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  • alpha
  • We observe 1,091 A 2 of buried surface area mediated by an extensive array of contacts involving residues on armadillo repeats 2-7, utilising both the major and minor NLS binding sites of IMP alpha to contact bipartite NLS clusters (17)RAKKMSK(23) and (KR4)-K-3, respectively. (edu.au)
  • residues
  • These results showed that functional P. sojae PY-NLSs include an additional cluster of basic residues for efficient nuclear import. (frontiersin.org)
  • We observe 1,091 A 2 of buried surface area mediated by an extensive array of contacts involving residues on armadillo repeats 2-7, utilising both the major and minor NLS binding sites of IMP alpha to contact bipartite NLS clusters (17)RAKKMSK(23) and (KR4)-K-3, respectively. (edu.au)
  • A single amino acid residue within the template sequence indicated at the top in the matrix was replaced with various other residues indicated in the left column, and the nuclear import activity was assayed in yeast. (nih.gov)
  • pathways
  • The precise tissue-specific and temporal regulation of nuclear protein import is also critical in the regulation of cell cycle progression and in developmental and signal transduction pathways (reviewed in K affman and O'S hea 1999 ). (genetics.org)
  • In particular, our analysis of protein-protein interaction maps reveals that nuclear EGFR (nEGFR) pathways are different from that of membrane EGFR and EGF is not found in nEGFR network, while androgen receptor (AR) is found, which suggests the evolution of prostate cancer, a well-known AR driven cancer, through changes in androgen- or EGF-dependence. (jcancer.org)
  • Upon binding to EGF, membrane EGFR dimerizes leading to kinase activation ( 10 ) to stimulate several downstream signaling pathways, such as PLC-γ-PKC, PI-3K-Akt-mTOR, and JAK2-STAT3 ( 11 ). (jcancer.org)
  • mediates
  • Mediates nuclear import of STAT1 homodimers and STAT1/STAT2 heterodimers by recognizing non-classical NLSs of STAT1 and STAT2 through ARM repeats 8-9. (abcam.com)
  • Recognizes influenza A virus nucleoprotein through ARM repeat 7-9 In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS. (abcam.com)
  • crucial
  • Nuclear transport is crucial to cell function, as movement through the pores is required for both gene expression and chromosomal maintenance. (wikibooks.org)
  • Interaction between glutamate and dopamine signaling is crucial for the control of movement and reward-driven learning, and its alterations are implicated in several neuropsychiatric disorders including Parkinson's disease and drug addiction. (frontiersin.org)
  • substrate
  • Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. (abcam.com)
  • mainly
  • The major and minor NLS binding sites are mainly involved in recognition of simple or bipartite NLS motifs. (abcam.com)