AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and Processes
BleomycinLungLung DiseasesPulmonary FibrosisLung NeoplasmsLung InjuryAntibiotics, AntineoplasticCarcinoma, Non-Small-Cell LungLung TransplantationAcute Lung InjuryPeplomycinHydroxyprolineVinblastinePhleomycinsBronchoalveolar Lavage FluidPulmonary AlveoliInstillation, DrugLung Volume MeasurementsEtoposideVincristineLung Diseases, InterstitialElectrochemotherapyCisplatinProcarbazineHodgkin DiseaseTesticular NeoplasmsDoxorubicinAntineoplastic Combined Chemotherapy ProtocolsMechlorethamineMice, Inbred C57BLCobalt RadioisotopesTotal Lung CapacityInjections, IntralesionalIdiopathic Pulmonary FibrosisDacarbazinePneumoniaNeoplasms, Germ Cell and EmbryonalExtravascular Lung WaterGerminomaPrednisoneFibroblastsSmall Cell Lung CarcinomaCarcinoma, Small CellDNA DamageLung AbscessZinostatinAdenocarcinomaMacrophages, AlveolarVentilator-Induced Lung InjuryCell SurvivalRespiratory Distress Syndrome, Adult
TissueToxicityCharacterizing bleomycin-inducedAcute lung iFibroblastsIntratrachealMice were intratracheallyInduceDoses of bleomycinAdministration of bleomycinAgent bleomycinSulfateTransplantationChemotherapyTumorsRespiratoryPirfenidonePulmonary injuryInjectionReducing lung fibrosisFibrotic lung diseasesModel of lung fibrosisVitroTreatmentIdiopathicInjuryFibrogenesisVivoSevereTherapeuticMethotrexateDiseasesSpecificityMurine lungAntineoplasticDeadly interstitialSecretionFibrocytesInflammatoryDiseaseMacrophagesPneumonitisPathologyChronicCollagenComputerized tomographyHistologicalEnzyme-linkeUsual interstitAccumulationAntibioticSalineCancersPathwaysInterstitial pneumoniaEosinophilicProgressive lungOccurUltrastructural ChangesBALBPatientMoleculePleuralInfiltrates
Tissue19
  • Bronchoalveolar lavage (BAL) and lung tissue were collected 7d later. (nih.gov)
  • Additionally, OA-NO2 attenuated increases in mature, activated interstitial macrophages (23 ± 4.8 vs. 43 ± 5.4%) in lung tissue digests. (nih.gov)
  • embolic PH (PAP 40.3 ± 7.8), and the remaining 10 and Nicola Petrosillo* patients (PAP 37.1 ± 12.2 mm Hg) had PH associated with Human herpesvirus 8 (HHV-8) antibodies were detect- connective tissue disease (4 patients), HIV infection (3 ed in 1 of 33 patients with pulmonary hypertension (includ- patients), and lung disease (3 patients). (cdc.gov)
  • lung tissue from 1 large-scale multicenter study that employed a consensus- of these patients was positive for latency-associated nuclear based method for defining the "true" status of specimens, antigen-1 (3). (cdc.gov)
  • tension (PH) had HHV-8 gene sequences in lung tissue (2). (cdc.gov)
  • Because of bleomycin's sensitization of lung tissue, patients who have received bleomycin are at greater risk of developing pulmonary toxicity when oxygen is administered in surgery. (cancermonthly.com)
  • Our therapy is based on correcting the molecular cause of pulmonary fibrosis in patients with short telomeres, introducing into the cells of damaged lung tissue the only enzyme capable of lengthening telomeres, telomerase. (eurekalert.org)
  • In lung fibrosis, the lung tissue develops scars that cause a progressive loss of respiratory capacity. (eurekalert.org)
  • Their current publication shows that activating the telomerase enzyme to lengthen the telomeres in the lung tissue may constitute an effective therapeutic strategy to treat human pulmonary fibrosis. (eurekalert.org)
  • Investigators, partially supported by the National Institute of Arthritis and Musculoskeletal and Skin Diseases, have found that a deficiency in the protein caveolin-1 (cav-1) is linked to the development of interstitial lung disease, the scarring of lung tissue that causes disability and death in people with scleroderma. (nih.gov)
  • Fibrocytes express a protein called CXCR4, which helps fibrocytes migrate from the blood to lung tissue, where they contribute to lung fibrosis. (nih.gov)
  • From previous work, Dr. Tourkina's group also knew that levels of cav-1 protein were significantly reduced in the fibrotic lung tissue of people with systemic sclerosis, and in a mouse model of fibrotic lung disease. (nih.gov)
  • Their results showed reduced CXCR4 expression, and-using a laboratory procedure that mimics the movement of monocytes into damaged lung tissue-reduced monocyte migration. (nih.gov)
  • For example, connective tissue diseases-associated lung fibrosis is very common and sometimes leads the prognosis, such as in patients with systemic sclerosis or rheumatoid arthritis [ 13 ]. (ersjournals.com)
  • Idiopathic Pulmonary Fibrosis (IPF), the most severe interstitial lung disease, is a devastating condition characterized by deregulation of tissue repair processes subsequent to lung tissue damage. (univ-orleans.fr)
  • Our research aims to identify endogenous molecules (danger signals released following lung tissue damage), their sensors as well as the signaling pathways activated during the establishment of innate and adaptive immune responses. (univ-orleans.fr)
  • Lung fibrosis, also known as pulmonary fibrosis, is a progressive lung disease characterized by the formation of scar tissue (fibrosis) in the lungs. (cowurine.com)
