• Average leukocyte telomere lengths and peripheral blood mononuclear cells' telomerase activity were measured pre- and post-intervention. (nih.gov)
  • The aim of this study was to investigate the relation between different lipoprotein subfractions with intima-media thickness of the common carotid artery in a free-living, healthy population, and to evaluate whether in patients with comparable LDL-C, the different lipoprotein subclasses differently affected the expression of chemokines, cytokines and adhesion molecules in peripheral blood mononuclear and endothelial cells. (unipd.it)
  • However, one study identified a population of African children who had a high prevalence of overweight/obesity at the time of arrival, 5 and other data have identified overweight/obesity and associated medical consequences in the newly arriving Iraqi population. (cdc.gov)
  • ORs for comorbidities adjusted for age, sex, smoking status and body mass index (BMI) were meta-analysed using a random effects model.RESULTS: The prevalence of AO was 2.1% (95% CI 2.0% to 2.2%) in population-based, 21.1% (95% CI 18.6% to 23.8%) in asthma-based and 16.9% (95% CI 15.8% to 17.9%) in COPD-based cohorts. (kb.se)
  • A systematic review of studies documenting the prevalence or incidence of anemia in HIV-infected patient populations reported prevalence rates from 1.3% to 95% [ 5 ]. (biomedcentral.com)
  • There was a slight increase in NAFLD in males, there was a high prevalence of NAFLD in the urban population. (scirp.org)
  • 1 RA affects approximately 1% of the general population worldwide and the prevalence increases with age. (bmj.com)
  • The condition currently affects about 11 million Americans and 170 million people worldwide, and the prevalence is expected to increase over the coming decades as the proportion of older people in the population increases. (medlineplus.gov)
  • Side effects caused by different drugs affecting the lung tissue are observed increasingly in different patient populations, however incidence and prevalence are poorly understood. (lu.se)
  • A modest increase in risk was also seen in people with obesity (30-39.9kg/m 2 ), which affects a quarter of the UK population, and those who were underweight. (eurekalert.org)
  • Prof Sir Aziz Sheikh said: "Our findings demonstrate that protection gained through COVID-19 vaccination drops off faster for people with severe obesity than those with a normal body mass index. (eurekalert.org)
  • The University of Cambridge team - jointly led by Dr James Thaventhiran, from the MRC Toxicology Unit and Prof Sadaf Farooqi from the Wellcome-MRC Institute of Metabolic Science - studied people with severe obesity attending Addenbrooke's Hospital in Cambridge, and compared the number and function of immune cells in their blood to those of people of normal weight. (eurekalert.org)
  • Population studies show a strong association between indices of inflammation, and abnormal lipid and carbohydrate metabolism, obesity and atherosclerosis. (lww.com)
  • Conclusions Three patterns of obesity changes prior to diabetes diagnosis were accompanied by distinct trajectories of insulin resistance and other cardiometabolic risk factors in a white, British population. (ucl.ac.uk)
  • The Joslin study also suggests that the increased risks of obesity may be driven by boosted levels of certain lipids (fats and other substances that are not soluble in water) in the maternal blood that flows through the umbilical cord, says Isganaitis. (sciencedaily.com)
  • The Joslin team discovered that in these cells, increased obesity in the mothers correlated with lower expression of genes regulating mitochondria (which act as the cell's powerhouses) and of other genes regulating the production and metabolism of lipids. (sciencedaily.com)
  • Changes in these cells were similar to some known to occur in obesity, insulin resistance and type 2 diabetes, she adds. (sciencedaily.com)
  • She hopes that eventually it will be possible to use blood markers to identify embryos at risk for obesity or related conditions such as type 2 diabetes, and to follow up with suitable medical interventions. (sciencedaily.com)
  • According to the Centers for Disease Control (CDC), obesity affects approximately one-third of the adult population in the United States . (eatingdisorders.com)
  • Obesity is generally defined as having a body mass index (BMI) greater than or equal to 30, or having 25% or greater fat mass for males or having 30% or greater fat mass for females. (eatingdisorders.com)
  • As not only the amount, but also the type of fat and where it is stored may impact the risk of complications of e.g. obesity and diabetes, determining our weight or body mass index (BMI) is not enough. (lu.se)
  • Autologous dendritic cells previously loaded ex-vivo with SARS-CoV-2 spike protein. (wikipedia.org)
  • The cells are incubated ex vivo in the presence of a recombinant fusion protein PA2024 containing a prostate antigen, prostate acid phosphatase and GM-CSF, an immune-cell activator. (wikipedia.org)
