Biomarkers with contrast molecular imaging. Medical search. Frequent questions

UBM is useful to investigate the growth and differentiation of tumors as well as to detect early molecular expression of cancer-related biomarkers in vivo and to monitor the effects of cancer therapies. (hindawi.com)
The intent of the EDRN BDL Project, titled New Tools for Prostate Cancer Detection and Prognostication, is to first outline the adaptation of a newly-developed magneto-nano sensor to multiplex blood biomarkers for prostate cancer detection and prognostication (in vitro), then to subsequently propose the adaptation of the latest ultrasound technology using tumor angiogenesis-targeted microbubbles to image prostate cancer (in vivo). (nanowerk.com)
The Canary Center at Stanford hopes to combine these in vitro and in vivo platforms in an integrated approach that will lead to an accurate blood test for the early detection and prognostication of prostate cancer, along with an imaging strategy that will enable the accurate localization and biopsy of prostate lesions. (nanowerk.com)
Molecular imaging emerged in the mid twentieth century as a highly specialized discipline at the intersection of molecular biology and in vivo imaging, focusing on imaging molecules of medical interest within intact living subjects. (stanford.edu)
In vivo perfusion imaging techniques provide additional information regarding tumor physiology and hemodynamics, which may help in better characterizing glioma malignancy and may also overcome some of the limitations of histologic grading and conventional morphologic imaging. (ajnr.org)
Hence, there is a need for noninvasive in vivo clinical imaging tools that can study perfusion in the entire tumor, can be used to assess much larger volumes than small biopsy samples, and can probably guide biopsy and excision sites for better results. (ajnr.org)
Their most recent efforts have focused on providing in vivo maps of kidney structure and function at the scale of individual nephrons and linking observed changes in imaging to detect progression of kidney disease. (wustl.edu)
Ex vivo macroscopic three-dimensions (3D) PA imaging with IR820-E[c(RGDfK)]2 staining was also performed in surgical biospecimens from patients with HCC. (visualsonics.com)
We demonstrated an optoacoustic and fluorescent system for not only imaging tumor hypoxia in vivo but also achieving tumor inhibition. (thno.org)
Nanomedicine is an exciting field that aims to improve patient outcomes through transformative treatments, imaging agents, and ex vivo diagnostics. (news-medical.net)
Artificial intelligence (AI) could be used to identify both in vivo and ex vivo biomarkers that reflect a specific disease state, determine the most effective therapy or combination of therapies, and interpret the results of therapeutic responses, even among various patient subpopulations. (news-medical.net)
These microbubbles can either be Non-targeted for visualization of blood flow and perfusion, or conjugated to a molecular target to enable true in vivo molecular imaging. (visualsonics.com)
Apart from morphologic features on unenhanced T2-weighted images, two different non-contrast molecular approaches were mainly run in vivo: proton MR spectroscopy (1H-MRS) and diffusion-weighted imaging (DWI). (univr.it)

Few years ago, research applications of noninvasive imaging methods such as optical imaging, computed tomography, magnetic resonance, micro-PET-SPECT, and ultrasound were limited to larger animals such as dogs and nonhuman primates. (hindawi.com)
For example, magnetic iron oxide nanomaterials are used for magnetic resonance imaging (MRI) and myocardial perfusion imaging (MPI), while gold nanomaterials can be used for computed tomography (CT) imaging. (news-medical.net)
Anatomic imaging with conventional modalities, particularly computed tomography (CT), has been used in patients with head and neck SCCs, but this approach has limitations. (rsna.org)
No laboratory biomarkers exist for the condition, and findings on routine magnetic resonance imaging and computed tomography scans are unremarkable. (medscape.com)
Structural imaging, preferably with MRI when possible and with computed tomography (CT) when not, should be performed as a first-tier approach. (medscape.com)
Improved Liver Lesion Conspicuity With Iterative Reconstruction in Computed Tomography Imaging. (lu.se)