  • This scar tissue gradually replaces healthy lung tissue, making it difficult for the lungs to function properly. (cowurine.com)
  • Lung fibrosis can occur as a complication of autoimmune or connective tissue diseases, such as rheumatoid arthritis, systemic sclerosis (scleroderma), lupus, polymyositis, and dermatomyositis. (cowurine.com)
Toxicity8
  • Here, using A549 human lung cells or BEAS-2B cells lunc cells, we show that the cell toxicity of BLM can be suppressed by addition of inorganic polyphosphate (polyP), a physiological polymer that accumulates and is released from platelets. (nih.gov)
  • This case illustrates that eosinophilic pneumonia may be a late sequela of bleomycin toxicity, and may respond dramatically to steroid treatment. (medscape.com)
  • He claims the Gemcitabine (The G in AVG) that replaces Bleomycine and Dacarbazine has less lung-toxicity and less side effects. (cancer.org)
  • The lung toxicity that is caused by Bleo is a serious side effect for lots of people. (cancer.org)
  • Hi there, my dad had gone through 4 cycles of ABVD and 1/2 way through he had the Bleomycin removed due to mild lung toxicity. (cancer.org)
  • Some published reports have suggested that the risk of pulmonary toxicity may be increased when bleomycin is used in combination with G-CSF (filgrastim) or other cytokines. (cancermonthly.com)
  • Because of lack of specificity of the clinical syndrome, the identification of patients with pulmonary toxicity due to BLENOXANE (bleomycin sulfate for injection, USP) has been extremely difficult. (cancermonthly.com)
  • Pulmonary fibrosis is the most severe toxicity associated with bleomycin. (druglib.com)
Characterizing bleomycin-induced1
  • CPMG-T(2) and Hahn-T(2) measurements can be valuable as a potentially noninvasive method for characterizing bleomycin-induced lung injury and pathologically related lung disorders. (nih.gov)
Acute lung i2
  • The molecular mechanisms of acute lung injury resulting in inflammation and fibrosis are not well established. (jci.org)
  • Our results provide direct evidence that eosinophils undergo degranulation during transmigration of arterioles during bleomycin-induced acute lung injury, suggesting that degranulation may play an important role during eosinophil arteriolar transmigration in bleomycin-injured lung. (nih.gov)
Fibroblasts7
  • Although the pathogenic pathways involved in IPF have not been fully elucidated, IPF is believed to be caused by repetitive alveolar epithelial cell injury and dysregulated repair, in which there is uncontrolled proliferation of lung fibroblasts and differentiation of fibroblasts into myofibroblasts, which excessively deposit extracellular matrix (ECM) proteins in the interstitial space. (ersjournals.com)
  • In vitro experiments with primary lung fibroblasts from patients with IPF and from control donors, and in vivo studies in animal models of lung fibrosis, are summarised. (ersjournals.com)
  • A portion of the rat CTGF gene was cloned and used to show that primary isolates of both murine and human lung fibroblasts express CTGF mRNA in vitro. (utmb.edu)
  • There was a greater than twofold increase in CTGF expression in both human and murine lung fibroblasts 2, 4, and 24 h after the addition of TGF- β1 in vitro. (utmb.edu)
  • In vivo differences in the CTGF expression between the two mouse strains were not due to an inherent inability of BALB/c lung fibroblasts to respond to TGFβ1 because fibroblasts from untreated BALB/c mouse lung upregulated their CTGF message when treated with TGF-β1 in vitro. (utmb.edu)
  • These data demonstrate that CTGF is expressed in lung fibroblasts and may play a role in the pathogenesis of lung fibrosis. (utmb.edu)
  • then transition to using primary human lung fibroblasts purchased from Lonza to determine if the RNAseq data can be replicated. (aspetjournals.org)
Intratracheal4
  • NMR, histologic, and biochemical (collagen content measurement) analyses were performed 1, 2, 4, and 8 weeks after intratracheal instillation of saline (control lungs) or 10 U/kg bleomycin sulfate. (nih.gov)
  • In our study, we mimicked IPF by administering intratracheal bleomycin , and we administered oral URB878 at a dose of 5 mg/kg. (bvsalud.org)
  • The most frequently used model to study IPF involves intratracheal delivery of the DNA-damaging agent bleomycin to mice. (nih.gov)
  • 1983. Chronic airway obstruction and bronchiectasis in the rat after intratracheal bleomycin. (nih.gov)
Mice were intratracheally2
  • C57BL/6 J male mice were intratracheally administered bleomycin (3 U/kg, ITB), to induce pulmonary inflammation and acute injury, or saline and were treated with 50 μL OA-NO2 (50 μg) or vehicle in the same instillation and 72 h post-exposure to assess anti-inflammatory properties. (nih.gov)
  • Female adult mice were intratracheally instilled with bleomycin (3.33 U/kg) and lungs were isolated at day 9-11 following bleomycin. (nih.gov)
Induce2
  • The most widely used model until then was to apply bleomycin into the mouse lungs to induce damage, in an attempt to reproduce the environmental insult. (eurekalert.org)