  • The C-reactive protein (CRP) and white blood cell (WBC) counts were measured the 2nd and 7th post-operative days. (bvsalud.org)
  • Iron contained in blood serum (or plasma) is normally bound to the protein transferrin. (irondisorders.org)
  • Most of the body's iron (about 60%) is contained in hemoglobin, which is the essential oxygen carrying protein of the blood. (irondisorders.org)
  • Another 30% is stored in ferritin, a protein found throughout the body (although this percentage can be significantly higher or lower in cases of iron overload or deficiency), and a few percent in myoglobin, a protein specifically utilized by muscle cells. (irondisorders.org)
  • Ferritin is a protein synthesized by the body that is mainly utilized to store iron for future use. (irondisorders.org)
  • Protein-rich foods like chicken and fish do not contain carbohydrates so they will not raise your blood sugar levels. (healthxchange.sg)
  • Regular consumption of soy protein by healthy adult populations has been associated with a reduction in risk of both breast and prostate cancer. (ucdavis.edu)
  • The research team, led by Baylor College of Medicine's diabetes, endocrinology and metabolism division chief, Dr Lawrence Chan, found high levels of the arterial wall cell surface protein known as angiotensin type 1 receptor in the plaques of the mice expressing CRP, and lower levels in the mice who did not express CRP. (lifeextension.com)
  • They would be specified as the reduction of neuroinflammation, the elimination of amyloid-β, neurofibrillary tangles, and abnormal protein degradation, the promotion of autophagy-associated and blood-brain barrier recoveries, the upregulation of acetylcholine levels, improved cognition, and the recovery of mitochondrial transport. (j-alz.com)
  • Because cholesterol is unable to dissolve in the blood, it has to be transported to and from the cells by carriers called lipoproteins. (goredforwomen.org)
  • Atherosclerosis, which is characterized by chronic inflammation in the arterial wall, is driven by immune cells and cytokines. (hindawi.com)
  • Further studies have shown that Th1 cells promote atherosclerosis initiation and progression [ 6 , 7 ]. (hindawi.com)
  • However, the role of Th2 cells in atherosclerosis remains controversial. (hindawi.com)
  • Importantly, recent studies have shown that the importance of type 17 T helper cells (Th17 cells) and regulatory T cells (Tregs) in the pathogenesis of various immune disorders, particularly in atherosclerosis. (hindawi.com)
  • There was no blood pressure difference between the two groups of mice, indicating that the atherosclerosis-promoting effect of CRP via angiotensin type 1 receptor was not brought about by the receptor's hypertensive property. (lifeextension.com)
  • The results of this study revealed the nism of atherosclerosis, cell ageing, following data. (who.int)
  • Traditional risk factors for atherosclerosis include elevated body mass index, hypertension, smoking, and increased blood cholesterol. (mayoclinic.org)
  • Myeloid or conventional DCs (cDCs) are derived from myeloid progenitor cells in the bone marrow and are characterized by expression of CD11c. (wikipedia.org)
  • Results: In newborn CBMCs from women with high BMI, we observed changes in frequency and phenotype of immune cell populations, including significant increases in CD4 + T cells and decreases in myeloid cell populations. (elsevierpure.com)
  • ADA clarified how A1C should be used to help diagnose and monitor diabetes, recommending that clinicians use alternatives such as fasting plasma glucose or oral glucose tolerance tests in the event that A1C results and blood glucose levels don't agree. (aacc.org)
  • A study in adults with well-controlled type 1 diabetes found that flash CGM users spent less time in hypoglycemia than those using [self-monitoring of blood glucose]. (aacc.org)
  • yet, it is diagnosed by measuring a single blood-borne metabolite, glucose, irrespective of etiology. (cdc.gov)
  • Diabetes is a serious chronic metabolic disorder characterised by excess glucose (sugar) in the blood. (healthxchange.sg)
  • Without insulin's action, cells are unable to absorb and utilise glucose effectively. (healthxchange.sg)
  • Harmful glucose levels can then build up in your blood. (healthxchange.sg)
  • As simple carbohydrates (sugary foods), such as glucose and fructose, can cause a surge in blood sugar levels, consume them in moderation. (healthxchange.sg)
  • By drawing blood, your health care professional can conduct a lipid profile to check your blood cholesterol and glucose tests to check your blood sugar. (goredforwomen.org)
  • Easy-to-use home glucose monitors, blood pressure monitors and scales are available at retailers, pharmacies and online. (goredforwomen.org)
