AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and ProcessesDisciplines and OccupationsAnthropology, Education, Sociology and Social PhenomenaInformation ScienceNamed GroupsHealth Care
Peripheral Blood Stem Cell TransplantationTransplantation, AutologousHematopoietic Stem Cell TransplantationHematopoietic Stem Cell MobilizationTransplantation ConditioningTransplantation, HomologousMelphalanGranulocyte Colony-Stimulating FactorAntigens, CD34LeukapheresisHematologic NeoplasmsCombined Modality TherapyStem CellsStem Cell TransplantationBlood Component RemovalHematopoietic Stem CellsCyclophosphamideMultiple MyelomaAntineoplastic Combined Chemotherapy ProtocolsGraft vs Host DiseaseMyeloablative AgonistsBusulfanGraft SurvivalTreatment OutcomeBone Marrow TransplantationLymphoma, Non-HodgkinEtoposideThiotepaAntineoplastic Agents, AlkylatingRemission InductionAdult Stem CellsRecurrenceCytophagocytosisCarmustineCord Blood Stem Cell TransplantationEmbryonic Stem CellsIfosfamideSalvage TherapyHematopoiesisVincristineAmyloidosisCytarabineTransplantation ChimeraDisease-Free SurvivalHodgkin DiseaseTissue DonorsRetrospective StudiesNeoplasmsSurvival RateWhole-Body IrradiationTime FactorsSurvival AnalysisCell DifferentiationHistocompatibility TestingHistocompatibilityInfectionBlood Cell CountLymphoma, T-CellPlatelet CountDoxorubicinTransplantation, IsogeneicPOEMS SyndromeBlood CellsPrednisoneCarboplatinLeukemia, Myeloid, AcuteImmunosuppressive AgentsLeukemiaDexamethasoneVidarabineFollow-Up StudiesRecombinant ProteinsAntineoplastic AgentsBone Marrow PurgingLymphomaProspective StudiesCytomegalovirus InfectionsGraft vs Leukemia EffectFatal OutcomeFeasibility StudiesMyelodysplastic SyndromesImmunophenotypingMesenchymal Stem Cell TransplantationLymphocyte DepletionAnemia, AplasticLeukemia, Myelogenous, Chronic, BCR-ABL PositiveHematologic DiseasesBlood Transfusion, AutologousT-LymphocytesHLA AntigensLiver TransplantationBone MarrowBlood DonorsLeukocytes, MononuclearFlow CytometryCell SeparationPluripotent Stem CellsOpportunistic InfectionsHistiocytosis, Non-Langerhans-CellLivedo Reticularis
Multiple MyelomaTransplantMarrowHSCTProgenitor cell transplantationMelphalanTransplantsChemotherapy followedPatient'sASCTRemissionPatientsHematopoietic progenitorLymphomasInfusionEfficacyHSCsImmuneLevels in peripheral bloodPost-transplantationTumorsProcedureMobilizationCyclophosphamidePediatricMyeloma cells2018Lymphoproliferative disordersUmbilicalPatientDiffuse large B-DonorLymphocytesTherapyImmunologyCancersCONCLUSIONSMorbidity and mortaUndergoLymphoidFilgrastim2016Tumor cellsMalignantClinical trialsSurvivalTreatment
Multiple Myeloma14
Transplant26
  • Forty-two female patients (median age of 46 years) with breast cancer refractory to neoadjuvant chemotherapy received HDCT (cyclophosphamide, carmustine and thiotepa) supported by an autologous peripheral blood stem cells transplant. (elsevierpure.com)
  • 1 Significant advances have been made by combining novel agents with autologous peripheral blood stem cell transplantation which allows for long-term disease-free survival in the majority of transplant-eligible patients. (haematologica.org)
  • These data suggest that with appropriate pre-transplant clinical evaluation, high-dose cyclophosphamide and irradiation in the BMT preparative phase does not result in frequent, clinically relevant short-term cardiac toxicity [31]. (slideshare.net)
  • In April 1960, Dr. Álvaro Gómez-Leal, presented during the first meeting of the Agrupación Mexicana para el Estudio de la Hematología, A.C., data on a transplant of allogeneic stem cells in a patient with acute leukemia done in Monterrey, Mexico: the patient received high-dose chemotherapy followed by stem cells from the bone marrow of his brother, improving and obtaining remission for months but relapsing and subsequently died. (revistadehematologia.org.mx)
  • Treatment for Hodgkin lymphoma (HL) is tailored to each individual and may include surgery, radiation therapy, chemotherapy, precision cancer medicines and or stem cell transplant in selected situations. (hoapb.com)
  • The Dana-Farber/Boston Children's Stem Cell Transplant Center offers autologous and allogeneic stem cell transplants and is active in researching new stem cell techniques. (dana-farber.org)
  • What is an autologous stem cell transplant? (leukaemia.org.au)
  • Most people have a single autologous transplant. (leukaemia.org.au)
  • It's important to realise that the processes involved in a stem cell transplant are often long and complex. (leukaemia.org.au)
  • In the week leading up to your transplant you will be given a few days of very high-dose chemotherapy, and sometimes radiotherapy , to destroy your underlying disease. (leukaemia.org.au)
  • In the week following the transplant, your blood counts drop dramatically. (leukaemia.org.au)
  • A hematopoietic stem cell transplant replaces faulty cells so the body can produce normal, healthy cells again. (mdanderson.org)
