Bk in kidney transplant recipients bk virus. Medical search. Frequent questions

Impact of CYP3A5 genotype on de-novo LCP tacrolimus dosing and monitoring in kidney transplantation. (nih.gov)
Over the last several decades, the field of solid organ transplantation (SOT) science and practice has advanced significantly, only to be continually challenged by the risks for infection in SOT recipients. (medscape.com)
The September 2019 issue of the American Journal of Transplantation contains a comprehensive review of the various topics within the scope of infections in SOT recipients. (medscape.com)
As a result, practitioners are challenged to help solid organ transplantation (SOT) recipients retain their transplanted organs, prevent SOT-related infections, and improve their quality of life. (medscape.com)
Early diagnosis and treatment of Polyomavirus BK Nephropathy (PVBKN) is a challenging issue in the management of patients with kidney transplantation. (biomedcentral.com)
Polyomavirus BK nephropathy (PVBKN) is an important cause of allograft dysfunction in patients with kidney transplantation [ 1 ]. (biomedcentral.com)
After immunosuppression, following transplantation, the virus activates, replicates, and damages urothelial cells as well as renal parenchymal tubules. (biomedcentral.com)
New onset diabetes after kidney transplantation in Asian Americans - Is there an increased risk? (elsevierpure.com)
This study is the first to link 2 common complications of kidney transplantation, namely BK viremia and donor-specific antibodies," said Dr. Sawinski. (transplantfamilies.org)
It takes advantage of combining data from all transplant programmes in one unique system to perform comprehensive nationwide reporting and to promote translational and clinical post-transplant outcome research in the framework of Swiss transplantation medicine. (bmj.com)
While dialysis does offer life sustaining treatments for those without sufficient kidney function, kidney transplantation is the optimal treatment for this patient population. (gwdocs.com)
Healthy kidneys for transplantation can be from a living or deceased donor. (gwdocs.com)
The transplant nephrologist is specially trained to identify the appropriate candidate to undergo transplantation, choose and optimize the immunosuppressive medications, and manage specific transplant related complications, such as opportunistic infections, malignancy, and heart disease. (gwdocs.com)
This case emphasizes the importance of eculizumab to treat atypical hemolytic uremic syndrome (aHUS) after kidney transplantation and discusses therapeutic considerations. (ekjt.org)
aHUS after kidney transplantation (KT) can cause irreversible graft failure. (ekjt.org)
Transplant infectious disease : an official journal of the Transplantation Society 2020 Apr e13300. (cdc.gov)
As a dual transplant recipient, I've experienced firsthand that transplantation is not a singular event, or a cure, but a lifelong journey. (newsbiztrends.com)
These are the use of induction immunosuppression, donor seropositivity, old donors, simultaneous kidney-pancreas transplantation, presence of allograft rejection and concurrent infection from other viruses. (nephrologistinagartala.com)
These include kidney-pancreas transplantation with bladder drainage, deceased-donor transplant, prolonged catheterization, increased immunosuppressed state and the use of ureterovesical stents. (nephrologistinagartala.com)
The faculty have a variety of clinical protocols dealing with diabetic nephropathy, bone disease, progression of kidney disease, kidney transplantation, vitamin deficiency in chronic kidney disease, end-stage renal disease, transplantation and nutrition in patients with acute kidney injury. (usc.edu)
Kidney transplantation within 24 months prior to enrollment 3. (trialstoday.org)
Recipients who are treated or planned to be treated with a mammalian Target of Rapamycin (mTOR) inhibitor or belatacept as part of their immunosuppression regimen post-transplantation at the time of enrollment and during the study period. (trialstoday.org)
Recipients with known donor-specific antibodies (DSA) (de novo or pre-transplantation). (trialstoday.org)
Skin grafts Many different types of tissues can be transplanted, including skin, bone, cartilage, adrenal tissue, fetal thymus, corneas, and composite transplantation of tissues to restore the face or extremities. (msdmanuals.com)
Some research is ongoing in transplantation of non-human organs, such as heart, kidney and liver transplantation. (msdmanuals.com)
The onset of metabolic syndrome (MS) after kidney transplantation (KTx) is evidenced in the literature and this is characterized by alterations that confer a reduction in the function of the transplantation. (bvsalud.org)
METHODS@#We retrospectively analyzed the clinical data of 135 recipients with graft loss after renal transplantation in the Eighth Medical Center of Chinese PLA General Hospital from January 1, 2002 to January 1, 2022. (bvsalud.org)
CONCLUSION@#The main cause of graft loss after renal transplantation is graft rejection, and the secondary cause is death of the recipient with functional graft, and other reasons can be rare. (bvsalud.org)
Until recently, ABO-incompatible living donor kidney transplantation was regarded as an absolute contraindication. (revistanefrologia.com)
However, this kind of kidney transplantation has been used in the last years, with good results. (revistanefrologia.com)
ABO incompatible living donor kidney transplantation after conditioning with rituximab, plasmapheresis/immunoadsorption and immunoglobulins is a valid option offering excellent outcomes.as survival and acute rejections without increasing infectious complications. (revistanefrologia.com)
Polyoma virus infection after renal transplantation. (mcw.edu)
This CME symposium will offer approximately 20 hours of continuing medical education and is geared towards nephrologists, pulmonologists, hepatologists, cardiologists, gastroenterologists, and allied health professionals dedicated to the treatment and management of transplantation recipients and patients with end-stage organ diseases. (myast.org)
The symposium will feature two concurrent educational tracks, Thoracic and Abdominal, both focusing on the appropriate care of transplant recipients and donors before, during, and after transplantation. (myast.org)
The purpose of this study was to evaluate clinical findings and risk factors for BKV in pediatric patients after kidney transplantation. (e-cep.org)
Despite the high incidence of reactivation of the JC virus in recipients of renal transplantation, a small fraction of patients eventually show JC virus-associated nephropathy, which may lead to rejection of the transplant [ 11 ]. (biomedcentral.com)
OBM Transplantation is committed to rapid review and publication, and we aim at serving the international transplant community with high accessibility as well as relevant and high quality content. (lidsen.com)
Cytomegalovirus (CMV) is a beta variant of the Herpes Simplex Virus (HSV), a highly prevalent opportunistic pathogen with over 50% of adults infected worldwide by age [ 1. De Matos SB, Meyer R, de Mendonça Lima FW. Cytomegalovirus infection after renal transplantation: Occurrence, clinical features, and the cutoff for antigenemia in a university hospital in Brazil. Infect Chemother. 2017; 49: 255-261. [ CrossRef ] ">1 ]. (lidsen.com)
Anatomic issues related to solid organ transplantation are specific to the organ transplanted and time since transplantation but generally involve thrombosis, stricture, or breakdown and leakage of the anastomoses. (canadiem.org)

