• The concentration of doxorubicin was significantly higher in all brain areas of rats pretreated with morphine than in control tissues (P ,0.001). (unifi.it)
  • This finding might provide the rationale for clinical applications in the treatment of refractory brain tumors and pave the way to novel applications of active but currently inapplicable drugs. (unifi.it)
  • Our group recently verified that morphine pre-treatment facilitates doxorubicin delivery beyond the blood brain barrier (BBB) to the brain in the absence of signs of increased acute systemic toxicity in a rat model. (unifi.it)
  • Brain-penetrating antibodies and viruses could, for example, ferry therapeutic cargo across the border. (pnas.org)
  • Finding ways to stealthily shuttle drugs across the blood-brain barrier could have big therapeutic implications. (pnas.org)
  • The treatment of central nervous system (CNS) diseases can be particularly challenging because many of the therapeutic agents such as recombinant proteins and gene medicines are not easily transported across the blood-brain barrier (BBB). (newswise.com)
  • The group is investigating the feasibility of using heparin, a common anticoagulant, to enhance the delivery of therapeutic macromolecules using ultrasound into the brain. (newswise.com)
  • Working with mice, Johns Hopkins researchers have shed light on the activity of a protein pair found in cells that form the walls of blood vessels in the brain and retina, experiments that could lead to therapeutic control of the blood-brain barrier and of blood vessel growth in the eye. (redorbit.com)
  • Nanowerk Spotlight ) The challenge in treating most brain disorders is overcoming the difficulty of delivering therapeutic agents to specific regions of the brain by crossing the blood-brain barrier (BBB). (nanowerk.com)
  • Thus, while the BBB naturally evolved in order to protect the brain from invasion of various circulating toxins and other harmful molecules, it also serves as a major impediment towards the brain-specific delivery of various diagnostic/therapeutic molecules needed for combating various neuronal disorders. (nanowerk.com)
  • To date, delivery of therapeutic molecules into the brain often involves highly invasive techniques (like drilling a hole in the skull). (nanowerk.com)
  • The utter scarcity of techniques for brain-specific delivery of therapeutic molecules using non-invasive approaches has led researchers to increasingly explore the vast potential of nanotechnology toward the diagnosis and treatment of diseases/disorders incurable with present techniques. (nanowerk.com)
  • By linking transferrin with rod-shaped semiconductor nanocrystals (quantum rods) - an up and coming diagnostic agent which can also multitask as carriers of therapeutic molecules - it was found that the transferrin helps the linked quantum rods to 'sneak' across the BBB into the brain. (nanowerk.com)
  • This finding can have significant potential implications towards the development of brain-directed nanoparticle based diagnostic and therapeutic agents using minimally invasive procedures. (nanowerk.com)
  • Our work demonstrates a nanoparticle-based platform that will not only allow a direct visualization of the transmigration ability of various kinds of biomolecules across the BBB, but also facilitate the development of novel diagnostic and therapeutic nanoprobes for early diagnosis and therapy of various disorders of the brain, following systemic administration,' Dr. Paras N. Prasad tells Nanowerk. (nanowerk.com)
  • These nerve fibers are responsible for sensing odors and chemicals, and according to Dr. Frey, are capable of carrying therapeutic agents directly to the brain and spinal cord. (prohealth.com)
  • In bypassing the blood-brain barrier, through these pathways, therapeutic agents can be delivered without being modified and without the need for a carrier. (prohealth.com)
  • Preclinical studies suggest, for example, that intranasal delivery of antioxidants or of natural therapeutic proteins may be able to dramatically reduce brain damage and improve neurologic function after stroke. (prohealth.com)
  • But the same system that protects the brain also stymies many therapeutics that could potentially treat disease. (pnas.org)
  • However, finding a way to "prop the door open" to allow therapeutics to reach diseased tissue without damaging normal brain tissue is the focus of a new study by a team of researchers at the Institute of Biomedical Engineering at National Taiwan University presenting at the 57th Annual Meeting of the Biophysical Society (BPS), held Feb. 2-6, 2013, in Philadelphia, Pa. (newswise.com)
  • The team also used the spheroids to identify new brain-penetrant molecules, which could hold high potential for delivering therapeutics across the blood-brain barrier. (eurekalert.org)
  • Right now, 98 percent of small molecule drugs and 100 percent of large molecule drugs and antibodies can't get through the blood-brain barrier," said Chenghua Gu, Ph.D., associate professor of neurobiology at HMS and senior author of the study. (genengnews.com)
  • The blood-brain barrier also restricts the entry of antibodies that help to fight bacterial infections that do occur and makes it difficult for the delivery of water-soluble drugs that have been developed to treat diverse conditions. (newworldencyclopedia.org)
  • The BBB controls the delivery of important nutrients, blocks substances that can harm the brain, and removes waste from the brain. (medicalnewstoday.com)
  • Eat a healthy diet to provide your brain with all the important nutrients it needs. (livestrong.com)
  • Protein, fat, carbohydrate, vitamins and minerals provide nutrients that keep your brain functioning, prevent deficiencies and promote the activities of substances known as neurotransmitters -- the chemical messengers in the brain. (livestrong.com)