  • An autologous stem cell transplant uses the patient's own cells for treatment. (mdanderson.org)
  • An allogeneic stem cell transplant is similar, but we take cells from someone other than the patient. (mdanderson.org)
  • Where do allogeneic stem cell transplant donor cells come from? (mdanderson.org)
  • With a peripheral blood cell transplant, the donor receives growth factor shots to stimulate the bone marrow to push the stem cells into the blood. (mdanderson.org)
  • The cells for a cord blood transplant come from an umbilical cord collected at birth by the MD Anderson Cord Blood Bank . (mdanderson.org)
  • For many patients who don't have a well-matched, healthy donor, a cord blood transplant is a viable option. (mdanderson.org)
  • In this month's Pharmacy SIG Literature Update: Impact of anti-T-lymphocyte globulin dosing on GVHD in MUD SCT, impact of MRD status before alloHCT on outcomes in secondary AML, low-dose post- transplant cyclophosphamide with low-dose antithymocyte globulin for prevention of GVHD in MUD SCT and more. (astct.org)
  • The research team is working to reduce treatment toxicity and improve patient outcomes using leading-edge research to advance hematopoietic stem cell transplant methods. (lovesorghum.com)
  • p>A blood and bone marrow transplant takes unhealthy stem cells out of the bone marrow and replaces them with healthy stem cells, with the intent to treat childhood cancers and nonmalignant blood and bone marrow diseases. (nemours.org)
  • This study will evaluate pediatric patients with malignant or non-malignant blood cell disorders who are having a blood stem cell transplant depleted of T cell receptor (TCR) alfa and beta cells that. (childrenshospital.org)
  • Since the first successful organ transplant in 1954, advancements in medical technology, immunology, and pharmacology have increased the success rate of solid organ transplantation. (pocketdentistry.com)
  • Data from the United Network of Organ Sharing ( UNOS ) and the Organ Procurement and Transplantation Network ( OPTN ) catalog over 175,000 transplants between the years 2000 and 2015 (Optn.transplant.hrsa.gov 2016 ). (pocketdentistry.com)
  • Hopefully, following the recommendations made in the guidelines will reduce morbidity and mortality from opportunistic infections in hematopoietic stem cell transplant recipients. (cdc.gov)
  • For the purposes of this document, HSCT is defined of the CDC, the Infectious Diseases Society of America, as any transplantation of blood or marrow-derived he- and the American Society of Blood and Marrow Trans- matopoietic stem cells, regardless of transplant type plantation," which was published in the Morbidity and (allogeneic or autologous) or cell source (bone marrow, Mortality Weekly Report [1]. (cdc.gov)
Marrow44
HSCT11
  • Cardiac complications have been described in HSCT with the majority of reported cardiac complications during HSCT attributed to the use of high-dose cyclophosphamide [30]. (slideshare.net)
  • This was the first report of a hematopoietic stem cell transplantation (HSCT) conducted in Mexico, only 4 years after the pioneer work by E. Donnall Thomas in Cooperstown, New York, USA (Ruiz-Argüelles et al. (revistadehematologia.org.mx)
  • The successful application of HSCT for diseases such as leukemia, lymphoma, myeloma, and inherited blood disorders underscored its broad applicability in clinical practice (Snowden et al. (revistadehematologia.org.mx)
  • 30,000 patients with blood-related malignancies receive HDC, which, if the response is satisfactory, could subsequently be followed by hematopoietic stem cell transplantation (HSCT). (bdbiosciences.com)
  • this is used in both autologous and allogenic HSCT. (bdbiosciences.com)
  • Patient will undergo autologous HSCT next month. (pocketdentistry.com)
  • Opportunistic infections (OIs) are defined as any in- the infusion of hematopoietic stem cells from a donor fections that occur with increased frequency or severity into a patient who has received chemotherapy, which in HSCT patients. (cdc.gov)
  • There pediatric and adult autologous and allogeneic HSCT patients. (cdc.gov)
  • are basically 3 phases of immune recovery for HSCT patients, The purposes of the guidelines are (1) to summarize the beginning at day 0, the day of transplantation. (cdc.gov)
  • Hematopoietic stem cell transplantation (HSCT) affects serious risks for the patient, including death. (bvsalud.org)
  • Also, drastic changes in daily living habits, qualified and responsible for the implementation of changes in body image, long duration of treatment, HSCT since 2004, agreed to the Brazilian Unified periods of hospitalization and protective isolation, Health System, which meets the needs of the feeling of loss of control, fear of death and lack of patients with an indication for transplantation. (bvsalud.org)
Progenitor cell transplantation2
