• A tentative degradation pathway of drug in acidic and alkaline condition was predicted. (ijpsonline.com)
  • He is director of research at CNRS and, since 2001, is the head of the Laboratory of Bacterial Envelopes and Antibiotics which, for more than 30 years, has been studying the biochemistry, genetics and physiology of the bacterial cell-wall peptidoglycan biosynthesis pathway as a whole. (degruyter.com)
  • Ureidosuccinase, an inducible enzyme in the pathway for pyrimidine degradation has been shown to convert ureidosuccinate to aspartate, CO 2 and NH 3 as reported by Liebenmm and Kornberg (7). (pdx.edu)
  • The sweetness is due to steviol glycosides, the glucosylated steviol derivatives of steviol glycoside biosynthesis pathway. (scialert.net)
  • In present study, we analyzed the effect of varying sucrose (1, 3 and 5%) concentrations on the genes involved in steviol glycoside biosynthesis pathway and content of steviol glycosides. (scialert.net)
  • Present work thus suggests that sucrose might be acting as an enhancer of transcriptional trigger to the genes of steviol glycoside biosynthesis pathway that could positively manipulate the production of steviol glycosides. (scialert.net)
  • Steviol glycoside biosynthesis pathway has sixteen steps catalyzed by different enzymes. (scialert.net)
  • The next four steps share similarity with gibberellic acid biosynthesis pathway. (scialert.net)
  • Presence of two functional copies of these genes has suggested their efficient role in steviol glycoside biosynthesis pathway as well. (scialert.net)
  • The rest five downstream steps are specific for steviol glycoside biosynthesis pathway. (scialert.net)
  • cumini infection through up-regulation of steroid biosynthesis, limonene and pinene degradation and butanoate metabolism pathways. (bvsalud.org)
  • Anaerobic toluene degradation proceeds by fumarate addition to produce (R)-benzylsuccinate as first intermediate, which is further degraded via β-oxidation by five enzymes encoded in the conserved bbs operon. (nih.gov)
  • In addition to the endocannabinoids and their receptors, this endocannabinoid system (thereafter called ECS) comprises synthesis and degradation enzymes and transporters [ 14 ]. (biomedcentral.com)
  • For more than 30 years, his main research interests have been the functional and structural study of the enzymes of peptidoglycan biosynthesis, the determination of the structure of peptidoglycan from certain bacterial species, and the search for peptidoglycan biosynthesis inhibitors that could act as antibacterial agents. (degruyter.com)
  • Like most enzymes of peptidoglycan biosynthesis, MurD constitutes an attractive target for the design and synthesis of new antibacterial agents. (degruyter.com)
  • Cells grown on orotate contained high levels of an induced system for the degradation of pyrimidines whereas cells grown on glucose contained a constitutive level of enzymes for pyrimidine biosyntheses. (pdx.edu)
  • Both the structure of the PGs and the GAG chains, and the expression of the enzymes involved in their biosynthesis and degradation, vary between normal cells and tumor cells. (lu.se)
  • This bioactive nucleotide is an intermediate in the biosynthesis of nicotinamide adenine dinucleotide or NAD+. (articlecity.com)
  • Cells grown on glucose showed a high level of a Mn +2 dependent aspartate transcarbamylase (the analogous enzyme to ureidosuccinase which is operative during pyrimidine biosynthesis) which forms ureidosuccinate from aspartate and carbamyl phosphate. (pdx.edu)
  • In this revised model ( i SO595), we decoupled glycogen biosynthesis/degradation from growth, thus enabling dynamic allocation of carbon storage. (biorxiv.org)
  • In many bacteria, the poly(A) tail promotes degradation of the mRNA. (wikipedia.org)
  • On mRNAs, the poly(A) tail protects the mRNA molecule from enzymatic degradation in the cytoplasm and aids in transcription termination, export of the mRNA from the nucleus, and translation. (wikipedia.org)
  • Perfect base pairing leads to the degradation of the mRNA (similar to siRNA), while imperfect complementarity inhibits translation. (genengnews.com)
  • beta-1,4-Gatactosyltransferase 7 (beta 4GalT7) is an essential enzyme in the biosynthesis of glycosaminoglycan (GAG) chains of proteoglycans (PGs). (lu.se)
  • Without the proper enzymatic degradation of the mucopolysaccharides, clinical symptoms, such as auditory and visual defects, cardiovascular pathologies, hepatosplenomegaly, and dysostosis multiplex, occur due to their accumulation in organ systems. (medscape.com)
  • It was noted that deacetylanisomycin was a prominent product in the first few days of fermentation, suggesting that acetylation of the C-3 hydroxyl group by acetyl Co-A is the final step in the biosynthesis of anisomycin. (wikipedia.org)
