Biomechanical properties of cornea. Medical search. Frequent questions

Scholars@Duke publication: Evaluation of the influence of corneal biomechanical properties on intraocular pressure measurements using the ocular response analyzer. (duke.edu)
PURPOSE: The Ocular Response Analyzer (ORA) proposes to measure corneal biomechanical properties in vivo by monitoring and analyzing the corneal behavior when this structure is submitted to a force induced by an air jet. (duke.edu)
6. Ramm L, Herber R, Spoerl E, Pillunat LE, Terai N. Measurement of corneal biomechanical properties in diabetes mellitus using the Ocular Response Analyzer and the Corvis ST. Cornea 2019;5:595-99. (prelekara.sk)
In addition to Corneal Hysteresis, Ocular Response Analyzer provides Corneal Compensated Intraocular Pressure (IOPcc), a better indication of the true pressure, proven to be less influenced by corneal properties than Goldmann or other methods of tonometry. (calcoastophthalmic.com)
Numerous studies utilizing the Ocular Response Analyzer have confirmed the importance of the cornea in glaucoma decision making and, in fact, demonstrated that Corneal Hysteresis is of far greater significance than CCT. (calcoastophthalmic.com)
Ocular Response Analyzer takes corneal biomechanical properties into consideration, providing Corneal Compensated IOP (IOPcc). (calcoastophthalmic.com)

Franco S, Lira M. Biomechanical properties of the cornea measured by the ocu-lar response analyzer and their association with intraocular pressure and thecentral corneal curvature. (rcipublisher.org)

The stiffness of the cornea increases with age, apparently as a result of natu ral collagen crosslinking. (aao.org)
Part of Roberts' goal is to pin down a good way to separate the effect of IOP from the effect of stiffness in the cornea of living patients. (osu.edu)
are directly correlated with the tissue elastic properties the stiffness distribution in a tiny region of the cornea can be found by a mechanical B/D scan. (techuniq.com)
Stiffness parameter A1 (SP-A1), deformation amplitude ratio (DA ratio), and other biomechanical parameters were recorded using Corvis ST. The vertical and horizontal thickness profiles of central 3 mm corneal epithelium, Bowman's layer, and stroma as measured by the perpendicular distance between the neighboring interfaces were generated using UHR-OCT. The flat keratometry and steep keratometry were obtained using Pentacam. (biomedcentral.com)
Significant and different correlations were noted between corneal stiffness and corneal sublayer thickness in different groups, indicating that corneal sublayers may play different roles in maintaining corneal biomechanical stability between keratoconus and normal eyes. (biomedcentral.com)
We developed novel methods to characterize individual corneal material properties including the anisotropic collagen fibrils distribution, collagen fiber stiffness and nonlinearity using optical information to overcome the traditional challenges in corneal material characterization. (rochester.edu)
One method (Ecalc) is applicable to the general corneal condition, and Eiopg to the normal cornea, and these results can be used to calculate corneal stiffness. (prelekara.sk)
7. Eilaghi A., Flanagan J.G., Simmons C.A., Ethier C.R. Effects of scleral stiffness properties on optic nerve head biomechanics. (glaucomajournal.ru)
BOSS is a non-contact, confocal, high-resolution optical scanning platform targeted at identifying the biomechanical properties of eye tissues such as the cornea or lens, to build a spatially resolved profile of tissue stiffness in vivo . (intelon.com)
In a biomechanical paradigm, the stress and strain will alter the blood flow (primarily), and the delivery of nutrients (secondarily) through chronic alterations in connective tissue stiffness and diffusion properties. (entokey.com)
During disease progression, Descemet membrane's (DM), the corneal endothelial basement membrane, biomechanical properties such as surface topography and stiffness are affected and form guttatas, pillar-like structures, with different geometries and varied stiffness. (uwaterloo.ca)
The growth of biomechanics-based techniques is being spurred by an increased understanding of ways in which biomechanical properties, such as tissue stiffness, can play a significant role in both the development of disease and subsequent recovery from treatment. (optics.org)

