Loading...
  • liver
  • On physical examination, characteristic findings are the presence of a raised jugular venous pressure, a palpable parasternal heave, a heart murmur due to blood leaking through the tricuspid valve, hepatomegaly (an enlarged liver), ascites and leg edema. (wikipedia.org)
  • In humans, chemerin mRNA is highly expressed in white adipose tissue, liver and lung while its receptor, CMKLR1 is predominantly expressed in immune cells as well as adipose tissue. (wikipedia.org)
  • Growth hormone is made in the anterior pituitary gland, is released into the blood stream, and then stimulates the liver to produce IGF-1. (wikipedia.org)
  • Abdominal fat is a marker of visceral fat (stored around important internal organs such as the liver, pancreas and intestines) and has greater blood flow and more receptors for cortisol than peripheral fat. (wikipedia.org)
  • Subsequent studies have defined LECT2 as a hepatokine, i.e. a substance made and released into the circulation by liver hepatocyte cells that regulates the function of other cells: it is a hepatocyte-derived, hormone-like, signaling protein. (wikipedia.org)
  • The liver hepatocyte is considered to be the source of the LECT2 circulating in blood. (wikipedia.org)
  • levels
  • Medical practitioners should not use BMI as a shortcut but instead examine a patient's body fat percentage, family history, eating patterns and activity levels to determine whether or not someone is obese. (reference.com)
  • In a study on 4631 adult men and women that spanned almost nine years, it was concluded that skipping breakfast may increase the risk of type 2 diabetes, independent of lifestyles and baseline levels of body mass index (BMI). (lifespa.com)
  • In a small proportion of cases, the disease develops into the life-threatening dengue hemorrhagic fever, resulting in bleeding, low levels of blood platelets and blood plasma leakage, or into dengue shock syndrome, where dangerously low blood pressure occurs. (wikipedia.org)
  • The researchers suggested a thorough examination for evidence of silent stroke in all severely anemic children in order to facilitate timely intervention to ameliorate the potential brain damage.Sickle cell anemia: is an autosomal recessive genetic blood disorder caused in the gene (HBB gene) which codes for hemoglobin (Hg) and results in lowered levels. (wikipedia.org)
  • In males, these are usual late pubertal effects, and occur in women after prolonged periods of heightened levels of free testosterone in the blood. (wikipedia.org)
  • Impaired fasting blood sugar and impaired glucose tolerance are two forms of prediabetes that are similar in clinical definition (glucose levels too high for their context) but are physiologically distinct. (wikipedia.org)
  • However, its expression in these cells is extremely low or undetectable even though these cells express very high levels of LECT2 mRNA. (wikipedia.org)
  • Using very sensitive methods, LECT2 protein can also be detected at low levels in the endothelial cells of hepatic arteries and veins including central veins. (wikipedia.org)
  • Other issues that may affect the results surrounding this method for children and adolescents includes their age, sex, ethnicity muscle and bone mass, their height as well as their sexual maturation levels. (wikipedia.org)
  • Another common finding is high blood calcium levels. (wikipedia.org)
  • Myeloma cells produce monoclonal proteins of varying types, most commonly immunoglobulins (antibodies) and free light chains, resulting in abnormally high levels of these proteins in the blood. (wikipedia.org)
  • hemoglobin
  • Pathway analysis revealed that an increase in hemoglobin leads to decreased stability of the cell, probably through a process mediated by an increase in mean corpuscular volume. (deepdyve.com)
  • Furthermore, an increase in the mean corpuscular hemoglobin (MCH) leads to an increase in erythrocyte membrane stability, probably because higher values of MCH are associated with smaller quantities of red blood cells and a larger contact area between the cell membrane and ethanol present in the medium. (deepdyve.com)
