Bleomycin induced lung fibrosis. Medical search. Frequent questions

The deadly interstitial lung condition known as idiopathic pulmonary fibrosis (IPF) worsens over time and for no apparent reason. (bvsalud.org)
Idiopathic pulmonary fibrosis (IPF) is also a progressive and fatal fibrotic pulmonary disease without effective available therapies. (ersjournals.com)
Idiopathic pulmonary fibrosis (IPF) is a fatal disorder without an effective therapy to date. (atsjournals.org)
Idiopathic pulmonary fibrosis (IPF) is a relentlessly progressive and fatal disorder characterized by high-resolution computed tomography (HRCT) and histologic features of usual interstitial pneumonia (UIP) in adults over 50 years of age with exertional dyspnea, abnormal pulmonary function tests (PFTs), and ineffective therapy ( 1 , 2 ). (atsjournals.org)
Background Bronchiolisation of distal airspaces is an unexplained feature of idiopathic pulmonary fibrosis (IPF). (bmj.com)
Immunostaining for components of those pathways and mucins were performed on lung tissue obtained from patients with IPF (n=20), chronic obstructive pulmonary disease (n=13), idiopathic pulmonary artery hypertension (n=5) and from organ donors (n=6). (bmj.com)
Abnormal differentiation of the respiratory epithelium is a feature of idiopathic pulmonary fibrosis (IPF). (bmj.com)
Genetic variants associated with susceptibility to idiopathic pulmonary fibrosis in people of European ancestry: a genome-wide association study. (nature.com)
Single-cell RNA sequencing identifies diverse roles of epithelial cells in idiopathic pulmonary fibrosis. (nature.com)
Transforming growth factor-β (TGFβ) is a major mediator of normal wound healing and of pathological conditions involving fibrosis, such as idiopathic pulmonary fibrosis. (aspetjournals.org)
Mesenchymal cells in the lung are crucial during development, but also contribute to the pathogenesis of fibrotic disorders, including idiopathic pulmonary fibrosis (IPF), the most common and deadly form of fibrotic interstitial lung diseases. (researchgate.net)
Aberrant vascular remodeling contributes to the progression of many aging-associated diseases, including idiopathic pulmonary fibrosis (IPF), where heterogeneous capillary density, endothelial transcriptional alterations and increased vascular permeability correlate with poor disease outcomes. (researchgate.net)
During the past decade important progress has been made regarding the pathogenesis of idiopathic pulmonary fibrosis (IPF), which is the most devastating form of idiopathic interstitial pneumonia with a median survival of 3 years. (ersjournals.com)
Idiopathic pulmonary fibrosis (IPF) is the most frequent and devastating form of idiopathic interstitial pneumonia [ 1 ]. (ersjournals.com)
Here, we identified miR-323a-3p to be downregulated in the epithelium of lungs with bronchiolitis obliterans syndrome (BOS) after lung transplantation, idiopathic pulmonary fibrosis (IPF), and murine bleomycin-induced fibrosis. (escholarship.org)
Juvenile idiopathic arthritis (JIA) treatment is aimed at inducing remission to prevent joint destruction and disability. (cn1699.cn)
Interstitial lung diseases such as idiopathic pulmonary fibrosis (IPF) are caused by persistent micro-injuries to alveolar epithelial tissues accompanied by aberrant repair processes. (lu.se)
Of the idiopathic interstitial pneumonias, idiopathic usual interstitial pneumonia (UIP) is the most common condition associated with honeycomb lung. (medscape.com)
In honeycomb lung associated with idiopathic UIP, most patients are over 50 years old and have had symptoms for over 6 months. (medscape.com)
The clinical symptoms of idiopathic pulmonary fibrosis (IPF) are nonspecific. (medscape.com)
Dyspnea, which is the most prominent symptom in idiopathic pulmonary fibrosis, usually begins insidiously and is often progressive. (medscape.com)
The reported median duration of symptoms before the diagnosis of idiopathic pulmonary fibrosis is established is one to two years. (medscape.com)
Approximately 5% of patients have no presenting symptoms when idiopathic pulmonary fibrosis is diagnosed. (medscape.com)
Among asymptomatic patients with idiopathic pulmonary fibrosis (diagnosed by radiographic abnormalities found on routine chest radiograph screening and lung biopsy showing usual interstitial pneumonia), symptoms developed approximately 1000 days after the recognition of the radiographic abnormality. (medscape.com)
Oxidant stress from smoking may damage alveolar epithelial cells and contribute to the pathogenesis of idiopathic pulmonary fibrosis. (medscape.com)
[ 36 ] Any patient with idiopathic pulmonary fibrosis who is a current smoker should be encouraged to quit. (medscape.com)
Physicians should pay attention to historical clues that may suggest the presence of obstructive sleep apnea (OSA) because a 2009 study demonstrated the high prevalence of OSA in patients with idiopathic pulmonary fibrosis. (medscape.com)
Fifty outpatients with stable idiopathic pulmonary fibrosis were prospectively evaluated for the presence of OSA. (medscape.com)
[ 37 ] Therefore, the prevalence of OSA in this sample was 88%, suggesting that OSA in patients with idiopathic pulmonary fibrosis may have been previously underrecognized. (medscape.com)
In most patients with idiopathic pulmonary fibrosis (IPF), the physical examination reveals fine bibasilar inspiratory crackles (Velcro crackles). (medscape.com)
Additionally, digital clubbing is seen in 25-50% of patients with idiopathic pulmonary fibrosis. (medscape.com)
[ 12 ] Extrapulmonary involvement does not occur with idiopathic pulmonary fibrosis, and, therefore, physical examination findings do not help to confirm the diagnosis. (medscape.com)
Pulmonary hypertension is a common comorbidity in patients with idiopathic pulmonary fibrosis, and an estimated 20-40% of patients with idiopathic pulmonary fibrosis who are evaluated or listed for lung transplantation have pulmonary hypertension at rest. (medscape.com)