Biomechanical properties of the cornea measured with a dynamic Scheimpflug analyzer in young healthy adults. (eyereum.com)

Bacterial keratitis denotes a bacterial infection of the eye that causes inflammation and, potentially, ulceration of the cornea, whereas corneal ulcer describes a loss of corneal tissue due to many possible causes. (medscape.com)
Abstract The cornea is a load-bearing tissue. (techscience.com)
Lower biomechanical properties in the local tissue of keratoconic cornea evoke mechanical stress increase. (techscience.com)
The cornea does so by having an organization consisting of three tissue layers: the epithelium, stroma, and endothelium. (molvis.org)
In the grant study, Roberts will first change the IOP in tests of tissue from paired donors, where one cornea is stiffened and the other is left unchanged. (osu.edu)
Tissue engineered corneas offer an alternative which more closely mimic the morphological, physiological and biomechanical properties of native corneas. (lboro.ac.uk)
Intelon Optics, Inc. is a medical device company focusing on the development and commercialization of the Brillouin Optical Scanner System, or BOSS™, a technology that enables revolutionary, point-by-point biomechanics imaging of eye structures extending from the front of the eye, or the cornea, to the back of the eye, empowering eye care professionals to make treatment decisions with confidence based on biomechanical tissue properties. (intelon.com)
The company's products will bring novel and unique solutions to aid the prediction of surgical outcomes, controlled treatment results, and confident decision-making for clinicians and surgeons, based on biomechanical tissue properties relevant to correcting refractive errors. (intelon.com)
By applying a high-powered laser beam to the cornea, the tissue can be remodeled, altering the corneal refraction to allow a clear image to be projected on the retina. (uantwerpen.be)
Variations of orientation distributions and anisotropies may imply varying out-of-plane tissue mechanical properties around the eye globe. (bvsalud.org)

Background/aims The authors estimated the association between corneal biomechanical properties and axial length in myopic children and verified the relationship between axial length and intraocular pressure (IOP). (bmj.com)
The model assumes that the cornea is a thin spheroid shell with an elastic response to intraocular pressure. (asme.org)
The purpose of this study was to evaluate the relationship between corneal biomechanical properties and corneal-compensated intraocular pressure (IOPCC) measurements as obtained by the ORA and Goldmann applanation tonometry (GAT) measurements. (duke.edu)
1. Orssengo G.J., Pye D.C. Determination of the true intraocular pressure and modulus of elasticity of the human cornea in vivo. (glaucomajournal.ru)
One hundred eleven newly diagnosed POAG patients, including 43 high tension glaucoma (HTG) and 68 normal tension glaucoma (NTG), were measured by Corvis ST to obtain intraocular pressure (IOP), central corneal thickness (CCT) and corneal biomechanical parameters at baseline and at each follow-up visit after initiation of PGA treatment. (biomedcentral.com)
The biomechanical properties of cornea may determine its deformation response to applanation, which influences the intraocular pressure (IOP) measurement [ 2 , 3 ]. (biomedcentral.com)

Regional elastic performance of the human cornea. (aao.org)
To develop a method, using current clinical instrumentation, to estimate the Young's modulus of the human cornea in vivo. (prelekara.sk)
Two methods have been developed to estimate the Young's modulus of the human cornea in vivo using current clinical instrumentation. (prelekara.sk)
Biomechanical studies of the human cornea. (prelekara.sk)
14. Elsheikh A, Wang D, Pye D. Determination of the modulus of elasticity of the human cornea. (prelekara.sk)

