• Upon injury the axolotl generates a population of regeneration-competent limb progenitor cells known as the blastema, which will grow, establish pattern, and differentiate into the missing limb structures. (nih.gov)
  • We also discuss how the presence of cells from the different axes of the limb is required for the continued growth and establishment of pattern in the blastema as described in the polar coordinate model, and how this positional information is reprogrammed in blastema cells during regeneration. (nih.gov)
  • Multiple cell types from the mature limb stump contribute to the blastema at different stages of regeneration, and we discuss the contribution of these types to the regenerate with reference to whether they are "pattern-forming" or "pattern-following" cells. (nih.gov)
  • We recently showed that apoptosis-induced compensatory proliferation provides a mechanism to launch a complex regeneration program such as head regeneration. (unige.ch)
  • Its cellular organization is rather simple, with two cell layers, the ectoderm and the endoderm separated by an extracellular collagenoeous matrix, the mesogolea. (unige.ch)
  • These different cell types differentiate from three distinct stem cell populations: myoepithelial cells located in the ectoderm, myoepithelial cells located in the endoderm and interstitial cells that are multipotent stem cells giving rise to neurons, mechano-sensory cells (nematocytes or cnidocytes), gland cells and gametes [3, 4]. (unige.ch)
  • In this review we focus on the crucial early events that occur during wound healing, the neural-epithelial interactions that drive the formation of the early blastema, and how these mechanisms differ from those of other species that have restricted regenerative potential, such as humans. (nih.gov)
  • 1 Department of Developmental and Cell Biology University of California Irvine California USA. (nih.gov)
  • Hydra differentiates all cell types required for neuro-muscular transmission, digestion, secretion and sexual reproduction. (unige.ch)