• Recently we demonstrated in a mouse model for allergic airway inflammation that particle-derived oxidative stress plays a crucial role during augmentation of allergen-induced lung inflammation by ultrafine carbon particle (UfCP) inhalation. (biomedcentral.com)
  • Lungs and AM were analysed for pro- and anti-inflammatory lipid mediators, namely leukotriene B 4 (LTB 4 ), prostaglandin E 2 (PGE 2 ), 15(S)-hydroxy-eicosatetraenoic acid (15(S)-HETE), lipoxin A 4 (LXA 4 ) and oxidative stress marker 8-isoprostane by enzyme immunoassays and immunohistochemistry. (biomedcentral.com)
  • Although CNC exposures are associated with pulmonary inflammation and damage as well as oxidative stress responses and genotoxicity in vivo, studies evaluating cell transformation or tumorigenic potential of CNC's were not previously conducted. (cdc.gov)
  • In various mouse and rat models of obesity and type 1 and 2 diabetes mellitus, eCBs generated in various renal cells activate CB 1 receptors and contribute to the development of oxidative stress, inflammation, and renal fibrosis. (degruyter.com)
  • Studies on endurance athletes show that deficiency of L-glutamine is linked with inflammation, oxidative stress, and interruptions in immune system functioning, as well as reduced stamina and performance. (doctorherdmanclinic.com)
  • Alendronate also led to reductions in the levels of inflammation-related molecules, including mitogen-activated protein kinase, p53, pro-inflammatory cytokines, and pro-inflammatory mediators. (en-journal.org)
  • Of these mediators, cytokines play a single nucleotide polymorphisms (SNP) in pro-inflammatory cytokine genes and asthma phenotypes (Che et al. (cdc.gov)
  • they appear within minutes upon stimulation, as opposed to peptide mediators such as cytokines, which require hours to be generated. (biomedcentral.com)
  • The mechanism of its action is thought to be due to its ability to inhibit prostaglandin biosynthesis. (nih.gov)
  • Prostaglandin-endoperoxide synthase (PTGS), also known as cyclooxygenase, is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. (bioss.com.cn)
  • However, the physiologic significance of prostaglandin production did not unfold until 1971, when Vane, Smith, and Willis discovered that aspirin and indomethacin inhibited prostaglandin biosynthesis. (medscape.com)
  • Prostaglandins have been shown in many animal models to be mediators of certain kinds of intraocular inflammation. (nih.gov)
  • Prostaglandins also appear to play a role in the miotic response produced during ocular surgery by constricting the iris sphincter independently of cholinergic mechanisms. (nih.gov)
  • They are important in cellular functions such as signal transduction via biosynthesis of leukotrienes and prostaglandins. (fapesp.br)
  • Tissue injury, allergens or microbes activate formation and release of arachidonic acid-derived lipid mediators, such as prostaglandins and leukotrienes, which regulate early events in the inflammatory response. (biomedcentral.com)
  • The arachidonic acid, released by phospholipase A2, is an important substrate for the production of a group of lipid mediators known as leukotrienes, which induce proinflammatory signaling through the activation of specific BLT and CysLT receptors. (hindawi.com)
  • Cysteinyl leukotrienes (Cys-LTs) are potent inflammatory lipid mediators derived from the 5-lypoxygenase (5-LO) pathway of arachidonic acid (AA) metabolism [ 1 ], initially identified to have important effects on pathogenetic aspects of allergic rhinitis and bronchial asthma and approved in the late 1990s for the relief of perennial and seasonal allergic rhinitis symptoms, and the treatment of mild persistent bronchial asthma [ 2 - 5 ]. (hindawi.com)
  • Prostanoids, as they are known today, are a specific class of bioactive mediators generated via initial actions of cyclooxygenase. (jci.org)
  • Moreover, cell-free media from MWCNT-polarized macrophages induced the migration of neutrophils, which was blocked by Acebilustat, a specific leukotriene A4 hydrolase inhibitor, or LY239111, a LTB4 receptor antagonist, but not the cyclooxygenase 2 inhibitor, NS-398, revealing LTB4 as a major mediator of neutrophil chemotaxis from MWCNT-polarized macrophages. (cdc.gov)
  • The prostanoids are a family of lipid mediators generated by the action of cyclooxygenase on a 20-carbon unsaturated fatty acid, arachidonic acid. (fapesp.br)