Here, we investigated bleomycin-induced lung injury responses in young and aged mice at single-cell resolution to gain insights into the cellular and molecular contributions of aging to fibrosis. (researchgate.net)
Objective： To evaluate the effect of water channel aquaporin 4 （AQP4） on bleomycininduced lung fibrosis in mice. (zjujournals.com)
Methods： In wild type and AQP4 gene knockout （AQP4-/-） mice， lung fibrosis was induced by injection of bleomycin （3 mg/kg） into the trachea and saline injection was used as a control. (zjujournals.com)
At d3， 7， 14， 28 after bleomycintreatment， mice were randomly sacrificed in batch and the lung coefficient was determined. (zjujournals.com)
There was a tendency that serum TGFβ1 and TNFα levels increased in bleomycintreated mice， but no significant difference was found between wild type and AQP4-/- mice. (zjujournals.com)
AQP4knockout showed no effects on pathological changes of lung tissues with HE staining and Massons staining in mice with bleomycininduced lung fibrosis. (zjujournals.com)
Conclusion： AQP4 might not be involved in bleomycininduced lung fibrosis in mice. (zjujournals.com)
Th2- and Th17-like cell proportions in skin-homing Tregs were increased in bleomycin-treated Fli1 +/− mice compared with bleomycin-treated wild-type mice, whereas Th1-, Th2-, and Th17-like cell proportions in splenic Tregs were comparable. (biomedcentral.com)
However, mice with kidney fibrosis had increased metastasis to their lungs. (tmc.edu)
Pulmonary treatment of mice with bleomycin-induced pulmonary fibrosis shows strong inhibition of the progression of the disease and significant prolongation of animal survival. (cdc.gov)
IFN-γ production is upregulated in lung cells (LC) of bleomycin-treated C57BL/6 mice. (tau.ac.il)
IFN-γ mRNA in LC from bleomycin-treated mice peaked 3 days after intratracheal instillation. (tau.ac.il)
IL-12 mRNA levels were increased at 1 day in LC of bleomycin-treated mice. (tau.ac.il)
To define the role of endogenous IFN-γ in the evolution of bleomycin lung injury, we compared the effect of bleomycin in mice with a targeted knockout mutation of the IFN-γ gene (IFN-γ knockout) and wild-type mice. (tau.ac.il)
Our data show that enhanced IFN-γ production in the lungs of bleomycin-treated mice is at least partly IL-12 and IL-18 dependent. (tau.ac.il)
Absence of IFN-γ in IFN-γ knockout mice does not increase pulmonary fibrosis. (tau.ac.il)
Intratracheal administration of PDGF-BB in mice is sufficient to induce TNF-alpha Proteins Recombinant Proteins mesenchymal cell proliferation and collagen deposition (47). (amparinhibitor.com)
In vivo inhibition of Src protects against bleomycin-induced fibrosis in mice (64). (amparinhibitor.com)
In this study we show Ogg1-targeting siRNA mitigates bleomycin-induced pulmonary fibrosis in male mice, highlighting OGG1 as a tractable target in lung fibrosis. (lu.se)
In addition, TH5487 decreases levels of pro-inflammatory mediators, inflammatory cell infiltration, and lung remodeling in a murine model of bleomycin-induced pulmonary fibrosis conducted in male C57BL6/J mice. (lu.se)

