• Thiotepa is also used with high-dose chemotherapy with HPCT support to treat certain solid tumors in adult and children. (wikipedia.org)
  • The company's pipeline product candidates include zanzalintinib, XB002 and XL102 for the treatment of advanced or metastatic solid tumors and CBX-12 for advanced metastatic refractory solid tumors. (pharmaceutical-technology.com)
  • TROP2 (trophoblast cell-surface antigen 2) is a transmembrane glycoprotein that is highly expressed on several types of solid tumors. (adcreview.com)
  • A phase I/II, First-in-Human Study of SKB264 in Patients with Locally Advanced Unresectable/Metastatic Solid Tumors who are refractory to Available Standard Therapies. (adcreview.com)
  • Phase 1/Phase 2] Phase I/II, FIH, TROP2 ADC, Advanced Unresectable/Metastatic Solid Tumors, Refractory to Standard Therapies (A264) - NCT04152499. (adcreview.com)
  • In this report, the biologic functions of MDSC are defined and evidence linking MDSC with the response to cancer immunotherapies in solid tumors are reviewed. (iospress.com)
  • The safety, tolerability, PK parameters, and preliminary antitumor activity of IMGS-001 will be assessed in adult patients with advanced solid tumors refractory to appropriate standard of care (SOC) treatments. (drugtrialsformoney.com)
  • A solid tumor at the dome and two papillary tumors at the right lateral region of the bladder were observed. (elsevierpure.com)
  • A pathological examination revealed adenocarcinoma from the solid tumor and urothelial carcinoma from the papillary tumors. (elsevierpure.com)
  • Many cancers form solid tumors, but cancers of the blood, such as leukemias , generally do not. (cancer.gov)
  • LianBio is currently conducting a Phase 2a clinical trial in China to evaluate the safety and efficacy of infigratinib in patients with locally advanced or metastatic gastric cancer or gastroesophageal junction adenocarcinoma with FGFR2 gene amplification and other advanced solid tumors with FGFR alterations. (tropicalhainan.com)
  • and LYT-210, a gamma delta-1 T cell receptor against solid tumors. (meefro.com)
  • TOKYO―FUJIFILM Corporation (President and CEO, Representative Director: Teiichi Goto) today announced that it has begun implementation of a phase 2a study in the U.S. to evaluate safety, tolerability, and preliminary efficacy of FF-10832, a liposomal drug candidate, in combination therapy with Merck & Co., Inc., Rahway, N.J., U.S.A.'s anti-PD-1 therapy KEYTRUDA® (pembrolizumab) for patients with advanced solid tumors. (fujifilm.com)
  • FF-10832 is a liposomal formulation which encapsulates gemcitabine* 1 , an approved anti-cancer agent indicated for the treatment of a variety of solid tumors. (fujifilm.com)
  • The primary focus of the trial is to establish the safety and tolerability of FF-10832 in combination with KEYTRUDA in patients with advanced solid tumors, and evaluate its preliminary efficacy in non-small cell lung cancer (NSCLC)* 2 and urothelial cancer (UC)* 3 patients who have progressed after standard therapy, including immune checkpoint inhibitor therapy. (fujifilm.com)
  • Fujifilm is focused on the development of liposomes/LNPs to meet unmet medical needs, including hard-to-treat cancers such as advanced solid tumors," said Junji Okada, general manager of pharmaceutical products division, FUJIFILM Corporation. (fujifilm.com)
  • The primary endpoint of the study is OS, and secondary endpoints include progression-free survival (PFS) and objective response rate (ORR) as assessed by blinded independent central review (BICR) per Response Evaluation Criteria in Solid Tumors (RECIST) v1.1 modified for mesothelioma, safety and quality of life. (merck.com)
  • Carcinomas of the lung, bladder, stomach, and cutaneous melanoma were the frequent tumors demonstrating BRCAm in males, of which the majority were stage II or III diseases with a higher frequency of BRCA2 mutations. (biomedcentral.com)
  • Although immune checkpoint inhibitors have opened a new mode of treatment for solid tumors, their efficacy in nasopharyngeal carcinoma (NPC) needs to be further investigated. (jcancer.org)
  • This proposed Phase I clinical trial of SON-DP is an FIH, open-label, Phase Ia/Ib dose escalation and expansion study to evaluate the safety, tolerability, PK, and PD of SON-DP in participants with relapsed/refractory/intolerant to standard of care therapies, for advanced/ metastatic solid tumors. (policylab.us)
  • Even though developed for AML patients, our pan-cancer analyses demonstrate a wider application of the IPRP signature for prognostic prediction and analysis of tumor-immune interplay also in multiple solid tumors. (nature.com)
  • Adenocarcinomas, which may occur as primary tumors or rarely reflect metastasis from intestinal carcinoma. (msdmanuals.com)
  • 40% of patients, tumors recur at the same or another site in the bladder, particularly if tumors are large or poorly differentiated or if several tumors are present. (msdmanuals.com)
  • In a phase II study of pembrolizumab in patients with microsatellite-high (MSI-H) solid tumors, the objective response rate was 39.6% (95% CI = 31.7% to 47.9%), including 7.4% complete responses (CRs) and 32.2% partial responses (PRs). (medscape.com)