  • Breu et al 34 demonstrated that acid lipophilic compounds of SPE inhibited the biosynthesis of cyclooxygenase and 5-lipoxygenase metabolites with the same intensity as SPE. (illnesshacker.com)
  • We also report alterations for less known components in intestinal inflammation, such as GPR119, OEA and LPI. (nature.com)
  • Herb-partitioned moxibustion may inhibit excessively activated autophagy and modulate the expression of immune-related factors by regulating the LKB1-mTOR-PI3KC signal transduction networks, thereby alleviating intestinal inflammation in CD rats. (hindawi.com)
  • From the conditioned reflex activity in gastric acid secretion discovered by Pavlov to the recognition of the role of CNS in stress-induced gastric ulcer and exacerbation of intestinal inflammation, all these facts confirm the significance of brain-gut axis. (cyberleninka.ru)
  • BACKGROUND: Vascular leak is a hallmark of severe dengue, and high leukotriene levels have been observed in dengue mouse models, suggesting a role in disease pathogenesis. (bvsalud.org)
  • CONCLUSIONS: Our data suggest that LTE4 could play a role in disease pathogenesis and since there are safe and effective cysteinyl leukotriene receptor blockers, it would be important to assess their efficacy in reducing dengue disease severity. (bvsalud.org)
  • Resident and recruited macrophages in the lung produce high levels of cysteinyl LTs (cysLTs) and leukotriene B 4 (LTB 4 ), thereby promoting granulocyte infiltration, airway inflammation and tissue remodeling 8 . (nature.com)
  • Several reports have indicated that the biosynthesis of SPM is impaired, especially in severe asthma, which suggests that chronic inflammation in the lung might result from a resolution defect. (nih.gov)
  • CAD) Thromboxane A2 is clearly involved in CAD due to its acute and chronic role in promotion of vasoconstriction and platelet aggregation. (chronicinflammationtest.com)
  • Some glycemic alterations that cause a detrimental cascade effect have also been linked to chronic inflammation, cardiovascular diseases, and gut dysbiosis, where the loss of several butyrate-producing bacteria has been observed ( 4 ). (frontiersin.org)
  • 47. The eicosanoid cascade: Lipid mediators of chronic inflammation. (ncgmlipidsp.jp)
  • Our recent work had shown that patients suffering from chronic airway inflammation exhibit transcriptional reprogramming of MDM 14 , a cell type implicated in COVID-19 pathogenesis 7 . (nature.com)
  • Ageing is accompanied by a state of low-grade chronic inflammation [ 6 ]. (aging-us.com)
  • We therefore determined the role for the endogenous H 2 S producing enzyme cystathionine-β-synthetase (CBS) in a validated rat model of IBS-like chronic visceral hyperalgesia (CVH). (biomedcentral.com)
  • May have a role as a major mediator of inflammation and/or a role for prostanoid signaling in activity-dependent plasticity. (bioss.com.cn)
  • Alendronate is an anti-inflammatory molecule and may therefore be of benefit in the treatment of the inflammation associated with spinal cord injury. (en-journal.org)
  • We hypothesize that inhalation of UfCP may disturb the balance of pro- and anti-inflammatory lipid mediators in: i) a model for acute allergic pulmonary inflammation, exposing mice for 24 h before allergen challenge to UfCP inhalation (51.7 nm, 507 μg/m 3 ), and ii) an in-vitro model with primary rat alveolar macrophages (AM) incubated with UfCP (10 μg/1 x 10 6 cells/ml) for 1 h. (biomedcentral.com)
  • Our results suggest that UfCP exposure affects the balance between pro- and anti-inflammatory lipid mediators. (biomedcentral.com)
  • In allergic mice, where the endogenous balance of pro- and anti-inflammatory mediators is already altered, UfCP exposure aggravates the inflammation and the increase in anti-inflammatory, pro-resolving lipid mediators is insufficient to counterbalance the extensive inflammatory response. (biomedcentral.com)
  • Considering the relationships among surgical treatments, inflammation and carcinogenesis, non-steroidal anti-inflammatory drugs (NSAIDs) are a candidate postoperative treatment for preventing recurrence and maintaining QOL. (bmj.com)
  • Anti-inflammatory effects - Inflammation was frequently observed in hormonally induced hypertrophied prostates of dogs and in a study of human BPH. (illnesshacker.com)