One of the goals of the five-year, $1.9 million National Institute of Health/National Eye Institute study is to find biomechanical biomarkers for different disease processes in keratoconus, diabetic retinopathy, glaucoma, and ocular hypertension. (osu.edu)
In ophthalmology detecting the biomechanical properties of the cornea can provide valuable information about various corneal pathologies including keratoconus and the phototoxic effects of ultraviolet radiation on the cornea. (techuniq.com)
To explore the relationship between corneal biomechanical parameters and corneal sublayer thickness using corneal visualization Scheimpflug technology (Corvis ST) and ultrahigh-resolution optical coherence tomography (UHR-OCT) in clinical and suspected keratoconus and normal eyes. (biomedcentral.com)
Until recently, there was no method to change the integrity and strength of the cornea itself for keratoconus patients. (shekhareyecare.com)
The viscoelasticity properties of the cornea did not change significantly when wearing corneoscleral contact lenses for one year, and therefore, these lenses seem to be safe and healthy and are a reasonable alternative option for keratoconus management," researchers said. (reviewofoptometry.com)
Corneal biomechanical properties have recently attracted increasing attention for its involvement in glaucoma and in other ocular diseases, such as keratoconus [ 1 ]. (biomedcentral.com)
These devices use different techniques to assess the in-vivo shape and material properties of the cornea for signs of early keratoconus. (uantwerpen.be)

These noninfectious ulcerations touch the peripheral cornea and have been classified into 2 clinical types. (medscape.com)
Peripheral ulcerative keratitis (PUK) is a rare manifestation of RA characterized by a progressive thinning of the peripheral cornea. (medscape.com)
The paracentral and peripheral cornea are stiffer than the central cornea because of differing orientation and number of collagen fibrils. (aao.org)
In-depth fiber orientation distributions and anisotropy (degree of fiber alignment) accounting for fiber density were quantified over the whole sclera and in 15 regions: central cornea, peripheral cornea, limbus, anterior equator, equator, posterior equator, posterior sclera and peripapillary sclera on both nasal and temporal sides. (bvsalud.org)

Properties of the cornea are important in the relationship of central corneal thickness (CCT) and IOP measurement error-in a stiff eye CCT is a large source of error, but in a soft eye CCT creates very little error," Roberts explains. (osu.edu)
Photodisruption with the Technolas femtosecond laser (Technolas Perfect Vision, Munich, Germany) creates changes inside the stroma, altering its biomechanical properties and reshaping the cornea itself, but not necessarily its thickness. (crstodayeurope.com)
Most of the biomechanical parameters and corneal sublayer thickness profiles showed statistical differences among three groups. (biomedcentral.com)
Corneal Hysteresis is an indication of the biomechanical properties of the cornea differing from thickness or topography, which are geometrical attributes. (calcoastophthalmic.com)
is performed to evaluate anterior corneal surface further, to determine corneal thickness, including the exact location of the thinnest spot of the cornea, to evaluate posterior cornea, and to perform ectasia risk assessment with advanced software that compares multiple parameters of the patient's cornea to those found in a general population of people with normal corneas. (pacificvision.org)

The value of the Young's modulus of the post-operative cornea and its dependence on the geometric parameters of the ablation zone are estimated employing "best-fit" approach to nomograms currently used in corneal refractive surgery. (asme.org)
With this model, we studied the relative contribution of various geometrical and material parameters to corneal biomechanical and optical behaviors. (rochester.edu)
In this investigation, Spanish researchers analyzed the changes in corneal biomechanical parameters of keratoconic eyes with and without intracorneal ring segment (ICRS) implants after one year of CScL wear. (reviewofoptometry.com)
Researchers found the corneal biomechanical parameters were lower in keratoconic corneas than in healthy ones. (reviewofoptometry.com)
After one year of CScL wear, no statistically significant differences in corneal biomechanical parameters were reported in any of the groups, although slight differences (0.13-0.27mm Hg) were found. (reviewofoptometry.com)
Impact of corneoscleral contact lens usage on corneal biomechanical parameters in keratoconic eyes. (reviewofoptometry.com)
Our previous study conducted by Corvis ST observed significant differences in biomechanical parameters between treatment naïve POAG patients and patients with long-term therapy of PGA, even after adjusting for other confounding factors that might influence biomechanics, such as IOP and CCT [ 17 ]. (biomedcentral.com)
Advances in biomechanical parameters for screening of refractive surgery candidates: A review of the literature, Part III. (pacificvision.org)

