• Purpose: To determine the tolerability and feasibility of double-cycle, high-dose chemotherapy followed by peripheral blood stem-cell transplantation (PBSCT) after conventional chemotherapy or chemoradiotherapy for small cell lung cancer (SCLC). (the-medical-dictionary.com)
  • Combination chemotherapy with cisplatin and etoposide (cisplatin-etoposide [PE]) has long been the mainstay of treatment for small cell lung cancer (SCLC). (the-medical-dictionary.com)
  • Neupogen is indicated for the reduction in the duration of neutropenia and the incidence of febrile neutropenia in patients treated with established cytotoxic chemotherapy for malignancy (with the exception of chronic myeloid leukaemia and myelodysplastic syndromes) and for the reduction in the duration of neutropenia in patients undergoing myeloablative therapy followed by bone marrow transplantation considered to be at increased risk of prolonged severe neutropenia. (medicines.org.uk)
  • Following established chemotherapy for solid tumours, lymphomas, and lymphoid leukaemia, it is expected that the duration of treatment required to fulfil these criteria will be up to 14 days. (medicines.org.uk)
  • Following induction and consolidation treatment for acute myeloid leukaemia the duration of treatment may be substantially longer (up to 38 days) depending on the type, dose and schedule of cytotoxic chemotherapy used. (medicines.org.uk)
  • The recommended dose is 250 mcg/m2/day administered IV over a 2-hour period beginning two to four hours after bone marrow infusion, and not less than 24 hours after the last dose of chemotherapy or radiotherapy. (wikidoc.org)
  • Neupogen is indicated for the mobilisation of peripheral blood progenitor cells (PBPCs). (medicines.org.uk)
  • A single injection of 12 mg pegfilgrastim was used to mobilize peripheral blood progenitor cells (PBPCs) from healthy donors in some studies. (bvsalud.org)
  • In patients, children or adults, with severe congenital, cyclic, or idiopathic neutropenia with an absolute neutrophil count (ANC) of ≤ 0.5 × 10 9 /l, and a history of severe or recurrent infections, long term administration of Neupogen is indicated to increase neutrophil counts and to reduce the incidence and duration of infection-related events. (medicines.org.uk)
  • Neupogen is indicated for the treatment of persistent neutropenia (ANC less than or equal to 1.0 × 10 9 /l) in patients with advanced HIV infection, in order to reduce the risk of bacterial infections when other options to manage neutropenia are inappropriate. (medicines.org.uk)
  • Although a strong response was observed for CAR-T cells in patients with treatment-refractory haematologic malignancies, only modest outcomes have been reported in solid tumours. (nature.com)
  • Patients should not receive Sargramostim until the post marrow infusion ANC is less than 500 cells/mm3. (wikidoc.org)
  • This phase I trial tests the safety and effectiveness of total marrow and lymphoid irradiation (TMLI) and alemtuzumab as a conditioning regimen in patients with sickle cell disease. (scdstudies.com)
  • Patients must have previously received at least 3 different treatment regimens for MM. (survivornet.com)
  • Aim: To Describe our population of patients with AML and report the outcomes of our treatments. (scielo.org)
  • Added to this, there are patients who do not improve on any immunosuppressive treatment, with subsequent deteriorated quality of life and high mortality. (scielo.org)
  • Methods: A retrospective analysis was performed on patients with severe GVHD refractory to corticosteroids. (scielo.org)
  • Causes of mortality in those patients were severe viral pneumonia, post-transplantation hemophagocytic syndrome and meningeal GVHD refractory to ruxolitinib. (scielo.org)
  • Ruxolitinib treatment in patients with a very poor prognosis showed encouraging results. (scielo.org)
  • Currently more than 60% of ALOHT reported to the Center for International Bone Marrow Transplantation Research (CIBMTR) are performed in patients older than 40 years. (scielo.org)
  • Graft-versus-host disease (GVHD) is a complication that may occur after hematopoietic cell transplantation (HCT) in which donated cells view the recipient's cells as foreign and attack them. (scdstudies.com)
  • The optimal schedule for PBPC collection has not been established. (wikidoc.org)
  • Leukapheresis was scheduled to commence on day 4 of the mobilization regimen. (bvsalud.org)
  • This appearance is most frequently observed in conditions that cause bone marrow expansion, such as severe anaemia, thalassemia, and sickle cell disease. (passmed.uk)
  • Symptoms include fevers, rigors, rash, and jaundice, which are less severe and more gradual in onset than acute haemolytic reactions. (passmed.uk)
  • The overall response to ruxolitinib treatment for acute GVHD was 80%, 40% with partial response and 40% with complete remission. (scielo.org)
  • Aim: To report our experience with ALOHT in acute myelogenous leukemia (AML), analyzing patient age at transplantation in different periods and transplant results in different age groups. (scielo.org)