  • We employ experimental models of pulmonary pathologies such as mouse exposure to cigarette smoke or other pollutants, as well as the administration into the respiratory tract of bleomycin to induce fibrosis, or of proteases to induce pulmonary emphysema. (univ-orleans.fr)
Doses of bleomycin1
  • The authors conclude that a stimulation/inhibition relationship exists between bleomycin and taurine on cellular oxidation at subcytotoxic doses of bleomycin, and suggest that the oxidative effect of the intracellular bleomycin/iron complex is important in the initiation of the fibrotic process. (cdc.gov)
Administration of bleomycin2
  • CTGF mRNA expression was upregulated in the sensitive, but not in the resistant, mouse strain after administration of bleomycin. (utmb.edu)
  • Patients with creatinine clearance values of less than 50 mL/min should be treated with caution and their renal function should be carefully monitored during the administration of bleomycin. (druglib.com)
Agent bleomycin3
  • Lung toxicities resulting from the chemotherapeutic agent bleomycin encompass a variety of pathological changes, including bronchiolitis obliterans organizing pneumonia, interstitial pneumonitis and progressive interstitial fibrosis. (medscape.com)
  • A variety of cancers are treated with the anti-tumor agent bleomycin, though its disease-fighting properties remain poorly understood. (sciencedaily.com)
  • WT, Sting-/- and type I IFN receptor (Ifnar1-/-) deficient mice were treated with saline (NaCl) or the fibrosis inducing agent (bleomycin, BLM 3 mg/kg intranasaly) and the lungs were collected after 14 days. (univ-orleans.fr)
Sulfate13
  • Each vial of Amneal Biosciences' product contains 15,000 IU of Bleomycin Sulfate Powder for Injection, which is equivalent to Bleomycin Sulfate USP 15 units (1000 IU of Bleomycin Sulfate Powder for Injection = 1 unit of Bleomycin Sulfate USP). (nih.gov)
  • Due to the current critical shortage of Bleomycin Sulfate for Injection, USP, 15 units and 30 units per vial in the United States (U.S.) market, Amneal Biosciences is coordinating with the U.S. Food and Drug Administration (FDA) to increase the availability of Bleomycin Sulfate for Injection, USP, 15 units per vial. (nih.gov)
  • Amneal Biosciences has initiated temporary importation of a non-FDA approved product, Bleomycin Sulfate Powder for Injection 15,000 IU per vial to the U.S. market: lot numbers GE50604, GE60003, GE60012. (nih.gov)
  • The Bleomycin Sulfate Powder for Injection 15,000 IU product being distributed by Amneal Biosciences was manufactured by Cipla Ltd. from its FDA-inspected facility in Verna, Goa, India, for Amneal Pharma Australia Pty Ltd and was sold in Australia under the WIllow Pharmaceutical label. (nih.gov)
  • At this time, no other entity except Amneal Biosciences is authorized by the FDA to import or distribute Amneal Pharma Australia Pty Ltd.'s Bleomycin Sulfate Powder for Injection 15,000 IU product. (nih.gov)
  • FDA has not approved the Bleomycin Sulfate Powder for Injection 15,000 IU product being distributed by Amneal Biosciences in the United States. (nih.gov)
  • Amneal Biosciences' Bleomycin Sulfate Powder for Injection 15,000 IU product contains the same active ingredient, bleomycin sulfate, in the same strength as the U.S. FDA-approved Bleomycin Sulfate for Injection, USP, 15 units per vial. (nih.gov)
  • Bleomycin Sulfate Powder for Injection 15,000 IU product being distributed by Amneal Biosciences is approved in Australia and is dispensed with a Medication Guide. (nih.gov)
  • This letter is not intended as a complete description of the benefits and risks related to the use of Bleomycin Sulfate Powder for Injection 15,000 IU. (nih.gov)
  • Please refer to the package insert for the U.S. FDA-approved Bleomycin Sulfate for Injection, USP for full prescribing information. (nih.gov)
  • Please note that the barcode used for Amneal Biosciences' Bleomycin Sulfate Powder for Injection, 15,000 IU product may not be appropriately recognized by scanning systems used in the United States. (nih.gov)
  • The Bleomycin Sulfate Powder for Injection 15,000 IU product distributed by Amneal Biosciences should be handled exactly as you have handled the U.S. FDA-approved Bleomycin Sulfate for Injection, USP. (nih.gov)
  • bleomycin sulfate. (cancermonthly.com)
Transplantation4
  • In international guidelines for the management of IPF, published in 2011 [ 4 ], the treatment options that were strongly recommended were limited to oxygen supplementation and lung transplantation. (ersjournals.com)
  • Human and serologic (hepatitis C virus, hepatitis B virus, HHV-8, Herpesvirus 8 and and cytomegalovirus) evaluation for lung transplantation. (cdc.gov)
  • The 75 patients (38 male), who were candidates for Conversely, Japanese researchers failed to confirm the lung transplantation, were all born and living in Italy. (cdc.gov)
  • Treatments for fibrotic lung disease have been only moderately successful, and lung transplantation is often needed. (nih.gov)
Chemotherapy4
  • Bleomycin is a type of antibiotic that is only used in cancer chemotherapy. (medlineplus.gov)