6. Elsheikh A., Wang D. Numerical modelling of corneal biomechanical behaviour. (glaucomajournal.ru)

Cross linking of the cornea is a new minimal invasive surgical treatment, based on collagen cross linking with Ultraviolet A (UVA, 365nm) and riboflavin (Vitamin B 2), a photosensitizing agent. (kpjhealth.com.my)
A 400 µ cornea soaked with riboflavin absorbs about 95% of the total radiation so that only a small amount reaches the endothelium. (kpjhealth.com.my)
The surface of the eye (cornea) is treated with application of Riboflavin eye drops for 30 minutes. (shekhareyecare.com)
The original protocol, referred to as the 'Dresden protocol', consisted of 30 minutes of iso-osmolaric riboflavin instillation on a de-epithelialised cornea, followed by irradiation at 365 nm and 3 mW/cm2 for 30 minutes. (touchophthalmology.com)
10 In its initial stages, the saturation of the corneal stroma through an intact epithelium remained poor, but modified solutions and, later, the use of iontophoresis managed to increase the concentration of riboflavin in the cornea to levels almost comparable to the levels achieved in classic 'epi-off' CXL. (touchophthalmology.com)
Although epi-off was considered more effective, modern epi-on protocols have overcome limitations such as oxygen diffusion, riboflavin penetration, and UV-A light blocks to ensure a similar biomechanical effect as the accelerated epithelium-off CXL protocol. (uantwerpen.be)
Corneal cross-linking (CXL) is a procedure that combines stromal riboflavin saturation and ultraviolet (UV) light to strengthen the cornea. (touchophthalmology.com)

The biomechanics of the cornea has a significant impact on its optical behavior. (rochester.edu)
The Corvis ST uses an ultra-high-speed Scheimpflug camera to record corneal deformation in real time and provides direct information on corneal biomechanical behavior [ 15 ] and could potentially provide more information on corneal biomechanics than ORA [ 16 ]. (biomedcentral.com)
The biomechanics of the cornea is described using two main sets of data as measured by ORA. (ophthalmologytimes.com)

4. Alastrue V., Calvo B., Pena E., Doblare M. Biomechanical modeling of refractive corneal surgery. (glaucomajournal.ru)

An analytically solvable model that considers the elasticity of the cornea is developed for use in the current and novel corneal refractive surgery procedures. (asme.org)
On the biomechanical properties of the cornea with particular reference to refractive surgery. (forexmangates.com)
As the field of refractive surgery matured, new methods of examining cornea have been added. (pacificvision.org)
We now have 5 different methods to evaluate cornea prior to refractive surgery. (pacificvision.org)

is a sophisticated technology designed to test the elasticity of the cornea and its ability to remain strong and stable after Laser Vision Correction. (pacificvision.org)
Zvietcovich was recently lead author on a paper using OCE to non-destructively map the elasticity of individual layers in the ex vivo corneas of pigs, producing descriptions of the layers with what the paper described as unprecedented contrast. (optics.org)

The TBI was developed by Dr. Ambrósio and colleagues in a multicenter study including one randomly selected eye from subgroups of patients with normal (n = 480) or keratoconic corneas (n = 204) and using the random forest method with leave-one out cross-validation, an efficient artificial intelligence technique for classification.1 The study also included 94 eyes with normal topography from patients with VAE. (ophthalmologytimes.com)

The integrated Scheimpflug-based corneal tomography and biomechanical analysis provided with the Pentacam and Corvis systems (both Oculus) generates the Tomographic and Biomechanical Index (TBI), which was developed to enhance diagnostic sensitivity, he said. (ophthalmologytimes.com)
The TBI was demonstrated to be more accurate for detecting ectasia than both the tomography-derived Belin/Ambrósio Deviation score and the biomechanical information alone, and external validation studies were performed in India, Germany, Iran, United States, and Brazil using data from several independent patient populations," Dr. Ambrósio said. (ophthalmologytimes.com)
Published case reports further illustrate the value of including tomography and biomechanical assessments for the diagnostic evaluation of patients in clinical practice. (ophthalmologytimes.com)
This ectasia is caused by the decompensation of the corneal material properties and is diagnosed based on postoperative tomography. (uantwerpen.be)
Moreover, a recent review of literature by Moshirfar M, et al has concluded that technologies such as ORA are essential for screening of corneal ectasia because "changes in biomechanical properties may occur before disease becomes apparent via tomography or topography. (pacificvision.org)