  • An I.V. in my left arm would feed precise amounts of glucose and insulin into my bloodstream, while from my right arm a nurse would periodically draw blood to test for glucose. (technologyreview.com)
  • These people are thought to secrete less insulin, a crucial hormone that signals cells to store glucose for energy. (technologyreview.com)
  • We estimated differences in self-reported health outcomes, complete blood counts, cholinesterase activity, and serum/urine calcium and creatinine concentrations at baseline between farmworkers and comparison workers, and after pesticide spraying in farmworkers only. (cdc.gov)
  • Farmworkers also had significantly lower monocyte counts (P = .01), serum calcium (P = .01), red blood count (P = .01), white blood cell count (P = .04), and butyrylcholinesterase activity (P (cdc.gov)
  • This study aimed to examine the associations of dietary and serum omega-3 fatty acids with insulin resistance (IR) and body composition among PCOS patients. (frontiersin.org)
  • The multivariable linear regression model was applied to analyze the associations of dietary and serum omega-3 fatty acids with the levels of Homeostasis Model Assessment for Insulin Resistance (HOMA-IR) and body composition parameters among PCOS patients. (frontiersin.org)
  • Higher levels of dietary and serum omega-3 PUFAs, particularly long-chain omega PUFAs (DPA and DHA), might have beneficial effects on metabolic parameters and body composition among PCOS patients. (frontiersin.org)
  • includes measurements of baseline renal function (eg, serum creatinine, blood urea nitrogen [BUN]), funduscopic examination, and directed cardiovascular evaluation (auscultation and sometimes ECG, echocardiography, or both). (msdmanuals.com)
  • It is present in small concentrations in blood, and the serum ferritin concentration normally correlates well with total-body iron stores, making its measurement important in the diagnosis of disorders of iron metabolism. (medscape.com)
  • Serum ferritin levels can be measured with a sensitive and specific immunoassay, serving as an index of body iron stores. (medscape.com)
  • 1 In fact, the large number of U.S. entries from Southeast Asia during this period likely contributed to the increases observed in overall rates of stunting among the general U.S. Asian population. (cdc.gov)
  • Linear increases in blood pressure and an exponential increase in insulin resistance a few years before diagnosis accompanied the weight gain. (ucl.ac.uk)
  • Smoking causes atheroma to build up in your arteries which restricts the blood flow and increases your chances of having a blood clot. (hollandandbarrett.com)
  • Cox regression models were used to calculate hazard ratios with 95% confidence intervals for MI, adjusted for age, sex, body mass index, smoking, hemoglobin, white blood cells, platelets, and other traditional cardiovascular risk factors. (edu.au)
  • The body requires iron to make hemoglobin for blood and myoglobin for muscles. (irondisorders.org)
  • A number of different factors can affect the results of this test, including assay interference, hemoglobin variants, and variations in red blood cell turnover rates, as well as age, pregnancy, and ethnicity. (aacc.org)
  • Blood sugar is also measured by the amount of glycosylated hemoglobin (HbA1c) in your blood. (goredforwomen.org)
  • Researchers now have demonstrated that umbilical cells from children of obese or overweight mothers show impaired expression of key genes regulating cell energy and metabolism, compared to similar cells from babies of non-obese mothers. (sciencedaily.com)
  • Costa recruited 24 overweight or obese women (with a body mass index over 25 before pregnancy) and 13 women who were not overweight for the study. (sciencedaily.com)
  • When the researchers followed up by analyzing fetal blood from the umbilical cord vein, "we found that the infants of obese mothers had significantly higher levels of many lipids that are known to be metabolically deleterious, like saturated fatty acids," Isganaitis says. (sciencedaily.com)
  • Fat tissues in the obese mothers may shed fatty acids that make their way into the fetal blood and create a kind of "fuel overload" for the embryo, she remarks. (sciencedaily.com)
  • According to the World Health Organization, an adult with a body mass index (BMI) ≥25 is overweight and ≥30 is obese. (frontiersin.org)
  • If you have a body mass index (BMI) of between 25 and 29, you're officially classed as overweight and if your BMI is 30 or above, you're classed as obese. (hollandandbarrett.com)
  • Furthermore cholesterol levels lipoprotein subfractions within the TGRL and sdLDL density range are independent predictors of IMT variance and are associated with a pro-inflammatory activation of PBMC and endothelial cells. (unipd.it)
  • Seventy percentage of overweight PCOS patients were accompanied by IR, with the majority of overweight PCOS patients also being accompanied by hyperinsulinemia ( 8 ), suggesting potential relationships between body fat with PCOS. (frontiersin.org)
