell anemia, suggesting new ways scientists can make the types of blood cells a patient needs. (scienceblog.com)
  • Investigators studying diseases as diverse as cancer and sickle-cell anemia have relied on the cells collected by the Seattle research center. (washingtontimes.com)
  • petri dish
  • In the second study, a team led by Shahin Rafii at Weill Cornell Medicine in New York City used adult mouse cells as their starting material, and then guided them through several steps - including exposure to some of the same gene-activating proteins - to create mature blood stem cells in a petri dish. (seeker.com)
  • differentiation
  • Is the Subject Area "Cell differentiation" applicable to this article? (plos.org)
  • This novel method skips the generally accepted process of mixing iPSCs with either mouse or human stromal cells during the differentiation process and, in essence, ensures no outside and potentially harmful DNA is introduced into the reprogrammed cells. (technologynetworks.com)
  • In order to expand cord blood stem cells in culture, conditions must maximize proliferation and limit their differentiation to mature white blood cells. (fredhutch.org)
  • The combination of both Delta1 and SR1 increased progenitor numbers and decreased the differentiation of cells to more mature myeloid cells compared to SR1 alone. (fredhutch.org)
  • patient's own cells
  • The discovery of iPSCs holds great promise for regenerative medicine since it is possible to produce patient-specific iPSCs from the individual for potential autologous treatment - that is, treatment using the patient's own cells. (technologynetworks.com)
  • regenerative
  • As such, it could lead to a purer, safer therapeutic grade of stem cells for use in regenerative medicine. (technologynetworks.com)
  • This method, which uses only a small blood sample, may represent an option for generating iPSCs that maintains their genomic integrity," said Anthony Atala, MD, Editor of STEM CELLS Translational Medicine and director of the Wake Forest Institute for Regenerative Medicine. (technologynetworks.com)
  • Endometrial regenerative cells are stem cells taken from menstrual blood that are capable of forming into at least nine different tissue types, including heart, liver and lung. (upi.com)
  • Thus, these results highlight a unique role for GATA2 function in mouse embryonic hematopoiesis and should inform future regenerative approaches designed to treat blood diseases. (nih.gov)
  • proteins
  • As cells and tissues develop in the embryo, the process by which they take on specific characteristics involves cellular proteins called transcription factors, which regulate whether genes are turned on or off. (nih.gov)
  • They tested many combinations of the proteins, and found five that worked together to encourage their stem cells to become blood stem cells. (newscientist.com)
  • Transcription factors are proteins that bind DNA to influence gene expression.The authors inserted the transcription factors in various combinations into the haemogenic endothelial cells they made before, to see if they could trigger their transformation into blood stem cells. (eurostemcell.org)
  • autologous
  • We describe the results of a clinical trial to evaluate the feasibility and toxicity of autologous hematopoietic stem cell transplantation (auto-HSCT) for patients with progressive multiple sclerosis (MS). Fifteen patients (all patients with secondary progressive MS) were enrolled. (springer.com)
  • laboratory
  • When examining human and mouse blood stem cells with and without Tie2, they found that those with Tie2 have superior ability to grow and repeatedly give rise to new daughter stem cells over longer periods of time in the laboratory, creating many generations of blood stem cells. (nih.gov)
  • 1 Molecular Genetics of Stem Cells Laboratory, Institute of Research in Immunology and Cancer, University of Montreal, Montreal, QC H3C 3J7, Canada. (sciencemag.org)
  • tissues
  • These tumors, which contain a mixture of cells from a variety of tissues and organs of the body, are typically benign. (phys.org)
  • Biologists have long wondered why the embryonic heart begins beating so early, before the tissues actually need to be infused with blood. (scienceblog.com)
  • convert
  • Zambidis' team also found a way around the use of viruses to convert the cells to a stem cell state. (newswise.com)
  • In ongoing studies, Zambidis and colleagues are testing the quality of the newly formed iPS cells and their ability to convert to other cell types, as compared with iPS cells made by other methods. (newswise.com)
  • Mitochondria are referred to as the "powerhouses" of the cell because these small organelles take energy that is ingested in the form of sugars or fats and convert it to fuel for the cell in a process called respiration. (nih.gov)
