Urinary bladderMuscle-invasive bladder cancerUrothelial CarcinomaAQP3OutcomesTumorPatientsBiomarkersMetastasis2018DetectMolecularPancreaticProstate CancerIncreasesDecreases19802022Gene expressionBreastRegulationPreventionWidelyKidneyCellsTargetsPregnancyActivationBiologicalCellResearchDevelopmentShowEmerging technologyMonthsCommonRelationship
Urinary bladder1
- Intracellular calcium in hypertrophic smooth muscle from rat urinary bladder. (mdc-berlin.de)
Muscle-invasive bladder cancer2
- Introduction: Level I evidence supports the use of cisplatin-based neoadjuvant chemotherapy (NAC) for muscle-invasive bladder cancer prior to radical cystectomy (RC). (sagepub.com)
- Neoadjuvant immunotherapy, chemotherapy, and combination therapy in muscle-invasive bladder cancer: A multi-center real-world retrospective study. (nih.gov)
Urothelial Carcinoma1
- Aquaporin 3 Expression Loss in Urothelial Carcinoma: Association with Tumor Invasion Depth, but not with Grading? (sagepub.com)
AQP312
- We have previously provided molecular evidence of expression of aquaporin 3 (AQP3) in normal human urothelium and in UBC of various stages. (sagepub.com)
- Whereas former studies demonstrated that loss of AQP3 was associated with invasive and high-grade disease and worse progression-free and cancer-specific. (sagepub.com)
- Here, our study demonstrated that AQP3 and c-Met were overexpressed in 52.5% and 83.1% of breast cancer tissue specimens, respectively. (scite.ai)
- Background Aquaporin 3 (AQP3) and Cellular-mesenchymal to epithelial transition factor (c-Met) are both overexpressed in human breast cancer and highly related to proliferation and migration. (scite.ai)
- The study objective was to explore the relationship between c-Met and AQP3 in human breast cancer. (scite.ai)
- Methods We used immunohistochemistry to determine the expression of AQP3 and c-Met in breast cancer tissue specimens and analysed whether there was any correlation between the two molecules. (scite.ai)
- Real-time quantitative polymerase chain reaction and Western blotting were used to detect AQP3 expression in MCF-7 and MDA-MB-231 cells after human hepatocyte growth factor (hHGF) treatment and/or transfection with c-Met silencing small interfering (si)RNA. (scite.ai)
- Results Based on the immunohistochemical results combined with the clinicopathological data of 59 breast cancer patients, c-Met exhibited a significant correlation with AQP3 in breast cancer tissue. (scite.ai)
- Studies have shown that hHGF can increase c-Met phosphorylation, and we discovered that the hHGF-induced increase in AQP3 expression was dose dependent. (scite.ai)
- However, after reducing c-Met expression with c-Met-specific siRNA, AQP3 expression decreased accordingly. (scite.ai)
- Additionally, the wound scratch assay showed that AQP3-specific siRNA or c-Met-specific siRNA significantly inhibited breast cancer cell migration, which was promoted by hHGF. (scite.ai)
- Conclusions Our study indicated that AQP3 expression was regulated by c-Met in human breast cancer. (scite.ai)
Outcomes1
- Identifying a cost-effective and widely available diagnostic aid may improve bladder cancer outcomes. (sagepub.com)
Tumor2
- The extracellular matrix (ECM) is a crucial component of the tumor microenvironment involved in numerous cellular processes that contribute to cancer progression. (scite.ai)
- As a superficial tumor, the causes of death in patients with breast cancer are reported to be due to cancer metastasis and/or relapse, which are significantly associated with the favorable tumor microenvironment [ 4 ]. (biomedcentral.com)
Patients3
- Dr. Oliver discovered that blood leukocytes from CSU patients display decreases in surface CRTh2 expression and function, consistent with in vivo PGD2 exposure. (grantome.com)
- Additionally, he found that treatment with an oral CRTh2 antagonist increases CRTh2 expression, increases circulating eosinophils, and decreases patient-reported itch in CSU patients. (grantome.com)
- In addition a tool determination be needed to iden- tify patients with P-glycoprotein over-expression in search any appositeness of healthy approaches aiming to bested transporter-mediated resistance. (rayart.lt)
Biomarkers2
- Research efforts targeting the identification of bladder cancer biomarkers have been extensive during the past decade. (sagepub.com)
- Cancer Epidemiology Biomarkers & Prevention 16 (6): 1121-1127. (mdc-berlin.de)
Metastasis2
- concluded that c-Met is related to the development and metastasis of a number of malignancies, including breast cancer. (scite.ai)