  • By studying transcriptome- and lipid mediator profiles in MDM of convalescent SARS-CoV-2-infected individuals with previous mild disease, we show that inflammatory gene expression and eicosanoid profiles as well as altered responsiveness to inflammatory cues are maintained at 3-5 months post infection as well as throughout macrophage differentiation. (nature.com)
  • The identified differential metabolites included arachidonic acid derivatives, omega-3 fatty acids, omega-6 fatty acids, and omega-9 fatty acids that were related to unsaturated fatty acid metabolism, which plays a role in the inflammatory responses. (biomedcentral.com)
  • Indeed, a platelet hyperreactive phenotype with biochemical evidence of persistent in vivo platelet activa- tion, with enhanced thromboxane (TX) biosynthesis, has been described in diabetic patients in different stages along the natural history of the impairment of glucose metabolism, even in the preclinical phases. (unich.it)
  • 64. New challenge for lipid mediators and phospholipid metabolism. (ncgmlipidsp.jp)
  • 63. Lipid mediators and lipid metabolism. (ncgmlipidsp.jp)
  • 61. Lipid mediators and glycerophospholipid metabolism. (ncgmlipidsp.jp)
  • 59. Studies on lipid mediators and lipid metabolism. (ncgmlipidsp.jp)
  • 57. Lipid mediators and phospholipid metabolism. (ncgmlipidsp.jp)
  • 52. Lipid mediators and phospholipid metabolism. (ncgmlipidsp.jp)
  • IL-6, the most abundant cytokine in the circulation, may have a major role in bone metabolism [ 9 ]. (aging-us.com)
  • Polarization of the macrophages regulates the production of proinflammatory and pro-resolving lipid mediators (LMs) to mediate acute inflammation and its resolution in a time-dependent manner. (cdc.gov)
  • The ubiquitous expression and the broader ligand specificity suggest that BLT2 may mediate distinct biological and pathophysiological roles from BLT1. (hindawi.com)
  • LPS (also referred to as endotoxin) is one of the important virulence factors that is known to mediate inflammation and apoptosis ( 2 ). (spandidos-publications.com)
  • Each class of enzymatically produced eicosanoids governs a specific set of functions and is thought to serve as a mediator or autacoid, acting within a local microenvironment to orchestrate key cellular responses. (jci.org)
  • Eicosanoids play pivotal roles in parturition, inflammation, hemodynamics, and renal function, and our appreciation of their bioimpact and relevance to human diseases is still evolving. (jci.org)
  • The 10th International Conference on Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation and Related Diseases, Montreal, Canada, Sep. (ncgmlipidsp.jp)
  • Plenary lecture), The 9th International Conference on Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation and Related Diseases, San Francisco, CA, Sep. (ncgmlipidsp.jp)
  • Monocyte-derived macrophages (MDM) drive the inflammatory response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and they are a major source of eicosanoids in airway inflammation. (nature.com)
  • Eicosanoids are bioactive metabolites of polyunsaturated fatty acids (PUFAs) with key roles in infection and inflammation 8 . (nature.com)
  • Serum and airway prostanoid- and LT levels are increased in severe COVID-19 10 , 11 , suggesting a role for eicosanoids in the immune response to SARS-CoV-2 infection. (nature.com)
  • The TNF-family member Receptor Activator of NF-kappaB (RANK) is known for its role in bone homeostasis and is increasingly recognized as a central player in immune regulation and epithelial cell activation. (cnrs.fr)
  • The restoration of homeostasis is coordinated by specific mediators and cellular events. (biomedcentral.com)
  • SPMs are biologically active mediators which promote resolution by dampening the inflammatory immune response and enhancing the return to homeostasis. (ucf.edu)
  • Studies in human microbiota dysbiosis have shown that short-chain fatty acids (SCFAs) like propionate, acetate, and particularly butyrate, positively affect energy homeostasis, behavior, and inflammation. (frontiersin.org)
  • The gut microbiota plays a pivotal role in regulating energy homeostasis. (frontiersin.org)
  • Among other host factors, this balance between energy intake and expenditure relies on the microorganisms and their metabolites, helping in nutrient processing, nutrient access regulation, and storage in the body by secreting hormones and mediators of energy homeostasis ( 3 ). (frontiersin.org)