Perfusion imaging of brain tumors has been performed by using various tracer and nontracer modalities and can provide additional physiologic and hemodynamic information, which is not available with routine morphologic imaging. (ajnr.org)
Bennett's lab develops new contrast techniques, agents and analytical tools using a range of radiological imaging modalities aimed at detecting pathologies at the earliest possible stage. (wustl.edu)
Varied programs conducted by our Medical Imaging faculty members have made strong contributions not only to image science but also to the practice of clinical medicine and preclinical biomedical research as the majority of research projects include members of our clinical faculty with significant expertise and experience across all clinical modalities. (arizona.edu)
Functional imaging, that is, modalities that offer information on factors that influence treatment outcome (e.g., tumor burden, proliferation, and hypoxia), is expected to provide the biologic target volume for such dose painting ( 2 , 3 ). (snmjournals.org)
In addition to the endoscopic evaluation of CD strictures, this review summarizes the currently available imaging modalities, including ultrasound and cross-sectional imaging techniques. (wjgnet.com)
The imaging modalities include ballistic imaging, quasi-ballistic imaging (optical coherence tomography), diffusion imaging, and ultrasound-aided hybrid imaging. (lu.se)
A variety of imaging modalities, including structural and functional magnetic resonance imaging (MRI) and positron emission tomography (PET) studies of cerebral metabolism, have shown characteristic changes in the brain of patients with Alzheimer disease in prodromal and even presymptomatic states. (medscape.com)

Our research spans "bench to bedside," including basic science investigations, small animal imaging studies, and clinical translation. (mdanderson.org)
The magneto-nano sensor is an ultra-sensitive magnetic sensor that can measure biomarkers in a host of clinical samples such as blood, urine, and saliva. (nanowerk.com)
Canary's RGD-based novel imaging agent [18F] FPPRGD2 has excelled in safety and efficacy studies and with the FDA-approved eIND, clinical trials can be performed. (nanowerk.com)
These clinical trials are being conducted by the Nuclear Medicine and Molecular Imaging Clinic of Stanford University Medical School's Department of Radiology, under the leadership of Dr. Gambhir. (nanowerk.com)
This Funding Opportunity Announcement (FOA) invites grant applications proposing exploratory research projects focused on further development and validation of emerging technologies offering novel capabilities for targeting, probing, or assessing molecular and cellular features of cancer biology for basic, clinical, or epidemiological cancer research. (nih.gov)
Her strong education background in biological sciences and biomedical engineering followed by postdoctoral training in translational and clinical research have helped her develop multiple disease-specific molecular probes and imaging strategies for early cancer diagnosis, image-guided surgery, therapeutic delivery prediction and at-risk cardiovascular plaque detection. (stanford.edu)
Dr. Zhou has been able to formulate the involved clinical and biological problems into biomedical engineering frameworks and find ways to exploit a variety of modern techniques and approaches from photoacoustic imaging, fluorescence-guided surgery, micro-electromechanical systems and therapeutic delivery strategies in developing elegant and effective solutions. (stanford.edu)
The rising number of deaths from cancer brings an urgent need for clinical biomarkers that can determine the risk of developing the disease, serve as an initial diagnostic tool and monitor disease progression. (ddw-online.com)
Aside from providing useful information to guide clinical decision-making, cancer biomarkers are increasingly linked to specific molecular pathway deregulations and/or cancer pathogenesis to justify application of certain therapeutic/interventional strategies (2). (ddw-online.com)
PATIENTS AND METHODS: Our research aims to correlate to each other and to angiogenesis four different tissue parameters (MCs density positive to chymase, MCs area positive to chymase, microvascular density and endothelial area) together with the main clinical-pathological characteristics in 52 patients surgically resected for pancreatic ductal adenocarcinoma, employing immunohistochemistry and image analysis system. (bvsalud.org)
Inspired by the high resolution of photoacoustic (PA) imaging and established clinical efficacy of 18F-Alfatide that is specific for integrin αvβ3-overexpressed tumors, we herein developed a fluorescent analogue IR820-E[c(RGDfK)]2, and a proof-of-concept intraoperative multispectral PA imaging navigation for precise irregular hepatectomy using hand-held PA/US imaging system. (visualsonics.com)
IR820-E[c(RGDfK)]2 has the potential to be an investigational new drug for clinical use in multispectral photoacoustic imaging-guided irregular hepatectomy. (visualsonics.com)
The exact rates of imaging changes in patients and what clinical and semiological characteristics govern such changes remains unclear. (tcd.ie)
In clinical trials, amyloid PET scans showed reductions in amyloid burden, with imaging radiotracers used to quantify plaque levels. (auntminnie.com)
PET imaging has revealed brain pathology linked to faster clinical progression of Alzheimer's disease (AD) in patients with ApoE4 gene variants. (auntminnie.com)
Magnetic resonance imaging (MRI) of the breast gained a role in clinical practice thanks to the optimal sensitivity of contrast-enhanced (CE) protocols. (univr.it)
They likely represent a continuum of different diseases that may share biological mechanisms ( i.e. endotypes), and present similar clinical, functional, imaging and/or biological features that can be observed ( i.e. phenotypes) which require individualised treatment. (ersjournals.com)
To investigate the performance of diffusion-weighted (DW) MRI with mono-, bi- and stretched-exponential models in predicting pathologic complete response (pCR) to neoadjuvant chemotherapy (NACT) for breast cancer, and further outline a predictive model of pCR combining DW MRI parameters, contrast-enhanced (CE) MRI findings, and/or clinical-pathologic variables. (springer.com)
Clinical and Translational Imaging. (lu.se)