  • Although most clinicians would agree that hematopoietic progenitor cell transplantation after reinduction therapy is frontline therapy for these patients, there is no consensus as to what type of hematopoietic progenitor cell transplantation promises the best event-free and overall survival. (jnccn.org)
  • 1 - 3 However, those with relapsed and/or refractory (R/R) disease have had a historically dismal OS of ≤30% despite reinduction therapy and autologous hematopoietic progenitor cell transplantation (autoHCT) ( Figure 1 ). (jnccn.org)
Melphalan2
Transplants7
  • At the time they performed the first transplants surprisingly little was known about hematopoietic stem cells, immune responses to transplants or the complex human leucocyte antigen system. (revistadehematologia.org.mx)
  • In autologous stem cell transplants, the patient is their own stem cell donor. (leukaemia.org.au)
  • Autologous transplants are used to treat a number of different blood cancers. (leukaemia.org.au)
  • Autologous transplants allow the use of high-dose chemotherapy, which provides some patients with a better chance of cure or long-term control of their disease. (leukaemia.org.au)
  • To understand the different types of stem cell transplants and how they work, we spoke with Borje S. Andersson, M.D., Ph.D. Here's what he had to say. (mdanderson.org)
  • What are the types of stem cell transplants? (mdanderson.org)
  • Stem cell transplants fall into two categories: autologous and allogeneic. (mdanderson.org)
Chemotherapy followed4
Patient's6
  • Stem cell transplantation is performed after high-dose chemotherapy (HDC) to restore a cancer patient's blood and immune cell production capacity. (bdbiosciences.com)
  • They are used to replace stem cells that have been damaged by high doses of chemotherapy , used to treat the patient's underlying disease. (leukaemia.org.au)
  • Stem cells are usually collected when the patient's disease is in remission or their disease is in a more stable state. (leukaemia.org.au)
  • The patient has low blood counts until the replaced cells replenish the patient's body with healthy cells. (mdanderson.org)
  • The transplanted cells kill any remaining cancer cells and restore the patient's immune system. (mdanderson.org)
  • If the donor cells aren't a close enough match, the patient's body may recognize the donor cells as foreign and reject them. (mdanderson.org)
ASCT1
  • OBJECTIVE: To assess the prognostic value of various parameters including positron emission tomography / computed tomography (PET/CT) and identify risk factors for survival of patients with non-Hodgkin's lymphoma (NHL) and Hodgkin's lymphoma (HL) treated with autologous stem cell transplantation (ASCT). (smw.ch)
Remission5
Patients33
  • The role of high-dose chemotherapy (HDCT) in patients with refractory breast cancer is not well established. (elsevierpure.com)
  • In order to assess the incidence and analyze reasons which cause prolongation of hospital stay in patients engrafted after peripheral blood stem cell transplantation (PBSCT), we performed this retrospective analysis. (nature.com)
  • Neoepitope specific peptide vaccines targeting the clonal driver mutation H3 K27M have been shown to illicit cytotoxic T-cell and T-helper cell responses in patients with diffuse midline glioma. (wikipedia.org)
  • In 15 to 20% of patients, plasma cells secrete only Bence Jones protein. (merckmanuals.com)
  • Rarely, patients have no M-protein in blood and urine, although the currently used serum free light chain assay now demonstrates monoclonal light chains in many of these formerly so-called nonsecretory patients. (merckmanuals.com)
  • Of the NHL patients, 59 (44%) had diffuse large B-cell lymphoma (DLBCL). (smw.ch)
  • High dose sequential chemotherapy and autologous stem cell transplantation in patients with relapsed/refractory lymphoma. (smw.ch)
  • Low-dose filgrastim significantly enhances neutrophil recovery following autologous peripheral-blood stem-cell transplantation in patients with lymphoproliferative disorders: evidence for clinical and economic benefit. (smw.ch)
  • Treatment recommendations for patients with diffuse large B-cell lymphoma (DLBCL) begin with evaluating the extent of the disease, performance status of the patient, and histologic subtypes. (medscape.com)
  • Results Natural killer cells from healthy donors and myeloma patients expanded a median of 804- and 351-fold, respectively, without significant T-cell expansion. (haematologica.org)
  • Seven eighty six patients undergoing allogeneic (n=550) or autologous (n=236) BMT were evaluated by physical examination, history, rest and exercise ECG, chest x-ray, two-dimensional echocardiography, and radionuclide ventriculography (RNV) before BMT, and monitored for 5 months thereafter. (slideshare.net)
  • Thirty-eight patients (4.83%) had pathologic findings before transplantation. (slideshare.net)