  • A number of substances can be used for this, such as talc, the antibiotic doxycycline, or a chemotherapy drug like bleomycin. (cancer.org)
  • Myelodysplastic Syndrome (MDS) and Acute Myeloid Leukemia (AML): Monitor patients with breast and lung cancer using RELEUKO in conjunction with chemotherapy and/or radiotherapy for signs and symptoms of MDS/AML. (nih.gov)
  • Examples include some chemotherapy drugs (such as bleomycin and methotrexate), certain antibiotics (such as nitrofurantoin and sulfasalazine), and some cardiovascular medications (such as amiodarone). (cowurine.com)
Tumors3
  • It is also used to treat pleural effusions (a condition when fluid collects in the lungs) that are caused by cancerous tumors. (medlineplus.gov)
  • If you have bulky tumors I would go with the ABVD and just have the doctor monitor your lungs. (cancer.org)
  • His clinical research has involved the pathology of coronary atherosclerosis, sudden cardiac death, cardiomyopathy, cardiac tumors, carcinomas of the lung, interstitial lung disease, and mesotheliomas of the peritoneum and pleura. (umaryland.edu)
Respiratory7
  • 2021. Automated monitoring of respiratory rate as a novel humane endpoint: A refinement in mouse metastatic lung cancer models. (awionline.org)
  • Pulmonary fibrosis (PF) is a progressive fibrosing illness, characterised by extreme accumulation of extracellular matrix (ECM) and reworking of the lung structure, which lastly end in respiratory failure. (ncbcs.org)
  • Acute respiratory distress syndrome (ARDS): Evaluate patients who develop fever and lung infiltrates or respiratory distress for ARDS. (nih.gov)
  • Our team studies danger signals, sensors and signaling pathways involved in lung inflammation in conditions such as Acute Respiratory Distress Syndrome (ARDS), pulmonary fibrosis and emphysema. (univ-orleans.fr)
  • Unbalanced repair results in lung scarring leading to a gradual loss of respiratory function. (univ-orleans.fr)
  • Certain herbs and herbal formulations are believed to have properties that support respiratory health and may help in managing symptoms associated with lung fibrosis. (cowurine.com)
  • Lung fibrosis can be effectively treated using cow urine as it has various medicinal properties like anti-fungal, anti-bacterial, anti-infectious etc., which helps treat lung fibrosis and other respiratory problems. (cowurine.com)
Pirfenidone11
  • Pirfenidone (PD) is known for its antifibrotic effects in the bleomycin (BL) hamster model of lung fibrosis. (nih.gov)
  • The aim of this study was to investigate whether pirfenidone inhibits fibrocyte pool size in the lungs of bleomycin-treated mice. (nih.gov)
  • Bleomycin (100 mg/kg) was infused with osmotic pumps into C57BL/6 mice, and pirfenidone (300 mg/kg/day) was orally administered daily for 2 wk. (nih.gov)
  • In a therapeutic setting, pirfenidone administration was initiated 10 days after bleomycin treatment. (nih.gov)
  • For chemotaxis assay, lung fibrocytes were isolated with immunomagnetic selection (CD45-positive mesenchymal cells) after culture and allowed to migrate toward chemokines in the presence or absence of pirfenidone. (nih.gov)
  • Pirfenidone is an orally active small molecule that has recently been evaluated in large clinical trials for the treatment of idiopathic pulmonary fibrosis, a fatal disease in which the uncontrolled deposition of extracellular matrix leads to progressive loss of lung function. (ersjournals.com)
  • This review describes the activity of pirfenidone in several well-characterised animal models of fibrosis in the lung, liver, heart and kidney. (ersjournals.com)
  • Subsequently, pirfenidone has been shown to attenuate fibrosis in numerous animal models, including fibrosis of the lung, liver, heart and kidney. (ersjournals.com)
  • The most extensive clinical studies of pirfenidone are for treatment of IPF, a chronic interstitial lung disease characterised by the unregulated deposition of ECM leading to the unremitting destruction of normal lung. (ersjournals.com)
  • 1,000 patients, support a protective effect of pirfenidone to limit the decline of lung function in patients with IPF [ 7 ]. (ersjournals.com)
  • Unless we have this vocabulary, we should probably consider that pirfenidone use be limited to patients who meet the inclusion criteria of the CAPACITY (Clinical Studies Assessing Pirfenidone in IPF: Research of Efficacy and Safety Outcomes) trials, i.e. forced vital capacity ≥50% predicted and a diffusing capacity of the lung for carbon monoxide ≥35% pred [ 5 ]. (ersjournals.com)
Pulmonary injury1
  • 13. Nodular form of bleomycin-related pulmonary injury in patients with osteogenic sarcoma. (nih.gov)
Injection4
  • Some people who have received bleomycin injection for treatment of lymphomas had a severe allergic reaction. (medlineplus.gov)
  • tell your doctor and pharmacist if you are allergic to bleomycin or any of the ingredients in bleomycin injection. (medlineplus.gov)
  • You should not become pregnant while you are receiving bleomycin injection. (medlineplus.gov)