These results suggest that sivelestat alleviated bleomycin-induced pulmonary fibrosis via inhibition of both TGF-β activation and inflammatory cell recruitment in the lung. (ersjournals.com)

Sivelestat significantly inhibited the increase in lung collagen content, fibrotic changes, the numbers of total cells (including macrophages, neutrophils and lymphocytes), the levels of the active form of TGF-β1 and phospho-Smad2 in bleomycin-induced early-stage pulmonary fibrosis. (ersjournals.com)
The degree of fibrosis is a major determinant of clinical outcome in patients with fibrotic pulmonary diseases because current therapies are ineffective or only marginally effective. (ersjournals.com)
Recent studies have suggested that increased collagen turnover and fibrotic changes are earlier events within 14 days in the BLM-induced fibrosis [ 8 - 11 ] and these changes were used commonly as a pulmonary fibrosis model. (ersjournals.com)
To elucidate the fibrotic effect on tumor organotropism we induced fibrosis in the organotropic lungs and in the non-organotropic kidney of two mouse models of breast cancer, the 4T1 murine cancer cell line model and the genetic MMTV-Pymt model, both of which are known to metastasize. (tmc.edu)
In fact, while fibrotic lungs showed decreased expression of endothelial tight gap junction protein Claudin-5, the fibrotic kidneys had an elevated expression of Claudin-5. (tmc.edu)
Assessment parameters including changes in physical and physiological parameters along with alterations in lung injury markers, oxidative-stress, inflammatory status and fibrotic condition were evaluated during the study. (ijpsonline.com)
The total lung volume increased significantly (p=0.001) and dose-dependently compared to Saline control, although the functional lung volume decreased due to development of lesions (oedema or fibrotic tissue formation). (lu.se)
OGG1 and SMAD7 interact to induce fibroblast proliferation and differentiation and display roles in fibrotic murine and IPF patient lung tissue. (lu.se)
In pathology, honeycomb lung refers to the fibrotic cystic changes (honeycomb changes) seen in the lungs of those with certain end-stage interstitial lung diseases (ILDs). (medscape.com)

Bleomycin (BLM)-induced inflammation and fibrosis represent an experimental model for IPF as well as ALI/ARDS. (ersjournals.com)
Furthermore, in the context of respiratory research, local expertise include a large number of animal models including bleomycin-induced pulmonary inflammation and fibrosis, endotoxin- and ventilation- induced acute lung injury, ovalbumin-induced pulmonary allergic inflammation, as well as KRAS-driven or chemically-induced lung cancer. (ersnet.org)
In addition, bronchoalveolar lavage fluid (BALF) was analysed for inflammatory cells and proteins, as well as histological analysis was performed and scored for inflammation and fibrosis. (lu.se)
We observed increased MRI signal correlating to inflammation and fibrosis as confirmed by BAL and tissue markers. (lu.se)

It is also thought that BMP-7 reverses fibrosis and EMT through reduction in monocyte infiltration into inflamed tissue. (wikipedia.org)