  • We explored whether stem cell therapy was effective for animal models and patients with Crohn's disease (CD). (biomedcentral.com)
  • In phase I, doses of bortezomib (.7, 1.0, and 1.3 mg/m 2 ) with BuMel were administered to groups of 3 patients each. (elsevierpure.com)
  • Except for 3 patients with transplantation-related mortality due to sepsis, other adverse events were manageable. (elsevierpure.com)
  • These findings demonstrate that bortezomib is safe and has a potential role in conditioning regimens in combination with BuMel for patients with transplantation-eligible MM. (elsevierpure.com)
  • Background: Patients with systemic lupus erythematosus (SLE) who experience persistent multiorgan dysfunction, despite standard doses of intravenous cyclophosphamide, represent a subset of patients at high risk of early death. (northwestern.edu)
  • We investigated the safety and efficacy of immune suppression and autologous haemopoietic stem-cell infusion to treat such patients. (northwestern.edu)
  • Patients underwent dose-intense immune suppression and autologous haemopoietic stem-cell (CD34) infusion. (northwestern.edu)
  • Results: Nine patients underwent stem-cell mobilisation but two were excluded before transplantation because of infection. (northwestern.edu)
  • Interpretation: Patients remained free from active lupus and improved continuously after tranplantation, with no immunosuppressive medication or small residual doses of prednisone. (northwestern.edu)
  • This complex treatment offers a huge benefit for patients: even more resistant cancer cells are killed by the more intensive treatment process. (leading-medicine-guide.com)
  • Fifteen patients could receive high-dose ICE followed by PBSCT twice, and 3 patients could receive it once. (the-medical-dictionary.com)
  • Conclusion: Double-cycle, high-dose ICE therapy followed by PBSCT is tolerable and feasible even after conventional chemotherapy or chemoradiotherapy in patients with SCLC. (the-medical-dictionary.com)
  • For example, absolute lymphocyte counts (ALCs), a simple laboratory parameter that is routinely evaluated in the clinical setting, has been found to be associated with treatment outcomes in patients with diffuse large B cell lymphoma, follicular lymphoma, or acute leukemias ( Am J Hematol 84(2) (2009)">1 - Br J Haematol 134(6) (2006)">3 ). (cancerdiagnosisprognosis.org)
  • Although lenalidomide is considered to exert dual antitumor effects, including the activation of normal immune system through the activation of cytotoxic lymphocytes and the proteasome-dependent degradation of transcription factors such as IKZF1 and IKZF3 in myeloma cells ( J Mol Med (Berl) 94(12) (2016)">13 - Blood Rev 24(Suppl 1) (2010)">15 ), there is no clinical evidence that directly proves the association between changes in the profile of immune system and treatment efficacy in patients with MM treated with this agent. (cancerdiagnosisprognosis.org)
  • The patients were evaluated based on PBSC mobilization and collection parameters, including overall collection results, CD34 + cell levels in peripheral blood, leukapheresis (LP) delays, overall number of LP sessions, and the rate of rescue mobilization with plerixafor. (biomedcentral.com)
  • Patients treated with isatuximab-RVd (six cycles) had lower numbers of collected stem cells compared to those receiving RVd (six cycles) induction (8.8 × 10 6 /kg bw versus 9.7 × 10 6 /kg bw, p = 0.801), without experiencing significant delays in LP or increased numbers of LP sessions in a multivariable logistic regression analysis. (biomedcentral.com)
  • Physicians and scientists work side by side to set standards for stem cell transplantation and improve long-term outcomes for both pediatric and adult patients. (lovesorghum.com)
  • A national data registry of patients receiving fecal microbiota transplantation (FMT) or other gut-related-microbiota products designed to prospectively assess short and long-term safety and. (childrenshospital.org)
  • In total, 67.5% of patients reached the stem cell collection goal of 6x10 6 CD 34-positive cells/kg or more in 2 apheresis sessions by a central laboratory. (cancernetwork.com)
  • To describe the psychological suffering developed by patients transplanted with hematopoietic stem cells from a referral service in the state of Rio Grande do Norte. (bvsalud.org)
  • and umbilical cord blood (PUCB), capable of 2017), associated with the results of the procedure restoring spinal cord function and immunology of and require a process of hospitalization and patients with indication for transplantation, with the prolonged hospital recovery. (bvsalud.org)
Hematopoietic progenitor1
  • This article contains highlights of "Guidelines for Pre- allogeneic or autologous, depending on the source of venting Opportunistic Infections among Hematopoi- the transplanted hematopoietic progenitor cells. (cdc.gov)
Lymphomas4
  • However, there are several slow growing B-cell lymphomas that occur in this young age group. (dana-farber.org)
