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  • alveolar
  • Regulation of alveolar macrophage transforming growth factor-beta secretion by corticosteroids in bleomycin-induced pulmonary inflammation in the rat. (uptodate.com)
  • In this study, we have demonstrated that alveolar macrophages stimulated by bleomycin-induced injury secrete large quantities of biologically active TGF-beta 1 when explanted into tissue culture. (uptodate.com)
  • High doses of the corticosteroid methylprednisolone given intramuscularly before and concomitantly with bleomycin administration prevented the influx of alveolar macrophages into the lungs, diminishing both the number of macrophages present in the alveoli and the total lung content of TGF-beta. (uptodate.com)
  • The findings in this study demonstrate that during bleomycin-induced injury, alveolar macrophages not only secrete large quantities of active TGF-beta 1, but are a predominant source of the enhanced TGF-beta response seen in this model. (uptodate.com)
  • lymphoma
  • Bleomycin is a member of the antibiotics/antineoplastics drug class and is commonly used for Hodgkin's Lymphoma, Malignant Pleural Effusion, Non-Hodgkin's Lymphoma, and others. (drugs.com)
  • oxygen
  • High concentrations of oxygen, such as those often used in surgery, can trigger lung damage in patients who have received bleomycin, even years later. (wikipedia.org)
  • patients
  • Studies have been conducted of 111 In-labeled bleomycin as a tumor-imaging agent in patients with a wide variety of neoplasms. (google.com)
  • Role of single-breath carbon monoxide-diffusing capacity in monitoring the pulmonary effects of bleomycin in germ cell tumor patients. (uptodate.com)
  • Current studies for elderly patients incorporating novel agents for HL, such as the ongoing study with sequential brentuximab vedotin and AVD ( clinicaltrials.gov # NCT01476410 ) may obviate the need for bleomycin in this population. (bloodjournal.org)