  • Anemia: children with acute anemia caused by medical conditions other than sickle cell anemia with hemoglobin below 5.5 g/dL. (wikipedia.org)
  • adipocytes
  • Studies with 3T3-L1 cells have shown chemerin expression is low in pre-differentiated adipocytes but its expression and secretion increases both during and after differentiation in vitro. (wikipedia.org)
  • Loci
  • A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure. (nih.gov)
  • In single variant tests, it has been shown that SNPs were enriched for variants associated with adiposity, type 2 diabetes, coronary heart disease and kidney function in previously published GWAS, providing evidence that genetic loci related to blood pressure contribute to cardiovascular outcomes. (wikipedia.org)
  • bone
  • Vital Roles of β-catenin in Trans-differentiation of Chondrocytes to Bone Cells. (nih.gov)
  • Periodontal Biology: Stem Cells, Bmp2 Gene, Transcriptional Enhancers, and Use of Sclerostin Antibody and Pth for Treatment of Periodontal Disease and Bone Loss. (nih.gov)
  • Anabolic effects include growth of muscle mass and strength, increased bone density and strength, and stimulation of linear growth and bone maturation. (wikipedia.org)
  • These include adult-type body odor, increased oiliness of skin and hair, acne, pubarche (appearance of pubic hair), axillary hair (armpit hair), growth spurt, accelerated bone maturation, and facial hair. (wikipedia.org)
  • The plasma cells can also form a mass in the bone marrow or soft tissue. (wikipedia.org)
  • Multiple myeloma is diagnosed based on blood or urine tests finding abnormal antibodies, bone marrow biopsy finding cancerous plasma cells, and medical imaging finding bone lesions. (wikipedia.org)
  • CRAB symptoms and proliferation of monoclonal plasma cells in the bone marrow are part of the diagnostic criteria of multiple myeloma. (wikipedia.org)
  • The breakdown of bone also leads to the release of calcium into the blood, leading to hypercalcemia and its associated symptoms. (wikipedia.org)
  • It results from the replacement of normal bone marrow by infiltrating tumor cells and inhibition of normal red blood cell production (hematopoiesis) by cytokines. (wikipedia.org)
  • patients
  • Patients were stratified into three groups using the COR-BMI score, which is based on two objective and easily measurable parameters: red blood cell distribution width (RDW) and body mass index (BMI). (jcancer.org)
  • Bivariate and Multivariate Analyses of the Influence of Blood Variables of Patients Submitted to. (deepdyve.com)
  • The validity of this type of analysis depends on the homogeneity of the population and on the variability of the studied parameters, conditions that can be filled by patients who undergo bariatric surgery by the technique of Roux-en-Y gastric bypass since they will suffer feeding restrictions that have great impact on their blood composition. (deepdyve.com)
  • Iron is absorbed in the more proximal parts of the small bowel, the duodenum and jejunum, and patients with malabsorption of iron can develop a microcytic anemia, with small red blood cells. (wikipedia.org)
  • Vitamin B12 is absorbed in the last part of the small bowel, the ileum, and patients who malabsorb vitamin B12 can develop a megaloblastic anemia with large red blood cells. (wikipedia.org)
  • Patients with blood pressures over 130/80 mmHg along with Type 1 or Type 2 diabetes, or kidney disease require further treatment. (wikipedia.org)
  • cardiovascular disease
  • Although having a high body mass index (BMI) is a known risk factor for cardiovascular disease, researchers are only beginning to understand how BMI affects the physiological processes involved in the development of the disease. (medicalxpress.com)
  • They also analyzed the women's blood for platelet count, platelet reactivity, populations of activated cell membrane-derived thrombogenic microvesicles, and the amount of high-sensitive C-reactive protein and activated protein C. Finally, the women underwent computer tomography scans to test for the presence of calcium in their coronary arteries, an indicator of cardiovascular disease. (medicalxpress.com)
  • acute
  • In human T cells, telomerase activity increases with acute antigen exposure but decreases with repeated antigen stimulation and as the cells approach senescence ( 7 ). (pnas.org)