  • There are also rare T-cell lymphomas that are more frequently seen in adults but occasionally occur in children. (dana-farber.org)
  • Impact of autograft-absolute lymphocyte count on survival in double/triple hit lymphomas post-autologous stem cell transplantation. (astct.org)
  • Anaplastic large cell lymphomas (ALCLs) are distinguished from other lymphomas by their anaplastic cytology and constant membrane expression of the CD30 antigen (an activation marker for B or T cells). (medscape.com)
Infusion3
  • The remaining seven received high-dose chemotherapy and stem-cell infusion. (northwestern.edu)
  • For many hematopoietic malignancies, collection and infusion of CD34+ hematopoietic stem/progenitor cells following chemotherapy is critical. (bdbiosciences.com)
  • An A-ALC cell infusion containing 0.5 x 109 cells/kg was chosen as a cutoff to evaluate for prognosis. (astct.org)
Efficacy3
  • Antibody- and T-cell-based approaches to targeting of B-cell maturation antigen have shown efficacy. (merckmanuals.com)
  • the efficacy of the combination therapy is well demonstrated by large-scale studies, regardless of initial therapy or refractory/relapsed status ( N Engl J Med 372(2) (2015)">16 - Blood 131(3) (2018)">22 ). (cancerdiagnosisprognosis.org)
  • The purpose of this study is to assess AR101's safety, tolerability and efficacy over an extended dosing period. (childrenshospital.org)
HSCs3
  • Mesenchymal stem cells (MSCs) and hematopoietic stem cells (HSCs) have been shown to counter rheumatoid arthritis, autoimmune hepatitis, and systemic sclerosis [ 8 ]. (biomedcentral.com)
  • This pharmacologically induced egress of HSCs into peripheral blood, called mobilization, is utilized as the preferred strategy for generating HSCs for transplantation. (bdbiosciences.com)
  • 4 CD34 expression is historically related to hematopoietic cells and it is considered as the marker of HSCs. (bdbiosciences.com)
Immune8
  • 1957). This pioneering work laid the foundation for the exploration of hematopoietic stem cells and their role in treating diseases of the blood and immune system. (revistadehematologia.org.mx)
  • The immune system is a network of cells, tissues, and biologic substances that defend the body against viruses, bacteria, and cancer. (hoapb.com)
  • The immune system recognizes cancer cells as foreign and can eliminate them or keep them in check-up to a point. (hoapb.com)
  • Cancer cells are very good at finding ways to avoid immune destruction, however, so the goal of immunotherapy is to help the immune system eliminate cancer cells by either activating the immune system directly or inhibiting the mechanisms of suppression of the cancer. (hoapb.com)
  • One type creates a new, individualized treatment for each patient by removing some of the person's immune cells, altering them genetically to kill cancer, and then infusing them back into the bloodstream the other uses precision medications to enhance the immune systems response to the cancer. (hoapb.com)
  • PD-1 and PD-L1 are proteins that inhibit certain types of immune responses, allowing cancer cells to evade detection and attack by certain immune cells in the body. (hoapb.com)
  • Dana-Farber/Boston Children's offers internationally renowned care for children with cancers of the blood and immune system. (dana-farber.org)
  • IMiDs are known to enhance the immune system by NK cell expansion and activation, regulatory T cell (Treg) inhibition, and/or restoration of T cell function in in vitro studies ( J Mol Med (Berl) 94(12) (2016)">13 - Blood Rev 24(Suppl 1) (2010)">15 ). (cancerdiagnosisprognosis.org)
Levels in peripheral blood1
  • Longitudinal analysis of CD4+ T cell levels in peripheral blood and in tissues at necropsy revealed that they were preserved in 4'-ethynyl-2-fluoro-2'-deoxyadenosine-treated BLT mice (Figure S1). (natap.org)
Post-transplantation1
  • For post-transplantation best response, an 83% rate of VGPR or better (68% CR) was observed. (elsevierpure.com)
Tumors15
  • Germ cell tumors of the mediastinum are uncommon. (medscape.com)
  • Fewer than 5-7% of germ cell tumors occur outside the gonads, but of the extragonadal sites, the mediastinum is the most common location for these tumors. (medscape.com)
  • Other areas where germ cell tumors can occur are the retroperitoneum, the intra-abdominal cavity, and the chest. (medscape.com)
  • The exact mechanism whereby germ cell tumors originate in the mediastinum remains unknown. (medscape.com)
  • Germ cell tumors in the mediastinum were first reported more than 50 years ago. (medscape.com)
  • The first theory on extragonadal malignant germ cell tumors postulated that the tumors developed from primitive germ cells in the endoderm of the yolk sac or from the urogenital ridge. (medscape.com)
  • Other researchers hypothesized that these totipotential cells become detached during embryogenesis and result in primitive masses, which may develop into germ cell tumors. (medscape.com)