1 During initial treatments, the anterior and posterior surfaces of the cornea remained intact, and the epithelium and Bowman's layer were not disturbed. (crstodayeurope.com)

Cynthia Roberts, PhD, and her research team will use the Corvis ST Tonometer to tease out the properties of the cornea that impact measurement error in disease detection. (osu.edu)
The CorVis ST, a new Scheimpflug-based device, has the potential to analyze ocular biomechanical properties for further research. (ophthalmologytimes.com)
Recently, a new Scheimpflug-based device, named CorVis ST (Corneal Visualization Scheimpflug Technology, CorVis ST, Oculus Inc., Wetzlar, Germany) was introduced for measuring new ocular biomechanical properties. (ophthalmologytimes.com)

In vivo Heidelberg retinal tomograph (HRT II) confocal microscopy, second harmonic generated (SHG) confocal microscopy, histology, and immunofluorescence microscopy were used to assess the corneal transparency of the regenerated corneas. (molvis.org)
UMSC transplantation with a fibrin plug improves the healing of injured corneas and regeneration of transparent corneas, as determined with in vivo HRT II confocal microscopy. (molvis.org)
To date, BOSS is the only technology allowing in vivo , localized quantification of Young's modulus, a direct gauge of the stress-strain relationship of ocular tissues that influences the refractive performance of the eye from the cornea, where the light enters the eye, to the retina - the sensory system. (intelon.com)

To investigate the corneal biomechanical changes in primary open angle glaucoma (POAG) patients treated with long-term prostaglandin analogue (PGA). (biomedcentral.com)

The greatest advantage of the IIT is its ability to characterize local mechanical properties of biological tissues at the scale of cellular (multi)layers in order to understand their mechanical behavior. (anton-paar.com)
This is often done to find potential replacement materials whose properties and behavior need to closely match the replaced tissues. (anton-paar.com)

Vascular endothelial growth factor A (VEGF-A), which is present in the cornea, is a potent angiogenic agent. (aao.org)
Accumulation of lactic acid in the cornea has detrimental consequences for vision, such as edema (due to an increase in an osmotic solute load) or stromal acidosis, which can change endothelial morphology and function. (aao.org)
The amount of total UV-A energy (fluence) needed to cross-link the cornea was determined with two considerations in mind: avoiding endothelial damage by staying below the damage threshold of 0.35 mW/cm 2 , and inducing an effect in the anterior, mid and deep stroma. (touchophthalmology.com)
Currently, endothelial cell injection therapy is being developed and the effects of biomechanical cues on cell therapy is largely unknown. (uwaterloo.ca)

Experimental mice, i.e., wild-type, Col5a1 f/f and Kera-Cre/Col5a1 f/f ( Col5a1 ∆st/∆st , collagen V null in the corneal stroma) mice in a C57BL/6J genetic background, were subjected to a lamellar keratectomy, and treated with or without UMSC (10 4 cells/cornea) transplantation via an intrastromal injection or a fibrin plug. (molvis.org)
Dr. Ruiz found that this noninvasive procedure avoided many of the problems associated with laser procedures that open the cornea to ablate the stroma. (crstodayeurope.com)

thus, laser in situ keratomileusis (LASIK) flap creation and interruption of the anterior stromal lamellae are thought to disproportionately weaken the cornea and contribute to ectasia. (aao.org)
In the quest for enhanced ectasia diagnosis, we have to go beyond topography, which only provides two-dimensional information about the front surface of the cornea,' said Dr. Ambrósio, professor of ophthalmology, Federal University of the State of Rio de Janeiro (UniRIO), Brazil. (ophthalmologytimes.com)
While objective indices for the categorization of tomographic data have been developed, recognizing that ectasia risk is influenced by the biomechanical status of the cornea supports the use of biomechanical characterization. (ophthalmologytimes.com)
Postoperative ectasia is typically treated using corneal cross-linking (CXL), which strengthens the impaired mechanical properties of the cornea. (uantwerpen.be)