  • Cohort 5: Gastric or esophageal cancer (gastroesophageal junction (GEJ) or esophageal adenocarcinoma). (drugtrialsformoney.com)
  • Aidexi is indicated for the treatment of locally advanced or metastatic gastric cancer (including gastroesophageal junction adenocarcinoma) with HER2 over-expression in patients who have received at least two types of systemic chemotherapy. (pharmaceutical-technology.com)
  • The subgroup analysis demonstrated that BRCAm was associated with increased OS in gastric and bladder cancers, decreased PFS in prostate, esophageal, and head and neck cancers, and decreased OS in glioma/glioblastoma in males. (biomedcentral.com)
  • Gastric adenocarcinoma is the second leading cause of cancer death worldwide, following lung cancer. (medscape.com)
  • Anti-PD-1 or PD-L1 antibodies alone or in combination with CTLA-4 were shown to induce objective responses in approximately 10% to 20% of patients with gastric and gastroesophageal adenocarcinoma in small nonrandomized trials. (medscape.com)
  • The best results are found in the treatment of adenocarcinoma of the breast, adenocarcinoma of the ovary, papillary thyroid cancer and bladder cancer. (wikipedia.org)
  • Thiotepa is used as intravesical chemotherapy in bladder cancer. (wikipedia.org)
  • Cabometyx is under clinical development by Exelixis and currently in Phase II for Bladder Cancer. (pharmaceutical-technology.com)
  • According to GlobalData, Phase II drugs for Bladder Cancer have a 31% phase transition success rate (PTSR) indication benchmark for progressing into Phase III. (pharmaceutical-technology.com)
  • Bladder cancer is the most common malignancy of the urinary tract, and the 9th most common cancer diagnosis worldwide, with more than 330,000 new cases each year and more than 130,000 deaths per year. (biomedcentral.com)
  • At any point in time 2.7 million people have a history of urinary bladder cancer [ 1 ]. (biomedcentral.com)
  • The patient was diagnosed with bladder cancer, urinary tract infection and anemia. (biomedcentral.com)
  • Associations of MDSC in clinical bladder cancer cohorts are outlined in addition to evaluation of the suggested roles of MDSC in pre-clinical bladder cancer models. (iospress.com)
  • Human clinical trials that investigate possible MDSC modulators are highlighted, and therapeutic strategies to leverage MDSC biology in bladder cancer immunotherapy are outlined. (iospress.com)
  • Developing effective systemic therapy for bladder cancer continues to present a challenge to oncology physicians and researchers. (iospress.com)
  • An immune cell in the tumor microenvironment that may be important for inhibiting the immune response against bladder cancer is the myeloid derived suppressor cell (MDSC). (iospress.com)
  • This review summarizes what is currently known about MDSC function, known roles of MDSC in cancer, and how MDSC have been implicated in bladder cancer prognosis and in the context of different bladder cancer therapies. (iospress.com)
  • Finally, knowledge gaps and areas for advancement in the study of MDSC to enhance bladder cancer immunotherapy are presented. (iospress.com)
  • Accordingly, there is an unmet need for targeting of solid tumor cells for the treatment of malignant diseases that will show an affinity for cancer cells, deliver therapeutic payloads that inhibit proliferation and/or destroy cancerous tumor cells without inhibiting and/or destroying normal cells. (justia.com)
  • 3: Cancer that begins in urothelial cells that line the urethra, bladder, ureters, renal pelvis, and other related organs. (fujifilm.com)
  • The activity of NEK6 is enhanced in several cancer cells, including colon adenocarcinoma (COAD) cells. (hindawi.com)
  • Bladder cancer is any of several types of cancer arising from the tissues of the urinary bladder. (kuality.ca)
  • Any cancer/malignancy (either a "solid tumor" or a leukemia/lymphoma/bone marrow malignancy/"liquid tumor", i.e. any ICD10 code from C00-C99) can be a comorbid diagnosis --- BUT it's vital to distinguish malignancies in this category based on whether they are believed to be cured or not. (kuality.ca)
  • GATA3 staining aided in the diagnosis of urothelial bladder cancer with left supraclavicular node metastasis. (biomedcentral.com)
  • Compared to that in the non-BRCAm group, cutaneous melanoma (16.3 vs. 5.0%), lung cancer (19.4 vs. 11.8%), bladder cancer (15.6 vs. 5.6%), and stomach cancer (11.9 vs. 5.5%) accounted for a higher proportion in the BRCAm group. (biomedcentral.com)
  • A 62-year-old woman with a history of hysterectomy and oophorectomy for uterine cancer, left parathyroidectomy for Warthin's tumour and bladder neoplasia treated with transurethral resection (TUR), complaining of back pain. (elsevier.es)
  • This less than 8-minute video includes: a transperitoneal laparoscopic vesico-bladder fistula repair due to an iatrogenic obstetric hysterectomy, the second part is a transperitoneal laparoscopic radical nephrectomy of a central kidney cancer, and finally an extraperitoneal radical prostatectomy. (oatext.com)
  • Bladder cancer is more common among White people than Black people, and incidence increases with age. (msdmanuals.com)