Recently, the introduction of ultrasound contrast agents (lipid shell gas-filled 1-4 micron sized microbubbles) enhances UBM applications for detection and characterization of focal lesions. (hindawi.com)
Nanowerk News ) Canary Foundation researchers at Stanford University received the National Cancer Institute (NCI) Early Detection Research Network (EDRN) Biomarker Development Laboratory (BDL) Grant. (nanowerk.com)
The FDA approved an exploratory investigational new drug (eIND) for the first-in-human testing of molecular imaging agents that can detect small tumors earlier in lung cancer, allowing for non-invasive detection and potentially improved characterization of smaller lung nodules. (nanowerk.com)
Dr. Gambhir is also head of Nuclear Medicine and Director of the Canary Center at Stanford for Cancer Early Detection, a world-class facility dedicated to the development of blood tests and molecular imaging approaches to detect and localize early cancers. (nanowerk.com)
This grant signifies EDRN's recognition of molecular imaging in cancer early detection strategies. (nanowerk.com)
It is suitable for biomarker detection, tissue classification, pathology research, and imaging the distributions of drugs and metabolites for drug development. (photonics.com)
Nanomaterials can enhance the detection of cellular and molecular biomarkers associated with CVD, such as troponins and C-reactive protein (CRP), by utilizing their physicochemical and magnetic properties to amplify signals and increase sensitivity during imaging. (news-medical.net)
We synthesize magnetic nanostructures with tailored texture, morphology and properties for different biomedical applications: tissue engineering, cell tracking and molecular imaging nanoprobes, contrast agents for MRI/PET, theragnostic agents ( drug delivery& imaging), nanoprobes for early detection of biomarkers in highly sensitive and specific kits. (nanomag.es)
The goal of nonlinear contrast imaging is to suppress the tissue signal while increasing the detection of the contrast agents, providing a much more sensitive imaging technique. (visualsonics.com)
The addition of this new technology, used in a handful of universities in the Southeast, will make Georgia State a hub for MRI research, allowing faculty to conduct animal research using one of the world's strongest imaging machines available for the detection of disease. (gsu.edu)
Here, we report the elevated expression of chemokine receptor 4 (CXCR4) in liver metastases in UM patients and metastatic UM mouse models, and development of a CXCR4-targeted MRI contrast agent, ProCA32.CXCR4, for sensitive MRI detection of UM liver metastases. (gsu.edu)
Further development of the CXCR4-targeted imaging agent should have strong translation potential for early detection, surveillance, and treatment stratification of liver metastases patients. (gsu.edu)
We are developing spectrally-resolved fluorescence correlation imaging for cancer detection. (uiowa.edu)