  • The multi‑dimensional nature of their roles in cellular homeostasis, cell‑to‑cell and tissue‑to‑tissue communication at the level of the organism, as well as their actions on the holobiome (intra‑/interspecies interaction), have garnered the interest of a large number of researchers. (spandidos-publications.com)
  • The profound roles of exosomes in homeostasis, stress and several pathological conditions, in conjunction with their selective and cell‑specific composition/function, allude to their use as promising circulating clinical biomarkers of systemic stress and specific pathologic states, and as biocompatible vehicles of therapeutic cargo. (spandidos-publications.com)
  • Exosomes, via their cargo or surface composition, are signals/mediators of systemic homeostasis and stress for specific cell-to-cell or tissue-to-tissue communication ( 5 ). (spandidos-publications.com)
  • Because of their expanding roles in the endocrine regulation of homeostasis and stress, and their involvement in human pathophysiology, exosomes are now the epicenter of a new field, termed 'exosomics' ( 3 ). (spandidos-publications.com)
  • 30 kg/m2, triglycerides 150 Germany) and height was measured dicators of systemic inflammation [3]. (who.int)
  • Dendritic cells (DCs) play a crucial role in initiating and shaping immune responses. (nih.gov)
  • The activation of autophagy helps to relieve the excessive inflammatory response, and its dysfunction can lead to the occurrence of a variety of inflammation, immune, and metabolic disorders [ 7 ]. (hindawi.com)
  • Functional analysis showed that the muscle contraction, immune system/inflammation, and extracellular matrix pathways were the most affected pathways. (cdc.gov)
  • For immune support in athletes, L-glutamine is needed for formation of white blood cells, particularly by lymphocyte immune cells that use it at high rates for nucleotide biosynthesis and resulting cell proliferation. (doctorherdmanclinic.com)
  • Thus, the aim of this work is to carry out a review of the literature on the role of bacterial endotoxin in the etiology of periapical lesions, its mechanism of action, and to elucidate molecular mechanisms involved in endotoxin's recognition by the immune system and cell activation. (bvsalud.org)
  • Therefore, the objective of this study is to carry out a review of the literature on the role of bacterial endotoxin in the etiology of periapical lesions, as well as to elucidate molecular mechanisms involved in its recognition by the immune system and in cell activation. (bvsalud.org)
  • The success of low-dose aspirin in prevention of CAD is explained by platelet COX-1 inhibiting thromboxane A2 biosynthesis. (chronicinflammationtest.com)
  • Urinary 11-dehydro-thromboxane B 2 levels are associated with vascular inflammation and prognosis in atherosclerotic cardiovascular disease. (chronicinflammationtest.com)
  • In contrast, nonplatelet thromboxane generation in the early postoperative period appears to be dirven predominantly by inflammation and did not independently predict long-term clinical outcome. (chronicinflammationtest.com)
  • Using overexpression studies, we demonstrate that RIP2 promotes the modification and relocalization of various enzymes involved in SPM biosynthesis. (ucf.edu)
  • The eCB system is comprised of eCBs, anandamide, and 2-arachidonoyl glycerol, their cannabinoid-1 and cannabinoid-2 receptors (CB 1 and CB 2 , respectively), and the enzymes involved in their biosynthesis and degradation. (degruyter.com)
  • Specialized pro-resolving mediators (SPM: protectins, resolvins, and maresins) are generated from omega-3 fatty acids such as EPA and DHA via several enzymatic reactions. (nih.gov)
  • More importantly, this finding shattered a dogma of the time that held that fatty acids played only structural roles in cells, thus opening the way for discovery of the many other important bioactive fatty acid-derived products. (jci.org)
  • Role of dietary polyunsaturated fatty acids (PUFA) on tumorigenesis. (springer.com)
  • In U. N. DAs (Ed.), Metabolic syndrome pathophysiology: the role of essential fatty acids (pp. 181-200). (springer.com)
  • Polyunsaturated fatty acids and inflammation. (springer.com)
  • Here, we focus on newly uncovered pathways, involving either the cyclooxygenases (COXs) or nonenzymatic chemical transformations, that lead to the formation of bioactive prostanoids and of previously unknown lipid mediators produced by COX-2. (jci.org)
  • SAAS peptide could play a role in the decrease of PC1/3. (moam.info)