Future treatment strategies should focus on simultaneously clearing BK infections while protecting against risks of transplant rejection. (transplantfamilies.org)
The most common approach to BK infection in transplant patients is to reduce their anti-rejection medications so that their immune systems can fight off the infection. (transplantfamilies.org)
Deirdre Sawinski, MD (Perelman School of Medicine at the University of Pennsylvania) and her colleagues looked at the health of 785 kidney transplant recipients, 132 of whom who had persistent BK infections despite reducing their anti-rejection medications. (transplantfamilies.org)
Secondly, JC virus nephropathy seems to be associated with a less aggressive and more protracted clinical course when compared with BK virus with lower rate of graft rejection and better survival. (cytopathology.ca)
Immunosuppressive medications are required to prevent rejection of the transplanted kidney. (gwdocs.com)
Her laboratory results indicated significant hemolysis, with a hemoglobin level of 7.0 g/dL, platelet count of 20 ×10 3 /μL, and a lactate dehydrogenase level of 3,207 IU/L. Kidney biopsy showed severe thrombotic microangiopathy without any evidence of acute rejection. (ekjt.org)
Dr. Sharma is well published and has been a recipient of research funding for investigator-initiated studies and clinical trials his clinical research interest is focused on novel diagnostics and therapeutics for antibody-mediated rejection and kidney transplant. (newsbiztrends.com)
Nephropathy from BK virus is an increasing problem in renal transplant recipients and has been correlated with newer immuno-suppressive agents and the decline in acute rejection rates. (ectrx.org)
It is difficult to make a clear differential diagnosis between BK virus nephropathy and acute cellular rejection. (ectrx.org)
Factors that may be associated with the risk of BK virus nephropathy include older age, male sex, white ethnicity, diabetes, renal tissue injury from ischemia, presence of cytomegalovirus, acute rejection, and treatment with high-dose steroid pulses. (ectrx.org)
Recipients with kidney transplant rejection or focal segmental glomerulosclerosis (FSGS) shown by renal biopsy 10. (trialstoday.org)
We compared transplant characteristics, acute rejection rates, one-year renal function and graft and patient survival using univariate and multivariable models. (atcmeetingabstracts.com)
One-year acute rejection rates were slightly higher among recipients on GTAc (8.1% vs 7.3%, p=0.02). (atcmeetingabstracts.com)
Structural and antigenic studies have revealed that JCV is closely related to BKV, which was coincidently discovered and associated with nephropathy and graft rejection in renal transplant recipients [ 2 ]. (biomedcentral.com)
Mycophenolate mofetil is an antimetabolite immunosuppressant indicated for the prophylaxis of organ rejection in recipients of allogeneic kidney, heart or liver transplants, and should be used in combination with other immunosuppressants. (nih.gov)
The possibility of organ rejection, infection, or drug toxicity should be considered in all organ transplant patients who present to the ED, because the presentations can be subtle. (canadiem.org)
Differentiation of infection and rejection is often difficult in the ED. Determination is often made only after biopsy of the transplanted organ or positive culture results are identified. (canadiem.org)
Rejection involves a complex set of T-cell receptor mediated pathways that lead to cytotoxic activity, B-cell memory and antibody formation, and cell death of the transplant allograft. (canadiem.org)