We build various prototype and preclinical imaging probes and systems, which are now opening new opportunities for endoscopic procedures. (ren-lab.org)
Contrast agents for molecular imaging encompass a variety of molecular probes known as biomarkers to help image particular targets or pathways with SPECT, PET, MRI, ultrasound, and optical imaging devices. (arizona.edu)

Additionally, this technique is useful to image the fetal mouse [ 4 - 6 ] and to obtain high-resolution images of mice tumors [ 7 , 8 ]. (hindawi.com)
Traditionally, perfusion imaging of brain tumors has been performed with MR imaging, by using various perfusion imaging techniques and estimating tumor blood volume, blood flow, and permeability. (ajnr.org)
In view of the wider availability, faster scanning times, and low cost compared with MR perfusion, PCT is potentially well-suited to study brain tumors 6 , 7 and could potentially be useful as an easy tool for quantitative estimates of perfusion parameters and their use as imaging biomarkers. (ajnr.org)
Treatment planning of gastrointestinal stromal tumors (GISTs) includes distinguishing GISTs from other intra-abdominal tumors and GISTs' molecular analysis. (springer.com)
Patients diagnosed at the Erasmus MC between 2004 and 2017, with GIST or non-GIST intra-abdominal tumors and a contrast-enhanced venous-phase CT, were retrospectively included. (springer.com)
Tumors were segmented, from which 564 image features were extracted. (springer.com)
Patients from our institute between 2004 and 2017 with a histopathologically proven primary GIST or intra-abdominal tumors resembling GIST with at least a contrast-enhanced venous-phase CT prior to treatment [ 3 , 18 ] were retrospectively included. (springer.com)
Molecular biomarker imaging is a new non-invasive approach for detecting early stage tumors. (gsu.edu)
Cerebellar hemispheric tumors of older children and adults show similar imaging features, except that contrast enhancement is more variable than in young children. (medscape.com)

The algorithm provides unique selectivity and image contrast to assist in the classification of cancer biopsies and other tissue samples. (photonics.com)
3 - 5 However, PCT, which has also been used recently for glioma grading, 6 , 7 provides a linear relationship between tissue attenuation and tissue concentration of a contrast agent, unlike perfusion MR imaging, and, hence, probably provides a more robust and less biased estimation of hemodynamic (tumor blood volume) and physiologic (tumor vascular leakiness) parameters. (ajnr.org)
We synthesize scattering nano-constructs to label specific proteins and demonstrated their visualization in large tissue samples with high molecular specificity and at high throughput by combining our labeling and imaging approaches. (ren-lab.org)
1 - 12 ] but the pure optical imaging methods have such limitations as low spatial resolution with unsatisfactory penetration depth due to high-degree light scattering by tissue. (thno.org)
Microbubble ultrasound contrast agents have been used in imaging as a means of improving the visualization of blood flow with respect to the surrounding tissue. (visualsonics.com)
Prediction of such molecular characteristics based on imaging could guide treatment planning while awaiting the results of a final tissue biopsy. (springer.com)
In this novel imaging technique, each tissue location is investigated by two-dimensional fluorescence correlation spectroscopy (2D FCS). (uiowa.edu)
By combining both spectral and temporal information of the tissue fluorescence, 2D FCS provides a high contrast between samples, forming the basis for cancer diagnosis. (uiowa.edu)
In conjunction with tissue spectroscopy, fluorescence imaging and chemical separations are used to elucidate the molecular and morphological changes in tissue upon cancerous transformation. (uiowa.edu)
The heart of the book covers the essential topics of tissue optics, as well as optical imaging system design concepts. (lu.se)
This entry-level textbook, covering the area of tissue optics, is based on the lecture notes for a graduate course (Bio-optical Imaging) that has been taught six times by the authors at Texas A&M University. (lu.se)

