Biotransformation of xenobiotics. Medical search. Frequent questions

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Anatomy10

Microsomes, Liver Liver Hepatocytes Microsomes Bile Feces Intestines Kidney Cytosol Cells, Cultured

Organisms25

Cunninghamella Gordonia Bacterium Oncorhynchus kisutch Rats, Sprague-Dawley Berberidaceae Rats, Inbred F344 Hepatophyta Mucorales Ictaluridae Rats, Wistar Dogs Rhodococcus Pseudomonas putida Aspergillus ochraceus Nuphar Lactobacillus brevis Macaca fascicularis Photinia Micromonospora Fungi Chlorella Mucor Pseudomonas mendocina Anemarrhena Rats, Inbred Strains

Diseases1

Drug-Induced Liver Injury

Chemicals and Drugs149

Xenobiotics Cytochrome P-450 Enzyme System Cytochrome P-450 CYP3A Glucuronosyltransferase Glutathione Transferase Aryl Hydrocarbon Hydroxylases Cytochrome P-450 CYP1A1 Environmental Pollutants Glucuronides Ketoconazole Mixed Function Oxygenases Oxidoreductases, N-Demethylating Cytochrome P-450 CYP1A2 Oxygenases Pharmaceutical Preparations Phenobarbital Trichloroethanes Isoenzymes Hydrocarbons, Halogenated Cytochrome P-450 CYP2E1 Safrole Trinitrotoluene Sulfotransferases Receptors, Steroid Arylamine N-Acetyltransferase Glucuronates Arylsulfotransferase Sydnones Polychlorinated Biphenyls Dinitrochlorobenzene Atrazine Water Pollutants, Chemical Carboxylesterase Glutathione beta-Naphthoflavone Chlorobutanol Phenols Receptors, Aryl Hydrocarbon Fungicides, Industrial Epoxide Hydrolases P-Glycoprotein Steroid Hydroxylases Troleandomycin Hydrocarbons, Chlorinated Benzo(a)pyrene Methylcholanthrene Herbicides Steroid 16-alpha-Hydroxylase Isoflavones Coumarins NADPH-Ferrihemoprotein Reductase Equol Carcinogens Methoxyflurane Estrogens, Non-Steroidal Toluene Multidrug Resistance-Associated Proteins Nitroglycerin Porphyrinogens NAD(P)H Dehydrogenase (Quinone)Recombinant Proteins Fenthion Monoterpenes Polycyclic Hydrocarbons, Aromatic Cytochrome P-450 CYP2D6 Carbon Radioisotopes Pregnenolone Carbonitrile Enzyme Inhibitors P-Glycoproteins Norisoprenoids ATP-Binding Cassette Transporters Insecticides Ethylmorphine Benzaldehydes Cytochrome P-450 CYP2B1 Hydrocarbons, Aromatic Prodrugs 7-Alkoxycoumarin O-Dealkylase Ethylmercuric Chloride Glutathione S-Transferase pi Eugenol Ethyl Ethers Soil Pollutants Alprazolam Ethoxyquin Receptors, Cytoplasmic and Nuclear RNA, Messenger Triazines Hydroxytestosterones Ethylmercury Compounds Parathion Oxazines Flame Retardants tert-Butyl Alcohol Catechols Triazolam Carcinogens, Environmental Acrylonitrile Carboxylic Ester Hydrolases Coumaric Acids Pyrazolones Acetaminophen DDT Skin Lightening Preparations Lithocholic Acid Umbelliferones L-Lysine 6-Transaminase Arsenic Dichloroethylenes Octanes Tetrachlorodibenzodioxin Organic Anion Transporters Naphthols Fluorides Butylene Glycols Zearalenone Oxidoreductases Mercury Compounds Aminophenols Dichloroacetic Acid Mutagens Aldehyde Dehydrogenase Benzydamine Carbofuran Fluorenes Guaiacol Norbornanes Pyrrolizidine Alkaloids Trifluoroacetic Acid Organic Chemicals Chlordan Antimitotic Agents Aflatoxin B1 Transaldolase Xylenes Lindane Benzoflavones Adrenochrome Halothane Chenodeoxycholic Acid Alkanes Phosphoadenosine Phosphosulfate Nitro Compounds Styrenes Testosterone Bile Acids and Salts Aniline Hydroxylase Trichloroethylene Antioxidants