However, it is unclear if TRLs perform a similar role in transplanted organs under chronic immunosuppressed conditions. (jci.org)
Such donor-specific antibodies are known to be detrimental to the survival of transplanted organs. (transplantfamilies.org)
Growing evidence suggests liver allografts provide immunological protection to the simultaneously transplanted organs through different mechanisms. (myast.org)

Potent immunosuppression is believed to be the cause of the resurgence of BK virus in kidney transplant patients. (ectrx.org)
The BK polyomavirus-induced profound effects on cell activation, cell cycle shift to proliferation, and apoptosis inhibition, in the context of marked immunosuppression, constitute a potentially ideal background for malignant transformation. (northwestern.edu)
Successful treatment of BK viremia using reduction in immunosuppression without antiviral therapy. (mcw.edu)
Currently, there is no consensus on assessment of these patients' immunological risk, waitlist management or post-transplant immunosuppression. (myast.org)
BKPyV infects most people in the general population but remains dormant in the cells of the kidney and bladder, reactivating to cause disease in patients who are receiving immunosuppression, such as after transplant. (chop.edu)
who are latently infected with an on- Certain pharmaceutical drugs, Immunosuppression as a medi- cogenic virus are at greatly increased ionizing and ultraviolet radiation, cal therapy is used to treat autoim- risk for developing virus-related or infection with certain viruses mune diseases such as lupus ery- cancers when they become immu- and parasites can cause immu- thematosus or rheumatoid arthritis. (who.int)
Immunosuppression by a kidney or heart transplant. (who.int)

There is no clear consensus about routine IHC tests in the pathologic evaluation of transplanted kidney biopsy samples. (biomedcentral.com)
The current study was conducted on transplanted kidney biopsy samples, since 2016 to 2019. (biomedcentral.com)
All these biopsy samples were evaluated with routine renal biopsy stains as well as IHC for SV40 (Simvian Virus 40) antigen. (biomedcentral.com)
Routine IHC study for SV40 in all transplanted kidney biopsy samples with new onset of allograft dysfunction, will enhance the diagnostic sensitivity of early stage disease detection. (biomedcentral.com)
The concurrent renal biopsy of the patient's transplant kidney demonstrates some tubular cells with enlarged nuclei and hyperchromasia. (cytopathology.ca)
The purpose of this study is to evaluate the safety, tolerability, and efficacy of AntiBKV in reducing BK viremia and progression to biopsy-confirmed BKVAN in Kidney Transplant Recipients (KTRs). (trialstoday.org)
Recipients who have medical conditions that prevent the recipient from undergoing allograft biopsy due to chronic anticoagulation or antiplatelet agents (except for low dose aspirin) 11. (trialstoday.org)

Polyomavirus BK versus JC replication and nephropathy in renal transplant recipients: a prospective evaluation. (cytopathology.ca)
Dendritic cell deficiency associated with development of BK viremia and nephropathy in renal transplant recipients. (cdc.gov)