  • Neupogen therapy should only be given in collaboration with an oncology centre which has experience in G-CSF treatment and haematology and has the necessary diagnostic facilities. (medicines.org.uk)
  • In the absence of response to corticosteroids, several immunosuppressive drugs can be used, but they entail an elevated risk of severe infections. (scielo.org)
  • CONCLUSIONS: Sharp recanalization performed centrifugally with the stiff end of the microguidewire could be an cost-effective and safe alternative procedure for the treatment of refractory central venous occlusion that cannot be recanalized with conventional technique. (bvsalud.org)
  • For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. (hemonc.org)
  • If a severe adverse reaction occurs, the dose can be reduced by 50% or temporarily discontinued until the reaction abates. (wikidoc.org)
  • Sargramostim treatment should be interrupted or the dose reduced by half if the ANC exceeds 20,000 cells/mm3. (wikidoc.org)
  • Dosing should continue at the same dose through the period of PBPC collection. (wikidoc.org)
  • The transferred, expanded natural killer cells proliferated in vivo in an interleukin-2 dose-dependent fashion, persisted up to 4 weeks, were readily detectable in the human bone, inhibited myeloma growth and protected bone from myeloma-induced osteolysis. (haematologica.org)
  • Genetically engineered T cells expressing a chimeric antigen receptor (CAR) are rapidly emerging a promising new treatment for haematological and non-haematological malignancies. (nature.com)
  • Compared with CAR-T cells, CAR exosomes do not express Programmed cell Death protein 1 (PD1), and their antitumour effect cannot be weakened by recombinant PD-L1 treatment. (nature.com)
  • The blood will be separated and T cells removed. (survivornet.com)
  • In these conditions, the bone marrow produces an increased number of red blood cells, leading to expansion of the bone marrow cavity and compression of the surrounding bone. (passmed.uk)
  • These mice are devoid of endogenous natural killer and T-cell activity and were used to determine whether adoptively transferred expanded natural killer cells could inhibit myeloma growth and myeloma-associated bone destruction. (haematologica.org)
  • Yellow marrow is found in the large cavities of large bones and consists mostly of fat cells and a few primitive blood cells. (lookformedical.com)
  • Bone marrow is made up of a framework of connective tissue containing branching fibers with the frame being filled with marrow cells. (lookformedical.com)
  • Participants will have 8 follow-up visits over the next year for blood and urine tests. (survivornet.com)
  • Participants blood will be collected regularly over the next several years. (survivornet.com)
  • A 36-year-old woman, who has received a 3-unit blood transfusion following a hysterectomy, begins to feel unwell with a fever and chills 3 or 4 days later. (passmed.uk)
  • What is the most likely diagnosis for this 36-year-old woman who has received a 3-unit blood transfusion following a hysterectomy and is experiencing fever, chills, and mild jaundice without signs of active bleeding? (passmed.uk)
  • This type of reaction occurs when a patient without certain red cell antigens is exposed to these antigens through blood transfusion, resulting in the development of new antibodies and haemolysis after 3-14 days. (passmed.uk)
  • Medical management of this patient will involve screening for a wider range of possible antigens and access to a blood bank with a sufficient number of available units for a clean transfusion. (passmed.uk)
  • Serious complications of blood transfusion are rare due to screening techniques, leukocyte depletion, and improved collection and storage. (passmed.uk)
  • Multiple myeloma (MM) is a malignant plasma cell disorder with debilitating symptoms related to anemia, immunosuppression, bone destruction, and renal failure. (haematologica.org)
  • Transplantation of an individual's own tissue from one site to another site. (lookformedical.com)
  • Red marrow is a hematopoietic tissue and is the site of production of erythrocytes and granular leukocytes. (lookformedical.com)
  • It is characterized by hyperglobulinemia, excess Bence-Jones proteins (free monoclonal IMMUNOGLOBULIN LIGHT CHAINS) in the urine, skeletal destruction, bone pain, and fractures. (lookformedical.com)
  • History of one or more severe vaso-occlusive pain crises per year in the 2-year period preceding enrollment despite the institution of supportive care measures (i.e. a pain management plan and/or treatment with hydroxyurea). (scdstudies.com)
  • It is advised to drink lots of fluids after treatment to prevent damage to the bladder and kidneys, typically 1.5 to 3.5 litres of water on the day of treatment and for several days after. (the-medical-dictionary.com)
  • In clinical studies, collection of PBPC was usually begun by day 5 and performed daily until protocol specified targets were achieved. (wikidoc.org)
  • If the drug is given by IV it must be done slowly over a 30 to 60 minute period because it can lower blood pressure as it is being administered. (the-medical-dictionary.com)