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  • HSCs
  • The engineered protein maintains the expanded HSCs in a stem-like state -- meaning, they will not differentiate into specialized blood cell types before they are transplanted in the recipient's bone marrow. (redorbit.com)
  • Bone marrow is the home of HSCs that produce all blood cells, including all types of immune cells. (redorbit.com)
  • Because of these issues of extracting donor bone marrow, there have been a number of attempts to expand HSCs that have focused on the transcription factor HOXB4, which stimulates HSCs to make copies of themselves. (redorbit.com)
  • Since life isn't perfect and most of us get sick, become injured, or otherwise make sudden and unexpected demands of our blood systems, dormant HSCs can be called to action. (ucdenver.edu)
  • We are studying how cytokines such as IL-1 change the global transcriptional, epigenetic, and metabolic status of HSCs and the progenitor cells they differentiate into, thereby altering HSC fate and blood output. (ucdenver.edu)
  • In adult mammals, HSCs are rare cells mainly located in the bone marrow (BM) and able to generate all mature blood cells. (bloodjournal.org)
  • abnormal
  • Chapters cover methods of culture, observation and evaluation of cell cultures, cultures of normal and abnormal blood and bone marrow cells, and effect of nutrients and stimulants and of cytotoxic therapeutic agents. (annals.org)
  • researchers
  • Researchers have developed an artificial tissue in which human blood stem cells remain functional for a prolonged period of time. (eurekalert.org)
  • For several years, researchers have been trying to reproduce natural bone marrow in the laboratory in order to better understand the mechanisms of blood formation and to develop new therapies - such as for the treatment of leukemia. (eurekalert.org)
  • The researchers have developed an artificial tissue that mimics some of the complex biological properties of natural bone marrow niches. (eurekalert.org)
  • transplanting healthy
  • In the late 1940s, University of Chicago researcher Dr. Leon Jacobson discovered that he could save a mouse, whose bone marrow and spleen had been destroyed with radiation, by transplanting healthy spleen tissue from another mouse. (uchospitals.edu)
  • treatment
  • Testing the blood is an easy way for doctors to look for signs of disease and manage treatment for disease. (cancer.ca)
  • Our mission is to make discoveries that may lead to better therapeutic approaches for the treatment of deregulated blood production in disease conditions. (ucdenver.edu)
  • rapidly
  • Inherent in the ability of our blood systems to respond to these diverse requirements is the capacity to rapidly adapt to specific needs, such as producing more myeloid cells following infection, or more erythrocytes to respond to the slightly thinner atmosphere while visiting, or living in, Denver. (ucdenver.edu)
  • Bone marrow re-grows rapidly to replace the donated cells. (nzblood.co.nz)