  • It is recommended that Bleomycin for Injection, USP be administered under the supervision of a qualified physician experienced in the use of cancer chemotherapeutic agents. (druglib.com)
Reducing lung fibrosis1
  • Our results highlight the ability of CSD peptide to reduce fibrocyte migration to the lungs, thereby reducing lung fibrosis," says Dr. Tourkina. (nih.gov)
Fibrotic lung diseases2
Model of lung fibrosis2
  • We evaluated whether pretreatment of hamsters with PD could influence the effects of BL-induced overexpression of platelet-derived growth factor (PDGF)-A and PDGF-B genes and proteins in the same model of lung fibrosis. (nih.gov)
  • Longitudinal free-breathing MRI measurement of murine lung physiology in a progressive model of lung fibrosis. (uc.edu)
Vitro2
  • Bleomycin has been shown to be mutagenic both in vitro and in vivo. (cancermonthly.com)
  • A study was undertaken to determine the expression of 5-HT receptors in IPF and experimental lung fibrosis and to investigate the effects of therapeutic inhibition of 5-HTR 2A/B signalling on lung fibrosis in vivo and in vitro. (bmj.com)
Treatment14
  • PD treatment also decreased the mitogenic activity in the BAL fluid from BL-treated hamster lungs. (nih.gov)
  • A 44-year-old Hispanic man with a primary mediastinal seminoma complicated by superior vena cava syndrome underwent treatment with four cycles of bleomycin, etoposide and cisplatin. (medscape.com)
  • Bleomycin is an antineoplastic agent derived from Streptomyces verticillus , and is widely used in the treatment of testicular carcinoma, Hodgkin's and non-Hodgkin's lymphoma as well as squamous cell carcinomas of the head and neck. (medscape.com)
  • [ 1 ] This report illustrates a rare case of severe bleomycin-associated eosinophilic pneumonia (EP) that responded to steroid treatment. (medscape.com)
  • by bleomycin treatment. (sdu.edu.tr)
  • Following 4 weeks of bleomycin treatment, the lungs were examined histologically (using light and electron microscopes) and the hydroxyproline level was measured at 4th, 6th, 8th, and 10th weeks of the experiment. (sdu.edu.tr)
  • My dad finished out his treatment without the Bleomycin. (cancer.org)
  • pulmonary fibrosis, 2 with sarcoidosis, 3 with pulmonary fibrosis secondary to bleomycin treatment). (cdc.gov)
  • A study in F344-type male rats demonstrated an increased incidence of nodular hyperplasia after induced lung carcinogenesis by nitrosamines, followed by treatment with bleomycin. (cancermonthly.com)
  • The treatment consisted of introducing the telomerase gene into the lung cells using gene therapy. (eurekalert.org)
  • IL-6 recombinant protein treatment increased AEC2 proliferation, renewal, and reduced epithelium permeability of bleomycin injured Tlr4-/- mice in vivo. (ca.gov)
  • Achievement of the goals of this application will result in a completely novel approach to the treatment of lung diseases. (ca.gov)
  • This treatment, they found, slowed monocyte and fibrocyte migration to the lungs and also slowed disease progression in the mice. (nih.gov)
  • Moreover, with treatment, lung function, as measured by forced vital capacity, which measures the total air that can be exhaled, continues to decline during therapy. (aspetjournals.org)
Idiopathic10
  • Idiopathic pulmonary fibrosis (IPF) is a progressive and ultimately fatal disease characterised by fibrosis of the lung parenchyma and loss of lung function. (ersjournals.com)
  • The deadly interstitial lung condition known as idiopathic pulmonary fibrosis (IPF) worsens over time and for no apparent reason. (bvsalud.org)
  • The 42 patients ing in 1 of 16 with idiopathic pulmonary arterial without PH included 29 patients with cystic fibrosis (PAP hypertension), 5 of 29 with cystic fibrosis, and 3 of 13 with 21.1 + 3.3 mm Hg) and 13 patients with interstitial lung interstitial lung disease. (cdc.gov)
  • Idiopathic pulmonary fibrosis (IPF) is a fatal lung disease for which no effective medical therapies exist. (ca.gov)
  • Despite the increased knowledge through basic and clinical research over the last decade, idiopathic pulmonary fibrosis (IPF) remains one of the most elusive lung disorders associated with a fatal outcome. (ersjournals.com)
  • Pulmonary fibrosis is associated with numerous diffuse parenchymal lung diseases, of which the most common are idiopathic pulmonary fibrosis (IPF) and sarcoidosis [ 1 ]. (ersjournals.com)
  • IPF is the most common and most life-threatening of the idiopathic interstitial pneumonias (IIPs), a heterogeneous group of diffuse parenchymal lung disorders that are diagnosed on the basis of clinical, radiological and histological features [ 1 ]. (ersjournals.com)
  • Idiopathic fibrotic nonspecific interstitial pneumonia is also a progressive fibrotic lung disease with a significant mortality, although it has a better prognosis than IPF [ 16 ]. (ersjournals.com)
  • Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive interstitial lung disease (ILD) characterized by unexplained lung's scarring and extensive remodeling [ 1 , 2 ] . (medsci.org)
  • Lung fibrosis can have various causes, including environmental factors, occupational exposure to certain substances, certain medications, autoimmune diseases, and sometimes the exact cause is unknown (idiopathic pulmonary fibrosis). (cowurine.com)
