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  • Donnall Thomas
  • Early research in bone marrow transplantation by E. Donnall Thomas and colleagues demonstrated that this process of splitting TBI into multiple smaller doses resulted in lower toxicity and better outcomes than delivering a single, large dose. (wikipedia.org)
  • grafts
  • We previously reported early results of a clinical trial using ex vivo induction of alloanergy in donor T cells within bone marrow (BM) grafts via CTLA4-Ig-mediated CSB. (bloodjournal.org)
  • immunotherapy
  • As one of Hadassah University's senior scientists, Prof. Or continues to conduct research on various clinical topics, including the prevention of liver complications following bone marrow transplantation and immunotherapy using donor derived lymphocytes (immune cells) for the eradication of malignant diseases that would otherwise prove fatal. (isracast.com)
  • Registries
  • Provides both EBMT members and other physicians involved in bone marrow transplant with information on related meetings, registries and data management, transplant guidelines, accreditation and corporate sponsorship. (dmoztools.net)
  • disorders
  • 1 Congenital disorders account for approximately one third of cases of bone marrow failure in childhood and include many different genetic diseases, such as Fanconi anemia, dyskeratosis congenita (DC), 2 Diamond-Blackfan anemia (DBA) 3 and others. (haematologica.org)
  • Beta thalassemias (β thalassemias) are a group of inherited blood disorders. (wikipedia.org)
  • Neutrophil
  • Myelokathexis is a congenital disorder of the white blood cells that causes severe, chronic leukopenia (a reduction of circulating white blood cells) and neutropenia (a reduction of neutrophil granulocytes). (wikipedia.org)
  • citation needed
  • citation needed] Possible mechanisms of recovery include: Generation of heart muscle cells Stimulation of growth of new blood vessels to repopulate damaged heart tissue Secretion of growth factors Assistance via some other mechanism It may be possible to have adult bone-marrow cells differentiate into heart muscle cells. (wikipedia.org)
  • spleen
  • In the late 1940s, University of Chicago researcher Dr. Leon Jacobson discovered that he could save a mouse, whose bone marrow and spleen had been destroyed with radiation, by transplanting healthy spleen tissue from another mouse. (uchospitals.edu)
  • Physical symptoms generally include coarse or rough facial features (including a flat nasal bridge, thick lips, and enlarged mouth and tongue), short stature with disproportionately short trunk (dwarfism), dysplasia (abnormal bone size and/or shape) and other skeletal irregularities, thickened skin, enlarged organs such as liver (hepatomegaly) or spleen (splenomegaly), hernias, and excessive body hair growth. (wikipedia.org)
  • Increased gastrointestinal iron absorption is seen in all grades of beta thalassemia and increased red blood cell destruction by the spleen due to ineffective erythropoiesis further releases additional iron into the bloodstream. (wikipedia.org)
  • scientists
  • This groundbreaking work influenced many scientists investigating bone marrow transplant for humans, including the winner of the 1990 Nobel Prize in Physiology or Medicine. (uchospitals.edu)
  • regimen
  • He was responsible for the creation of a model that detailed a regimen of minimal pre-transplant conditioning for the preparation for stem cell transplantation in order to reduce the toxicity of therapy. (isracast.com)