Washington, DC (September 25, 2014) - Kidney transplant recipients infected with BK virus are more likely to develop antibodies against their kidney transplants than uninfected patients, according to a study appearing in an upcoming issue of the Journal of the American Society of Nephrology (JASN). (transplantfamilies.org)
Founded in 1966, and with more than 14,000 members, the American Society of Nephrology (ASN) leads the fight against kidney disease by educating health professionals, sharing new knowledge, advancing research, and advocating the highest quality care for patients. (transplantfamilies.org)
The Journal publishes articles on basic or clinical research relating to nephrology, arterial hypertension, dialysis and kidney transplants. (revistanefrologia.com)
The Transplant Nephrology Fellowship Program at NewYork-Presbyterian/Weill Cornell Medicine (NYP-WCM) provides advanced education and training to the next generation of transplant nephrologists. (cornell.edu)

Findings to date Detailed clinical and laboratory data in high granularity as well as patient-reported outcomes from transplant recipients and activities in Switzerland are available in the last decade. (bmj.com)
His surgical philosophy is centered on delivering best possible care and achieving best possible outcomes for transplant recipients and their families. (newsbiztrends.com)
While there may be variation in outcomes between different generic formulations, there is no evidence of significant adverse outcomes for kidney transplant recipients with use of generic tacrolimus. (atcmeetingabstracts.com)
The choice of antiviral medication and duration of treatment are important considerations to ensure optimal patient outcomes and kidney graft function and survival. (lidsen.com)
Neither pre-transplant clinical characteristics nor transplant characteristics are reliably predictive of GvHD outcomes. (cryostem.org)

The Division of Kidney Disease and Hypertension at The GW Medical Faculty Associates is dedicated to the comprehensive and personalized care of kidney and kidney-pancreas transplant patients. (gwdocs.com)
He has been a tenure track assistant professor for transplant surgery at University at Buffalo in Buffalo, New York, Director of kidney and pancreas transplant programs at Penn State Hershey medical center in Hershey, PA, and an associate professor of surgery at University of Nevada, Las Vegas, Nevada. (newsbiztrends.com)
We report 2 cases of kidney ± pancreas transplant recipients with evidence of BK polyomavirus reactivation, who developed aggressive urinary bladder urothelial carcinomas with adenocarcinomatous and/or micropapillary differentiation. (northwestern.edu)

Worldwide, an estimated 152,863 solid organ transplants were performed in 2019. (medscape.com)
Participants Over 5500 solid organ transplant recipients have been enrolled in all six Swiss transplant centres by end of 2019, around three-quarter of them for kidney and liver transplants. (bmj.com)
Urine and plasma samples were collected from a total of 120 consecutive renal‐transplanted patients without preliminary screening from Jan 2018 to Mar 2019. (biomedcentral.com)

Living donors are often used for kidney and hematopoietic stem cell transplants, less frequently for segmental liver transplants, and rarely for pancreas and lung transplants. (msdmanuals.com)
The much enhanced safety profile may also allow the drug to be used for prophylaxis in both hematopoietic stem cell transplants and some sold organ transplants. (smithonstocks.com)

Persons in this study (73 male and demonstrated that antibody titers among kidney transplant 127 female) ranged in age from 12-35 years (median age donors refl ect the activity and transmissibility of BKV 30 years). (cdc.gov)
Our providers perform kidney transplants using kidneys from both living and deceased donors. (gwdocs.com)
We aimed to evaluate the effect of BK virus-positive kidney donors on the outcome of kidney transplant recipients after mean follow-up 21 months. (ectrx.org)
Among 18 kidney donors with BK virus in blood and urine, 5 donors were fit for donation. (ectrx.org)
Clinical information was reviewed for the 5 kidney transplant recipients who received kidney allografts from these donors (mean donor age, 35 ± 3 y). (ectrx.org)

Moreover, in these tough times, when Corona cases have spread all over the world, post-COVID-19 pneumonia can lead to serious complications in kidney transplant recipients. (nephrologistinagartala.com)
So, if you need to undergo a kidney transplant, consult your doctor and take the necessary precautions to avoid complications after the surgery. (nephrologistinagartala.com)
Post-transplant complications of the ABO incompatible. (revistanefrologia.com)
Although short in duration, this chapter has straightforward and useful information for emergency physicians in regards to complications possible with transplant recepients. (canadiem.org)

It is also associated with hemorrhagic cystitis in allogeneic hematopoietic cell transplant recipients. (cytopathology.ca)
In the section on aspergillosis, the revised recommendations include the use of a room with high-efficiency particulate air filters rather than laminar airflow as the protective environment for allogeneic HSCT recipients and the use of high-efficiency respiratory-protection devices (e.g. (cdc.gov)