Analytical, Diagnostic and Therapeutic Techniques and Equipment18

Chromatography, High Pressure Liquid Mass Spectrometry Gas Chromatography-Mass Spectrometry Magnetic Resonance Spectroscopy Chromatography, Liquid Tandem Mass Spectrometry Toxicity Tests Administration, Oral Spectrometry, Mass, Electrospray Ionization Metabolic Engineering Batch Cell Culture Techniques Spectrophotometry, Ultraviolet Metabolic Clearance Rate Models, Biological Anesthesia, Inhalation Chromatography, Thin Layer Mutagenicity Tests Drug Evaluation, Preclinical

Phenomena and Processes31

Biotransformation Metabolic Detoxication, Drug Hydroxylation Dealkylation Metabolic Detoxication, Phase II Metabolic Detoxication, Phase I Oxidation-Reduction Molecular Structure Enzyme Induction Stereoisomerism Kinetics Species Specificity Substrate Specificity Drug Interactions Gene Expression Regulation, Enzymologic Tissue Distribution Half-Life Biocatalysis Pharmacokinetics Dose-Response Relationship, Drug Biological Availability Catalysis Polymorphism, Genetic Biological Transport Metabolic Clearance Rate Intestinal Absorption Amino Acid Sequence Time Factors Metabolic Networks and Pathways Halogenation Drug Resistance, Multiple

Disciplines and Occupations2

Toxicology Biotechnology

Anthropology, Education, Sociology and Social Phenomena1

Safety-Based Drug Withdrawals

Technology, Industry, Agriculture3

Metabolic Engineering Skin Lightening Preparations Biotechnology

Information Science3

Molecular Sequence Data Amino Acid Sequence Databases, Pharmaceutical

Health Care3

Biodegradation, Environmental Environmental Exposure Safety-Based Drug Withdrawals

Anatomy Organisms Diseases Chemicals and Drugs Analytical, Diagnostic and Therapeutic Techniques and Equipment Phenomena and Processes Disciplines and Occupations Technology, Industry, Agriculture Information Science Health Care

Biotransformation Xenobiotics Cytochrome P-450 Enzyme System Microsomes, Liver Cunninghamella Metabolic Detoxication, Drug Cytochrome P-450 CYP3A Glucuronosyltransferase Chromatography, High Pressure Liquid Hydroxylation Glutathione Transferase Dealkylation Aryl Hydrocarbon Hydroxylases Liver Metabolic Detoxication, Phase II Biodegradation, Environmental Metabolic Detoxication, Phase I Cytochrome P-450 CYP1A1 Environmental Pollutants Glucuronides Ketoconazole Mixed Function Oxygenases Mass Spectrometry Oxidoreductases, N-Demethylating Cytochrome P-450 CYP1A2 Oxygenases Oxidation-Reduction Pharmaceutical Preparations Molecular Structure Phenobarbital Trichloroethanes Isoenzymes Hydrocarbons, Halogenated Enzyme Induction Hepatocytes Cytochrome P-450 CYP2E1 Safrole Gas Chromatography-Mass Spectrometry Trinitrotoluene Microsomes Sulfotransferases Receptors, Steroid Arylamine N-Acetyltransferase Glucuronates Stereoisomerism Bile Arylsulfotransferase Sydnones Kinetics Species Specificity Polychlorinated Biphenyls Dinitrochlorobenzene Atrazine Gordonia Bacterium Water Pollutants, Chemical Carboxylesterase Magnetic Resonance Spectroscopy Chromatography, Liquid Glutathione beta-Naphthoflavone Chlorobutanol Substrate Specificity Phenols Receptors, Aryl Hydrocarbon Fungicides, Industrial Epoxide Hydrolases P-Glycoprotein Steroid Hydroxylases Troleandomycin Drug Interactions Oncorhynchus kisutch Hydrocarbons, Chlorinated Benzo(a)pyrene Methylcholanthrene Herbicides Steroid 16-alpha-Hydroxylase Isoflavones Gene Expression Regulation, Enzymologic Rats, Sprague-Dawley Coumarins NADPH-Ferrihemoprotein Reductase Tandem Mass Spectrometry Toxicology Tissue Distribution Equol Carcinogens Methoxyflurane Estrogens, Non-Steroidal Toluene Multidrug Resistance-Associated Proteins Half-Life Nitroglycerin Molecular Sequence Data Toxicity Tests Berberidaceae Porphyrinogens Rats, Inbred F344 Feces Administration, Oral NAD(P)H Dehydrogenase (Quinone)

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