  • found
  • The cells showed chemical markers that were identical to primitive blood cells found naturally in the human body. (sun-sentinel.com)
  • We also found that MNCs can be efficiently reprogrammed into iPSCs as readily as CD34+ cells. (technologynetworks.com)
  • The investigators found that deficiency in a protein component of the mitochondrial respiration process, called RISP, resulted in a mouse fetus that developed fewer red blood cells than normal and subsequently died. (nih.gov)
  • They showed that shear stress - the frictional force of fluid flow on the surface of cells lining the embryonic aorta - increases the expression of master regulators of blood formation, including Runx1, and of genetic markers found in blood stem cells. (scienceblog.com)
  • They found they could make cells lacking Ptpn21 stiff again by interfering with the function of another protein, Septin1. (eurekalert.org)
  • And the cells are not quite as efficient at making blood as those found in the body. (newscientist.com)
  • Both studies noted that, while the lab-grown blood stem cells were very similar to those found in the body, they were not identical. (eurostemcell.org)
  • genes involved
  • Further analysis of mouse Tie2-containing blood stem cells showed that these cells "turn on" several genes involved in the degradation of mitochondria, which helps cells remain healthy by selectively removing damaged mitochondria. (nih.gov)
  • disorders
  • This step opens up an opportunity to take cells from patients with genetic blood disorders, use gene editing to correct their genetic defect, and make functional blood cells," said Ryohichi Sugimura, a doctor at Boston Children's Hospital and lead author of one of the studies. (seeker.com)
  • Metabolic/storage disorders e.g. leukodystrophies,mucopolysaccharidoses as Hurler disease;Stem cell defects e.g.reticular agenesis, among many other rare similar conditions. (clinicaltrials.gov)
  • Blood stem cell transplantation is used to treat patients with blood disorders. (fredhutch.org)
  • Qu is professor of pediatrics at Emory University School of Medicine, Winship Cancer Institute and Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta. (eurekalert.org)
  • This helps us better understand the pathogenesis of blood disorders associated with loss of stem cell quiescence. (eurekalert.org)
  • research
  • The work was supported by grants from the National Heart, Lung, and Blood Institute, (1U01HL099775 and U01HL100397), the National Cancer Institute (CA60441), both part of the National Institutes of Health, and the Maryland Stem Cell Research Fund (2011-MSCRF II-0008-00 and 2007-MSCRF II-0379-00). (newswise.com)
  • The achievement comes as Congress is about to begin examining President Bush's controversial new policy on federal funding of stem cell research. (sun-sentinel.com)
  • See recent posts MIT Technique To Produce Large Numbers Of Adult Stem Cells , Stem Cells On Spinal Cord Injury Opened Connection To Brain , and Adult Stem Cell Research Promising For Heart, Lung Disease . (futurepundit.com)
  • One team, led by Leonard Zon, MD, of the Division of Hematology/Oncology at Children's and Director of its Stem Cell research program, used zebrafish, whose transparent embryos allow direct observation of embryonic development. (scienceblog.com)
  • The results from animal research were published on March 14 in the journal Cell Stem Cell . (eurekalert.org)
  • Blood stem cells were first identified in the early 1960s and launched a new era of research. (washingtontimes.com)
  • A single vial of CD34-positive cells, a type of stem cell vital for research, could cost $2,500 from a commercial provider. (washingtontimes.com)
  • types
  • Stem cells are renowned for their capacity to develop into a wide range of mature cell types but they cannot maintain this flexibility on their own. (phys.org)
  • Different stem cells may develop into specific types of mature cells. (cancerconnect.com)
  • Publishing in Cell , Zon and colleagues discovered that compounds that modulate blood flow had a potent impact on the expression of a master regulator of blood formation, known as Runx1, which is also a recognized marker for the blood stem cells that give rise to all the cell types in the blood system. (scienceblog.com)
  • These cell types don't have a nucleus, so are unable to divide and potentially cause cancer. (newscientist.com)
  • placebo
  • After the 24-week follow-up testing is conducted, the groups will crossover so that patients who initially received AUCB will receive placebo and patients who received placebo at baseline will receive the cord blood. (clinicaltrials.gov)
  • Hematology
  • 2 Division of Hematology and Leukemia Cell Bank of Quebec, Maisonneuve-Rosemont Hospital, Montreal, QC H1T 2M4, Canada. (sciencemag.org)