Injury12
  • Epithelial-fibroblast interactions in bleomycin-induced lung injury and repair. (nih.gov)
  • The response of the NMR relaxation times (T(1), CPMG T(2), and Hahn T(2)) to bleomycin-induced lung injury was studied in excised, unperfused rat lungs. (nih.gov)
  • The spin-spin relaxation times for the fast and intermediate components of the CPMG decay (T(2f) and T(2i), respectively) increased 1 week after bleomycin injury (acute inflammatory stage) and then progressively decreased during the following 2-8 weeks (i.e., with the development of the chronic, fibrotic stage of the injury). (nih.gov)
  • Lung water content increased 1 week after injury. (nih.gov)
  • Our results indicate that NMR relaxation time measurements (particularly T(2)) reflect the structural changes associated with bleomycin injury. (nih.gov)
  • Here we show that human primary lung adenocarcinomas are characterized by the emergence of regenerative cell types, typically seen in response to lung injury, and by striking infidelity among transcription factors specifying most alveolar and bronchial epithelial lineages. (nature.com)
  • Fatty acid nitroalkenes inhibit the inflammatory response to bleomycin-mediated lung injury. (nih.gov)
  • Secretory leukocyte protease inhibitor gene deletion alters bleomycin-induced lung injury, but not development of pulmonary fibrosis. (nottingham.ac.uk)
  • The lung has evolved mechanisms for repairing injury due to exogenous noxious agents. (ca.gov)
  • The timely repair of lung injury is essential and determines the outcome of life or death. (ca.gov)
  • Our preliminary studies have led to the hypothesis that interactions between components of the innate immune system expressed by lung alveolar epithelial cells and the cell surface glycosaminoglycan hyaluronan are essential for stem cell renewal and lung repair after injury, and loss of this interaction results in severe lung fibrosis. (ca.gov)
  • We have found that Tlr4 expression in alveolar type II cells was down regulated following bleomycin lung injury in a similar pattern to the damage and renewal of AEC2s after lung injury. (ca.gov)
Fibrogenesis1
  • To assess the effects of 5HTR 2A/B inhibition on fibrogenesis in vivo, mice were subjected to bleomycin-induced lung fibrosis and treated with the 5-HTR 2A/B antagonist terguride (or vehicle) in a therapeutic approach (days 14-28 after bleomycin). (bmj.com)
Vivo1
  • Zeldin's group found that TH17 cell numbers in the lung are significantly lower in COX-2 null mice, but not COX-1 null mice, relative to wild type mice following allergen sensitization/exposure in vivo. (nih.gov)
Severe5
  • Bleomycin may cause severe or life-threatening lung problems. (medlineplus.gov)
  • Severe lung problems may occur more commonly in older patients and in those receiving higher doses of this medication. (medlineplus.gov)
  • Dysregulation of Mesenchymal Cell Survival Pathways in Severe Fibrotic Lung Disease: The Effect of Nintedanib Therapy. (uc.edu)
  • A severe idiosyncratic reaction consisting of hypotension, mental confusion, fever, chills, and wheezing has been reported in approximately 1% of lymphoma patients treated with bleomycin. (druglib.com)
  • Pulmonary Recovery 12 Months after Non-Severe and Severe COVID-19: The Prospective Swiss COVID-19 Lung Study. (unibe.ch)
Therapeutic6
  • In conclusion, bleomycin-induced lung pathology required the inflammasome and IL-1R1/MyD88 signaling, and IL-1 represented a critical effector of pathology and therapeutic target of chronic lung inflammation and fibrosis. (jci.org)
  • Elucidating the mechanisms by which endogenous matrix and innate immune components interact to promote stem cell renewal could lead to novel therapeutic approaches to lung diseases. (ca.gov)
  • The concept of IPF as a lethal malignant disorder of the lung might extend beyond the pathogenic link between these two diseases and disclose new pathogenic mechanisms leading to novel therapeutic options, adopted from cancer biology. (ersjournals.com)
  • In conclusion, LPEs might ameliorate the BLM-induced lung fibrosis, thus suggesting that LPEs might function a possible therapeutic strategy for PF. (ncbcs.org)
  • Asbestosis and chronic hypersensitivity pneumonitis are environment-induced lung fibrotic diseases with a poor prognosis and limited therapeutic possibilities [ 14 , 15 ]. (ersjournals.com)
  • Blockade of 5-HTR 2A/B signalling by terguride reversed lung fibrosis and is thus a promising therapeutic approach for IPF. (bmj.com)
Methotrexate1
Diseases1
  • Our research studies aim to identify the cellular and molecular mechanisms underlying chronic lung diseases to guide the development of new therapies. (uc.edu)
Specificity2
  • Roy is particularly interested in the subtle biochemistry of bleomycin, including the specificity of its binding regions along the DNA strand and the drug's detailed mechanisms of DNA cleavage. (sciencedaily.com)