  • Mediastinal germ cells tumors are now postulated to be autonomous oncologic entities. (medscape.com)
  • Of the germ cell tumors, benign teratomas (ie, dermoid cysts) are the most commonly diagnosed mediastinal mass and are present in 50-70% of infants and children with germ cell tumors. (medscape.com)
  • These tumors are composed of large cells with multiple nuclei, which closely resemble syncytiotrophoblasts. (medscape.com)
  • Unlike other germ cell tumors, seminomas tend to remain localized in the chest, and only occasionally do they invade adjacent structures. (medscape.com)
  • Individuals with this syndrome, consisting of an extra X chromosome, are known to develop mediastinal germ cell tumors at least 10 years earlier than those without the syndrome. (medscape.com)
  • By nature, these tumors invade diffusely throughout the brain stem, growing between normal nerve cells. (wikipedia.org)
  • Adoptive transfer of expanded natural killer cells inhibited the growth of established OPM2 and high-risk primary myeloma tumors grown in the murine model. (haematologica.org)
  • Radiation therapy uses x-rays or other high-energy rays to kill cancer cells and shrink tumors. (marystolfacancerfoundation.org)
Procedure2
  • This procedure starts with the patient receiving intensive chemotherapy with or without total body irradiation in an attempt to kill all cancerous cells. (lovesorghum.com)
  • Two died while receiving high-dose systemic corticosteroids, methotrexate, and after recent exposure to anti-tumor necrosis factor-α biological DMARDs, and 2 during hematopoietic stem cell transplantation procedure. (cdc.gov)
Mobilization6
  • 1989). Hematopoietic stem cells could be harvested easier from peripheral blood after mobilization with G-CSF (Sheridan et al. (revistadehematologia.org.mx)
  • Quantitating the CD34+ cell population can also be useful during mobilization as well as for determining the optimal timing of apheresis sessions to make sure that enough CD34+ cells have been harvested. (bdbiosciences.com)
  • However, during stem cell mobilization and -collection, no study-specific therapeutic intervention was performed. (biomedcentral.com)
  • PBSC mobilization should be performed after induction therapy to ensure collection of a sufficient number of cells. (biomedcentral.com)
  • Plerixafor may cause mobilization of leukemic cells and subsequent contamination of the apheresis product. (fresenius-kabi.com)
  • Innovation in this area of medicine has been needed, and today's approval of [motixafortide] addresses the demand for new therapies that can meet today's challenges by delivering more reliability in stem cell mobilization, [vs] filgrastim alone, with fewer days of apheresis sessions and fewer doses of filgrastim for people living with this cancer. (cancernetwork.com)
Cyclophosphamide1
Pediatric1
  • Orthopedists (bone specialists) and orthopedic surgeons at Nemours Center for Cancer and Blood Disorders make our pediatric orthopedics programs among the largest and most respected in the world. (nemours.org)
Myeloma cells2
  • We tested whether natural killer cells expanded by co-culture with K562 cells transfected with 41BBL and membrane-bound interleukin-15 could kill myeloma cells with a high-risk gene expression profile in vitro and in a unique model which recapitulates human myeloma. (haematologica.org)
  • Expanded natural killer cells killed both allogeneic and autologous primary myeloma cells avidly via a perforin-mediated mechanism in which the activating receptor NKG2D, natural cytotoxicity receptors, and DNAX-accessory molecule-1 played a central role. (haematologica.org)
20181
  • increased number of NK cells (particularly mature NK cells), helper T cells, and depleted Tregs can positively affect clinical outcomes ( Cancer Biomark 24(4) (2019)">4 - Leuk Res 66 (2018)">10 ). (cancerdiagnosisprognosis.org)
Lymphoproliferative disorders1
  • PC-ALCL is one of the primary cutaneous CD30 + T-cell lymphoproliferative disorders, a wide spectrum of disease, with lymphomatoid papulosis (LyP) at the benign end of the spectrum and PC-ALCL at the malignant end. (medscape.com)
Umbilical2
Patient5
  • Thereafter, the patient received autologous peripheral blood stem cell transplantation with high-dose chemotherapy (combination of ifosphamide, carboplatin and etoposide) as pretreatment. (karger.com)
  • We extract blood cells, treat the cancer with high-dose chemotherapy , then place the cells back into the patient. (mdanderson.org)
  • Once the cancer is less active and the patient has been pre-treated with chemotherapy (known as conditioning), he or she receives the donor's healthy stem cells. (mdanderson.org)
  • This allows us to collect more cells in a short period, decrease patient/donor downtime and freeze the cells for future use. (mdanderson.org)