In human lung tissue TGF-β 1 produced by bronchial epithelial cells stimulates fibroblasts to proliferate in vitro. (bmj.com)
and both can effectively induce epithelial mesenchymal transition (EMT) or abnormally activated fibroblasts. (frontiersin.org)
In this study, we examined the underlying processes of TGFβRI kinase activity in myofibroblast conversion of human lung fibroblasts using specific inhibitors of TGFβRI (SD-208) and p38 mitogen-activated kinase (SD-282). (aspetjournals.org)
Microarray analysis of human lung fibroblasts identified molecular fingerprints of these processes and showed that SD-208 had global effects on reversing TGFβ-induced genes involved in fibrosis, inflammation, cell proliferation, cytoskeletal organization, and apoptosis. (aspetjournals.org)
Fli1 haploinsufficiency increases the proportions of Th2- and Th17-like Tregs in bleomycin-induced profibrotic skin conditions, in which IL-33-producing dermal fibroblasts contribute to Th2-like Treg transdifferentiation, suggesting a critical role of Fli1 deficiency in the interaction of dermal fibroblasts with immune cells in pathological skin fibrosis. (biomedcentral.com)
Lung fibroblasts isolated from individuals with IPF exhibit higher expression of PDGFRs than those of nonfibrotic handle men and women (3, 524).FGFRs SrcSrc family members kinases (SFKs) comprise a big family of protooncogenic non-RTKs. (amparinhibitor.com)
In vitro FGF-2 stimulates ECM synthesis by lung fibroblasts isolated from individuals with IPF (57). (amparinhibitor.com)
In sufferers, higher FGFR2-b expression has been observed in lung fibroblasts isolated from patients with IPF (54), and concentrations of FGF-2 had been improved in BAL fluid from patients with IPF compared with wholesome handle men and women and correlated with poorer physiological functio. (amparinhibitor.com)
Broadly, inception of PF is considered as a cumulative effect of repetitive Alveolar Epithelial Cell (AEC) injury, abnormal wound healing, fibroblasts proliferation and subsequently their differentiation into myofibroblasts, which leads to accumulate voluminous Extracellular Matrix (ECM) within interstitial spaces and finally materialized as fibrosis[ 2 ]. (ijpsonline.com)

Pulmonary fibrosis is caused by a variety of insults to the lung, such as acute lung injury, irradiation and drugs [ 1 ]. (ersjournals.com)
Acute lung injury (ALI) or acute respiratory distress syndrome (ARDS) is associated with acute and diffuse alveolar damage, noncardiogenic pulmonary oedema and subsequent pulmonary fibrosis. (ersjournals.com)

Besides endothelial dysfunction, the progression of interstitial and perivascular fibrosis consecutively leads to impaired diastolic and systolic graft function, thus preservation of endothelial and vascular function is certainly a clinically desirable goal. (frontierspartnerships.org)
Persistent activation of underlying mechanisms primarily, oxidative-stress and inflammation in lung leads to pulmonary fibrosis progression and subsequently produces sub-therapeutic control even after prolonged drug therapy. (ijpsonline.com)
Fibrosis progression most often occurs in the long term, although the lung injury is initiated during the early stage with leakage of inflammatory cells and proteins from the circulation, into the lungs. (lu.se)

Antagomirs for miR-323a-3p augment, and mimics suppress, murine lung fibrosis after bleomycin injury, indicating that this miR may govern profibrotic signals. (escholarship.org)

After intratracheal instillation of bleomycin, sivelestat was administered intraperitoneally once a day for 7 or 14 days. (ersjournals.com)

Single-cell deconvolution of fibroblast heterogeneity in mouse pulmonary fibrosis. (nature.com)
Defining the activated fibroblast population in lung fibrosis using single-cell sequencing. (nature.com)
IGFBP5 mediates high glucose-induced cardiac fibroblast activation. (genscript.com)

It is critical to obtain a complete history, including medication history, drug use, social history, occupational, recreational, and environmental respiratory exposure history, risk factors for human immunodeficiency virus infection, and review of systems, to ensure other causes of interstitial lung disease are excluded. (medscape.com)

Transforming growth factor (TGF)-β, especially its isoform TGF-β1, is a profibrotic cytokine that is overexpressed in patients with fibrosis and was directly associated with fibrosis in multiple human settings and animal models [ 5 ]. (ersjournals.com)
These studies demonstrate that miR-323a-3p has a central role in lung fibrosis that spans across murine and human disease, and downregulated expression by the lung epithelium releases inhibition of various profibrotic pathways to promote fibroproliferation. (escholarship.org)
Endogenous IFN-γ may play a proinflammatory or profibrotic role in bleomycin-induced lung fibrosis. (tau.ac.il)

Insulin growth factor binding protein 5 (IGFBP-5), insulin growth factor (IGF-1) and transforming growth factor (TGF-beta1) in the type II alveolar epithelial cells (AECs) play a key role in lung injury caused by bleomycin and pioglitazone attenuates the lung injury/fibrosis by restoring IGFBP-5 and IGF-1 and decreasing TGF-beta1 expressions in the type II AECs. (genscript.com)
Conversely, inhibition of the PDGFR attenuates fibrosis in a rat model (51). (amparinhibitor.com)