  • The existence of this asthma-like phenotype is proof that vasoative intestinal peptide plays an essential role in maintaining normal airway function. (ersjournals.com)
  • Vasoactive intestinal peptide induces both tyrosine hydroxylase activity and tetrahydrobiopterin biosynthesis in PC12 cells. (ersjournals.com)
  • Inflammation is a key driver of the pathogenesis and progression of ASCVD in preclinical models and humans. (chronicinflammationtest.com)
  • The Nicotinamide phosphoribosyltransferase (Nampt)-NAD-Sirt1 pathway modulates processes involved in the pathogenesis of multiple diseases by influencing inflammation. (aging-us.com)
  • Lipid mediators, known to be immediately generated in response to tissue injury, might be strong candidates for priming this particle-triggered change of the inflammatory balance. (biomedcentral.com)
  • In response to inflammatory stimuli and injury, infiltrating leukocytes and tissue-resident cells interact to generate lipoxins, which are involved in the termination of inflammation [ 7 ]. (biomedcentral.com)
  • In addition to spontaneously expressing airway hyperresponsiveness, these mice also show airway inflammation, evidenced by lung inflammatory cell infiltrates, increased cytokine and chemokine levels in bronchoalveolar lavage fluid, and upregulation of pro-inflammatory genes in lung tissue 11 . (ersjournals.com)
  • Here, by performing immunoprecipitation of NRROS and mass spectrometric analysis, we describe the NRROS interactome in macrophages and demonstrate that NRROS interacts with molecular chaperones/co-chaperones and mediators of the endoplasmic reticulum associated degradation (ERAD) pathway such as calnexin, suggesting a broader role for NRROS in protein biosynthesis and the ER quality control machinery. (biorxiv.org)
  • The death receptor pathway plays an important role in cell apoptosis ( 12 ). (spandidos-publications.com)
  • 53. Pathway-oriented profiling of lipid mediators. (ncgmlipidsp.jp)
  • Nampt (also known as visfatin and pre-B-cell colony-enhancing factor (PBEF)) is the rate-limiting enzyme that converts nicotinamide to nicotinamide mononucleotide (NMN) in the nicotinamide adenine dinucleotide (NAD) salvage pathway of NAD biosynthesis in mammals [ 10 ]. (aging-us.com)
  • The Δ4-desaturation pathway for DHA biosynthesis is operative in the human species: differences between normal controls and children with the Zellweger syndrome. (springer.com)
  • In non-sensitized mice UfCP exposure induced a light non-significant increase of all lipid mediators. (biomedcentral.com)
  • Also sensitized and challenge mice exposed to filtered air showed a partially significant increase in all lipid mediators. (biomedcentral.com)
  • In sensitized and challenged mice UfCP exposure induced highest significant levels of all lipid mediators in the lungs together with the peak of allergic airway inflammation on day 7 after UfCP inhalation. (biomedcentral.com)
  • Here we examined the molecular mechanism by which multi-walled CNTs (MWCNTs) induce M1 polarization in vitro, with a focus on the induction of arachidonate 5-lipoxygenase (Alox5), a key enzyme in the biosynthesis of LMs. (cdc.gov)
  • ABSTRACT There is accumulating evidence suggesting that inflammation is the bridging link between cardiovascular disease and metabolic syndrome. (who.int)
  • supports the concept that metabolic reprogramming, inflammation, and genome instability (including epige- netic changes) underlie many of the other hal marks and foster multiple hallmark functions. (who.int)
  • Inflammation is one of Sina Hospital, Tabriz from April 2007 tional intake data were collected using the features of metabolic syndrome, to April 2008. (who.int)
  • In vascular endothelial cells, the activation of peroxisome proliferator-activated receptor (PPAR) by prostanoids inhibits endothelial inflammation by suppressing transcription of pro-inflammatory genes. (fapesp.br)
  • 1) VIP promotes the normal synthesis and functioning of endothelial NOS, by stimulation of tetrahydrobiopterin, which plays a pivotal role in NOS function 6 . (ersjournals.com)
  • Specialized pro-resolving mediators (SPM) play a crucial role in resolving inflammation, with 15-lypoxygenase-1 (15-LOX-1) as a key factor for SPM biosynthesis. (nutraingredients.com)
  • 55. Biochemical and pathophysiological roles of two types of leukotoriene B4 receptors (BLT1 and BLT2). (ncgmlipidsp.jp)