  • Cord blood metabolites and rapid postnatal growth as multiple mediators in the prenatal propensity to childhood overweight. (who.int)
  • Genetic data related to peripheral blood sorting counts of leukocytes were collected from a genome-wide association study by Blood Cell Consortium (BCX). (bvsalud.org)
  • Negative selection is a form of natural selection whereby rare genetic factors with harmful effect on survival and reproduction are removed from populations. (ukbiobank.ac.uk)
  • In the context of this paper, ancestry is defined using genetic variants based on the distribution of those variants in worldwide populations. (nature.com)
  • By comparing segments of DNA with the distribution of genetic variants in worldwide populations, it is possible to determine the likely "parental" or source population for each segment of DNA, indicating a component of the individual's overall ancestry. (nature.com)
  • He says that although it appears to be accurate-the variation has been linked to type 2 diabetes in multiple populations-"there is no evidence that this genetic test does result in an improved health outcome. (technologyreview.com)
  • Highlighting patients' other risk factors, such as body mass index, often fails to inspire lifestyle changes, he points out, and it's not clear that a piece of genetic information will be any different. (technologyreview.com)
  • Exploring the potential association between peripheral blood leukocyte counts and breast cancer risk by Mendelian randomization (MR) analysis methods. (bvsalud.org)
  • We aimed to phenotype AO in population- and clinic-based cohorts.METHODS: This cross-sectional multicohort study included adults ≥50 years from nine CADSET cohorts with spirometry data (N=69 789). (kb.se)
  • Patients and Methods: In this prospective study, telomere length was measured by quantitative PCR in baseline blood samples in a cohort of 300 patients with Barrett's esophagus followed for a mean of 5.8 years. (aacrjournals.org)
  • Body composition was measured by both dual-energy X-ray absorptiometry (DXA) and bioelectrical impedance (BIA) methods. (frontiersin.org)
  • Instead, methods are needed which non-invasively can localize, quantify and characterize fat in the human body. (lu.se)
  • We believe that MRI can provide the solution and we work on the development and improvement of methods for measuring the amount and chemical composition of fat in various parts of the human body. (lu.se)
  • defined or unidentifiable layer structure common acute conditions requiring All patients diagnosed with appendicitis of the appendiceal wall and severe en- urgent abdominal surgery in both over the study period were selected largement of the appendix to form a adults and children [1,2]. (who.int)
  • Then, the study population was divided into two groups according to the cut-off SIRI level in ROC curve analysis. (bvsalud.org)
  • We aimed to investigate whether RDW was associated with risk of first-ever MI in a large cohort study with participants recruited from a general population. (edu.au)
  • A team from the University of Edinburgh, led by Prof Sir Aziz Sheikh, looked at real-time data tracking the health of 3.5 million people in the Scottish population as part of the EAVE II study . (eurekalert.org)
  • A cross-sectional study was performed on 12,249 asymptomatic examinees who underwent an NK cell activity test, between January 2016 and May 2017. (jcpjournal.org)
  • This study suggests that cigarette smoke compromises host immunity, enabling cancer cells to evade immune responses. (jcpjournal.org)
  • The study would assess how effectively my body responded to sugar, a measure that predicts risk for developing type 2 diabetes. (technologyreview.com)
  • Since the generalizability of these findings is limited, the results need confirmation in other study populations. (ucl.ac.uk)
  • We leveraged the COVID-19 Host Genetics Initiative 6 , 7 to perform a genome-wide association study for Long COVID including up to 6,450 Long COVID cases and 1,093,995 population controls from 24 studies across 16 countries. (medrxiv.org)
  • Isganaitis and her colleagues will carry out further research on umbilical cells and blood among Boston newborns to see if the study results are confirmed in this population. (sciencedaily.com)
  • The letter, coauthored by vitamin D researcher Michael F Holick, summarized a study that included 12 children who with burn injuries averaging 52 percent of their body surface. (lifeextension.com)
  • The Iowa Women's Health Study is a population-based study begun in 1986 which included 41,836 between the ages of 55 and 69. (lifeextension.com)
  • This HEAL study of inflammation and breast cancer survival contributes uniquely to this emerging research in that it is the largest study to date to examine this association," said Rachel Ballard-Barbash, M.D., M.P.H., a co-author of the study and principal investigator of the HEAL study at NCI, in the Division of Cancer Control and Population Sciences. (nih.gov)
