• Overview of Vitamins Vitamins may be Fat soluble (vitamins A, D, E, and K) Water soluble (B vitamins and vitamin C) The B vitamins include biotin, folate, niacin, pantothenic acid, riboflavin (B2), thiamin (B1). (merckmanuals.com)
  • Biotin-NHS ester can react efficiently with primary amino groups (-NH2) to form stable, irreversible amide bonds. (axispharm.com)
  • The Androgen Receptor (Carboxy-terminal Antigen) Matched Antibody Pair is ideal for use with immunoassay technologies and high throughput ELISA platforms requiring antibody pairs with specialized or custom antibody labeling. (cellsignal.jp)
  • SIRT6 antibody was raised against a 17 amino acid synthetic peptide near the carboxy terminus of human SIRT6. (prosci-inc.com)
  • Vitiligo - Vitiligo is an autoimmune disorder, and, in some cases, it can be caused by nutrition deficiency such as deficiency of the B complex vitamin like biotin. (enhance-me-training.com)
  • Biotin (also known as Vitamin H), is a water-soluble B-complex vitamin (vitamin B7). (tullyspharmacycastlerea.ie)
  • Viviscal Hair Growth Supplements contain the exclusive marine complex AminoMar®, as well as Biotin, Zinc, Vitamin C, Horsetail Extract and Iron, to nourish hair from within. (yourpharmacy.ie)
  • The vitamin K-dependent proteins, osteocalcin and matrix gamma-carboxy-glutamyl (Gla) protein, may have important roles in bone and other tissues. (merckmanuals.com)
  • In Escherichia coli, the three components reside in separate subunits: a biotinyl domain is the functional portion of one of these, biotin carboxy carrier protein (BCCP). (rcsb.org)
  • Nail growth - the stimulation of protein from the increase of biotin is vital for nail growth and can prevent splitting. (enhance-me-training.com)
  • Biotin helps the body to metabolise carbohydrates, fats, and amino acids which are important as the building blocks of protein. (tullyspharmacycastlerea.ie)
  • Viviscal supplements are scientifically formulated with the important nutrients Biotin and Zinc, which help maintain normal healthy hair growth from within, and the unique marine protein complex AminoMar C. (com.sa)
  • The biotin group, which has a high affinity for avidin and streptavidin, can be used for a variety of applications, such as protein purification, cell labeling, and drug delivery. (axispharm.com)
  • Rhodamine-PEG-Biotin has been used to study a variety of biological processes, such as receptor-ligand interactions, protein-protein interactions, and cell signaling pathways. (axispharm.com)
  • The two ends of a peptide chain are described according to the nitrogen atom of the amino group as N-terminus and corresponding to the carbon atom of the carboxy group as C-terminus. (chemical-suppliers.eu)
  • In chemistry, the reaction of the carboxy group of one amino acid with the amino group of the other amino acid with elimination of water as condensation. (chemical-suppliers.eu)
  • Cognitive function - biotin is critically involved in the synthesis of myelin, which is a substance that coats and protects the components of your nervous system. (enhance-me-training.com)
  • B-Dyn ® contains vitamins B1, B3, B6, B12 and biotin, which contribute to a normal nervous system function and a normal psychological function. (metagenics.be)
  • These charges were obtained from 20 snapshots from MD simulations of avidin (full tetramer) with seven different biotin analogues (QM calculations from [A. Weis, K. Katebzadeh, P. Söderhjelm, I. Nilsson, U. Ryde (2006) "Ligand affinities predicted with the MM/PBSA method: dependence on the simulation method and the force field", J. Med. (lu.se)
  • Rhodamine-PEG-Biotin contains three functional groups: a rhodamine fluorescent dye, a PEG chain, and a biotin group. (axispharm.com)
  • 8-amino-7-oxononanoate synthase (EC 2.3.1.47 ) (7-KAP synthase), a bacterial enzyme (gene bioF) which catalyzes an intermediate step in the biosynthesis of biotin: the addition of 6-carboxy-hexanoyl-CoA to alanine to form 8- amino-7-oxononanoate. (expasy.org)
  • We have developed a series of NPs based on (bio)degradable and biocompatible poly(malic acid) derivatives, poly(benzyl malate) (PMLABe), with its PEG-grafted stealth analog and target-specific biotin-PEG- b -PMLABe one. (frontiersin.org)
  • It has also been used to develop targeted drug delivery systems, where the biotin group is used to target specific cells or tissues and the rhodamine fluorescent dye is used to monitor the delivery of the drug. (axispharm.com)
