• The approach relies on a blend of structural, biochemical, and biophysical methods to define the architecture, function, evolution, and regulation of protein/nucleic acid complexes. (hopkinsmedicine.org)
  • have performed a range of biochemical, biophysical and cell culture experiments to study how p63 is kept in its inactive form in the oocytes of mice. (elifesciences.org)
  • Our structures, combined with the results from other biophysical and biochemical assays, reveal a common disease mechanism: the mutations in PLN reduce its phosphorylation level by changing its conformation and weakening its interactions with PKA. (elifesciences.org)
  • Mechanism of biochemical reactions, biophysical structure, techniques for studying biochemical reactions. (hawaii.edu)
  • CMPS offers undergraduate and Master's level courses in biochemistry and biochemical techniques, as well as various courses in biophysical chemistry, NMR spectroscopy, and general physical chemistry. (lu.se)
  • is inclusive of papers focused on stucture, function, and properties of enzymes as well as catalytic and inhibition mechanisms of enzymes, mechanisms of drug action, and related advances on enzymes. (mdpi.com)
  • The second part is focused on a new family of two-component response regulator proteins that lack the catalytic aspartate residue that mimics the phosphorylation mechanism of typical 2-component response regulators. (uwm.edu)
  • Computational Evidence for the Catalytic Mechanism of Glutaminyl Cyclase. (unibo.it)
  • He is the director of the Institute for Basic Biomedical Sciences, professor of biophysics and biophysical chemistry at the Johns Hopkins University School of Medicine and co-director of the Cancer Chemical and Structural Biology Program for the Johns Hopkins Kimmel Cancer Center. (hopkinsmedicine.org)
  • Deepened knowledge on the biophysical chemistry of proteins with emphasis on properties rather than methods. (lu.se)
  • CMPS is a highly integrated center comprising the divisions of Biochemistry and Structural Biology (Faculty of Science) and Biophysical Chemistry (Faculty of Engineering, LTH). (lu.se)
  • 3) The interaction mechanism between active molecules and target proteins is elaborated by biophysics and bioinformatics, and the small molecule protein interaction sites are described by auxiliary molecular docking technology. (benthamscience.com)
  • We are using biophysical tools to determine the regulatory mechanisms of proteins with redox-sensitive ALR domains. (uwm.edu)
  • 2. We revealed the regulatory mechanisms of neutrophil function by macrophages, and the molecular mechanisms of netosis. (nii.ac.jp)
  • Dr. Silvaggi Lab is working on many proteins (like ADC family, RitR) and exploring the mechanisms based on their structure and enzyme kinetics. (uwm.edu)
  • We want to understand the molecular mechanisms of biological processes by exploring the structure, dynamics, interactions and function of proteins. (lu.se)
  • In Oct 2014, I became a Wellcome Investigator, and have used this opportunity to focus the lab more tightly around its core long-term interest of kinesin-microtubule interaction mechanisms. (warwick.ac.uk)
  • To this aim, in my PhD thesis I studied the molecular details, at level of peptide-lipid interaction, of the action mechanism of several antimicrobial peptides by a series of biophysical techniques. (unina.it)
  • Then, biophysical studies of its interaction with eukaryotic and bacterial model membranes were carried out. (unina.it)
  • In the chapter 4 is reported the biophysical characterization of the interaction of two P9Nal(SS)-derived peptides, named P9Nal(SR) and P9Trp(SS), with liposomes mimicking bacterial membrane. (unina.it)
  • The first part of my work is a mechanistic enzymology project aimed at understanding the structure and mechanism of the novel pyridoxal-5'-phosphate (PLP)-dependent L-arginine hydroxylase/deaminase, MppP, from Streptomyces wadayamensis (SwMppP). (uwm.edu)
  • For the September 2023 issue, we are highlighting Alexandra Ros, an associate editor for Biophysical Reports . (biophysics.org)
  • The ambitious goal of this project is to reveal the molecular mechanisms of presynaptic plasticity in the vertebrate brain. (europa.eu)
  • My ambitious aim is therefore to uncover the molecular and biophysical mechanisms of presynaptic plasticity. (europa.eu)
  • Additional research in Dr. Berger's laboratory is focused on understanding the molecular mechanisms and cellular functions of multisubunit assemblies that control the organization, preservation, and flow of genetic information. (hopkinsmedicine.org)
  • Activation follows a spring-loaded mechanism not requiring further translation of other cellular factors in oocytes and is associated with unfolding of the inhibitory structure that blocks the tetramerization interface. (elifesciences.org)
  • Investigating the cellular and circuit mechanisms underlying changes in cortical physiology with behavior. (alleninstitute.org)