  • This study joins an increasing body of research indentifying CRP and SAA as indicators of reduced survival from cancer. (nih.gov)
  • Participants completed a lifestyle questionnaire when they joined the study and the researchers collected blood samples (which were analyzed for CRP and SAA levels) and height and weight measurements at a subsequent visit two years later (approximately 2.5 years after their initial diagnosis). (nih.gov)
  • This is the first large, population-based study to look at the relationship between breast cancer survivorship and biomarkers of inflammation that were measured after treatment. (nih.gov)
  • To date, only one study evaluated the relation between retina layer parameters and the brain on a large-scale population level. (nature.com)
  • We used the 2002-2015 National Health Insurance Service-National Sample Cohort data and included a total of 535,186 adults as the study population. (biomedcentral.com)
  • 99:209 -215.doi:10.1007/s11060 - 010 - 0129 -5 cell carcinoma-a population-based study in with and without cervical cancer in Tbilisi, Georgia. (who.int)
  • Study Question Are fetal fraction, test failure rate and positive predictive value (PPV) of cell-free fetal DNA (cffDNA) testing different in singleton IVF conceptions compared to spontaneous conceptions? (medscape.com)
  • Dendritic cells (DCs) are antigen presenting cells for the induction of antigen specific T cell response. (wikipedia.org)
  • The most critical step in vaccination is the effective presentation of cancer antigens to T cells, and because of DCs are the most efficient antigen presenting cells, they are the promising option for improvement of therapeutic vaccines. (wikipedia.org)
  • IL-27 is a member of the IL-12 family and is composed of Epstein-Barr virus-induced gene3 (EBI3) and p28 subunits, which are produced by active antigen-presenting cells [ 1 ]. (hindawi.com)
  • Our objective is to carry out a data collection focusing on the profile of this population and the influence of the most frequently HFE variants. (scielo.br)
  • Variants in blood pressure genes and the risk of Accardi R, Rubino R, Scalise M et col . (2011). (who.int)
  • This occurs either because your body doesn't produce enough insulin or cannot use it properly. (healthxchange.sg)
  • Insulin resistance and abnormal electrocardiograms in patients with high blood pressure. (nhri.edu.tw)
  • The blood tests showed I was "insulin resistant," meaning that my muscle, fat, and liver cells were not responding to insulin as efficiently as they should-significantly boosting my risk of diabetes. (technologyreview.com)
  • They experienced slightly worsening of beta cell function and insulin sensitivity from 5 years prior to diagnosis. (ucl.ac.uk)
  • They experienced an initial beta cell compensation followed by loss of beta cell function, whereas insulin sensitivity was relatively stable. (ucl.ac.uk)
  • In other studies, a similar association was shown for SAA and gastric cancer and renal cell carcinoma. (nih.gov)
  • E6 and Metabolic syndrome and risks of colon and rectal renal cell carcinoma. (who.int)
  • Conclusions: This population of farmworkers had significant alterations in stress measures and clinical biomarkers, including decreased blood cell counts and cholinesterase activity, relative to matched controls. (cdc.gov)
  • Blood cell DNA methylation biomarkers in preclinical malignant pleural mesothelioma: The EPIC prospective cohort. (who.int)
  • The systemic inflammation response index (SIRI), an emerging inflammatory marker linked to conditions like stroke and cancer, has shown potential relevance. (bvsalud.org)
  • The systemic inflammation response index, a composite metric involving three distinct inflammatory cell counts, was computed as the product of neutrophil count and monocyte count divided by lymphocyte count. (bvsalud.org)
  • Production of the latter relates positively to adipose tissue mass and through its actions on immune function exerts a pro-inflammatory influence. (lww.com)
  • It has been reported that IL-27 performs an anti-inflammatory function by acting on conventional CD4 + T cells to induce IL-10-producing cells that are implicated in controlling inflammatory responses [ 3 ]. (hindawi.com)
  • in endothelial cells TGRL from pattern B subjects and much less those from pattern A induced the expression of pro-inflammatory genes while sdLDL from either pattern A or B subjects were less effective and showed comparable effects. (unipd.it)
  • Note the acute inflammatory cells in the necrotic tissue. (medscape.com)
  • The concentration of research and resources within one ancestral group has the potential to further perpetuate and even exacerbate known disparities that negatively affect populations with ancestry that is underrepresented in research (see Box 1: "What do we mean by ancestry? (nature.com)