- However, the mechanisms of the occurrence, development, and metastasis of breast cancer are very complicated and overlap, suggesting the necessity of different therapies to treat different subtypes of breast cancer. (biomedcentral.com)
20181
- Breast cancer has become the most common cancer and the leading cause of cancer-related deaths in females worldwide, according to a status report on the global cancer burden provided by Globocan 2018 [ 1 ]. (biomedcentral.com)
Detect2
- Introduction: There is a lack of evidence supporting the routine use of laboratory tests to detect bladder cancer. (sagepub.com)
- METHODS: The whole gene expression microarray was used to detect the differentially expressed lncRNA and mRNA between antimicrobial peptide BSN-37 activated RAW264.7 cells and normal RAW264.7 cells. (bvsalud.org)
Molecular4
- Therefore, understanding the mechanisms underlying the invasion, proliferation, and cell transfer of breast cancer and the discovery of new therapeutic molecular targets are extremely important. (scite.ai)
- Therefore, this article focused on the molecular mechanism and function of GPxs in the occurrence and development of breast cancer to understand their role in breast cancer and to provide a new theoretical basis for the treatment of breast cancer. (biomedcentral.com)
- Therefore, based on summaries of the research regarding the relationship between breast cancer and GPxs, this article focused on the molecular mechanism and function of different GPxs and their diverse roles in the occurrence and development of breast cancer, further clarifying the pathogenesis of breast cancer and providing a potential direction for further studies on the treatment of breast cancers. (biomedcentral.com)
- Expert Report of Noriyuki Kasahara, M.D. Ph.D. Expert Witness Statement - Noriyuki Kasahara I, Noriyuki Kasahara, declare the following: As detailed in my Curriculum Vitae, attached herewith as Exhibit B, I am currently an Assistant Professor of Pathology as well as Biochemistry & Molecular Biology, at the Institute for Genetic Medicine of USC/Norris Comprehensive Cancer Center. (healthdrugpdf.com)
Pancreatic1
- S3-Guidelines "Exocrine pancreatic cancer" 2007. (mdc-berlin.de)
Prostate Cancer1
- Serum insulin-like growth factor (IGF)-I and IGF-binding protein-3 concentrations and prostate cancer risk: results from the European Prospective Investigation into Cancer and Nutrition. (mdc-berlin.de)
Increases1
- SC-19220 increases the bladder capacity and reduced the voiding efficiency of micturition (elicited by slow transvesical filling) of urethane-anesthetized rats. (medchemexpress.com)
Decreases1
- Peptide-based PROTAC degrader of FOXM1 suppresses cancer and decreases GLUT1 and PD-L1 expression. (nih.gov)
19801
- The incubation and fledging durations 23±3 days 43±6 days (Medway 1957;Langham 1980;Lim 2002) Swiftlets engage in yearround breeding activities between the months of October and February (Langham 1980) Construction of a single nest by swiftlets typically requires around 30-45 days during the breeding season, but in the nonbreeding season, this process takes approximately 60-80 days (Aowphol et al. (researchgate.net)
20221
- 2022 Nov 15;3(11):100785. (nih.gov)
Gene expression1
- Large differences are due to loss or gain of entire genes, gene parts as well as sequences that regulate the gene expression. (healthdrugpdf.com)
Breast2
- These discoveries may help us comprehend the mechanisms underlying breast cancer development and invasion and offer another possibility for targeted treatment of breast cancer. (scite.ai)
- breast cancer is thought to be related to the increased production of reactive oxygen species, indicating the involvement of GPxs in these processes. (biomedcentral.com)
Regulation1
- CONCLUSION: This study provides the lncRNA and mRNA expression profiles of RAW264.7 macrophages stimulated by antimicrobial peptide BSN-37 and helps to provide a reference value for subsequent studies on lncRNA regulation of antimicrobial peptide BSN-37 immune function. (bvsalud.org)
Prevention1
- Fourmanagementstrategiesare available: (1) short-term antibacterial therapy, (2) prophylactic antibacterial therapy, (3) prevention and treatment of influenza, and (4) placement of a tympanostomytube. (spiritsong.org)
Widely1
- Online Shopping read poems in context greek poetry in the egyptian thebaid 200 600 ad sozomena studies in the recovery of AND CONGESTIVE HEART FAILURE Overview In this expression, we will be you how to be walls studied widely to heart and surgical natriuretic term. (seabaygame.com)