We specialize in the synthesis and characterization of chemical contrast agents for magnetic resonance imaging (MRI), positron emission tomography (PET), PET/MRI, and MultiSpectral Optoacoustic Tomography (MSOT). (mdanderson.org)
Functional imaging techniques, including positron emission tomography (PET) combined with CT or magnetic resonance (MR) imaging, offer complementary information and can be used noninvasively to assess a range of biomarkers in patients with head and neck SCCs, including hypoxia, cell proliferation and apoptosis, and epidermal growth factor receptor status. (rsna.org)
Second-tier imaging with molecular methods, preferably with fluorodeoxyglucose positron emission tomography (FDG-PET) (or single-photon emission CT [SPECT] if PET is unavailable), can provide greater diagnostic specificity. (medscape.com)

The emphasis of this FOA is on molecular analysis technologies with a high degree of technical innovation with the potential to significantly affect and transform investigations exploring the molecular and cellular bases of cancer. (nih.gov)
Technologies proposed for development may be intended to have widespread applicability but must be based on molecular and/or cellular characterizations of cancer. (nih.gov)
Her innovations in molecular imaging technology enables the visualization, characterization, and quantification of biologic processes taking place at the cellular and subcellular levels. (stanford.edu)
Aiming to bring the high-throughput imaging to the cellular/molecular level, we develop new biomarkers that scatter coherent photons. (ren-lab.org)
Molecular imaging is a biomedical research discipline that enable the visualization, characterization, and quantification of biologic processes at the cellular and subcellular levels in living subjects. (arizona.edu)
The uses of PET tracers for imaging cellular processes such as metabolism, proliferation, hypoxia, and cell membrane synthesis are explored, and applications for MR techniques such as dynamic contrast material-enhanced imaging, diffusion-weighted imaging, blood oxygenation level-dependent imaging, and MR spectroscopy are reviewed. (rsna.org)

MRI is a medical application of nuclear magnetic resonance (NMR) which can also be used for imaging in other NMR applications, such as NMR spectroscopy. (wikipedia.org)
Using imaging fluorescence correlation spectroscopy and single molecular spectroscopy, we are investigating interfacial behaviors inside nanometer sized pores. (uiowa.edu)
Numerous studies are under way to identify specific imaging markers for different types of dementia, including cerebral volumetric measurements, diffusion imaging, spectroscopy, very-high-field MRI scans of senile plaques, and PET scan markers of senile plaques. (medscape.com)

13 - 15 ] On the other hand, as a newly emerged imaging modality, the optoacoustic (photoacoustic) imaging can overcome these inherent drawbacks of fluorescent imaging. (thno.org)
Nanomaterials can create signal contrast that matches their cognate imaging modality. (news-medical.net)
The most commonly used functional imaging modality for radiotherapy planning is undoubtedly 18 F-FDG PET ( 4 ). (snmjournals.org)
Contrast-enhanced (CE) MRI is known as the standard imaging modality for treatment monitoring due to its high resolution and high sensitivity in breast tissues. (springer.com)
Diffusion-weighted (DW) MRI, a functional imaging modality which reflects Brownian motion of water molecules in biologic tissues, has been extensively explored for the potential to predict therapy outcome for responders. (springer.com)