Trichodysplasia spinulosa (also known by many other names, including viral-associated trichodysplasia spinulosa, viral-associated trichodysplasia, pilomatrix dysplasia and ciclosporin-induced folliculodystrophy, although the last is a misnomer) is a rare cutaneous condition that has been described almost exclusively in immunocompromised patients, usually organ transplant recipients, on regimens of immunosuppressive drugs. (wikipedia.org)
TS has been reported almost exclusively in immunocompromised patients, primarily organ transplant recipients on regimens of immunosuppressive drugs, and also in patients with hematolymphoid malignancies. (wikipedia.org)
The diagnosis of infection is made more arduous since SOT recipients may present with more than one infection or at later stages in the disease process or may experience drug toxicity from immunosuppressive agents, as well as from antibiotics. (medscape.com)
However, for transplant recipients and others who take immunosuppressive drugs, it can be problematic. (transplantfamilies.org)
After being diagnosed with JC virus-associated nephropathy, one of the patient's immunosuppressive agents was changed and the patient's creatinine returned to the baseline. (cytopathology.ca)
Therefore, a decrease or discontinuation of immunosuppressive agents is essential as initial treatment for BK virus nephropathy. (ectrx.org)
18 Although immunosuppressive agents are essential for therapy after organ transplant, these agents increase the incidence and deteriorate the severity of BK virus infection. (ectrx.org)
Seven days following the first IMP administration, participants will be re-evaluated for BK viremia and, if appropriate, changes of immunosuppressive treatment will be started. (trialstoday.org)

This assay detects and quantifies the level of BK virus (BKV) DNA present in the urine of kidney transplant recipients who are at risk of developing BKV-associated nephropathy or hemorrhagic cystitis leading to decreasing renal function and eventual renal failure. (marshfieldlabs.org)
There is the association of BK polyomavirus (BKV), which is a member of the polyoma family of viruses, with polyomavirus-associated hemorrhagic cystitis and polyomavirus-associated nephropathy (PyVAN). (nephrologistinagartala.com)
Hemorrhagic cystitis - or bleeding from the bladder - occurs in up to 25% of stem cell transplant recipients and is associated with BK polyomavirus (BKPyV) infection, although the exact cause of the bladder injury is not known. (chop.edu)
BKPyV replication in the urine can be detected in 80% of patients after stem cell transplant, but not all of these patients will develop hemorrhagic cystitis. (chop.edu)
The proposed research project will test the hypothesis that the risk of hemorrhagic cystitis in patients with BKPyV replication in the urine is due to the specific viral strain and the patient's response to the virus. (chop.edu)
Specifically, the team will test whether the strain of BKPyV is different between patients with and without hemorrhagic cystitis after stem cell transplant. (chop.edu)
Using proteomics techniques, they will also test whether a patient's cellular response to the virus is different between those with and without hemorrhagic cystitis. (chop.edu)

Based on our experience, a shorter interval between the clinical diagnosis of aHUS and administration of eculizumab increases the likelihood of rescuing the kidney. (ekjt.org)
A shorter interval between the clinical diagnosis of aHUS and the administration of eculizumab increases the chance of recovering kidney function. (ekjt.org)
Kidney transplant recipient with first-time BK viremia (evaluated during routine clinical monitoring by the local laboratory and acknowledged by a physician within 35 days prior to day 1). (trialstoday.org)
Clinical vigilance is warranted for early diagnosis of BK polyomavirus-related urothelial malignancies in transplant recipients. (northwestern.edu)
This course will review the most current clinical and experimental data, and identify areas for further research and allocation policies that will help transplant this difficult cohort of patients. (myast.org)
We report here the complete genome sequence of polyomavirus BK subtype Ib-1, isolate AR11, identified in urine from a human kidney transplant recipient with a clinical diagnosis of BK viremia. (johnshopkins.edu)
The research will provide the foundation for future clinical trials testing if strategies such as the infusion of virus fighting T-cells can prevent or treat BKPyV polyomavirus-associated disease and subsequently decrease morbidity and mortality for transplant patients. (chop.edu)
This study aimed to evaluate the clinical findings in pediatric rhabdomyolysis and the predictive factors for acute kidney injury (AKI) in Korean children. (e-cep.org)
The strongest clinical data for brincidofovir is a phase 2 study for prophylaxis of cytomegalovirus reactivation in hematopoietic stem cell transplant patients. (smithonstocks.com)
I was right in being concerned about the enthusiasm of investors about the Ebola virus as the company subsequently dropped clinical development. (smithonstocks.com)