Findings from anecdotal case reports are supported by clinical studies to highlight the relevance of advances in corneal imaging to help evaluating the cornea. (ophthalmologytimes.com)

It's 2019 and people still say 'the cornea is not a piece of plastic' at meetings. (osu.edu)

Fagan, M. The potential role of variations in juvenile hip geometry on the development of legg-calve-perthes disease: a biomechanical investigation. (isbweb.org)

The procedure requires a fast air pulse for applanation or flattening of cornea. (allinoneguestblog.com)
The ocular pressure of a patient is determined by recording force of this jet of air when the applanation of cornea is in process. (allinoneguestblog.com)

The characterization of mechanical properties of hydrogels used for cell cultures is therefore of great interest. (anton-paar.com)
It is a characterization of the cornea's ability to absorb and dissipate energy, which is a function of visco-elastic biomechanical properties of the cornea. (calcoastophthalmic.com)

Corneal topography is used to map the shape and features of the anterior surface of the cornea. (biomedcentral.com)

Compensated IOP (IOPcc) - A pressure measurement that is less affected by the cornea than other methods of tonometry. (calcoastophthalmic.com)

It is, therefore, essential that we don't rely on only several of these tests, but perform all 5 for each patient to accurately distinguish between healthy and structurally robust cornea vs. pre-ectatic vs. subclinical epithelial basement membrane dystrophy vs. contact lens warpage. (pacificvision.org)

Patients with thicker corneas tended to have higher GAT IOP measurements compared with IOPCC, whereas in patients with thin corneas, GAT IOP measurements tended to be lower than IOPCC. (duke.edu)
CONCLUSIONS: ORA IOPCC measurements seem to provide an estimate of IOP that is less influenced by corneal properties than those provided by GAT. (duke.edu)
The instrumented indentation technique (IIT) has been available in the last twenty to thirty years for hardness and elastic measurements of local mechanical properties, namely on thin films. (anton-paar.com)

Our findings indicate these formulations are interchangeable, paving the way for the development of novel PACK-CXL protocols for thin corneas and deep-seated infections. (arvojournals.org)

The cornea is transparent, and provides the major refractive power for producing a focused image on the retina. (molvis.org)

The value is used by this machine to rectify the effect of cornea on the measurement. (allinoneguestblog.com)

There are many reasons for local testing of the mechanical properties of soft biological tissues and biomaterials. (anton-paar.com)
Changes in mechanical properties are often related to diseased states of other tissues and can therefore provide information about the progress of the disease or effects of the medical treatment. (anton-paar.com)
The IIT also finds its use in the growing area of biomimetic research in which the structure and mechanical properties of tissues must be carefully characterized to develop graft materials with properties as close as possible to the real tissues. (anton-paar.com)
We have proposed that the ONH be understood as a biomechanical structure, and that the mechanical effects of IOP on the tissues of the ONH, namely forces and deformations, are central determinants of both the physiology and pathophysiology of the ONH tissues and their blood supply at all levels of IOP ( Figure 20.1 ). (entokey.com)
Within this framework, the susceptibility of a particular patient's ONH to IOP-related insult is a function of the biomechanical response of the constituent tissues and the resulting mechanical, ischemic, and cellular events driven by that response. (entokey.com)
These deformations depend on the particular geometry and material properties of the tissues of an individual eye. (entokey.com)
Although it is well-known that these fibers form a complex three-dimensional interwoven structure, biomechanical and microstructural studies often assume that the fibers are aligned in-plane with the tissues. (bvsalud.org)