  • tissues
  • Its primary action is mediated by binding to its specific receptor, the insulin-like growth factor 1 receptor (IGF1R), which is present on many cell types in many tissues. (wikipedia.org)
  • LECT2 has been detected in the blood and other tissues in a wide range of animal species from zebrafish to man. (wikipedia.org)
  • When these cells or tissues are subjected to inflammatory, fibrotic, and other insults, they commonly reduce their expression of LECT2. (wikipedia.org)
  • Pressure
  • Contributions of rare coding variants in hypotension syndrome genes to population blood pressure variation. (nih.gov)
  • For example, the mean blood pressure in the low BMI group was 115/72 mmHg, but 124/77 mmHg and 127/78 mmHg in the moderate and high BMI groups, respectively. (medicalxpress.com)
  • These readings are based on the average of seated blood pressure readings that were properly measured during 2 or more office visits. (wikipedia.org)
  • The majority of these studies support the concept that the inheritance is probably multifactorial or that a number of different genetic defects each has an elevated blood pressure as one of its phenotypic expressions. (wikipedia.org)
  • Pressure ulcers occur due to pressure applied to soft tissue resulting in completely or partially obstructed blood flow to the soft tissue. (wikipedia.org)
  • mRNA
  • A next generation sequencing based approach to identify extracellular vesicle mediated mRNA transfers between cells. (nih.gov)
  • peripheral
  • Here we provide evidence that psychological stress- both perceived stress and chronicity of stress-is significantly associated with higher oxidative stress, lower telomerase activity, and shorter telomere length, which are known determinants of cell senescence and longevity, in peripheral blood mononuclear cells from healthy premenopausal women. (pnas.org)
  • Given these observed links, we hypothesized that chronic psychological stress may lead to telomere shortening and lowered telomerase function in peripheral blood mononuclear cells (PBMCs) and to oxidative stress. (pnas.org)
  • immune cells
  • Conclusion: Our study provides normative values for circulating immune cells in adolescents, highlighting the importance of considering sex, age, pubertal maturation and BMI when establishing reference ranges for WBC in paediatric populations. (ljmu.ac.uk)
  • receptors
  • medical citation needed] IGF-1 binds to at least two cell surface receptors: the IGF-1 receptor (IGF1R), and the insulin receptor. (wikipedia.org)
  • syndrome
  • SAP, representing a paradigm of sterile inflammatory disease, is initiated by acinar cell injury-mediated local inflammation and progresses to the systemic inflammatory response syndrome, accompanied with inevitable multiple organ injury, and eventually leads to multiple organ dysfunction syndrome, which contributes to the main cause of morbidity and mortality in this condition [ 4 ]. (hindawi.com)
  • It is thus a metabolic diathesis or syndrome, and it usually involves no symptoms and only high blood sugar as the sole sign. (wikipedia.org)
  • occurs
  • Penha-Silva, Nilson 2013-01-24 00:00:00 The stability of the erythrocyte membrane, which is essential for the maintenance of cell functions, occurs in a critical region of fluidity, which depends largely on its composition and the composition and characteristics of the medium. (deepdyve.com)
  • Ischemic stroke: occurs when a blood vessel supplying blood to the brain becomes blocked. (wikipedia.org)
  • cerebral
  • Lacunar infarcts (LACI) are small (0.2 to 15 mm in diameter) noncortical (does not affect cerebral cortex) infarcts caused by the occlusion of a single penetrating branch of a larger blood vessel that provides blood to the brain's deep structures including the white matter. (wikipedia.org)
  • increases
  • Now, a study of a subset of women in the Kronos Early Estrogen Prevention Study (KEEPS), suggests that as BMI increases, so do platelet reactivity and thrombogenic microvesicles and activated protein C in the blood-all of which contribute to the formation of atherothrombosis and associated cardiovascular events. (medicalxpress.com)