  • Our results indicated that the dietary long-chain omega-3 polyunsaturated fatty acids (PUFA) intakes were negatively associated with HOMA-IR (β = -0.089, P = 0.040), fat mass (β = -0.022, P = 0.047), and body fat percentage (β = -0.026, P = 0.032). (frontiersin.org)
  • DPA, EPA, and DHA) were all negatively associated with fat mass and body fat percentage. (frontiersin.org)
  • We can used specific TAAs, tumor lysates, created DC-cancer cell fusions, electroporation/transfection of DCs with total cancer cell-mRNA or tumor derived exosomes (TDEs) by the stimulation. (wikipedia.org)
  • 2 Alongside joint involvement, the systemic inflammation distinctive for RA can affect other organs including the bowels, skin, lungs, kidneys, nervous system and also the heart and blood vessels. (bmj.com)
  • If you do find that you have high blood pressure, you should look at ways you can bring it down to a normal level as having high blood pressure puts a strain on your blood vessels and can lead to blood clots and heart failure. (hollandandbarrett.com)
  • PVD results from thickening of the lining of blood vessels caused by a buildup of plaque and leads to narrowing, blockage, or spasms in the arterial and venous blood vessels [ 13 , 14 ]. (biomedcentral.com)
  • The wet form is characterized by the growth of abnormal, fragile blood vessels underneath the macula. (medlineplus.gov)
  • These vessels leak blood and fluid, which damages the macula and makes central vision appear blurry and distorted. (medlineplus.gov)
  • In Singapore, approximately 10 per cent of the population aged 18 to 69 suffers from diabetes, according to the Ministry of Health (MOH) . (healthxchange.sg)
  • If you have prediabetes or diabetes, it's crucial to monitor blood cholesterol, blood pressure, blood sugar , and weight. (goredforwomen.org)
  • An A1c test gives you a picture of your average blood sugar control for the past 2 to 3 months and provides you with a better idea of how well your diabetes treatment plan is working. (goredforwomen.org)
  • 25kg/m 2 ) compared to women with a normal BMI (18-25kg/m 2 ), we evaluated differences in immune cell populations using single-cell mass cytometry (CyTOF). (elsevierpure.com)
  • When body iron stores increase above these relatively normal ratios, proportionally greater amounts of iron are stored in non-blood tissue in ferritin molecules or a complex called hemosiderin. (irondisorders.org)
  • This causes oxidative stress, a process that if not countered by the body's antioxidant defenses, will over time result in cell, tissue and DNA damage. (irondisorders.org)
  • Additionally, the reduced ability of skin adjacent to scar tissue to synthesize vitamin D shows that this phenomenon occurs in a total body surface area greater than that involved in the burn. (lifeextension.com)
  • Ferritin is found in virtually all cells of the body and in tissue fluids. (medscape.com)
  • The vision loss in this condition results from a gradual deterioration of light-sensing cells in the tissue at the back of the eye that detects light and color ( the retina ). (medlineplus.gov)
  • Both proteins are found in higher concentrations in the blood of people with low-grade chronic inflammation. (nih.gov)
  • Human Immunodeficiency Virus (HIV) infection is associated with hematological abnormalities, the most common manifestation being characterized by reduction in and impaired function of all blood cell lines: red blood cells (anemia), white blood cells (leucopenia or neutropenia) and platelets (thrombocytopenia) collectively called cytopenias. (biomedcentral.com)
  • Background: Red cell distribution width (RDW), a measure of the variability in size of circulating erythrocytes, is associated with mortality and adverse outcome in selected populations with cardiovascular disease. (edu.au)
  • Results depend on the characteristics of the population studied, the comparator treatment and the selected clinical outcome(s). (ersjournals.com)
  • Clinical investigations included this population [3]. (who.int)
  • Results of haematological examination in the first exposure survey showed that haemoglobin, packed cell volume, and red blood cell count in the male exposed workers were significantly lower than those in the comparison workers. (bmj.com)
  • Many studies have indicated that numerous immune cells promote chronic inflammation and progressive plaque growth [ 4 ]. (hindawi.com)
  • High levels of this receptor render cells more susceptible to inflammation. (lifeextension.com)
  • A team of researchers has found an association between breast cancer survival and two proteins that, when present in the blood in high levels, are indicators of inflammation. (nih.gov)
  • CRP and SAA accumulate in the blood in response to inflammation. (nih.gov)
  • SAA, which is also secreted by the liver, is involved in both the transport of cholesterol from the liver to the bile, and the recruitment of immune cells to sites of inflammation. (nih.gov)