In vivo assessment of angiogenesis using vWF immunostaining revealed that hAEC treatment decreased angiogenesis in a bleomycin model of lung fibrosis but increased angiogenesis in a neonatal model of hyperoxia-induced lung injury. (monash.edu)
Furthermore, inhibition of paracrine factor hepatocyte growth factor (HGF) signaling in vivo suppressed the BMPC-mediated inhibition of miR-155 expression and the associated protective effect on cardiac fibrosis and function. (indexindex.com)
Later, an in vivo study was planned to evaluate and compare the efficacy of two selected compounds namely forskolin (20 mg/kg) and rutin (100 mg/kg), individually and in combination against standard drug pirfenidone (50 mg/kg) using bleomycin-triggered pulmonary fibrosis murine model. (ijpsonline.com)
1993. Protective effects of chlorogenic acid, curcumin and beta-carotene against gamma-radiation-induced in vivo chromosomal damage. (cdc.gov)

These studies also revealed that although the p38 pathway may not be needed for appearance or disappearance of the myofibroblast, it can mediate a subset of inflammatory and fibrogenic events of the myofibroblast during the process of tissue repair and fibrosis. (aspetjournals.org)

Monocyte-derived alveolar macrophages drive lung fibrosis and persist in the lung over the life span. (nature.com)
Pulmonary Fibrosis (PF) is a continuous augmentative interstitial lung disease associated with poor prognosis and showing average survival span of around 2-3 y because of progressive restriction in lung function and alveolar spaces[ 1 ]. (ijpsonline.com)

Perfluorocarbon nanoemulsions enhance therapeutic siRNA delivery in the treatment of pulmonary fibrosis. (cdc.gov)
Additionally, due to large dose requirements in the treatment of pulmonary fibrosis unavoidable adverse effects are also an important concern. (ijpsonline.com)

In animal models of bleomycininduced pulmonary fibrosis, FGF-2 inhibition attenuated the development of pulmonary fibrosis in element by inhibiting the effects of TGF-b (56). (amparinhibitor.com)

This is pertinent in humans as well, because many diseases stemming from organ fibrosis occur via the EMT process. (wikipedia.org)
Interstitial lung diseases (ILDs) in childhood are a diverse group of conditions that primarily involve the alveoli and perialveolar tissues, leading to derangement of gas exchange and diffuse infiltrates on radiographs. (medscape.com)
Our findings suggest that inhibitors such as SD-208 may be therapeutically useful in human interstitial lung diseases and pulmonary fibrosis. (aspetjournals.org)
Understanding the dynamic pathogenesis and treatment response in pulmonary diseases requires probing the lung at cellular resolution in real time. (researchgate.net)
The Center has gained international recognition for its pioneering research towards understanding the molecular and cellular basis of human diseases such as autoimmune diseases, cancer, neurodegenerative disorders, pulmonary fibrosis and others, and the development of new approaches for their diagnosis and treatment. (ersnet.org)
Recently, PF is identified as most frequent and severe type of lung ailment amongst various categories of interstitial lung diseases[ 3 ]. (ijpsonline.com)
ILD, also called diffuse parenchymal lung disease, is a broad classification encompassing mainly non-neoplastic, inflammatory lung diseases that cause alterations to lung parenchyma in a diffuse pattern. (medscape.com)
Collagen vascular diseases (CVDs) can be associated with ILD and fibrosis with honeycomb changes. (medscape.com)

The histological changes, cell infiltration, pro-inflammatory cytokine production , inflammation , and nitrosative stress caused by bleomycin were all reduced by URB878. (bvsalud.org)
Our data clearly demonstrate for the first time that the inhibition of FAAH activity was able to counteract not only the histological alteration bleomycin -induced but also the cascade of related inflammatory events. (bvsalud.org)
BMP-7 expression is attenuated when the nephron is placed under inflammatory or ischemic stress, leading to EMT, which can result in fibrosis of the kidney. (wikipedia.org)
Reducing this inflammatory stress, in turn, reduces the chance of fibrosis. (wikipedia.org)
9 Previous animal and human studies have shown that high TGF-β 1 producers develop significantly more lung fibrosis in response to a number of inflammatory triggers such as radiation, 10 chemotherapy, 11 and lung transplantation. (bmj.com)
Examination of lung tissue in two patients with cystic fibrosis showed strong immunohistological staining of inflammatory tissue using an antibody against this cytokine. (bmj.com)
The increased inflammatory cells in lung increased at various time points, demonstrating how different immune cells dominated the different stages of progressive lung injury. (lu.se)