Eighty-eight paired porcine corneas were cross-linked by either RF (n = 11) or RF-D (n = 11) and ultraviolet light (UVA), or WST11 (n = 11) or WST-D (n = 11) and near-infrared (NIR) light, or used as paired control (n = 44). (arvojournals.org)
The Ultraviolet light dose used is designed to prevent damage to the cells that line the back of the cornea or the other structures within the eye. (shekhareyecare.com)

5. Wan K, Cheung SW, Wolffsohn JS, Orr JB, Cho P. Role of corneal biomechanical properties in predicting of speed of myopia progression in children wearing orthokeratology lenses or single-vision spectacles. (prelekara.sk)

11. Woo SL, Kobayashi AS, Schlegel WA, Lawrence C. Nonlinear material properties of intact cornea and sclera. (prelekara.sk)

Col5a1 ∆st/∆st mice display a cloudy cornea phenotype that is ameliorated following intrastromal transplantation of UMSCs. (molvis.org)
UMSC transplantation was successful in recovering some corneal transparency in injured corneas of wild-type, Col5a1 f/f and Col5a1 ∆st/∆st mice. (molvis.org)

That's why we need to characterize their biological and mechanical properties. (anton-paar.com)
Since then the biology and bioengineering fields have evolved and now knowledge of local mechanical properties of new types of soft biomaterials and biological materials is required in many applications. (anton-paar.com)

The biomechanical properties of the cornea affect its functional responses. (aao.org)
They affect functional responses of the cornea and the crystalline lens to light and greatly impact vision. (intelon.com)

Advancements from Carl Zeiss Medical AG in the cataract and cornea space include a new intraocular lens and therapeutic laser enhancements. (ophthalmologytimes.com)

Differences in corneal biomechanical properties may indicate more generalised structural differences between eyes. (bmj.com)

Just like other forms that tonometry has, this method works by recording the corneal reaction as some force is applied on cornea. (allinoneguestblog.com)

The rounder the cornea at highest concavity, the softer it is. (osu.edu)

The Orssengo and Pye algorithm was used to calculate the Young's modulus of the corneas of these subjects. (prelekara.sk)
The Young's modulus(E) of the corneas of the subjects using the PDCT and IOPG results (Ecalc) was 0.25 ± 0.10MPa, and without the PDCT results (Eiopg) was 0.29 ± 0.06MPa. (prelekara.sk)

Similar to enzyme crystallins of the lens, both aldehyde dehydrogenase and transketolase are thought to contribute to the optical properties of the cornea. (aao.org)
The cornea is the clear (transparent) surface at the front of the eye which focuses light onto the lens inside the eye. (new-glaucoma-treatments.com)

An understanding of these properties can help clinicians to better anticipate or understand the cornea's responses to stress and strain and also aid in diagnosing and treating corneal disease. (aao.org)

The tonometer makes use of air pulse for deforming cornea into a slight concave shape. (allinoneguestblog.com)

Anatomy67

Organisms10

Diseases32

Chemicals and Drugs21

Analytical, Diagnostic and Therapeutic Techniques and Equipment67

Phenomena and Processes45

Disciplines and Occupations1

Anthropology, Education, Sociology and Social Phenomena1

Technology, Industry, Agriculture9

Information Science5

Health Care3

Ocular Response Analyzer6

Response Analyzer1

Stiffness12

Analyzer1

Tissue10

Intraocular pressure6

Human cornea5

Keratoconus7

Peripheral cornea4

Thickness5

Parameters8

Modelling of corneal1

Riboflavin7

Biomechanics3

Modeling of refractive1

Refractive surgery4

Elasticity2

Keratoconic corneas1

Tomography5

Epithelium1

Corvis ST3

Vivo3

Glaucoma1

Behavior2

Endothelial4

Stroma2

Ectasia4

Clinical1

20191

Investigation1

Applanation2

Characterization2

Topography1

Methods1

Basement membrane1

Measurements3

Thin corneas1

Retina1

Measurement1

Tissues7

Ultraviolet2

Myopia1

Sclera1

Transplantation2

Mechanical properties2

Functional responses2

Cataract1

Differences1

Tonometry1

Highest concavity1

Young's2

Lens2

Clinicians1

Concave1