  • A biotinyl domain shuttles its covalently attached biotin prosthetic group between the active sites of a biotin carboxylase and a carboxyl transferase. (rcsb.org)
  • Find CTD (Carboxy-Terminal Domain, RNA Polymerase II, Polypeptide A) Small Phosphatase Like 2 Antibodies validated for a specific application such as WB, ELISA, FACS, IF (cc). (antibodies-online.com)
  • Vitamin H (Biotin) in food ELISA test kit is an Enzyme Immunoassay for the quantitative determination of Biotin (Vitamin H) in Food. (rapidtest.com)
  • 14. The usefulness of determining des-gamma-carboxy prothrombin by sensitive enzyme immunoassay in the early diagnosis of patients with hepatocellular carcinoma. (nih.gov)
  • As biotin is synthesized by the human intestinal flora, deficiency symptoms are rare, appear however after excessive ingestion of raw egg white, which can be explained by its content of biotinbinding avidin. (rapidtest.com)
  • Avidin, which shows a high affinity to biotin, is bound on the surface of a microtiter plate. (rapidtest.com)
  • 4Å (~5 atoms) is crucial between the carboxy group of the biotin and the 1st bulky amino acid of the peptide to allow the biotin to reach the avidin binding pocket. (pepscan.com)
  • 9. Serum des-gamma-carboxyprothrombin concentration determined by the avidin-biotin complex method in small hepatocellular carcinomas. (nih.gov)
  • These charges were obtained from 20 snapshots from MD simulations of avidin (full tetramer) with seven different biotin analogues (QM calculations from [A. Weis, K. Katebzadeh, P. Söderhjelm, I. Nilsson, U. Ryde (2006) "Ligand affinities predicted with the MM/PBSA method: dependence on the simulation method and the force field", J. Med. (lu.se)
  • These observations suggest that the biotin administration ameliorates abnormal glucose metabolism in diabetic patients, presumably by enhancing the activity of the biotin-dependent enzyme, pyruvate carboxylase, with a subsequent promotion of glucose utilization for the entry into the tricarboxylic acid cycle. (researchgate.net)
  • This compound is composed of several functional groups, including biotin, ethylenediamine (EDA), polyethylene glycol (PEG), and N-hydroxysuccinimide (NHS). (axispharm.com)
  • 8-Arm polyethylene glycol-Biotin (8-Arm PEG-Biotin) is a multi arm peg derivative with biotin groups at each terminal of the eight arms connected to one hexaglycerol core. (bocsci.com)
  • The data suggest that the concentration of circulating biotin is as low as 100 times below the Km of the enzyme, so that any increase in biotin concentration through dietary supplementation would result in saturation of the available mutant enzyme. (nih.gov)
  • A study conducted in 43 Japanese T2DM patients demonstrated a decrease of approximately 45% of FBG concentration after one month of oral supplementation of 9 mg of biotin per day (15, 27) . (researchgate.net)
  • Previous studies have reported that biotin supplementation may influence blood glucose and lipid level in patients with type 2 diabetes mellitus (T2DM).Methods We searched Pubmed, Embase, and Cochrane library databases up to 8th August 2022 for studies examining the effects of biotin supplementation in T2DM patients. (researchgate.net)
  • It was suggested that biotin supplementation for 28 to 90 days significantly decreased the level of fasting blood glucose (FBG) (MD: −1.21 mmol/L, 95% CI: −2.73 to 0.31), total cholesterol (TC) (MD: −0.22 mmol/L, 95% CI: −0.25 to −0.19) and triglycerides (TG) (MD: −0.59 mmol/L, 95% CI: −1.21 to 0.03). (researchgate.net)
  • Evidence for the impact of biotin supplementation on the levels of glycated hemoglobin (HbA1c), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) and very low-density lipoprotein cholesterol (VLDL-C) was limited to draw conclusion.Conclusions Biotin supplementation may decrease FBG, TC and TG levels. (researchgate.net)
  • Holocarboxylase synthetase (HCS) catalyses the biotinylation of the four biotin-dependent carboxylases found in humans. (nih.gov)
  • For this purpose, biotin is bound via its carboxy group to lysin residues of carboxylases, and the transfer of carbon dioxide takes place after its attachment to a nitrogen atom of biotin, forming the so-called active carbon dioxide. (rapidtest.com)
  • The rhodamine used in all of polysaccharide products is 5/6-carboxy-tetramethyl-rhodamine, (5/6-TAMRA). (creativepegworks.com)
  • The serum biotin concentration in the patients was significantly lower than that in the 64 healthy control subjects and inversely correlated with the fasting blood glucose level. (researchgate.net)