Ultrasound for molecular imaging and therapy in cancer. (stanford.edu)
Acoustic and photoacoustic molecular imaging of cancer. (stanford.edu)
Mark Pagel, Ph.D., is the professor in Cancer Systems Imaging at The University of Texas MD Anderson Cancer Center. (mdanderson.org)
When it is coupled to Doppler ultrasound with color and power Doppler, it can be used to quantify blood flow and to image microcirculation as well as the response of tumor blood supply to cancer therapy. (hindawi.com)
This award came at the same time as the U.S. Food and Drug Administration (FDA) approved an eIND for Canary Foundation research in the testing of molecular imaging agents for lung cancer. (nanowerk.com)
Sanjiv Sam Gambhir, MD, PhD a professor of Radiology and Bioengineering and head of the Molecular Imaging Program at Stanford and James Brooks, MD, Associate Professor in Urology were awarded the EDRN BDL grant for their project in prostate cancer. (nanowerk.com)
Dr. Brooks is a surgeon who specializes in prostate cancer care and directs a research group focused on biomarker discovery. (nanowerk.com)
The low background signal in the thorax using this imaging agent allows for high tumor-to-background contrast ratio in the lungs, a promising development for molecular imaging of lung cancer. (nanowerk.com)
This Funding Opportunity Announcement (FOA), issued by the National Cancer Institute (NCI), solicits grant applications proposing exploratory research projects focused on the inception and development of early stage, highly innovative, molecular analysis technologies or emerging technologies with significant transformative potential that has not yet been explored in a cancer-relevant use. (nih.gov)
The increasing availability and refinement of imaging technology can help to identify biomarkers that will be able to predict which patients with breast cancer are most likely to respond to bevacizumab. (unav.edu)
Cancer biomarkers are either produced by cancer cells themselves, or by non-cancer cells in response to cancer. (ddw-online.com)
This study was aimed to determine the diagnostic performance of perfusion-related parameters derived from intravoxel incoherent motion diffusion-weighted imaging (IVIM-DWI) by comparing them with quantitative parameters from dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) based on differentiation grades of rectal cancer. (bvsalud.org)
Nevertheless, CVD imaging can be used to identify a high prevalence of diverse populations when an effective imaging target is detected, which is in contrast to cancer that may not have the same level of prevalence. (news-medical.net)
Discrimination of Breast Cancer Based on Ultrasound Images and Convolutional Neural Network. (cdc.gov)
Parameter tuning in machine learning based on radiomics biomarkers of lung cancer. (cdc.gov)
Evaluation and Monitoring of Endometrial Cancer Based on Magnetic Resonance Imaging Features of Deep Learning. (cdc.gov)
Current effort in our group is directed towards spectroscopic imaging for cancer diagnosis and investigation of microscopic details in porous materials. (uiowa.edu)
To be a successful technique for cancer diagnosis, an optical method is required to provide a high contrast between normal/hyperplastic and adenomatous/adenocarcenomatous tissues. (uiowa.edu)

Perfusion imaging has been used to assess tumor grade and prognosis and, recently, to assess treatment response, which has attracted more attention due to the advent of newer therapeutic options, including antiangiogenic agents. (ajnr.org)
The potential of integrated PET/CT perfusion imaging and hybrid PET/MR imaging also is highlighted. (rsna.org)
PET and SPECT Tracers for Myocardial Perfusion Imaging. (nih.gov)

Researchers have shed light on events involved in the Alzheimer's disease "cascade hypothesis" - namely, the timing of biomarker progression that leads to neurodegeneration. (auntminnie.com)
Biomarkers can be used to establish a diagnosis, monitor disease progression, predict complications or disease recurrence, or designate who might benefit most from a specific treatment. (nih.gov)

The Molecular Imaging Program at Stanford developed the imaging agent, which targets an integrin receptor (a molecule on cell surfaces) called alpha v beta 3 (ανβ) integrin. (nanowerk.com)
Nanomaterials have limited molecular targets associated with CVD pathogenesis as compared to normal tissues due to a reduced number of molecular mechanisms that have been implicated in CVD. (news-medical.net)
Imaging plays a critical role in helping define the targets for radiation therapy, especially intensity-modulated radiation therapy, in which the dose gradients are steep. (rsna.org)