Association of interferon gamma gene polymorphisms with BK virus infection among Hispanic renal allograft recipients. (cdc.gov)

Participants aged 18 years or older, recipients of late KTx with follow-up longer than 6 months, were included. (bvsalud.org)

via Common Viral Infection in Kidney Transplant Recipients Increases Risk of Developing Donor-Specific Antibodies . (transplantfamilies.org)
A review on JC virus infection in kidney transplant recipients. (cytopathology.ca)
Human herpesvirus 7 primary infection in kidney transplant recipients. (isglobal.org)

Currently, approximately 400,000 patients with kidney disease are on dialysis. (gwdocs.com)
Current areas of investigation include the noradrenergic control of blood pressure in kidney disease, mechanisms and management of vascular calcifications in dialysis patients, detection and management of cardiovascular disease in dialysis patients and prevention of progressive renal disease in African-Americans. (usc.edu)

This can prevent a person from having a donor kidney match. (gwdocs.com)
A 61-year-old female patient with chronic kidney disease due to diabetes mellitus and hypertension-induced nephropathy received a deceased donor kidney transplant in March 2020. (ekjt.org)
HLA-E Polymorphism Determines Susceptibility to BK Virus Nephropathy after Living-Donor Kidney Transplant. (cdc.gov)

Comparison of polyomavirus (BK virus and JC viruses) viruria in renal transplant recipients with and without kidney dysfunction. (ac.ir)
The prevalence of JCV viruria and viremia among renal transplant recipients were 26 (21.67%) and 20 (16.67%), respectively. (biomedcentral.com)

This pattern is consistent with the behavior of other viral diseases found in immunocompromised patients, most relevantly with the nephropathy associated in kidney transplant recipients with the polyomavirus BK virus. (wikipedia.org)
However, virus-infected cells were identified just after IHC study in 4 (22.2%) of patients. (biomedcentral.com)
Among kidney transplant recipients, persistent infection with BK virus does not have a negative immediate-term impact on patient or kidney survival, but infected patients are more likely to develop antibodies against their kidney transplants. (transplantfamilies.org)
While there was no significant difference in terms of patient or kidney transplant survival after a median of 3 years, patients with BK infections were more likely to develop antibodies against their kidney transplants. (transplantfamilies.org)
However, we cannot comment on the exact mechanism by which BK viremia predisposes patients to the development of donor-specific antibodies. (transplantfamilies.org)
BK virus is associated with nephropathy and ureteral stenosis in kidney transplant patients. (cytopathology.ca)
JC virus is associated with progressive multifocal leukoencephalopathy in immunocompromised patients. (cytopathology.ca)
Although both BK and JC viruses can cause nephropathy in kidney transplant patients, there are many differences between the two. (cytopathology.ca)
Transplant Surgery at The GW Medical Faculty Associates is a comprehensive kidney transplant program along with the specialty services required to care for transplant surgery patients in the District of Columbia and the surrounding areas. (gwdocs.com)
From initial evaluations to surgical procedures and the necessary after care, transplant patients undergo the entire process at The GW Medical Faculty Associates and the George Washington University Hospital through The GW Transplant Institute . (gwdocs.com)
Sensitized kidney transplant patients have high antibody levels that react to foreign tissue. (gwdocs.com)
At last follow-up, all patients were enjoying functioning grafts without recurrence of BK virus infection. (ectrx.org)
9 In more recent reports, reactivation occurs soon after transplant and is identified in the urine of 30% to 50% patients at 3 months after transplant. (ectrx.org)
10,11 Only 1% to 10% affected patients change from reactivated infection to histologically confirmed BK virus nephropathy, usually at mean 10 to 13 months after transplant (range, 6 days to 5 years). (ectrx.org)
The BK virus nephropathy is 1 of the major causes of allograft dysfunction or graft loss in patients in an overly immunosuppressed state. (ectrx.org)
It has been showed that 45% patients with BK virus nephropathy progressed to irreversible graft failure with tubular atrophy and interstitial fibrosis. (ectrx.org)
GESITRA-SSEIMC/REIPI recommendations for the management of cytomegalovirus infection in solid organ transplant patients. (isglobal.org)
Wei J, Johansen KL, McCulloch CE, Lipkowitz M, Weir M, Lin F, Campese VM , Smogorzewski M, Ku E. Association Between APOL1 Genotype and Need for Kidney Replacement Therapy in Patients Without Diabetes: Does Age Matter? (usc.edu)
however, demand still far exceeds supply, and the number of patients waiting for organ transplants continues to grow. (msdmanuals.com)
Rapid kidney allograft failure in patients with polyoma virus nephritis with prior treatment with antilymphocyte agents. (mcw.edu)
Visit the UNOS TransplantPro website for information on a recorded presentation for transplant hospitals to use to instruct physicians who refer kidney patients for transplant about the new kidney allocation system. (healthytransplant.com)
Polyomavirus BK (BKV) infection is an important cause of graft loss in kidney transplant patients. (e-cep.org)
In the present study, we aimed to determine the probable predictive factors leading to JCV replication in renal transplant patients. (biomedcentral.com)
There was a statistically significant coexistence between BK and JC viruses among our patients ( P = 0.029). (biomedcentral.com)
The John Cunningham virus (JCV) is an ubiquitous human polyomavirus that was first discovered in 1971 from patients with progressive multifocal leukoencephalopathy (PML) [ 1 ]. (biomedcentral.com)
The Company will begin the SURPASS and SUSTAIN trials in kidney transplant patients in 2H, 2015. (smithonstocks.com)
The drug of choice for prevention of CMV disease in solid-organ transplant patients is valganciclovir. (medscape.com)
recipients constituted 42% of those patients, while underlying malignancies were found in 26% (Table 1). (who.int)