  • Four of the mutations, clustering in the putative biotin binding domain as deduced from the structure of the E. coli enzyme, are consistent with an explanation for biotin responsiveness based on altered affinity for biotin. (nih.gov)
  • The oral administration of biotin, 9mg daily, corrected the hyperglycemia in the patients with no change in their serum insulin level. (researchgate.net)
  • 5. Clinical utility of simultaneous measurement of serum high-sensitivity des-gamma-carboxy prothrombin and Lens culinaris agglutinin A-reactive alpha-fetoprotein in patients with small hepatocellular carcinoma. (nih.gov)
  • 16. Unique clinical characteristics of patients with hepatocellular carcinoma who present with high plasma des-gamma-carboxy prothrombin and low serum alpha-fetoprotein. (nih.gov)
  • 2. Plasma abnormal prothrombin (des-gamma-carboxy prothrombin) as a marker of hepatocellular carcinoma. (nih.gov)
  • 4. Abnormal prothrombin (DES-gamma-carboxy prothrombin) in hepatocellular carcinoma. (nih.gov)
  • 11. Production of abnormal prothrombin (des-gamma-carboxy prothrombin) by hepatocellular carcinoma. (nih.gov)
  • Depending on design and application we can insert a spacer/linker to couple a peptide to biotin , carrier proteins (KLH, BSA) , fluorescent dyes or other molecules. (pepscan.com)
  • It can be used to attach biotin to proteins, antibodies, and other molecules of interest, enabling the detection, purification, and targeting of these molecules. (axispharm.com)
  • 5-(and-6)-Carboxy-2′,7′-dichlorofluorescein diacetate, succinimidyl ester is a useful fluorescent tracer that can passively diffuse into cells and covalently label intracellular proteins, resulting in long-term cell labeling. (biotium.com)
  • [ 16 , 17 ] CAR belongs to the immunoglobulin superfamily and is composed of two extracellular immunoglobulin-like domains (D1 and D2) and a single membrane-spanning sequence connected to the carboxy terminal cytoplasmic domain. (medscape.com)
  • 1. Application of des-gamma-carboxy prothrombin as a complementary tumor marker with alpha-fetoprotein in the diagnosis of hepatocellular carcinoma. (nih.gov)
  • 7. Diagnostic Evaluation of Des-Gamma-Carboxy Prothrombin versus α-Fetoprotein for Hepatitis B Virus-Related Hepatocellular Carcinoma in China: A Large-Scale, Multicentre Study. (nih.gov)
  • 17. Evaluation of Tumor Response Using Alpha-fetoprotein and Des-gamma-carboxy Prothrombin in Hepatocellular Carcinoma Patients Who Underwent Transarterial Chemoembolization. (nih.gov)
  • 8. Prognostic roles of preoperative α-fetoprotein and des-γ-carboxy prothrombin in hepatocellular carcinoma patients. (nih.gov)
  • Similar effects were also observed in type 1 diabetic patients whose FBG levels decreased up to 50% after daily administration of 16 mg biotin for one week (28). (researchgate.net)
  • The result demonstrates that biotin administration is effective for the treatment of the patients. (researchgate.net)
  • The remaining mutations, located outside the biotin binding region, were associated with a more limited biotin responsiveness that may be explained by the degree of residual enzyme activity present. (nih.gov)
  • Amino-Modifier C6 dT 1 and its corresponding biotinylated product Biotin-dT have proved to be optimal for amino-modifying and biotinylating oligonucleotides within the sequence. (glenresearch.com)
  • Biotin can form photosensitive substances in the photoreceptor cells, maintain the integrity and soundness of epithelial tissue structure, and enhance the body's immune response and resistance. (bocsci.com)
  • We have evaluated the biotin responsiveness associated with six missense mutations previously identified in affected patients by expression of plasmids containing the mutated HCS in an Escherichia coli strain mutated in the corresponding BirA gene. (nih.gov)
  • The therapeutic efficacy of biotin was evaluated in 43 patients with non-insulin dependent diabetes mellitus. (researchgate.net)
  • 10. Clinicopathologic features of patients with hepatocellular carcinoma seropositive for alpha-fetoprotein-L3 and seronegative for des-gamma-carboxy prothrombin in comparison with those seropositive for des-gamma-carboxy prothrombin alone. (nih.gov)
  • 18. Clinical significance of simultaneous determinations of alpha-fetoprotein and des-gamma-carboxy prothrombin in monitoring recurrence in patients with hepatocellular carcinoma. (nih.gov)