  • In 2001, at age 21, the patient experienced an episode of severe pain and vomiting and was taken to the emergency room for a complete blood work up. (pocketdentistry.com)
Diffuse large B-2
Donor1
  • Or, the cells from the donor may recognize the new body as foreign and attack. (mdanderson.org)
Lymphocytes4
Therapy19
  • The best response after surgery, HDCT, and radiation therapy was assessed 60 days after transplantation. (elsevierpure.com)
  • Stem cell transplantation is a valuable supplementary therapy for CD. (biomedcentral.com)
  • Several studies have evaluated the safety and effectiveness of CD stem cell therapy, but the results remain controversial. (biomedcentral.com)
  • Three days after starting high-dose therapy, he developed a fever, and a chest X-ray revealed pneumonia in the right lower lung. (elsevierpure.com)
  • Systemic therapy is treatment directed at eliminating cancer cells throughout the body, and usually consists of chemotherapy. (radiationoncologyassociates.co)
  • Radiation therapy uses high-powered energy beams, such as X-rays or protons, to kill cancer cells. (hoapb.com)
  • The objective of radiation therapy is to kill cancer cells for a maximum probability of cure with a minimum of side effects. (hoapb.com)
  • Systemic therapy is any treatment directed at destroying cancer cells throughout the body and may include chemotherapy, immunotherapy or newer precision cancer medicines. (hoapb.com)
  • Once a genetic abnormality is identified, a specific targeted therapy can be designed to attack a specific mutation or other cancer-related change in the DNA programming of the cancer cells. (hoapb.com)
  • Radiation therapy has been used as part of the treatment for this lymphoma in adults but may not be necessary if high dose chemotherapy is used in the treatment plan. (dana-farber.org)
  • In Section II, Dr. James Griffin reviews the mechanisms that lead to activation of tyrosine kinases by mutations in AML, the consequences of that activation for the cell, and the opportunities for targeted therapy and discusses some examples of developing novel drugs (tyrosine kinase inhibitors) and their effectiveness in AML (FLT3). (ashpublications.org)
  • 0.5 x 109 cells/kg and being transplanted in CR1 versus CR/PR from second-line therapy were identified as independent predictors for OS and PFS. (astct.org)
  • This study demonstrates that stem cell collection is feasible after prolonged induction with isatuximab-RVd without collection failures and might be further explored as induction therapy. (biomedcentral.com)
  • If the leukemia cells have spread to the brain, radiation therapy to the brain or intrathecal chemotherapy will be given. (marystolfacancerfoundation.org)
  • This review outlines the disparate types of stem cell therapy that have been used in this difficult-to-treat population as well as the role of maintenance and CAR T-cell therapy in conjunction with stem cell therapy. (jnccn.org)
  • HCT, whether it be autologous, allogeneic, or tandem, has been and continues to be an integral part of therapy, with varying outcomes as delineated in Table 2 . (jnccn.org)
  • and the role of CAR T-cell therapy as it relates to HCT as therapies for R/R B-NHL. (jnccn.org)
  • Kaplan-Meier curve showing probability of overall survival in children and adolescents with mature B-cell non‐Hodgkin's lymphoma with refractory or relapsed disease during or after therapy in the FAB/LMB96 international study. (jnccn.org)
  • The Food and Drug Administration approved a treatment that uses gene therapy to treat severe hemophilia A, a rare and sometimes fatal blood disorder. (cdc.gov)
Immunology1
Cancers2
  • Through genomic-biomarker testing performed on cells from the biopsy or collected in blood doctors are increasingly able to define the genomic alterations in a cancers DNA that are driving the growth of the cancer. (hoapb.com)
  • Blood cancers multiply uncontrollably, hindering the growth of these cells. (mdanderson.org)
CONCLUSIONS1
  • Conclusions These studies provide the rationale for testing expanded natural killer cells in humans. (haematologica.org)
Morbidity and morta1
Undergo2
Lymphoid1
  • Akitsu A, Kakuta S, Saijo S, Iwakura Y. Rag2-deficient IL-1 Receptor Antagonist-deficient Mice Are a Novel Colitis Model in Which Innate Lymphoid Cell-derived IL-17 Is Involved in the Pathogenesis. (chiba-u.ac.jp)
Filgrastim2
  • The injectable agent's approval was supported by data from part 2 of the double-blind, placebo-controlled phase 3 GENESIS study (NCT03246529) in which the potential of motixafortide and filgrastim in mobilizing stem cells for transplantation was assessed vs placebo. (cancernetwork.com)
  • In the study's safety population, the experimental arm received a 1.25 mg/kg subcutaneous dose of motixafortide plus filgrastim (n = 92) and the control arm received placebo and filgrastim (n = 42). (cancernetwork.com)
20161
  • 2016). The high doses of chemotherapy used in al. (bvsalud.org)