  • The brain can't use a beef steak in its original form, but it can use the amino acids contained in the meat. (livestrong.com)
  • The OHSU Blood-Brain Barrier Program is a member of the OHSU Knight Cancer Institute and has strong affiliations with the National Institutes of Health in Washington, D.C., including the National Cancer Institute and the National Institute of Neurological Disorders and Stroke . (ohsu.edu)
  • The final chapter reviews various models of neurological disorders which can be used to unravel the complexity of the barrier in health and disease. (springer.com)
  • Breaching this barrier opens up a new frontier in treating brain disorders," Neal Kassell, chairman of the Focused Ultrasound Foundation, said in a press release . (the-scientist.com)
  • The goal of the Blood-Brain Barrier (BBB) Program is not only to prolong patients' length of survival, but also to improve the quality of their survival. (ohsu.edu)
  • The combination of polymeric vesicles with a small GM1-binding peptide and GM1/GT1b gangliosides as targeting sites for blood-brain barrier transport is unprecedented. (wur.nl)
  • "The fundamental hypothesis of this study was that blood vessel expansion and contraction induced by microbubble expansion and contraction can enhance the transport of intranasally-administered agents into the focused ultrasound-targeted brain region," ​ said Chen. (in-pharmatechnologist.com)
  • "Microbubbles are unique in that they expand and contract when sonicated by ultrasound, which pushes and pulls on the vessel wall and potentially contributes to the enhanced and localized brain drug delivery observed in this study," ​ Chen further explained. (in-pharmatechnologist.com)
  • Their work reveals a dual role for the protein pair, called Norrin/Frizzled-4, in managing the blood vessel network that serves the brain and retina. (redorbit.com)
  • So blood vessel defects in the retina generally starve it of oxygen, causing blindness. (redorbit.com)
  • All of these results suggest that Norrin and Frizzled-4 play an important role in the proper timing and arrangement of the retinal blood vessel network, Nathans says. (redorbit.com)
  • Reversible breakdown of the blood-brain barrier is produced by a class of electrolytes and nonelectrolytes which have little or no lipid solubility but which difler in chemical and ionic properties. (sciencemag.org)
  • Lipid-soluble nonelectrolytes damage the barrier irreversibly. (sciencemag.org)
  • Investigators at Brigham and Women's Hospital have developed an innovative but easily implemented approach that uses "spheroids" to mimic the blood-brain barrier more accurately, and appears to overcome several challenges for discovering and advancing new drugs for treating brain conditions. (eurekalert.org)
  • Adrian Joseph and his team utilized this principle to propel tiny vesicle nanoswimmers, known as polymerosomes, which are tiny vesicles filled with chemicals, to transport drugs into the blood brain barrier. (azonano.com)
  • While studying oxygen consumption in different organs, Ehrlich injected mice with an indicator dye that flowed throughout the body, staining all organs but one: the brain. (pnas.org)
  • A few regions in the brain, including the circumventricular organs, do not have a blood-brain barrier. (wikipedia.org)
  • Although the blood brain barrier helps protect individuals from the influence of some endogenous hormones and harmful chemicals, certain drugs such as drugs to treat brain ailments need to enter the brain to show their desired pharmacologic activity 2 . (azonano.com)
  • Being able to open and close the blood-brain barrier also promises to benefit basic research, enabling scientists to investigate how abnormal barrier formation affects brain development and what the relationship may be between barrier deterioration and disease. (genengnews.com)
  • An epileptic seizure, also known as an epileptic fit, is a brief episode of signs or symptoms due to abnormal excessive or synchronous neuronal activity in the brain. (wikipedia.org)
  • Transcytosis occurs frequently at other sites in the body but is normally suppressed at the blood-brain barrier (BBB). (genengnews.com)
  • Just as you eat to nourish the rest of your body, you must also nourish your brain. (livestrong.com)
  • Water, for example, may not be something you normally think of as a nutrient, but it is critical for proper body and brain function. (livestrong.com)
  • Seizures can also occur in people who do not have epilepsy for various reasons including brain trauma, drug use, elevated body temperature, low blood sugar and low levels of oxygen. (wikipedia.org)
  • Scientists have now reported a nanoparticle-based platform which 'tricks' the BBB into allowing the entry of the nanoparticle into the brain, using an approach that draws parallel to the 'trojan horse' concept. (nanowerk.com)
  • A handful of drugs slip into the brain by passive diffusion-among them, antidepressants and medications for schizophrenia and epilepsy, along with caffeine, alcohol, and nicotine. (pnas.org)
  • Delivering drugs to the brain is no easy task. (eurekalert.org)
  • They also could help clinicians develop a way to temporarily increase the penetrability of the blood-brain barrier, allowing critical drugs to pass through to the brain, says Jeremy Nathans, M.D., Ph.D., a Howard Hughes researcher and professor of molecular biology and genetics at the Institute for Basic Biomedical Sciences at the Johns Hopkins School of Medicine. (redorbit.com)
  • With this information in hand, we hope that someday it may be possible to temporarily loosen the blood-brain barrier, allowing life-saving drugs to pass through," says Nathans. (redorbit.com)