In immunocompromised populations, such as patients with AIDS and recipients of solid organ and hematopoietic stem cell transplants, BK polyomavirus (BKPyV) can reactivate and cause several diseases, which can lead to death in their severe forms. (biomedcentral.com)
BK polyomavirus (BKPyV) is a member of the Polyomaviridae family, and it was first identified in 1971 by electron microscopy of the urine and uroepithelial cells of a renal transplant recipient [ 1 ]. (biomedcentral.com)
BK Polyomavirus Subtypes II and IV in Hematopoietic Cell Transplant Recipients. (uc.edu)
Despite strong experimental evidence, BK polyomavirus involvement in human cancers has been controversial. (northwestern.edu)
We report 2 cases of kidney ± pancreas transplant recipients with evidence of BK polyomavirus reactivation, who developed aggressive urinary bladder urothelial carcinomas with adenocarcinomatous and/or micropapillary differentiation. (northwestern.edu)
The BK polyomavirus role in promoting urothelial neoplasia in transplant recipients may be partly indirect, based on the demonstration by polymerase chain reaction in both tumors of BK polyomavirus with intact open reading frames and close phylogenetic clustering with known replication- competent strains, and viral capsid protein VP1 messenger RNA and intranuclear virions by electron microscopy in 1 tumor. (northwestern.edu)
The BK polyomavirus-induced profound effects on cell activation, cell cycle shift to proliferation, and apoptosis inhibition, in the context of marked immunosuppression, constitute a potentially ideal background for malignant transformation. (northwestern.edu)
Clinical vigilance is warranted for early diagnosis of BK polyomavirus-related urothelial malignancies in transplant recipients. (northwestern.edu)
Infections16
Although a number of other febrile viral infections may produce hemorrhage, only the agents of Lassa, Marburg, Ebola, and Crimean-Congo hemorrhagic fevers are known to have caused significant outbreaks of disease with person-to-person transmission. (cdc.gov)
Las Vegas, Nevada, United States) As per DelveInsight's assessment, globally, BK virus infections pipeline constitutes 4+ key companies continuously working towards developing 4+ BK virus infections treatment therapies, analysis of Clinical Trials, Therapies, Mechanism of Action, Route of Administration, and Developments analyzes DelveInsight. (openpr.com)
BK virus infections Pipeline Insight, 2023" report by DelveInsight outlines comprehensive insights into the present clinical development scenario and growth prospects across the BK virus infections Market. (openpr.com)
The BK virus infections Pipeline report embraces in-depth commercial and clinical assessment of the pipeline products from the pre-clinical developmental phase to the marketed phase. (openpr.com)
Companies across the globe are diligently working toward developing novel BK virus infections treatment therapies with a considerable amount of success over the years. (openpr.com)
Emerging BK virus infections therapies in the different phases of clinical trials are- BK virus antiviral therapy, AIC 468, AntiBKV antibody, Brincidofovir, MAU868, ALVR 105, and others are expected to have a significant impact on the BK virus infections market in the coming years. (openpr.com)
This designation as an orphan drug recognizes the pressing need for novel therapeutic approaches for individuals who have received hematopoietic stem cell transplantation and are susceptible to viral infections and hemorrhagic cystitis. (openpr.com)
BK virus infections pipeline report provides the therapeutic assessment of the pipeline drugs by the Route of Administration. (openpr.com)
A slow virus, BK establishes latent infections in B-lymphocytes and attacks an immunosuppressed host upon reactivation. (stanford.edu)
However, those patients are highly susceptible to viral infections that can be fatal. (scienceboard.net)
Posoleucel is the first T-cell therapy to target BK virus, which can cause severe, painful bladder infections requiring immediate treatment. (scienceboard.net)
The trial enrolled 58 adult and pediatric patients who had undergone allo-SCT to treat blood diseases and had at least one of the six viral infections targeted by posoleucel. (scienceboard.net)
There were 70 total viral infections in the trial population, primarily from CMV and BK virus. (scienceboard.net)
Together with the emerging data from our multiple dose study of the IV brinci formulation, we now have a greater understanding of how to best utilize each of these options, as we develop this first broad spectrum antiviral for prevention and treatment of multiple viral infections. (seekingalpha.com)