  • Professor Dai used chemoproteomics, biochemistry, molecular biology and other technologies to deeply reveal the pharmacodynamic molecular mechanism of natural products. (benthamscience.com)
  • Work from their group is revealing important information about the mechanisms of origin processing, primer synthesis, and macromolecular assembly that occur during replisome construction. (hopkinsmedicine.org)
  • These scores will give precise quantitative measures for comparison between fruit flies with different gene knockdowns throughout different stages of development, and allow for a better understanding of the processes and mechanisms driving repeated pattern formation in this system. (clarkson.edu)
  • Using a model synapse, we relate the functions used in the fit to underlying biophysical processes. (jneurosci.org)
  • and (3) it should be possible to relate parameters extracted from fitting the data to the underlying biophysical processes governing the behavior of the synapse. (jneurosci.org)
  • Specifically, the statistics of the stimulus spike trains are restricted, and the method uses multivariable functions that are difficult to plot and describe and involves parameters that are not easily related to the relevant underlying biophysical processes. (jneurosci.org)
  • Incorporation of hydroxyapatite (HA) in a collagen scaffold dramatically improves bone morphogenic protein (BMP) sequestration via biophysical interactions with BMP, thereby providing more controlled BMP release compared with pristine collagen. (lu.se)
  • This research combines a quantitative biophysical approach to virology. (lu.se)
  • This project takes an interdisciplinary perspective and combines earth observation data with both biophysical, political, and socio-economic data to provide an integrated understanding of vegetation fires in drylands. (lu.se)
  • Dr. Berger has a twenty year history of studying the fundamental mechanisms of enzymes that control cell proliferation and small molecule inhibitors that target such systems. (hopkinsmedicine.org)
  • Lead author of the study Gareth Williams said his team coined the term "biophysical decoupling" to describe what they were seeing in coral reef islands with dense human populations versus remote reefs. (mongabay.com)
  • However, we know less about the biological effects of IL-21 and its signaling mechanisms in leukemia cells and monocytes. (intechopen.com)
  • These mechanisms drive much of the self-organisation behaviour of eukaryotic cells and understanding them is important both for fundamental science and for the development of improved chemical biology approaches to a range of important medical and agricultural problems. (warwick.ac.uk)
  • Thus, RitR is certainly not regulated by phosphorylation of the receiver domain, which means that RitR must necessarily have a different activation mechanism. (uwm.edu)
  • The work will be of interest to investigators of mechanisms of substrate recruitment by protein kinases, and particularly to those who are trying to understand the mechanisms of familial dilated cardiomyopathy. (elifesciences.org)
  • Computational Clues for a New Mechanism in the Glycosylase Activity of the Human DNA Repair Protein hOGG1. (unibo.it)
  • These samples would be pooled and processed by using available technology to isolate virus particles en masse, recover viral nucleic acids, produce amplified shotgun libraries, carry out shotgun sequencing of the mixture of viral genomes, and reconstruct these genomes in silico with the techniques originally developed to sequence the entire human genome from random fragments. (cdc.gov)
  • These studies will provide new insights into the key mechanisms facilitating as well as inhibiting viral infectivity. (lu.se)
  • Background Understanding the mechanisms behind resilience has become more relevant in the last decades, due to the increasing and intensifying disturbances from natural and anthropogenic sources that threaten biodiversity. (researchgate.net)
  • Understanding these mechanisms is important for manipulating ChAT's function and its involvement in various diseases such as Alzheimer's disease, schizophrenia, and congenital myasthenic syndromes (CMF). (lu.se)
  • Can evaluating exposure and dose metrics based on unproven biophysical mechanisms help avoid the uncertainties which now surround cancer risks from ELF fields? (cdc.gov)
  • Several mutations identified in phospholamban (PLN) have been linked to familial dilated cardiomyopathy (DCM) and heart failure, yet the underlying molecular mechanism remains controversial. (elifesciences.org)
  • Although many local signaling mechanisms that drive the formation of repeating patterns are understood, how these local signals upscale into tissue-wide patterns remains unclear. (clarkson.edu)
  • Research on vegetation fires, their spatiotemporal patterns, and their links to biophysical as well as political and socio-economic factors in drylands is limited and no large scale, interdisciplinary assessment of fire dynamics have been carried out for the Middle East - a politically complex dryland region where research on social-ecological systems has been limited. (lu.se)
