Acyl-CoA thioesteraseThioesteraseSynthetaseNovo biosynthesisEnzyme that catalyzesSynthaseCoenzymePutativeLIPIDSMetabolismPathwaysEndoplasmic reticulumPurineMembraneInosinePeroxisomalLysosomalEscherichiaCytosolicEnzymesPathwayCholesterolLipid transferCompoundFluorescent proteinKinaseInteractionDomainStructuresMRNAFamilyAlphaTypeRoleShownChainSmall
Acyl-CoA thioesterase1
- The thioesterase activity is performed by members of the acyl-CoA thioesterase (ACOT) family. (wikipedia.org)
Thioesterase5
- MenH (SHCHC synthase) was previously thought to be a thioesterase involved in hydrolyzing DHNA-CoA in a later step of menaquinone synthesis. (wikipedia.org)
- In 2008, it was determined that MenH has poor catalytic activity toward palmitoyl-CoA, casting doubt on its role as a thioesterase. (wikipedia.org)
- In 2009, it was proposed that a dedicated hotdog fold thioesterase would be needed to catalyze the hydrolysis of DHNA-CoA. (wikipedia.org)
- mouse-adcl3 Mus musculus (Mouse) Arylacetamide deacetylase-like 3 , mouse-adcl4 Mus musculus (Mouse) Arylacetamide deacetylase-like 4 Hypothetical esterase/lipase/thioesterase family active site containing protein , mouse-aryla Mus musculus (Mouse) arylacetamide deacetylase and 5033417e09rik protein , mouse-b1avu7 Mus musculus (Mouse). (inrae.fr)
- Palmitoyl protein thioesterase 1(PPT1) is a lysosomal enzyme that catalyzes the protein depalmitoylation. (bvsalud.org)
Synthetase4
- Nasu, S., Wicks, F.D. and Gholson, R.K. L -Aspartate oxidase, a newly discovered enzyme of Escherichia coli , is the B protein of quinolinate synthetase. (enzyme-database.org)
- Early investigations were focused on the 10-kDa ACBPs from mammals and yeast, and from these studies the 10-kDa ACBP has been implicated in biological roles ranging from acyl-CoA transport, maintenance of acyl-CoA pools within the cell and in the protection of acyl-CoAs in the cytosol from enzymes including acyl-CoA hydrolase, acetyl-CoA carboxylase and acyl-CoA synthetase [reviewed in 3]. (aocs.org)
- acyl-CoA synthetase long chain family m. (gsea-msigdb.org)
- Then, bile acyl-CoA synthetase teams up with 3a,7a-dihydroxycoprostanic acid to create 3a,7a-dihydroxy-5b-cholestanoyl-CoA. (smpdb.ca)
Novo biosynthesis1
- L -Aspartate oxidase catalyses the first step in the de novo biosynthesis of NAD + in some bacteria. (enzyme-database.org)
Enzyme that catalyzes1
- An enzyme that catalyzes reversibly the conversion of palmitoyl-CoA to palmitoylcarnitine in the inner mitochondrial membrane. (lookformedical.com)
Synthase4
- The crystal structure of the MenH enzyme in E.coli (SHCHC synthase) exists as a complex of three protein molecules shown in the diagram. (wikipedia.org)
- SHCHC synthase forms an alpha/beta hydrolase fold with a central set of seven parallel beta sheets surrounded by alpha helixes on both sides. (wikipedia.org)
- Longer-term (24 and 48 h) treatment reduced the expression of lipogenic markers (FA synthase and sterol regulatory element-binding protein-1) and increased the expression of lipolytic [hormone-sensitive lipase (HSL) and adipose triglyceride lipase (ATGL)] and mitochondrial (peroxisome proliferator-activated receptor γ coactivator-1α and carnitine palmitoyltransferase 1) markers. (academic-accelerator.com)
- The expression of regulatory molecules, TGF-β1/2, phospho-Akt (Ser473), PPARα, sterol regulatory element-binding protein 1 (SREBP-1), fatty acid synthase (FASN), hormone-sensitive lipase (HSL), and acyl dehydrogenases was analyzed in virus-infected hepatocytes. (academic-accelerator.com)
Coenzyme3
- A fatty acid coenzyme derivative which plays a key role in fatty acid oxidation and biosynthesis. (lookformedical.com)