However, the clinical success of this therapy is marred by the morbidity associated with viral infections, which are frequent (cytomegalovirus 15.6-28%, adenovirus 3-21%, BK virus 18.5-20.7%) post-transplant. (nih.gov)
In some people, ADA2 deficiency causes additional immune system abnormalities that increase the risk of bacterial and viral infections. (medlineplus.gov)
Went viral4
Last year, a video of him commemorating his 27 years of work where he never called in sick or missed time went viral. (restoreamericanglory.com)
Burger King in Thailand is taking that motto further by introducing a burger with just meat after its cheese-only burger went viral earlier this month. (kltv.com)
A tweet by @Imposter_Edits went viral as people on the platform accused the woman of fake crying and calling for help to gain sympathy. (pix11.com)
Replication6
Immunosuppression reactivates BK virus replication and is linked to hemorrhagic cystis in bone marrow transplants. (stanford.edu)
The synthetic opioid fentanyl enhances viral replication in vitro. (uc.edu)
No unique cancer-associated mutations were found, but some viral T antigen mutations were potentially associated with increased rate of viral replication and risk for "rare" carcinogenic events. (northwestern.edu)
CVB3-Mediated Mitophagy Plays an Important Role in Viral Replication via Abrogation of Interferon Pathways. (bvsalud.org)
CVB3 has been demonstrated to subvert host cellular responses via autophagy to support viral replication in neural stem cells . (bvsalud.org)
Rapamycin or carbonyl cyanide m-chlorophenyl hydrazone ( CCCP ) treatment led to increased CVB3 RNA copy number in a dose -dependent manner, suggesting enhanced viral replication via autophagy / mitophagy activation, whereas knockdown of PTEN-induced putative kinase protein 1(PINK1) led to impaired mitophagy and subsequent reduction in viral replication . (bvsalud.org)
Viruses5
The influenza viruses are the most common viral cause of pneumonia. (medscape.com)
DNA and RNA viruses are involved in the etiology of viral pneumonia. (medscape.com)
The term viral hemorrhagic fever (VHF) refers to the illness associated with a number of geographically restricted viruses. (cdc.gov)
Posoleucel, an allogeneic therapy comprising donor T cells, targets six of the most common viruses in patients following allo-SCT: adenovirus, BK virus, cytomegalovirus (CMV), Epstein-Barr virus, human herpes virus 6, and JC virus. (scienceboard.net)
The result is a transient period of immune compromise when hematopoietic stem cell transplant recipients are at risk of infectious complications associated with both latent (cytomegalovirus, Epstein-Barr virus, BK virus, human herpes virus 6, herpes simplex virus, varicella-zoster virus) and community-acquired viruses including adenovirus, respiratory syncytial virus, and parainfluenza virus. (nih.gov)
Antigen2
An immunohistological study of the distribution of viral antigen within the brain. (medscape.com)
Diffuse strong nuclear positivity for viral T antigen, p53, Ki-67, and p16 was observed in both malignancies. (northwestern.edu)
Adenovirus3
Within six weeks of treatment, 83% of the 12 adenovirus patients responded, as did 100% of the 27 BK virus patients, 96% of the 24 CMV patients, 100% of the two Epstein-Barr virus patients, and 75% of the four human herpes virus 6 patients. (scienceboard.net)
The mRNA vaccines contain only the code for the SARS-CoV-2 envelope spike protein, whereas the DNA-based vaccines both contain an adenovirus viral vector that has been augmented with DNA that codes for the SARS-CoV-2 spike protein. (theepochtimes.com)
Last week, we attended the BMT Tandem Meeting in Salt Lake City and presented data supporting viral burden as an appropriate endpoint for studies of brinci and adenovirus infection. (seekingalpha.com)
Center for Infectious Diseases4
Epidemic Intelligence Service (EIS) Officer, Special Pathogens Branch, Division of Viral Diseases, Center for Infectious Diseases (ext. 1344). (cdc.gov)
Chief, Special Pathogens Branch, Division of Viral Diseases, Center for Infectious Diseases: Joseph B. McCormick, M.D. (ext. 3308). (cdc.gov)
Senior Medical Officer, Special Pathogens Branch, Division of Viral Diseases, Center for Infectious Diseases: Susan P. Fisher-Hoch, M.D. (ext. 3308). (cdc.gov)
Director, Division of Viral Diseases, Center for Infectious Diseases (ext. 3574). (cdc.gov)
Pneumonia9
The reported incidence of viral pneumonia (see the image below) has increased during the past decade. (medscape.com)
Depending on the virulence of the organism, as well as the age and comorbidities of the patient, viral pneumonia can vary from a mild, self-limited illness to a life-threatening disease. (medscape.com)
Respiratory syncytial virus (RSV) is the most frequent cause of lower respiratory tract infection in infants and children and the second most common viral cause of pneumonia in adults. (medscape.com)