  • estrogen
  • The male brain is masculinized by the aromatization of testosterone into estrogen, which crosses the blood-brain barrier and enters the male brain, whereas female fetuses have α-fetoprotein, which binds the estrogen so that female brains are not affected. (wikipedia.org)
  • circulation
  • This may result in fluid accumulation in the chest and abdominal cavity as well as depletion of fluid from the circulation and decreased blood supply to vital organs. (wikipedia.org)
  • Anemia
  • Anemia may occur from a variety of mechanisms, as many of the nutrients involved in production of red blood cells are absorbed in the affected small bowel. (wikipedia.org)
  • kidney
  • The underlying mechanism involves abnormal plasma cells producing abnormal antibodies which can cause kidney problems and overly thick blood. (wikipedia.org)
  • The most common cause of kidney failure in multiple myeloma is due to proteins secreted by the malignant cells. (wikipedia.org)
  • potent
  • Retinoids exert biologic effects such as potent growth inhibitory and cell differentiation activities and are used in the treatment of hyperproliferative dermatological diseases. (wikipedia.org)
  • overweight
  • Furthermore, BMI does not consider people with large amounts of muscle mass, as it classifies them as overweight. (reference.com)
  • Body Mass Index (BMI) is a common and useful measurement of body fat that helps individuals understand the difference between being overweight and obese. (wikipedia.org)
  • protein
  • Leukocyte cell-derived chemotaxin-2 (LECT2) is a protein first described in 1996 as a chemotactic factor for neutrophils, i.e. it stimulated human neutrophils to move directionally in an in vitro assay system. (wikipedia.org)
  • The protein was detected in and purified from cultures of Phytohaemagglutinin-activated human T-cell leukemia SKW-3 cells. (wikipedia.org)
  • These factors are protein-calorie malnutrition, microclimate (skin wetness caused by sweating or incontinence), diseases that reduce blood flow to the skin, such as arteriosclerosis, or diseases that reduce the sensation in the skin, such as paralysis or neuropathy. (wikipedia.org)
  • reveals
  • RNA sequence analysis of inducible pluripotent stem cell-derived cardiomyocytes reveals altered expression of DNA damage and cell cycle genes in response to doxorubicin. (nih.gov)
  • GWAS of epigenetic aging rates in blood reveals a critical role for TERT. (nih.gov)
  • Outcomes
  • Wang Y, He SS, Cai Xy, Chen HY, Yang XL, Lu LX, Chen Y. The Novel Prognostic Score Combining Red Blood Cell Distribution Width and Body Mass Index (COR-BMI) Has Prognostic Impact for Survival Outcomes in Nasopharyngeal Carcinoma. (jcancer.org)
  • stability
  • As the composition of the erythrocyte membrane is influenced by several blood variables, the stability of the erythrocyte membrane must have relations with them. (deepdyve.com)
  • inflammation
  • A novel inflammation-and nutrition-based scoring system based on red blood cell distribution width and body mass index (COR-BMI) has prognostic value in nasopharyngeal carcinoma (NPC). (jcancer.org)
  • Chemerin was found to stimulate chemotaxis of dendritic cells and macrophages to the site of inflammation. (wikipedia.org)
  • mild
  • The severity of disease is based on body mass index (BMI) in adults with mild disease having a BMI of greater than 17, moderate a BMI of 16 to 17, severe a BMI of 15 to 16, and extreme a BMI less than 15. (wikipedia.org)
  • present
  • When only one mass is present, it is known as a plasmacytoma while more than one is known as multiple myeloma. (wikipedia.org)
  • plasma
  • Although the total immunoglobulin level is typically elevated in multiple myeloma, the majority of the antibodies are ineffective monoclonal antibodies from the clonal plasma cell. (wikipedia.org)
  • types
  • Typically hemorrhagic stroke is caused by two types of weakened blood vessel: aneurysms and arteriovenous malformations (AVMs). (wikipedia.org)
  • cellular
  • In addition to the insulin-like effects, IGF-1 can also regulate cell growth and development, especially in nerve cells, as well as cellular DNA synthesis. (wikipedia.org)