• the pathways of drug metabolism can be divided into: phase І phase II Drugs can undergo one of four potential biotransformations: Active Drug to Inactive Metabolite, Active Drug to Active Metabolite, Inactive Drug to Active Metabolite, Active Drug to Toxic Metabolite (biotoxification). (wikipedia.org)
  • The DMPK biotransformation group at Genentech is seeking a highly motivated individual to support development drug metabolism. (gene.com)
  • Fragmentation pattern obtained from the mass spectrum is utilized to identify the biotransformation site in the molecule, which is the metabolic soft spot. (omicsonline.org)
  • We hope to continue this tradition with the current compendium of mini-reviews that highlight novel biotransformation processes that were published during the past year. (wur.nl)
  • thus, here we examined the relative isomer-specific biotransformation rates of a model PFOS-precursor (N-ethylperfluorooctane sulfonamide, NEtFOSA) with human microsomes and recombinant human cytochrome P450s (CYPs) 2C9 and 2C19. (mendeley.com)
  • 2018. "Sequential Biotransformation of Antcin K by Bacillus subtilis ATCC 6633. (mdpi.com)
  • Biotransformation is the chemical modification (or modifications) made by an organism on a chemical compound. (wikipedia.org)
  • The knowledge of the biotransformation is important for the evaluation of these substances. (hu-berlin.de)
  • Studying the biotransformation of natural products by intestinal microflora is an important approach to understanding how and why some medicines-particularly natural medicines-work. (hindawi.com)
  • Designing, executing and reporting biotransformation studies to support drug development and regulatory filings. (gene.com)
  • Ravindran S, Basu S, Surve P, Lonsane G, Sloka N (2012) Significance of Biotransformation in Drug Discovery and Development. (omicsonline.org)
  • We further debate if uranium biotransformations provide bio-protection or bio-benefit to the microbe and highlight the need for more work in the field to understand if microbes use uranium reduction for energy gain and growth, as having the ability is separate from exercising it. (scirp.org)
  • The biotransformation of antcin K, a major ergostane triterpenoid from the fruiting bodies of Antrodia cinnamomea , by Bacillus subtilis ( B. subtilis ) ATCC 6633 was studied. (mdpi.com)