  • HHV-8 latency-associated nuclear antigen-1 this assay had the highest sensitivity of the assays evaluat- and HHV-8 viral cyclin gene were identified in the lung tis- ed (97.1%) and a specificity of 83.2% (8). (cdc.gov)
Murine lung1
  • Because TGF-β1 expression is upregulated in several models of fibroproliferative lung disease, we asked whether CTGF is also upregulated in a murine lung fibrosis model and whether CTGF could mediate some of the fibrogenic effects associated with TGF-β1. (utmb.edu)
Antineoplastic1
Deadly interstitial1
  • The most prevalent and deadly interstitial lung disease is IPF, a chronic and progressive condition that currently affects an estimated 132,000 to 200,000 people and causes approximately 50,000 new cases and 40,000 deaths each year in the U.S. alone. (nih.gov)
Secretion2
  • Bleomycin at 5 to 20 micrograms/milliliter had a moderate stimulatory effect on the secretion of superoxide-anion. (cdc.gov)
  • At 20 micrograms/milliliter, bleomycin inhibited cellular response to zymosan induced secretion of superoxide-anion. (cdc.gov)
Fibrocytes4
  • The lungs were removed, and single-cell suspensions were subjected to fluorescence-activated cell sorter (FACS) analysis to detect fibrocytes, which were defined as CD45 and collagen-I double-positive cells. (nih.gov)
  • Immunohistochemistry was performed on the lung specimens to quantify fibrocytes. (nih.gov)
  • These patients all had fibrocytes in their lungs, along with overexpressed CXCR4. (nih.gov)
  • Lungs from healthy controls, however, showed no fibrocytes or overexpressed CXCR4. (nih.gov)
Inflammatory3
  • In addition, nintedanib has shown consistent anti-fibrotic and anti-inflammatory activity in animal models of lung fibrosis. (ersjournals.com)
  • The histological changes, cell infiltration, pro-inflammatory cytokine production , inflammation , and nitrosative stress caused by bleomycin were all reduced by URB878. (bvsalud.org)
  • Our data clearly demonstrate for the first time that the inhibition of FAAH activity was able to counteract not only the histological alteration bleomycin -induced but also the cascade of related inflammatory events. (bvsalud.org)
Disease12
  • Tell your doctor if you have or have ever had lung disease. (medlineplus.gov)
  • Bleomycin is also used to treat Hodgkin's lymphoma (Hodgkin's disease) and non-Hodgkin's lymphoma (cancer that begins in the cells of the immune system) in combination with other medications. (medlineplus.gov)
  • IPF is a devastating and disabling progressive lung disease associated with a median survival of only 2-3 years after diagnosis [ 4 ]. (ersjournals.com)
  • 20. Computed tomography in the assessment of diffuse lung disease. (nih.gov)
  • αvβ6 integrin may be a potential prognostic biomarker in interstitial lung disease. (nottingham.ac.uk)
  • Consensus Gene Co-Expression Network Analysis Identifies Novel Genes Associated with Severity of Fibrotic Lung Disease. (uc.edu)
  • Notch3: A New Culprit in Fibrotic Lung Disease. (uc.edu)
  • Lung disease was assessed by scoring lung pathology and by measuring soluble collagen levels in lavage fluid. (dovepress.com)
  • In their study, Elena Tourkina, Ph.D., and her MUSC colleagues examined seven systemic sclerosis patients with interstitial lung disease. (nih.gov)
  • CSD peptide may, in fact, be valuable as a therapy for interstitial lung disease in systemic sclerosis patients. (nih.gov)
  • Altered monocyte and fibrocyte phenotype and function in scleroderma interstitial lung disease: reversal by caveolin-1 scaffolding domain peptide. (nih.gov)
  • Post-COVID Interstitial Lung Disease-The Tip of the Iceberg. (unibe.ch)
Macrophages3
  • Taken together, these data provide evidence that the protective effects of PD against BL-induced lung fibrosis may be mediated by a reduction in PDGF isoforms produced by lung macrophages. (nih.gov)
  • Fluoromicroscopic studies of bleomycin-induced intracellular oxidation in alveolar macrophages and its inhibition by taurine. (cdc.gov)
  • A fluoromicroscopic method for determining bleomycin (11056067) induced intracellular oxidation in alveolar macrophages (AM) and the inhibition of the bleomycin effect by taurine was reported. (cdc.gov)
Pneumonitis2
Pathology1
  • Exogenous rIL-1β recapitulated a high degree of bleomycin-induced lung pathology, and specific blockade of IL-1R1 by IL-1 receptor antagonist dramatically reduced bleomycin-induced inflammation. (jci.org)
Chronic3
  • Inhibition of Fatty Acid Amide Hydrolase (FAAH) Regulates NF-kb Pathways Reducing Bleomycin-Induced Chronic Lung Inflammation and Pulmonary Fibrosis. (bvsalud.org)
  • Bleomycin insult results in expression of neutrophil and lymphocyte chemotactic factors, chronic inflammation, remodeling, and fibrosis. (jci.org)
  • Repeated exposure to cigarette smoke is the leading cause of chronic lung inflammation and pulmonary emphysema characterized by irreversible damage of alveolar walls. (univ-orleans.fr)
Collagen4
  • The control lungs showed no important NMR, water content, histologic, or collagen content changes. (nih.gov)
  • T(1) and T(2) data were directly correlated with lung water content and inversely correlated with collagen content. (nih.gov)