Serial measurement (eg, once weekly) of BKV DNA in urine or plasma is recommended to determine the BKV replication status in a given transplant recipient. (marshfieldlabs.org)
Diagnosis of BK virus nephropathy is based on histologic appearance characterized by lymphocytic interstitial infiltrates, nuclear reaction to the anti-SV-40T antibody as evidence of viral replication, and positive PCR for BK virus DNA. (ectrx.org)
The BK polyomavirus role in promoting urothelial neoplasia in transplant recipients may be partly indirect, based on the demonstration by polymerase chain reaction in both tumors of BK polyomavirus with intact open reading frames and close phylogenetic clustering with known replication- competent strains, and viral capsid protein VP1 messenger RNA and intranuclear virions by electron microscopy in 1 tumor. (northwestern.edu)

Post-transplant renal function in the first year predicts long-term kidney transplant survival. (mcw.edu)
Appropriate patient surveillance and prophylaxis are essential to ensure the best long-term kidney transplant results. (lidsen.com)

Routine immunohistochemistry study for polyomavirus BK nephropathy in transplanted kidney biopsies, is it recommended? (biomedcentral.com)
Regular kidney biopsies will be performed at baseline (prior to infusion) and on Day 141 (8 weeks after full dosing). (trialstoday.org)

There is a decreased survival rate among kidney transplant recipients with HCV infection. (nephrologistinagartala.com)
There is a risk of Mycobacterium tuberculosis among kidney transplant recipients. (nephrologistinagartala.com)

Among the kidney transplant recipients, there are cases of morbidity and mortality due to infections. (nephrologistinagartala.com)
A major cause of morbidity and mortality after kidney transplant is infection from Epstein-Barr virus (EBV) as it has a connection with PTLD development. (nephrologistinagartala.com)
There are morbidity and mortality from HCV in kidney transplant recipients. (nephrologistinagartala.com)

Human polyomavirus 7: associated with a pruritic rash and viremia in lung transplant recipients. (cytopathology.ca)

Impact of genetic polymorphisms on tacrolimus trough blood concentration in Chinese liver transplant recipients. (nih.gov)

In adults, MCV is typically an asymptomatic, common, and occurs largely in childhood, with BKV seroprevalence commensal viral infection that initiates rare cancers after virus (rather than host cell) mutations. (cdc.gov)

In this study, we aimed to characterize the TRL compartment in human kidney transplant nephrectomies and examine its potential role in antiviral immunity. (jci.org)

His translational research interest is focused on bk virus-specific cell-mediated immune response and immune surveillance and kidney transplant recipients. (newsbiztrends.com)

The article, entitled "Persistent BK Viremia Does Not Increase Intermediate-Term Graft Loss But is Associated with De Novo Donor Specific Antibodies," will appear online at http://jasn.asnjournals.org/ on September 25, 2014. (transplantfamilies.org)
OBJECTIVE@#To investigate the causes of graft loss in kidney transplant recipients. (bvsalud.org)

