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  • Tumour
  • Minimally invasive liquid biopsies can give temporal resolution to a tumour's genetic profile and allow the monitoring of treatment response through levels of circulating tumour DNA (ctDNA). (biomedcentral.com)
  • Because of the clinical importance of tumour genomics, it is unsurprising that the sequencing of tumour biopsies prior to, and during, treatment regimens has become commonplace over the past several years. (biomedcentral.com)
  • However, spatial heterogeneity within a tumour can lead to an under-representation of intratumour heterogeneity and an inaccurate reporting of tumour genotypic information gleamed from punch biopsies (Sottoriva et al. (biomedcentral.com)
  • Thus, many researchers and clinicians alike have turned to so-called 'liquid biopsies' in an attempt to identify circulating mutant tumour DNA (ctDNA) in a patient's blood (Newman et al. (biomedcentral.com)
  • histological
  • Clinical response as evaluated by changes in serum PSA level and digital rectal examination as well as by histological alterations on re-biopsy and prostatectomy such as the presence of apoptosis, necrosis, tumor proliferation and immunologic response, will be assessed following HSV-tk + valacyclovir treatment. (clinicaltrials.gov)
  • malignant
  • Prostate adenocarcinoma is one of the most frequent malignant diseases in men. (chsjournal.org)
  • In urologic pathology, atypical small acinar proliferation, abbreviated ASAP, is a collection of small prostatic glands, on prostate biopsy, whose significance is uncertain and cannot be determined to be benign or malignant. (wikipedia.org)
  • While each gland may not be secreting the same substance, as long as there is an exocrine function to the cell, it is considered glandular and its malignant form is therefore named adenocarcinoma. (wikipedia.org)
  • The adenoma, lacking the "carcinoma" attached to the end of it, suggests that it is a benign version of the malignant adenocarcinoma. (wikipedia.org)
  • went on to suggest that loss of the DCC gene and of p53 result in a malignant adenocarcinoma. (wikipedia.org)
  • An anal sac adenocarcinoma is an uncommon and aggressive malignant tumor found in dogs that arises from the apocrine glandular tissue of anal sac. (wikipedia.org)
  • A biopsy is the only certain way to tell whether the tumorous growth is malignant or not. (wikipedia.org)
  • glands
  • Kris also said that the March 19 result of her mother's biopsy revealed the disease was primarily due to adenocarcinoma, where the cancer started on colon glands. (wikipedia.org)
  • In urologic pathology, high-grade prostatic intraepithelial neoplasia, abbreviated HGPIN, is an abnormality of prostatic glands and believed to precede the development of prostate adenocarcinoma (the most common form of prostate cancer). (wikipedia.org)
  • Adenocarcinomas can arise in many tissues of the body owing to the ubiquitous nature of glands within the body, and, more fundamentally, to the potency of epithelial cells. (wikipedia.org)
  • HGPIN
  • The exact timing of repeat biopsies remains an area of controversy, as the time required for, and probability of HGPIN transformations to prostate cancer are not well understood. (wikipedia.org)
  • esophagus
  • Adenocarcinoma arises from glandular cells present in the lower third of the esophagus, often where they have already transformed to intestinal cell type (a condition known as Barrett's esophagus). (wikipedia.org)
  • examination
  • A biopsy is a medical test commonly performed by a surgeon, interventional radiologist, or an interventional cardiologist involving extraction of sample cells or tissues for examination to determine the presence or extent of a disease. (wikipedia.org)
  • Because invasion must be ruled out, BAC can be diagnosed only after complete sectioning and examination of the entire tumor, not using biopsy or cytology samples. (wikipedia.org)
  • Circulating
  • The tests analyze circulating tumor cells (CTCs) Analysis of individual CTCs demonstrated a high level of heterogeneity seen at the single cell level for both protein expression and protein localization and the CTCs reflected both the primary biopsy and the changes seen in the metastatic sites. (wikipedia.org)
  • commonly
  • Additionally, we uncover several novel single-nucleotide variants present in more than 5% of patients, often in genes not commonly associated with lung adenocarcinoma. (biomedcentral.com)
  • Biopsies are most commonly performed for insight into possible cancerous and inflammatory conditions. (wikipedia.org)
  • Apocrine gland anal sac adenocarcinomas also have a tendency to metastasize to the regional lymph nodes, spleen, and eventually lungs and, less commonly, bones. (wikipedia.org)
  • procedure
  • The procedure for the Tao brush biopsy is: The patient will be asked to lie on the table with her feet in the stirrups, as for a routine pelvic exam. (wikipedia.org)
  • When an entire lump or suspicious area is removed, the procedure is called an excisional biopsy. (wikipedia.org)
  • small
  • Apocrine gland anal sac adenocarcinomas first appear as small lumps associated with one of the anal sacs (rarely bilateral), but they can grow to a large size. (wikipedia.org)
  • The Noguchi classification system for small adenocarcinomas has received considerable attention, particularly in Japan, but has not been nearly as widely applied and recognized as the WHO system. (wikipedia.org)
  • typically
  • Highly differentiated adenocarcinomas form SRCCs via a loss of adherens and tight junctions that typically separate MUC4, a mucin protein, and ErbB2, an oncogenic receptor. (wikipedia.org)
  • removal
  • MRI Biopsy: The removal of cells or tissues so they can be viewed under a microscope by a pathologist to check for signs of cancer. (wikipedia.org)
  • rare
  • Extramammary Paget's disease (EMPD), also extramammary Paget disease, is a rare, slow-growing, usually noninvasive intraepithelial (in the skin) adenocarcinoma outside the mammary gland and includes Paget's disease of the vulva and the extremely rare Paget's disease of the penis. (wikipedia.org)
  • help
  • Cameron wants to help with the biopsy but Chase tells her to stay home and rest, and that he will wake her up when he gets back. (wikipedia.org)
  • samples
  • Endometrial cancer is commonly diagnosed by endometrial biopsy or by taking samples during a procedure known as dilation and curettage. (wikipedia.org)
  • collection
  • Foreman notices the shape of the fluid collection is odd, House recommends they do a dural biopsy to confirm brain cancer. (wikipedia.org)