- W. using the condensation of palmitoyl coenzyme A (CoA) and serine by serine palmitoyltransferase (SPT), an enzyme that's negatively governed by ORM1-like proteins 3 (ORMDL3). (moonphase2018.com)
- Peroxisomal acyl coenzyme A oxidase 2 converts 3a,7a-dihydroxy-5b-cholestanoyl-CoA into 3a,7a-dihydoxy-5b-cholest-24-enoyl-CoA. (smpdb.ca)
Putative1
- Negative regulator of flavonoid biosynthesis, mutants accumulate flavonoid pigments in their seed coat, putative oxidoreductase. (or.jp)
LIPIDS4
- Covalent attachment of LIPIDS and FATTY ACIDS to other compounds and PROTEINS. (lookformedical.com)
- Physiological processes in biosynthesis (anabolism) and degradation (catabolism) of LIPIDS. (lookformedical.com)
- Although lipids are a distinct class of biomolecules, we shall see that they often occur combined, either covalently or through weak bonds, with members of other classes of bio-molecules to yield hybrid molecules such as glycolipids , which contain both carbohydrate and lipid groups, "and lipoproteins , which contain both lipids and proteins. (medmuv.com)
- Neuromelanin organelles are specialized autolysosomes that accumulate undegraded proteins and lipids in aging human brain and are likely involved in Parkinson's disease. (uni-bielefeld.de)
Metabolism1
- Initial, a lot of the regulatory enzymes and proteins involved with sphingolipid metabolism as well as the receptors for S1P have already been cloned. (moonphase2018.com)
Pathways2
- For example, deactivation of fatty acids at the ER may traffic fatty acids away from pathways associated with the ER membrane, such as glycerolipid biosynthesis. (wikipedia.org)
- Ceramide sets off many pathways that creates endothelial cell loss of life, including activation of caspases, or PP2A2 or PP1,55, and raising mitochondrial permeability by developing ceramide-enriched platforms with the capacity of translocating protein. (moonphase2018.com)
Endoplasmic reticulum2
- The N -terminal transmembrane domain of ACBP1 and ACBP2 targets each protein to the endoplasmic reticulum (ER) and the plasma membrane while ACBP3 is targeted extracellularly. (aocs.org)
- Revisiting 7a-hydroxy-cholestene-3-one, the second chain of reactions it is involved in follows a similar path as the first, moving through the mitochondria, endoplasmic reticulum and peroxisome until choloyl-CoA is formed, which then is used in three reactions so that its derivatives may leave the cell to interact with intestinal microflora and become taurodeoxycholic acid, deoxycholic acid glycine conjugate and deoxycholic acid. (smpdb.ca)
Purine1
- Bifunctional purine biosynthesis protein PurH-like [Interproscan]. (ntu.edu.sg)
Membrane2
- Depending on the length of their fatty acid chains and their degree of saturation, SL species have a strong impact on biophysical membrane parameters such as fluidity or rigidity and curvature, and on interaction with membrane proteins and/or cytoskeletal components, and membrane compartmentalization. (encyclopedia.pub)
- Stat3-mediated alterations in lysosomal membrane protein composition. (uni-bielefeld.de)
Inosine1
- protein_coding" "Cz09g17180.t1","No alias","Chromochloris zofingiensis","Inosine/uridine-preferring nucleoside hydrolase domain [Interproscan]. (ntu.edu.sg)
Peroxisomal2
Lysosomal1
- Differentially expressed genes (DEGs) were screened, and core lysosomal genes were obtained in combination with prognostic analysis and protein interaction networks. (bvsalud.org)
Escherichia1
- The function of the acyl-CoA-binding domain in recombinant Arabidopsis ACBPs expressed in the bacterium Escherichia coli was established using site-directed mutagenesis followed by in vitro binding assays. (aocs.org)
Cytosolic1
- The three other ACBPs (ACBP4, ACBP5 and ACBP6) are cytosolic proteins. (aocs.org)
Enzymes1