  • Transcriptomic profiling of T-cell populations in non-muscle invasive and muscle invasive bladder cancer. (lu.se)
  • Dietary fats and their sources in association with the risk of bladder cancer: A pooled analysis of 11 prospective cohort studies. (who.int)
  • Molecular Diagnostic and Prognostication Assays for the Subtyping of Urinary Bladder Cancer Are on the Way to Illuminating Our Vision. (who.int)
  • In 1959, thiotepa was registered with the Food and Drug Administration (FDA) as a drug therapy for several solid cancers. (wikipedia.org)
  • and RC28 molecule to treat WAMD (wet age-related macular degeneration) and multiple solid cancers. (pharmaceutical-technology.com)
  • Patients with resectable solid primary cancers and even limited number of metastases are potentially curable. (policylab.us)
  • Evidence for virus-mediated oncogenesis in bladder cancers arising in solid organ transplant recipients. (cdc.gov)
  • 90% of bladder cancers. (msdmanuals.com)
  • It is very difficult to differentiate between malignant or benign lesions, including especially calcified foci and solid areas. (balkanmedicaljournal.org)
  • As long as there are not excrescences with areas of irregular solid mixed with cystic, this is still unlikely to be a malignant process. (wdxcyber.com)
  • found that pyroptosis-related genes can be used for prognostic prediction of skin cutaneous melanoma and lung adenocarcinoma, respectively. (nature.com)
  • A 41-year-old female patient was presented with stage IIIC well-differentiated ovarian serous papillary adenocarcinoma in 2009. (frontiersin.org)
  • While it is possible that this represents a ovarian mass with mostly solid components, it is much more commonly a benign process involving the bowel, tube or adhesive disease around the ovary. (wdxcyber.com)
  • The authors sought to investigate the function of interleukin 22 (IL22) in lung oncogenesis, and found that higher expression of the interleukin receptor IL22R1 was associated with lower recurrence-free survival in patients with KRAS-mutant lung adenocarcinoma. (aacr.org)
  • The expression level of NEK6 in esophagitis tissue is similar to that in esophageal adenocarcinoma, and overexpression of the NEK6 gene increases in proportion to the severity of esophagitis [ 14 ]. (hindawi.com)
  • Niraparib-based treatment regimen may be a good choice for patients with well-differentiated serous adenocarcinoma of the ovary who are intolerant to chemotherapy. (frontiersin.org)
  • The presence of solid components increases the likelihood of a neoplastic process rather than a physiologic process of the ovary. (wdxcyber.com)
  • If an ovary is not distinctly seen on an imaging study but there is a mixed cystic and solid mass in the adnexal region, it is most likely to be a benign lesion. (wdxcyber.com)
  • Particularly, urachal malakoplakia should also be taken into consideration in the differential diagnosis of lesions which include solid areas and are located in the urachus. (balkanmedicaljournal.org)
  • A blood-based circulating microbial metagenomic panel for early diagnosis and prognosis of oesophageal adenocarcinoma. (cdc.gov)
  • Compared with solid tumor sampling, the bone marrow or peripheral blood of leukemia patients is easier to access, and therefore an accurate and practical prognostic signature for leukemia patients has potential for more direct clinical application. (nature.com)
  • Squamous cell carcinomas, which are less common and usually occur in patients with parasitic bladder infestation or chronic mucosal irritation. (msdmanuals.com)
  • or as a therapeutic agent to prevent recurrence after cystoscopic resection of bladder tumor (transurethral resection of bladder tumor, TURBT). (wikipedia.org)
  • Disseminated Intravascular Coagulation (DIC) complicates up to 7% of malignancies, the commonest solid organ association being adenocarcinoma. (biomedcentral.com)
  • On CT the inferior and posterior wall had become thickened and from which a 6.4 cm × 7.4 cm mass protruded into the bladder cavity and the urethra. (biomedcentral.com)
  • The existence of a hypodense multiseptated cystic lesion with irregular margins and solid areas located between anterosuperior of bladder and umbilicus was reported. (balkanmedicaljournal.org)
  • A 74-year-old woman with TCC bladder and DIC was found to have a cardiac lesion suspicious for metastatic disease. (biomedcentral.com)
  • Abdominal CT ( Fig. 1 A/B) and abdominal MRI ( Fig. 1 C /D/E) were performed, showing a 29-mm left adrenal nodule, well defined, hypointense and homogeneous in all sequences, compatible with adenoma and an ampullary lesion of 15 mm, solid hypointense in all sequences, compatible with ampullary tumour. (elsevier.es)
  • Ultrasonography demonstrated a 6.0 cm × 7.4 cm mass with low-level echo in the bladder, with an irregular shape and rich blood supply. (biomedcentral.com)
  • This chapter exposed adults, with a shorter laten onal solid tumours, are observed as summarizes the literature that docu cy period from the time of exposure tumours of adult life in conventional ments this high susceptibility of the to the carcinogen until the appear rodents. (who.int)