Donor pre-treatment with S-NO-HSA lead to reduced fibrosis and preservation of myocardial miR-126-3p and GATA2 levels in murine cardiac isografts 60 days after transplantation. (frontierspartnerships.org)
Chronic allograft injury (CAI), consisting of vasculopathy and interstitial fibrosis, affects approximately 50% of patients after 10 years and limits long-term survival following heart transplantation ( 1 ). (frontierspartnerships.org)
Also, because of progressive nature of this devastating ailment, transplantation of lung is only remained as the ultimate treatment option particularly in the advance stage of PF. (ijpsonline.com)

Meanwhile, the inhibitory effect of AK106-001616 was more effective than that of naproxen in the mouse collagen antibody-induced arthritis model with leukotrienes contributing to the pathogenesis. (aspetjournals.org)
Collagen-producing lung cell atlas identifies multiple subsets with distinct localization and relevance to fibrosis. (nature.com)
We demonstrated that SD-208, but not SD-282, inhibited TGFβ-induced SMAD signaling, myofibroblast transformation, and collagen gel contraction. (aspetjournals.org)
Maximal intrapulmonary recruitment of CD45(+)Col I(+)CXCR4(+) fibrocytes directly correlated with increased collagen deposition in the lungs. (wikigenes.org)

To elucidate the antifibrotic mechanisms of sivelestat, we examined a murine model of bleomycin-induced early-stage pulmonary fibrosis. (ersjournals.com)
Here we discuss the transformative experimental strategies that are being leveraged to dissect the key cellular and molecular mechanisms that regulate fibrosis, and the translational approaches that are enabling the emergence of precision medicine-based therapies for patients with fibrosis. (nature.com)
Unlike vascular effects, the anti-fibrosis mechanisms of BMPC, specifically under diabetic conditions, are poorly understood. (indexindex.com)
Although several miRs have been shown to be associated with lung fibrosis, the mechanisms by which miRs modulate epithelial behavior in lung fibrosis are lacking. (escholarship.org)
Thus, alternative drug therapy for pulmonary fibrosis, targeting to the aforementioned chief mechanisms is urgently required. (ijpsonline.com)

BACKGROUND Polymorphisms in transforming growth factor (TGF)-β 1 associated with variations in cytokine levels are linked to fibrosis in a number of tissues. (bmj.com)
However, the contribution of this cytokine to organ fibrosis in patients with cystic fibrosis is presently unclear. (bmj.com)
Fig. 4: Divergent cytokine pathways drive fibrosis. (nature.com)

Friend leukemia virus integration 1 (Fli1) deficiency, a predisposing factor of systemic sclerosis (SSc), induces SSc-like phenotypes in various cell types. (biomedcentral.com)
Systemic sclerosis (SSc) is a multisystem autoimmune disease characterized by vasculopathy and fibrosis of the skin and certain internal organs. (biomedcentral.com)
Interstitial lung disease (ILD) is the most common cause of death in patients with systemic sclerosis (SSc). (cn1699.cn)

CUR significantly improved the degree of fibrosis, levels of inflammation, and oxidative imbalances in lung tissue in animal models of PF. (frontiersin.org)

Fibroproliferation in the early response to lung injury could be an important therapeutic target. (ersjournals.com)
The primary site of lung injury is the interstitium, located between the epithelial and endothelial basement membranes ( American Thoracic Society and European Respiratory Society, 2002 ). (frontiersin.org)
Initial injury repairs and rebuilds the tissue under normal conditions, but in IPF impaired healing occurs and abnormal epithelial-mesenchymal interactions are induced ( Fernandez and Eickelberg, 2012 ). (frontiersin.org)
Role of insulin like growth factor axis in the bleomycin induced lung injury in rats. (genscript.com)
Lungs are constantly exposed to environmental perturbations and have therefore remarkable capacity to regenerate in response to injury. (researchgate.net)
Recent studies have demonstrated that supplementation of nitric oxide (NO), or increased expression of endothelial NO-synthase (eNOS) protects against both IR-injury and fibrosis ( 5 , 6 ). (frontierspartnerships.org)
Mitochondrial oxidative stress-induced transcript variants of ATF3 mediate lipotoxic brain microvascular injury. (ucdavis.edu)
Ultrafine Particulate Matter Combined With Ozone Exacerbates Lung Injury in Mature Adult Rats With Cardiovascular Disease. (ucdavis.edu)
The present study characterizes the time course, cellular source, and regulation of IFN-γ expression in bleomycin-induced lung injury. (tau.ac.il)
[ 4 ] Regardless of the underlying disease process, the universal pathophysiology is believed to be acute injury to lung parenchyma leading to chronic interstitial inflammation, tissue destruction, fibroblastic activation and proliferation, pulmonary fibrosis, and eventually architectural remodeling with honeycomb changes. (medscape.com)