Kidney3
- I have become particularly interested in variations of creatinine and glomerular filtration rate and declining levels of function at the stage 2 and stage 3 kidney disease. (drprincetta.com)
- However, I am interested in how to improve kidney function in early kidney decline such as with stage 2 and 3 kidney disease on an outpatient basis. (drprincetta.com)
- Stage 2 kidney disease is defined as an eGFR between 60 to 89 milliliters per minute, and stage 3 kidney disease is defined as an eGFR between 30 and 59 milliliters per minute. (drprincetta.com)
Cells3
- ADH activates V2 receptors on the basolateral membrane of principal cells in the renal collecting duct, initiating a cyclic AMP-dependent process that culminates in increased production of water channels (aquaporin 2), and their insertion into the cells' luminal membranes. (wikipedia.org)
- 14. Which of the following lymphatic cancers is associated with multinucleated Reed-Sternberg cells and EBV? (mockdocs.org)
- Monocarboxylate transporters and possibly sodium-dependent monocarboxylate transporter and aquaporins transport acetate into cells. (turkupetcentre.net)
Targets1
- The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
Pregnancy1
- failure: A important intervention, 10 cancer preferably, improving from the cardiac pregnancy to the Fiscal cartilage of the pathogenic viable rejection. (seabaygame.com)
Activation1
- Excessive ADH causes an inappropriate increase in the reabsorption in the kidneys of solute-free water ("free water"): excess water moves from the distal convoluted tubules (DCTs) and collecting tubules of the nephrons - via activation of aquaporins, the site of the ADH receptors - back into the circulation. (wikipedia.org)
Biological1
- The application of hydrogels as a matrix for 3-dimensional cell cultures has become an indispensable tool in tissue engineering, biotechnology and biomedical research due to the improved functionality and viability of the in vitro biological system. (heraldopenaccess.us)
Cell4
- Whole cell extracts (30 µg lysate) of HeLa (Lane 1), SH-SY5Y (Lane 2), A549 (Lane 3), A-431 (Lane 4) were electrophoresed using NuPAGE™ 4-12% Bis-Tris Protein Gel (Product # NP0321BOX). (thermofisher.com)
- The combination of 3-dimensional hydrogel cell cultures with microchip technology further allows (i) spatial and temporal control of cell growth, (ii) application of defined mechanical (e.g. shear, strain, stretch) and chemical (e.g. gradients) stimuli, as well as (iii) monitoring of dynamic cellular responses using integrated sensing strategies. (heraldopenaccess.us)
- This review focuses primarily on recent advances in biologically inspired microfluidic systems that are based on 3-dimensional hydrogel cell cultures and discusses advantages and current challenges, various applications of microfluidic hydrogel cell cultures and future perspectives. (heraldopenaccess.us)
- Starting from single cell analysis using miniaturized flow cytometers [3] a variety of microfluidic devices have been developed for cell studies to investigate cell transport and cultivation in the absence and presence of concentration and temperature gradients or shear force conditions. (heraldopenaccess.us)
Research1
- After signaling the research treatment, you include three systems:( 1) IBIDS Consumer Database,( 2) Full IBIDS Database, or( 3) Peer Reviewed interventions So. (seabaygame.com)
Development1
- Genes & Development 21 (3): 316-331. (mdc-berlin.de)
Show1
- Most bottle-fed babies will show a stool one or two times per age, but they may belong together 2 to 3 days without producing a stool. (mein-schoenefeld.info)
Emerging technology1
- Cold atmospheric plasma (CAP) treatment is a rapidly expanding and emerging technology for cancer treatment. (mdpi.com)
Months2
- 3 months, -20 to -70 °C under sterile conditions after reconstitution. (novusbio.com)
- Explain to the blood that the youth last will and testament necessary to stay the pediatric endocrinologist every 3 to 6 months to track for growth, against potential adverse effects, and an eye to compliance with therapy. (mein-schoenefeld.info)
Common1
- From common hepatic duct, bile is diverted either directly into the intestine or into the gall bladder. (spiritsong.org)
Relationship1
- As with tacrolimus, there have been reports of skin cancer and lymphoma, but a causal relationship has not been established. (spiritsong.org)