Their efficacy in patients with influenza viral pneumonia or severe influenza is unknown. (medscape.com)
Viral pneumonia decreases in frequency in healthy young and middle-aged adults, but it then increases substantially among the elderly. (medscape.com)
Viral pneumonia occurs due to aggression of the viral pathogens on the lung structures. (medscape.com)
Because of the clinical manifestations and the radiologic aspects, viral pneumonia was included in the broad category of atypical pneumonias. (medscape.com)
In this category, viral pneumonia and the other atypical bacterial pneumonias must be differentiated. (medscape.com)
Viral pneumonia can have different manifestations. (medscape.com)
Gone viral2
Tommy Rees has officially gone viral again. (uhnd.com)
NEW YORK (PIX11) - A New York City hospital worker has come under fire after a video of her arguing with a group of apparent teens over a Citi Bike has gone viral on social media. (pix11.com)
Burger King1
BK Chicken Fries are a fried chicken product sold by the international fast-food restaurant chain Burger King. (wikipedia.org)
Influenza1
Global patterns in seasonal activity of influenza A/H3N2, A/H1N1, and B from 1997 to 2005: viral coexistence and latitudinal gradients. (who.int)
Hepatitis1
Chronic infection with viral hepatitis affects half a billion individuals worldwide and can lead to cirrhosis, cancer, and liver failure. (wjgnet.com)
Pathogens2
Tissue-resident lymphocytes (TRLs) are critical for local protection against viral pathogens in peripheral tissue. (jci.org)
Paired single-cell transcriptome and T cell receptor (TCR) sequencing showed that donor and recipient tissue-resident memory T (TRM) cells exhibit striking similarities in their transcriptomic profiles and share numerous TCR clonotypes predicted to target viral pathogens. (jci.org)
Hemorrhagic1
As an opportunistic infection, if the subsequent viral card produces a primary infection the player will come down with hemorrhagic cystis and kidney injury. (stanford.edu)
Amplification1
Atypical herpes simplex virus encephalitis diagnosed by PCR amplification of viral DNA from CSF. (medscape.com)
Carcinogenic1
1979. Enhancement of viral transformation for evaluation of the carcinogenic or mutagenic potential of inorganic metal salts. (cdc.gov)
Clinical1
In healthy individuals BK produces no clinical outcome or mild respiratory disease. (stanford.edu)
Loads2
Return to routine maintenance immunosuppression after suc cessful clearance of BKPyV-DNAemia should be considered under careful monitoring plasma viral loads to counteract rejection. (guidelinecentral.com)
Results underscore the need for antiretroviral therapy optimization and prompt management of high viral loads in infants and pregnant and breastfeeding women. (cdc.gov)
Cultures1
Viral CSF cultures are rarely positive and should not be relied on to confirm the diagnosis. (medscape.com)
Chronic1
Chronic Cough Related to Acute Viral Bronchiolitis in Children: CHEST Expert Panel Report. (umassmed.edu)
Reduction1
Responses were defined as complete -- a viral load reduction to normal range with complete symptom resolution, or partial -- a 50% minimum viral load reduction or 50% symptom improvement. (scienceboard.net)
Immune1
Ultimately, because these agents do not address the underlying immune compromise, viral rebound often occurs. (nih.gov)
Video1
The fundraiser was created following a viral video that commemorated Ford's work for the past 27 years. (restoreamericanglory.com)
Infection with the BK virus (BKV): In 1971, a renal transplant recipient suffering from ureteric stenosis had the BK virus isolated from his urine. (openpr.com)
Cells1
genic models are inadequate for number of activated CD8-positive T LMP1 was strongly expressed in the understanding the cancer etiology in cells increased considerably in the lymphoma tissues but was hardly the context of natural viral infection. (who.int)
Treatment1
Dear Editor, Cryotherapy is a cost-effective treatment that can be performed by non-dermatologists for viral warts, which are very common.1,2 The National University Hospital, Singapore. (annals.edu.sg)
Patients1
Among the 12 patients with more than one viral infection, 10 (83%) responded. (scienceboard.net)
Role1
Inoculation with a high dose strains of LMP1 transgenic mice vide a powerful tool in mechanistic of EBV caused a B-cell lymphopro- were established that express LMP1 studies on the role of individual viral liferative disorder in these mice, under the control of the immunoglob- genes in cancer. (who.int)
Mild1
Power level is low in healthy children in whom the viral infection is subclinical or produces mild respiratory disease. (stanford.edu)