Tumor cells3
  • Rarely, tumor cells can appear as a solid tumor called an isolated granulocytic sarcoma or chloroma. (marystolfacancerfoundation.org)
  • ALCL was recognized in 1985, when tumor cells consistently demonstrated labeling by the monoclonal antibody Ki-1, a marker later shown to recognize the CD30 antigen. (medscape.com)
  • The effect of potential reinfusion of tumor cells has not been well-studied. (fresenius-kabi.com)
Malignant2
  • Lesions are caused by bone replacement by expanding plasmacytomas or by cytokines that are secreted by malignant plasma cells that activate osteoclasts and suppress osteoblasts, leading to bone loss. (merckmanuals.com)
  • Breast cancer, a common cancer in women, is a disease in which cancer (malignant) cells are found in the tissues of the breast. (stopgettingsick.com)
Clinical trials2
  • In clinical trials, stem cell transplantation reduced the CD activity index (SMD − 2.10, P = 0.000), the CD endoscopic index of severity (SMD − 3.40, P = 0.000) and simplified endoscopy score for CD (SMD − 1.71, P = 0.000) and improved the inflammatory bowel disease questionnaire score (SMD 1.33, P = 0.305) compared to control values. (biomedcentral.com)
  • His pioneering work spans discoveries in basic biology of blood stem cells and leukemia to first-in-human clinical trials for people with cancer and heart diseases, alongside shaping innovative policies in state health and healthcare financing. (ufl.edu)
Survival4
  • Other risk factors for survival were primary refractory disease, initial lymphoma stage, number of previous chemotherapy lines, and high amounts of blood product transfusions. (smw.ch)
  • Although children, adolescents, and young adults with newly diagnosed B-cell non-Hodgkin's lymphoma enjoy excellent overall survival with current chemoimmunotherapy, those with relapsed and/or refractory disease have a dismal prognosis. (jnccn.org)
  • Children, adolescents, and young adults (CAYAs) with newly diagnosed B-cell non-Hodgkin's lymphoma (B-NHL) enjoy excellent overall survival (OS) with current frontline chemoimmunotherapy. (jnccn.org)
  • Overall survival of children and adolescents with mature B cell non-Hodgkin lymphoma who had refractory or relapsed disease during or after treatment with FAB/LMB 96: a report from the FAB/LMB 96 study group. (jnccn.org)
Treatment14
  • In the animal studies, the disease activity index dramatically decreased in the mesenchymal stem cell (MSC) treatment groups compared to the control group. (biomedcentral.com)
  • 1992). Since then, hematopoietic stem cells, with their unique ability to differentiate into various blood cell types, have proven to be a revolutionary tool in the treatment of numerous hematological disorders. (revistadehematologia.org.mx)
  • Chemotherapy is any treatment involving the use of drugs to kill cancer cells. (hoapb.com)
  • The chance of recovery (prognosis) and choice of treatment depend on the stage of the cancer (whether it is just in the breast or has spread to other places in the body), the type of breast cancer, certain characteristics of the cancer cells, and whether the cancer is found in the other breast. (stopgettingsick.com)
  • An important focal point of Professor Graeven's range of services is haematology, i.e. the diagnosis and treatment of all conditions of the blood, the hematopoietic organs and the lymphatic system. (leading-medicine-guide.com)
  • In this regard, the essential hematopoietic stem cells are removed, whilst treatment with the chemotherapeutic agent, the dose of which is elevated by three to five times, takes place. (leading-medicine-guide.com)
  • Treatment for primary central nervous system lymphoma requires high doses of chemotherapy that enter the central nervous system, such as high-dose methotrexate and high-dose cytarabine. (dana-farber.org)
  • Combination chemotherapy with cisplatin and etoposide (cisplatin-etoposide [PE]) has long been the mainstay of treatment for small cell lung cancer (SCLC). (the-medical-dictionary.com)
  • After you have finished this treatment, your stem cells are thawed and reinfused through a vein into your bloodstream. (leukaemia.org.au)
  • and Hairy Cell Leukemia Treatment for more information. (marystolfacancerfoundation.org)
  • Chemotherapy is called a systemic treatment because the drug enters the bloodstream, travels through the body, and can kill cancer cells throughout the body. (marystolfacancerfoundation.org)
  • White blood cell counts should be monitored during treatment. (fresenius-kabi.com)
  • Advise females of reproductive potential to use an effective form of contraception during treatment with Plerixafor and for one week after the final dose. (fresenius-kabi.com)
  • Because of the potential serious adverse reactions in the breastfed child, advise females that breastfeeding is not recommended during treatment with Plerixafor and for one week after the final dose. (fresenius-kabi.com)