  • Although its pyrrolidine-based structure suggests that it is derived from proline, the results from the experiments indicated that tyrosine, glycine, methionine, and acetate are the primary precursors for the biosynthesis of anisomycin. (wikipedia.org)
  • Abiraterone acetate is an androgen biosynthesis inhibitor used in the treatment of prostate cancer. (ijpsonline.com)
  • This study focuses on a simple, economical and systematic liquid-chromatographic and mass spectroscopic method to study the stress degradation behavior of abiraterone acetate under various stress conditions along with its validation. (ijpsonline.com)
  • The chromatographic separation of abiraterone acetate and its major degradation product is achieved on Capcell PAK C 18 MG-III (100×4.6 mm, 3 μm) column using combination of 0.1 % acetic acid and acetonitrile as mobile phase with a flow rate of 1.2 ml/min and the wavelength of detection is selected as 251 nm. (ijpsonline.com)
  • Among the 976 genes of Pss B728a with no counterpart in Pst DC3000 are those encoding for syringopeptin, syringomycin, indole acetic acid biosynthesis, arginine degradation, and production of ice nuclei. (nih.gov)
  • Pancreatic uptake of 11 C-5-HTP in nonhuman primates was markedly decreased by inhibition of the enzyme dopa decarboxylase, which converts 11 C-5-HTP to 11 C-serotonin and increased after inhibition of monoamine oxidase-A, the main enzyme responsible for serotonin degradation. (snmjournals.org)
  • The PET ligand 5-hydroxy- l - 11 C-tryptophan ( 11 C-5-HTP) is the biogenic precursor for serotonin and was originally developed to assess the rate of serotonin biosynthesis by dopa decarboxylase (DDC) in the central nervous system ( 6 ). (snmjournals.org)
  • Abiotic degradation processes such as hydrolysis, oxidation, and photolysis are unlikely to play significant roles in the environmental fate of diethyl phthalate. (cdc.gov)
  • In the presence of sufficient nutrients, activation of mTOR inhibits the ULK1 complex, whereas, under conditions of nutrient starvation, AMPK inhibits mTOR and activates the ULK1 and PI3KC3 complex leading to initiation of phagophore biosynthesis. (hindawi.com)
  • Carrier Protein Mediated Formation of the Dihydropyridazinone Ring in Actinopyridazinone Biosynthesis. (go.jp)
  • Because of anisomycin's wide use as a protein synthesis inhibitor, there have been many studies centered on the biosynthesis of anisomycin. (wikipedia.org)
  • The biosynthesis of GAG chains is initiated by xylosylation of a serine residue of the core protein, followed by galactosylation by beta 4GalT7. (lu.se)
  • Autoxidation leads to degradation of organic compounds, including living matter. (wikipedia.org)
  • Responsible for the production of energy, biosynthesis of important substances, and degradation of various compounds. (diagnose-me.com)
  • Moreover, according to the International Conference on Harmonisation (ICH) guidelines, stress degradation studies for the compounds are mandatory not only to establish the inherent stability characteristics, but also to identify the degradation products. (ijpsonline.com)
  • Such compounds will be valuable tools for the exploration of GAG and PG biosynthesis and a starting point for development of anti-tumor agents. (lu.se)
  • In contrast, when polyadenylation occurs in bacteria, it promotes RNA degradation. (wikipedia.org)
  • The fully functional autolysosome then degrades the autolysosomal cargo and releases the degradation products into the cytosol for recycling. (hindawi.com)
  • We are studying the biosynthesis mechanism of sulfur-modification and its regulation mechanisms in order to develop new drugs. (go.jp)
  • Autophagy is a cellular catabolic process that eliminates damaged cell organelles, unfolded proteins, and various intracellular pathogens through lysosomal degradation. (hindawi.com)
  • In general, autophagy degrades long-lived damaged intracellular proteins, in contrast to the ubiquitin-proteasome system, which controls the degradation of short-lived proteins [ 2 ]. (hindawi.com)
  • Komov V.P., Kirillova N.V. (1981) Biosynthesis and degradation of aldolase in liver of tumor-bearing rats. (msk.ru)
  • For anabolic processes (conversion of small molecules into large), BIOSYNTHESIS is used. (bvsalud.org)
  • other degradation processes are not significant. (cdc.gov)
  • Our study implies that VK2 can enhance fat degradation and digestion to improve survival, supporting the effectiveness of VK2-based medical treatments. (frontiersin.org)
  • This study aimed to improve the phytate degradation in composite wheat-cassava-whole sorghum flour bread by adding a phytase releasing yeast Pichia kudriavzevii TY13 in baking, preincubated or not, with addition of yeast extract. (academicjournals.org)