  • Further work is now needed to investigate the exact molecular mechanisms behind the activation of p63. (elifesciences.org)
  • We then investigate the molecular mechanisms responsible for increased osteoinductive potential of a heterodimer BMP-2/7 with is clinically used counterpart, the BMP-2 homodimer. (lu.se)
  • The goal is to understand mechanisms of drug resistance and cross-reactivity and to guide the discovery and development of new compounds with improved therapeutic potential. (hopkinsmedicine.org)
  • We are trying to understand the molecular mechanisms of mechanochemical coupling. (warwick.ac.uk)
  • In the second part of the project, I faced the problem to understand the molecular details of the action mechanism of (P)GKY20, a natural amino acids-containing peptide modelled on the C-terminus region of the human thrombin. (unina.it)
  • From a societal perspective, it is important to understand how wildfires spread and what biophysical and political mechanisms prevent their suppression. (lu.se)
  • In 2010 I moved with a group of younger colleagues to Warwick Medical School to found a new Centre for Mechanochemical Cell Biology (CMCB), aiming to integrate biophysical and cell biological approaches to the mechanisms of life. (warwick.ac.uk)
  • Using a combination of biophysical methods as well as cell and ovary culture experiments we explain how TAp63α is kept inactive in the absence of DNA damage but causes rapid oocyte elimination in response to a few DNA double strand breaks thereby acting as the key quality control factor in maternal reproduction. (elifesciences.org)
  • Germ cells - from which egg cells and sperm cells develop - are particularly vulnerable as they contain sensitive quality control mechanisms that kill any cell that contain damaged DNA. (elifesciences.org)
  • The signaling mechanisms of IL-21 in different cell types have been identified. (intechopen.com)
  • Further evaluation of the molecular mechanisms responsible for this increased osteoinductivity at an early stage in the regeneration process indicated that the CHA+BMP-2/7 enhanced progenitor cell homing at the implantation site, upregulated the key transcriptomic determinants of bone formation, and increased the production of bone extracellular matrix components. (lu.se)
  • The lack of circadian system entrainment leads to poor sleep and could be an important biophysical mechanism underlying increased incidence of certain types of diseases, including cardiovascular (CV) disease (CVD). (cdc.gov)
  • I did my PhD work at Nottingham and my postdoctoral training as an EMBO Fellow with Vic Small at the IMB in Salzburg and as an MDA Fellow with John Kendrick Jones at the MRC Laboratory of Molecular Biology in Cambridge, working on the myosin II mechanism. (warwick.ac.uk)
  • In addition, we demonstrate that another more ubiquitous SERCA-regulatory peptide, called another-regulin (ALN), shares a similar mechanism mediated by PKA in regulating SERCA activity. (elifesciences.org)
  • Individuals and institutions should have mechanisms in place to initiate the prompt administration of medication when a patient presents with a hypertensive emergency. (medscape.com)
  • The major biophysical function of this lung surfactant film is to reduce the alveolar surface tension to near-zero value. (biophysics.org)
  • Spinelli, Domenico , Computational QM/MM Study of the Reaction Mechanism of Human Glutathione S-Transferase A3-3 , in: COMPUTATIONAL METHODS IN SCIENCE AND ENGINEERING: Theory and Computation: Old Problems and New Challenges. (unibo.it)
  • Depolarized dynamic light scattering, broadband dielectric spectroscopy, rheology, and differential scanning calorimetry were employed to systematically study the influence of MW on the mechanism of ionic transport and segmental dynamics in these materials. (osti.gov)
  • Herpes Simplex virus type 1 (HSV-1) is a prototypical model system to study the general infection mechanisms of herpesviruses. (lu.se)
  • According to the researchers from Scripps Institution of Oceanography and NOAA's Coral Reef Ecosystem Division (CRED) , human impacts are causing biophysical decoupling in many of the world's coral reefs. (mongabay.com)
  • Poor relationship between Caco-2 permeability and log Ko/w r2 = 0.097 THESE THEORIES OF DRUG UPTAKE WERE BIOPHYSICAL, 'LIPID-ONLY' THEORIES Corti et al. (slideshare.net)
  • Researchers have now investigated the biophysical details of this prey capture mechanism for the first time. (sciencedaily.com)
  • A joint project between the Plant Biomechanics Group of the University of Freiburg, led by Prof. Dr. Thomas Speck, and the Laboratoire de Spectrométrie Physique of the University of Grenoble has investigated the biophysical details of this prey capture mechanism for the first time. (sciencedaily.com)
  • The biophysical mechanisms through which farms interact with surrounding areas is poorly understood. (researchgate.net)