Bronchoalveolar lavage fluid and lung samples were examined on day 7 or day 14 after bleomycin instillation. (ersjournals.com)
At 14 days after intratracheal bleomycin, total bronchoalveolar lavage cell counts and lung hydroxyproline were decreased in IFN-γ knockouts compared with wild-type animals. (tau.ac.il)

It has long been thought to be relentlessly progressive and irreversible, but both preclinical models and clinical trials in various organ systems have shown that fibrosis is a highly dynamic process. (nature.com)
Clinical and basic science research has shown that fibrosis presents an environment that favors tumor growth, such as hepatocellular carcinoma being commonly preceded by liver cirrhosis, or bleomycin induced lung fibrosis enhancing pulmonary metastasis in mouse models of breast cancer. (tmc.edu)

It has been demonstrated that BMP7 treatment is sufficient to induce all of the genetic markers of osteoblast differentiation in many cell types. (wikipedia.org)

Genotype-related clinical characteristics and myocardial fibrosis and their association with prognosis in hypertrophic cardiomyopathy. (nature.com)

Methods: Rats received Bleomycin (or Saline as control) intratraceally and were longitudinally scanned at baseline, day 3, 7, 14 and 21 and 28 after Bleomycin administration. (lu.se)
Results: MRI scans showed increased signal (oedema) at day 3-7 and again at day 21 (fibrosis) in the lungs of Bleomycin exposed rats. (lu.se)

Critical role of insulin?like growth factor binding protein?5 in methamphetamine?induced apoptosis in cardiomyocytes. (genscript.com)
Insulin-like growth factor binding protein 5 (IGFBP5) mediates methamphetamine-induced dopaminergic neuron apoptosis. (genscript.com)

Dysregulated microRNAs (miRs) can regulate expression of multiple genes and fundamentally alter cellular phenotypes during fibrosis. (escholarship.org)

Local pulmonary administration of therapeutic siRNA represents a promising approach to the treatment of lung fibrosis, which is currently hampered by inefficient delivery. (cdc.gov)
The results show that the polycation/siRNA/PFOB nanoemulsions are capable of efficiently silencing the expression of STAT3 and inhibiting chemokine receptor CXCR4 - two validated targets in pulmonary fibrosis. (cdc.gov)

Inhibition of Fatty Acid Amide Hydrolase (FAAH) Regulates NF-kb Pathways Reducing Bleomycin-Induced Chronic Lung Inflammation and Pulmonary Fibrosis. (bvsalud.org)
In this work, pathways governing mucus cell differentiation were investigated in lung tissues from patients with IPF and other chronic pulmonary disorders. (bmj.com)

Conversely, CXCL12-induced calcium signaling and migration were increased in LPAR1 knockout cells, and LPA 1 -selective antagonists enhanced CXCL12-induced Gα i/o signaling and cell migration in the parental MDA-MB-231 cells but not in LPA 1 -deficient cells. (biomedcentral.com)

Kidney disease is characterized by derangement of the tubular architecture by both myofibroblast buildup and monocyte infiltration Because endogenous BMP-7 is an inhibitor of the TGF-β signaling cascade that induces fibrosis, the use of exogenous recombinant BMP-7 (rhBMP-7) could be a viable treatment of chronic kidney disease. (wikipedia.org)
Such evolution may be explained by different phenomena, the most evident being that many helminths undertake specific multiorgan migratory trajectories before reaching their final destination such as the lung, intestine, liver, or blood vessels where they can persist and cause chronic infections. (hindawi.com)
Genetic variation has a substantial contribution to chronic obstructive pulmonary disease (COPD) and lung function measurements. (escholarship.org)
These mediators are essential to induce correct healing and prevent from fibrosis and chronic inflammation. (ambiotis.com)
Other causes of honeycomb lung include pulmonary sarcoidosis, chronic hypersensitivity pneumonitis(HP), and drug-induced ILD. (medscape.com)

Bleomycin induced plasma leakage in the lungs, showing significantly increased immune cells as well as proteins found in the lung lumen (assessed in BALF). (lu.se)