  • This system is a group of proteins that work together to destroy foreign invaders (such as bacteria and viruses), trigger inflammation, and remove debris from cells and tissues. (medlineplus.gov)
  • Previous studies have shown an association between elevated levels of CRP and poor survival outcomes in metastatic prostate cancer, as well as gastroesophageal, colorectal, inoperable non-small-cell lung, and pancreatic cancers. (nih.gov)
  • Phagocytosis of lipoproteins by monocytes creates lipid-bloated foam cells, which release cytokines and effector molecules that promote myocyte migration while upregulating endothelial cell adhesion and platelet activation proteins and disrupting vasodilation mechanisms. (mayoclinic.org)
  • Only small amounts of iron are lost each day through urine and body, sweat or as skin cells slough off. (irondisorders.org)
  • Conclusion: RDW is associated with incident MI in a general population independent of anemia and cardiovascular risk factors. (edu.au)
  • The relations are complex, and our findings suggest that the dynamic network structure expands the range of QoL and blood markers research, making it possible to investigate a new range of questions and analyses. (bvsalud.org)
  • Our findings indicate a clear relationship between smoking and decreased NK cell activity. (jcpjournal.org)
  • As these initiatives are beginning to yield results and more findings from studies including diverse populations are accumulating, it is worthwhile to revisit the promises of this inclusion to evaluate whether the anticipated advances are, indeed, emerging. (nature.com)
  • Because vitamin D is involved in maintaining bone mass, a defect in the ability of the burned skin to produce this vitamin may be responsible for these findings. (lifeextension.com)
  • These findings were further confirmed by the findings for body composition measured by the BIA method. (frontiersin.org)
  • DNA methylation and copy number variation profiling of T-cell lymphoblastic leukemia and lymphoma. (cancercentrum.se)
  • We quantified exposure to pesticides , including chlorpyrifos, methomyl, and metalaxyl, by air sampling and liquid chromatography/mass spectrometry. (cdc.gov)
  • The dendritic cell-based cancer vaccine is an innovation in therapeutic strategy for cancer patients. (wikipedia.org)
  • They should prime naïve T cell, and induce transition from chronically activated non-protective CD8+ T cells to healthy CD8+ T cells that can produce cytotoxic T lymphocytes (CTLs), which recognize and eliminate cancer cells by recognizing specific antigens. (wikipedia.org)
  • There are different ways applied to generate cancer cells-specific DCs. (wikipedia.org)
  • Single nucleotide polymorphic loci predicting peripheral blood sorting counts of these leukocytes were selected as instrumental variables according to the correlation assumption, independence assumption and exclusivity assumption of MR. The data on breast cancer and its subtypes were obtained from Breast Cancer Association Consortium (BCAC) and FinnGen Consortium. (bvsalud.org)
  • Weakened NK cell activity and the consequent altered immune status in smokers may contribute to an increased cancer risk. (jcpjournal.org)
  • Blood Cancer Journal. (lu.se)
  • Regular intake of this food is thought to be partially responsible for the lower rates of heart disease, stroke, and cancer observed in Asian populations. (ucdavis.edu)
  • Cancer Lett, 300:215-224.doi:10.1016/j. squamous cell carcinoma in north-eastern Iran. (who.int)
  • Postdiagnosis body fatness, weight change and breast cancer prognosis: Global Cancer Update Program (CUP global) systematic literature review and meta-analysis. (who.int)
  • Postdiagnosis body fatness, recreational physical activity, dietary factors and breast cancer prognosis: Global Cancer Update Programme (CUP Global) summary of evidence grading. (who.int)
  • In recent decades, cancer mortality attributable to tobacco smoking has increased in the elderly, while stroke mortality attributable to high blood pressure has declined. (who.int)
  • This process also creates long-lived memory CD8+ T cells that will act to prevent relapse. (wikipedia.org)
  • ÓG, Vaitkeviciene G, Lepik K, Forslund A, Heyman M, Harila-Saari A. Impact of body mass index on relapse in children with acute lymphoblastic leukemia treated according to Nordic treatment protocols. (cancercentrum.se)
  • Mature DCs have ability to present antigens in the lymphoid tissues, and to prime, activate, and expand immune effector cells with unique functions and cytokine profiles. (wikipedia.org)
  • The initial studies showed that patients developed immune responses as measured by Interferon-gamma expression in the peripheral blood, systemic cytokine responses, or CD8+ antigen specific T cell expansion. (wikipedia.org)