  • 44. Lipid mediators in health and diseases. (ncgmlipidsp.jp)
  • FASEB Summer Research Conference on Lysophospholid Mediators in Health and Diseases. (ncgmlipidsp.jp)
  • TNF Alpha Inhibitors Market Overview 2023-2032 - Market Growth Analysis, Trends And Drivers - TNF alpha inhibitors refer to medications that are used to treat inflammatory diseases such as rheumatoid arthritis (RA), psoriatic arthritis, and juvenile idiopathic arthritis and that help to reduce or eliminate inflammation. (powershow.com)
  • The current review focuses on the role of the eCB system in normal kidney function and various diseases, such as diabetes and obesity, that directly contributes to the development of renal pathologies. (degruyter.com)
  • 2012). antigens that induce airway inflammation with the release of Although many studies investigated the association between inflammatory mediators. (cdc.gov)
  • ACULAR ® ophthalmic solution is also indicated for the treatment of postoperative inflammation in patients who have undergone cataract extraction. (nih.gov)
  • Prostanoids are generated widely in response to diverse stimuli and play important roles in normal physiology and disease. (fapesp.br)
  • Leptin or other physiological changes affects the biosynthesis and processing of many peptides hormones as well as the regulation of the family of prohormone convertases responsible for the maturation of these hormones. (moam.info)
  • HE BIOSYNTHESIS OF mammalian neuropeptide hormones follows the principles of the prohormone theory, which begins with an mRNA translation process into a large, inactive precursor polypeptide, followed by a limited posttranslational proteolysis to release different products of processing (1). (moam.info)
  • These findings have led to the hypothesis that low T levels may have a pathogenic role in RA. (brainimmune.com)
  • Overall, our findings shed light on novel functional roles for NOD2 and RIP2 outside of peptidoglycan sensing. (ucf.edu)
  • Despite these findings, its exact role remains unclear since obese individuals present higher fecal butyrate concentrations than the control group, with similar diet consumption ( 8 , 9 ). (frontiersin.org)
  • H 2 S enhances the excitability of colon specific sensory neurons in vitro and together these findings indicate an important role for H 2 S signaling in IBS-like visceral hyperalgesia. (biomedcentral.com)
  • Similarly but significantly in rat AM all lipid mediators were induced already within 1 h of UfCP stimulation. (biomedcentral.com)
  • We developed an in vitro model of lipopolysaccharide (LPS)-induced inflammation and showed that Nampt and Sirt1 were significantly upregulated in LPS-treated MC3T3-E1 cells. (aging-us.com)
  • A recent study by Rebecca Keith and co-workers from the National Jewish Health, Denver, CO, US, published in Arthritis and Rheumatism, provides further experimental evidence that testosterone deficiency might play a role in the development of arthritis. (brainimmune.com)
  • volume = {171}, number = {1879-0542 (Electronic)}, pages = {5--14}, abstract = {Antibodies play an important role in therapy and investigative biomedical research. (cnrs.fr)
  • Antibodies play an important role in therapy and investigative biomedical research. (cnrs.fr)
  • To elucidate whether epigenetic effects play a role for these gene expression changes, we performed whole genome bisulphite sequencing to assess DNA methylation patterns in the lungs 56 days after exposure to MWCNTs. (cdc.gov)
  • Our results suggest that upregulation of CBS expression in colonic DRG neurons and H 2 S signaling may play an important role in developing CVH, thus identifying a specific neurobiological target for the treatment of CVH in functional bowel syndromes. (biomedcentral.com)
  • Several disease-modifying agents, including lifestyle intervention, antidiabetic drugs and antiplatelet agents besides aspirin have been shown to reduce TX biosynthesis. (chronicinflammationtest.com)
  • In addition, the role of TSPO for behavior such as anxiety, fear and stress in relation to the modulating effects of TSPO ligands will be studied in respective animal models including PET labeling in relation to neurosteroidogenesis and spine plasticity. (uni-regensburg.de)
  • We sought to explore their role in acute dengue, by assessing levels of urinary LTE4 and urinary histamine in patients with varying severity of acute dengue. (bvsalud.org)