In most of the clinics, antibody for the anti-large T antigen of Simian virus 40 (SV40) is used. (biomedcentral.com)
If a recipient's blood contains antibodies that react to a potential donor's blood type, the antibody reaction will immediately reject the transplant. (gwdocs.com)
8. Recipients who in the opinion of the investigator are likely to require antibody-depletion therapy during trial participation. (trialstoday.org)
Recipients who are receiving a monoclonal antibody treatment for another indication (e.g. rituximab, infliximab etc.) 13. (trialstoday.org)
Humanized anti-CD20 monoclonal antibody (Rituximab) treatment for post-transplant lymphoproliferative disorder. (mcw.edu)

May 27, 2017 A new study indicates that receiving donor kidneys from individuals with diabetes may offer a greater survival benefit than remaining on the waitlist for many transplant candidates. (transplantfamilies.org)

Clin Transplant. (cornell.edu)

I was diagnosed with polycystic kidney disease at 10 years old which led to me needing a kidney transplant at 19 and a liver transplant at 35. (newsbiztrends.com)

[ 15 ] The focus of this article is adult populations, although infectious disease issues germane to the pediatric SOT recipient are discussed in Special Host Considerations. (medscape.com)
He completed his ASTS transplant surgery fellowship at Northwestern University Chicago and a pediatric transplant surgery fellowship at Children's Hospital of Pittsburgh of UPMC in Pittsburgh, Pennsylvania. (newsbiztrends.com)
Methods: This retrospective single-center study included 31 pediatric kidney transplant recipients from January 2002 to December 2017. (e-cep.org)

Finally, several areas related to infections in SOT recipients are unresolved and controversial. (medscape.com)
Overview of JC polyomarvirus, BK polyomavirus and other polyomavirus infections. (cytopathology.ca)
The most common bacterial infections, from which kidney transplant recipients suffer, are urinary tract infections (UTIs). (nephrologistinagartala.com)
There can be fungal infections in kidney transplant recipients, who are hospitalized. (nephrologistinagartala.com)
Despite the risk of infections associated with a kidney transplant, it is an important treatment option for kidney failure. (nephrologistinagartala.com)
The differentiating feature is a much improved side effect profile that will allow much greater use of brincidofovir for treating infections caused by double stranded viruses, notably cytomegalovirus, adenovirus, smallpox and BK virus. (smithonstocks.com)
CMV shares many attributes with other herpes viruses, including genome, virion structure, and the ability to cause latent and persistent infections. (medscape.com)

I am a two year post kidney transplant patient. (mayoclinic.org)

The patient is a 62 year old male who is a kidney transplant recipient due to end-stage renal disease secondary to sarcoidosis. (cytopathology.ca)
A family member or a friend agrees to donate a healthy kidney to someone with end-stage renal disease. (gwdocs.com)

An identical miRNA of the human JC and BK polyoma viruses targets the stress-induced ligand ULBP3 to escape immune elimination. (ictv.global)
Polyoma tumor development in neonatally polyoma-virus-infected CD4-/- and CD8-/- single knockout and CD4-/-8-/- double knockout mice. (ictv.global)
Variations in polyoma virus genotype in relation to tumor induction in mice. (ictv.global)
Polyoma BK virus-positive people can be accepted safely for kidney donation, especially with a possible protective role of human leukocyte antigen Cw7. (ectrx.org)
Polyoma BK viruses are widespread, double-stranded, nonencapsulated DNA viruses comprising BK and JC strains that are pathogenic in humans. (ectrx.org)

Anatomy13

Organisms35

Diseases48

Chemicals and Drugs47

Analytical, Diagnostic and Therapeutic Techniques and Equipment76

Psychiatry and Psychology2

Phenomena and Processes29

Disciplines and Occupations2

Information Science9

Named Groups2

Health Care42

Geographicals3

Transplantation39

Rejection18

Organs3

Immunosuppression7

Biopsy7

Nephropathy in renal transplant recipients2

Nephrology4

Outcomes5

Pancreas transplant3

20193

Hematopoietic stem cell transp2

Donors5

Complications4

Allogeneic2

Immunosuppressive8

Hemorrhagic7

Clinical10

Allograft recipients1

Aged 18 years or older1

Infection in kidney transplant3

Dialysis2

Donor kidney3

Viruria2

Patients28

Replication3

Long-term kidney transplant2

Biopsies2

Among kidney transplant2

Morbidity and morta3

Lung transplant recipients1

Liver transplant recipients1

Viral infection1

Human kidney transplant1

Translational research1

Graft loss2

Antibody5

Survival1

Clin Transplant1

Polycystic kidney1

Pediatric3

Infections7

Post kidney transplant1

Renal disease2

Polyoma5