  • The test quantitated the amount of interferon-γ secreted into the plasma by NK cells, using a patented stimulatory cytokine. (jcpjournal.org)
  • What is Already Known cffDNA testing, which analyses circulating cffDNA in maternal blood, has very high accuracy for detection of trisomy 21 in the general obstetric population. (medscape.com)
  • Likewise, people have no way of knowing they have high cholesterol or high blood pressure without being tested. (goredforwomen.org)
  • Get more information about high blood pressure . (goredforwomen.org)
  • The most likely customers for the new test are people with a family histories of the disease, like me, or early warning signs such as high blood sugar, says Ryan Phelan, founder and CEO of DNA Direct. (technologyreview.com)
  • These results suggest that strategies focusing on small weight reductions for the entire population may be more beneficial than predominantly focusing on weight loss for high-risk individuals. (ucl.ac.uk)
  • It's believed that around one in three adults (16 million) have high blood pressure in the UK. (hollandandbarrett.com)
  • Only half are receiving treatment and many will be unaware that their blood pressure is high, which is why it's often referred to as the "silent killer. (hollandandbarrett.com)
  • Binge drinking can also make your heart beat irregularly and cause you to have high blood pressure. (hollandandbarrett.com)
  • PPV was high for trisomy 21 in IVF conception (100.0%), but was lower for other trisomies when compared with the non-IVF population. (medscape.com)
  • No significant correlation between CRP and number of fusion levels, blood transfusion nor operative time. (bvsalud.org)
  • However, just because carbohydrates affect your blood sugar levels doesn't mean that they should be taken completely out of your diet. (healthxchange.sg)
  • This reduces spikes in your blood sugar levels after you eat. (healthxchange.sg)
  • Avoid skipping meals as you could risk suffering from hypoglycaemia (low blood sugar levels). (healthxchange.sg)
  • You should try to keep your blood sugar levels as stable as possible. (healthxchange.sg)
  • In the peripheral blood plasma, TGF- β and IL-10 expression were increased, while the levels of IFN- γ and IL-17 were reduced. (hindawi.com)
  • Low leptin levels in the blood signal an increase in feeding and a decrease in energy expenditure. (eatingdisorders.com)
  • An average of fourteen months following their injuries, 73 percent of the burn patients were found to have deficient blood levels of 25-hydroxyvitamin-D, the form of the vitamin that is the main criterion for determining vitamin D deficiency. (lifeextension.com)
  • Despite population-wide improvements in lipid levels, heart disease remains the No. 1 cause of death both within the U.S. and globally. (mayoclinic.org)
  • Infiltrating monocytes take up the modified low-density lipoproteins and become foam cells, which make plaques unstable, resulting in acute myocardial infarction [ 5 ]. (hindawi.com)
  • A validated novel continuous prognostic index to deliver stratified medicine in pediatric acute lymphoblastic leukemia. (cancercentrum.se)
  • Non-activated (immature) DCs are usually located in the peripheral non-lymphoid tissues and they can present self-antigens to T cells, that leads to immune tolerance either through T cell deletion or through the differentiation of regulatory T cells. (wikipedia.org)
  • The power of the thiol proteinases to cleave a multitude of substrates in response to calcium mineral activation allows their involvement in a variety of cell processes offering cell motility, sign transduction, apoptosis, cell differentiation and legislation of the cytoskeleton (3). (exposed-skin-care.net)
  • Recent studies have found evidence for negative selection acting on characteristics such as body mass index (BMI), blood pressure and height. (ukbiobank.ac.uk)
  • Some studies have reported a decrease in the natural killer (NK) cell activity in smokers. (jcpjournal.org)
  • 2 Population Studies Center, University of Pennsylvania, United States. (nih.gov)
  • Representation in genomics studies has been dominated by populations descending from Europe. (nature.com)
  • The results presented confirm the importance of encouraging such studies and reiterate the need for greater attention to this population. (scielo.br)
  • In vitro studies have shown that 2-ME itself evokes no toxic responses, either in Sertoli cell culture 9 or in rat whole embryo culture, whereas MAA does. (bmj.com)
  • The patient population will include the elderly and others at higher risk for poor outcomes after COVID-19 infection. (wikipedia.org)
  • To further improve population health, consistent and comparative evidence on mortality attributable to preventable risk factors is necessary for setting priorities for health policies and programs. (who.int)
  • There is a large potential population health gain if multiple risk factors are jointly controlled. (who.int)