Neuregulin1α, which drives mucus cell differentiation in vitro, was expressed in normal airway submucosal glands and in lungs from patients with IPF. (bmj.com)
Using histopathology, microarrays, gene expression by polymerase chain reaction, ELISA, chemokine array, and in vitro experiments we demonstrate that despite the pro-tumorigenic environment, kidney fibrosis does not redirect metastasis to the non-organotropic damaged organ. (tmc.edu)

Parasitic helminths generally induce strong type 2 immunity that normally controls parasite infection and is characterized by production of type 2 cytokines like interleukin- (IL-) 4, IL-5, and IL-13 by innate cells (group 2 innate lymphoid cells (ILC2s), basophils, eosinophils, neutrophils, and macrophages) and CD4 + T helper 2 (Th2) lymphocytes. (hindawi.com)

HE staining and Massons staining were performed to examine the pathological changes of lung tissues after bleomycintreatment. (zjujournals.com)

Most forms of chILD require surgical lung biopsy for definitive diagnosis. (medscape.com)
3) specific combinations of high-resolution computed tomography and surgical lung biopsy patterns in patients subjected to surgical lung biopsy [ 1 , 4 ]. (ersjournals.com)

Distinct mesenchymal lineages and niches promote epithelial self-renewal and myofibrogenesis in the lung. (nature.com)

In addition to the evidence indicating that fibrosis enhances primary tumor growth and metastasis it is also well characterized that primary tumor metastasis has specific organotropism, for example breast cancer commonly spreads to the lungs, brain, bone, liver and lymph nodes. (tmc.edu)

Originally thought to behave as supporting cells for the lung epithelium and endothelium with a singular f. (researchgate.net)
In the normal lung injuries are repaired with restitutio ad integrum , but in the IPF lung the epithelium fails to restore itself. (ersjournals.com)

Helminth infections induce strong type 2 cell-mediated immune responses, characterized among other things by production of high levels of interleukin- (IL-) 4 and IL-13. (hindawi.com)
An important aspect about type 2 cell-mediated responses against parasitic helminths is that they are induced for controlling parasite infection but they also mediate the tolerance of parasite persistence [ 1 ]. (hindawi.com)
Biological dose response to PM2.5: effect of particle extraction method on platelet and lung responses. (ucdavis.edu)

However, whether non-organtropic fibrosis can redirect metastasis to the damaged organ has not been investigated. (tmc.edu)

Total absence of dystrophin expression exacerbates ectopic myofiber calcification and fibrosis and alters macrophage infiltration patterns. (nature.com)

Lung regeneration deteriorates with aging leading to increased susceptibility to pathologic conditions, including fibrosis. (researchgate.net)
Honeycomb lung is a pathologic finding and not a specific disease entity. (medscape.com)

Besides, it synergistically inhibited biochemical alterations in lung with no significant difference as compared to pirfenidone treatment. (ijpsonline.com)
Further, forskolin and rutin co-administration showed effectively decline in Szapiel's and Ashcroft scores and maximally diminish mast cell accumulation than that manifested by pirfenidone in lungs. (ijpsonline.com)

Anatomy18

Organisms9

Diseases34

Chemicals and Drugs39

Analytical, Diagnostic and Therapeutic Techniques and Equipment21

Phenomena and Processes16

Disciplines and Occupations1

Information Science1

Health Care3

Idiopathic33

Mice20

Alleviated bleomycin-induced pulmonary1

Fibrotic9

Inflammation and fibrosis4

Inflamed tissue1

Fibroblasts9

Acute lung i2

Progression3

Murine lung fibrosis1

Intratracheal instillation1

Fibroblast3

Causes of interstitial lung di1

Profibrotic3

Attenuates2

Vivo4

Repair and fibrosis1

Alveolar2

Treatment of pulmonary fibrosis2

Development of pulmonary fibrosis1

Diseases8

Inflammatory7

Transplantation3

Collagen4

Mechanisms5

Cytokine3

Systemic3

Degree of fibrosis1

Injury10

Bronchoalveolar2

Shown that fibrosis2

Sufficient to induce1

Myocardial1

Rats2

Apoptosis2

Phenotypes1

SiRNA2

Pathways2

Knockout1

Chronic5

Significantly1

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Macrophages1

Pathological1

Surgical lung biopsy2

Mesenchymal1

Liver1

Epithelium2

Responses3

Metastasis1

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Pathologic2

Pirfenidone2