- Acetyl-CoA hydrolase, palmitoyl-CoA hydrolase, succinyl-CoA hydrolase, formyl-CoA hydrolase, acyl-CoA hydrolase are a few examples of this group of enzymes. (wikipedia.org)
Pathway1
- The enzyme participates in the menthol-biosynthesis pathway of Mentha plants. (enzyme-database.org)
Cholesterol1
- Biosynthesis and biotransformation of cholesterol. (medmuv.com)
Lipid transfer2
- In plants cells, lipid-transfer proteins (LTPs) and acyl-CoA-binding proteins (ACBPs) have been identified as candidates for lipid transfer within the cell [reviewed in 1,2]. (aocs.org)
- From there, propionyl-CoA and chenodeoxycholoyl-CoA join forces and enlist the help of non-specific lipid transfer protein to further chenodeoxycholoyl-CoAâ€TMs journey in the peroxisome. (smpdb.ca)
Compound1
- Palmityl-CoA is a strong basic compound (based on its pKa). (ymdb.ca)
Fluorescent protein1
- The six Arabidopsis ACBPs are subcellularly located in various compartments based on experimental results using a variety of techniques including fluorescent protein tagging in confocal microscopy, immunoelectron microscopy and western blot analysis of subcellular fractions from wild-type plants as well as from transgenic plants expressing fluorescent-tagged ACBPs. (aocs.org)
Kinase3
- A-kinase anchoring protein 9 [Source:HG. (gsea-msigdb.org)
- death associated protein kinase 1 [Sour. (gsea-msigdb.org)
- Cer is normally shipped by ceramide transportation proteins (CERT) or vesicular transportation towards the Golgi for synthesis of ceramide-1-phosphate (C1P) (by ceramide kinase, CERK), sphingomyelin (SM), and glucosylceramide (GluCer). (moonphase2018.com)
Interaction1
- ACBP4 and ACBP5 show conservation in a domain of five kelch motifs, which also enable interaction with protein partners. (aocs.org)
Domain4
- The presence of a conserved acyl-CoA-binding domain in each ACBP enables it to bind acyl-CoA esters. (aocs.org)
- These six ACBPs map to four distinct classes based on the presence of other protein domains besides the conserved acyl-CoA-binding domain. (aocs.org)
- ACBP1 and ACBP2 each possess a C-terminal domain of ankyrin repeats, which facilitates protein-protein interactions. (aocs.org)
- ACBP3 lacks both ankyrin repeats and kelch motifs but it is larger (39.3 kDa) than ACBP6 (10.4 kDa), which is the smallest member and consists of only the acyl-CoA-binding domain. (aocs.org)
Structures2
- Structures of three ependymin-related proteins suggest their function as a hydrophobic molecule binder. (uni-bielefeld.de)
- Many sphingolipid signalling proteins structures have already been solved, enabling rational drug style. (moonphase2018.com)
MRNA1
- Then, RT-qPCR and Western blotting were applied to determine mRNA and protein expression in CC and normal cells. (bvsalud.org)
Family1
- Given that recombinant Arabidopsis ACBPs show preferences for different acyl-CoA esters and phospholipids in in vitro binding assays, it was hypothesized that members in the Arabidopsis ACBP family have nonoverlapping functions in the plant cell. (aocs.org)
Alpha1
- 3a,7a-dihydroxy-5b-cholestanoyl-CoA remains intact while alpha-methylacyl-CoA racemase moves it along through the peroxisome. (smpdb.ca)
Type2
- Esterases, in turn, are one type of the several hydrolases known. (wikipedia.org)
- protein_coding" "Cz05g27200.t1","No alias","Chromochloris zofingiensis","SAM-dependent methyltransferase RsmB/NOP2-type [Interproscan]. (ntu.edu.sg)
Role1
- A protein was identified in 2013 that could fit this role. (wikipedia.org)
Shown1
- Recombinant ACBPs have been tested and shown to bind acyl-CoA esters in vitro using binding assays such as the Lipidex assay. (aocs.org)
Chain1
- acyl-CoA dehydrogenase medium chain [So. (gsea-msigdb.org)
Small1
- While LTPs are small proteins (~9 kDa), ACBPs in the model plant Arabidopsis range in size from 10 to 73 kDa. (aocs.org)