  • Terguride-treated mice had significantly improved lung function and histology and decreased collagen content compared with vehicle-treated mice. (bmj.com)
  • Histological lung sections stained with Red Sirius/Fast Green, which marks the collagen fibers in purple. (univ-orleans.fr)
Computerized tomography1
  • 17. [High-resolution volumetric computerized tomography of the lung: optimization of technique and image quality as a function of its clinical-diagnostic use and dose to the patient]. (nih.gov)
Histological1
Enzyme-linke1
  • Chemokines in the lung digests were measured with enzyme-linked immunosorbent assay. (nih.gov)
Usual interstit1
  • By definition, IPF is differentiated from other IIPs based on the presence of a pattern of usual interstitial pneumonia in lung histopathology. (ersjournals.com)
Accumulation1
  • Fibrocyte accumulation in the lungs of cystic fibrosis patients. (uc.edu)
Antibiotic1
  • The anti-cancer antitumor antibiotic bleomycin(s) (BLM) induces athyminic sites in DNA after its activation, a process that results in strand splitting. (nih.gov)
Saline1
  • We demonstrate elevated levels of PDGF-A and PDGF-B mRNAs in bronchoalveolar lavage (BAL) cells from lungs of BL-treated compared with saline control hamsters by RT-PCR analysis. (nih.gov)
Cancers3
  • Survival up to five years following diagnosis are presented for 10 leading cancers (female breast, colon, rectum, liver, lung, cervix, ovary, prostate, stomach and acute lymphoblastic leukemia in children) by race (black and white), state at diagnosis and stage at diagnosis (where applicable). (cdc.gov)
  • Acknowledging that the survival rate of IPF is worse than several cancers and that the similarities of the demographics of IPF compared with lung cancer are evident (figs 2 ⇓ , 3 ⇓ and 4 ⇓ ), we wish to link the concept of the aberrant fibroblast proliferation to cancer biology and alert the interests of basic and clinic scientists to provoke further research from an oncologist's view. (ersjournals.com)
  • Radiation therapy used to treat cancers in the chest or surrounding areas can cause lung fibrosis as a long-term complication. (cowurine.com)
Pathways1
  • A custom GSEA annotation file, assembled to query cell types and pathways related lung epithelial development and regeneration is provided in the Supplementary Dataset . (nature.com)
Interstitial pneumonia2
  • Methods and results Quantitative RT-PCR showed that the expression of 5-HTR 1A/B and 5-HTR 2B was significantly increased in the lungs of patients with IPF (n=12) and in those with non-specific interstitial pneumonia (NSIP, n=6) compared with transplant donors (n=12). (bmj.com)
  • Reply to: Pharmacotherapy for lung cancer with comorbid interstitial pneumonia: limited evidence requires appropriate evaluation. (unibe.ch)
Eosinophilic3
Progressive lung1
  • Furthermore, we observed a difference in lung progenitor cells, as well as cell surface hyaluronan, from patients with progressive lung fibrosis relative to normal donor lungs. (ca.gov)
Occur3
  • This reaction may occur immediately or several hours after the first or second dose of bleomycin is given. (medlineplus.gov)
  • Biochemical and structural changes that normally occur in lung fibrosis were also observed in our study. (sdu.edu.tr)
  • While long exposure to very high oxygen concentrations is a known cause of lung damage, after bleomycin administration, lung damage can occur at lower concentrations that are usually considered safe. (cancermonthly.com)
Ultrastructural Changes1
  • The present study was planned to investigate the ultrastructural changes and hydroxyproline level in the lungs of the mice induced. (sdu.edu.tr)
BALB1
  • A bleomycin-sensitive mouse strain (C57BL/6) and a bleomycin- resistant mouse strain (BALB/c) were given bleomycin, a known lung fibrogenic agent. (utmb.edu)
Patient3
  • Fully annotated count matrices are available for download at ( https://s3.amazonaws.com/dp-lab-data-public/lung-development-cancer-progression/PATIENT_LUNG_ADENOCARCINOMA_ANNOTATED.h5 and https://s3.amazonaws.com/dp-lab-data-public/lung-development-cancer-progression/MOUSE_LUNG_ADENOCARCINOMA_METASTASIS_ANNOTATED.h5 ). (nature.com)
  • Furthermore, we have make good progress on the study of AEC2 stem cells in IPF patient lungs. (ca.gov)
  • If bleomycin is used during pregnancy, or if the patient becomes pregnant while receiving this drug, the patient should be apprised of the potential hazard to the fetus. (druglib.com)
Molecule2
  • Following a binding event, a molecule of bleomycin can effectively slice through one or both strands of DNA. (sciencedaily.com)
  • Finally, we found that lung IL-1β production and inflammation in response to bleomycin required ASC, an inflammasome adaptor molecule. (jci.org)
Pleural1
  • When bleomycin is used to treat pleural effusions, it is mixed with liquid and placed in the chest cavity through a chest tube (plastic tube that is placed in the chest cavity through a cut in the skin). (medlineplus.gov)
Infiltrates1
  • He was subsequently treated with high-dose prednisone, resulting in a complete resolution of his symptoms and lung infiltrates. (medscape.com)