Recently, the introduction of ultrasound contrast microbubbles that is targeted to molecular markers expressed on the vasculature is able to image molecular events of disease and could be used for various applications including quantitative analysis of molecular biomarkers, perfusion studies, microvasculature targeting, and gene and drug delivery [ 7 , 11 ]. (hindawi.com)
The aim was to study the performance of the U-SPECT6/CT E-class system for preclinical imaging, to later demonstrate the viability of simultaneous multi-animal and multi-isotope imaging with reliable quantitative accuracy. (unav.edu)
This system provides quantitative images with suitable image quality for multi-mouse and multi-isotope acquisitions. (unav.edu)
This development is critical to enable quantitative biological investigation because scattering reporters, unlike the traditional fluorophors with photo-bleaching limit, exhibit long-lasting contrast that is pivotal for prolonged light exposure in large-scale imaging. (ren-lab.org)
Quantitative DW imaging parameters were computed according to the mono-exponential (apparent diffusion coefficient [ADC]), bi-exponential (pseudodiffusion coefficient and perfusion fraction), and stretched-exponential (distributed diffusion coefficient and intravoxel heterogeneity index) models. (springer.com)

Magnetic resonance imaging (MRI) is a medical imaging technique used in radiology to form pictures of the anatomy and the physiological processes of the body. (wikipedia.org)
Eliot Siegel, MD, discusses the rapidly emerging area of theranostics and the potential for interventional molecular radiology to join diagnostic radiology and interventional radiology as a third radiology pathway for residents and trainees. (auntminnie.com)

Ultrasound biomicroscopy (UBM) is a noninvasive multimodality technique that allows high-resolution imaging in mice. (hindawi.com)
UBM is a noninvasive real-time technique that allows accurate and reliable images of the heart and other organs in mice [ 1 - 3 ]. (hindawi.com)
Noninvasive imaging biomarkers readily assessed with PET/CT or MR imaging provide functional data that are absent from conventional anatomic imaging and that can be used to guide tailored treatment approaches in patients with squamous cell carcinomas of the head and neck. (rsna.org)

While previous studies have shown associations between BBB dysfunction and seizure activity in epilepsy, there is a paucity of investigations exploring the underlying molecular mechanisms that drive microvascular dysfunction in the condition. (tcd.ie)
Although the etiology and pathogenesis of medulloblastoma is not entirely understood at present, some recent molecular genetic studies have provided important insights into possible disease mechanisms. (medscape.com)

Metallic nanomaterials and quantum dots have been used in electrochemical methods to detect cardiac biomarkers such as troponin, CRP, creatine kinase, and myoglobin. (news-medical.net)
For example, there are biomarkers that might detect who is at risk for developing a disease. (nih.gov)

This funding opportunity is part of a broader NCI-sponsored Innovative Molecular Analysis Technologies (IMAT) Program. (nih.gov)

Cardiac MRI is complementary to other imaging techniques, such as echocardiography , cardiac CT and nuclear medicine . (alchetron.com)
The European nuclear medicine community could see increased demand for PET imaging if the monoclonal antibody lecanemab receives approval for the treatment of Alzheimer's disease, according to the European Association for Nuclear Medicine (EANM). (auntminnie.com)
The article was published online March 4 in the European Journal of Nuclear Medicine and Molecular Imaging . (auntminnie.com)

The microbubbles, small gas-filled spheres (coated with antibodies) that are injected into the bloodstream and only adhere to biomarkers found in tumor blood vessels, but not in healthy blood vessels, will image the tumor. (nanowerk.com)

The Contrast Agent Molecular Engineering Laboratory (CAMEL) has developed molecular imaging methods that evaluate biomarkers of the tumor microenvironment. (mdanderson.org)

Bennett is a biophysicist and engineer by training but has a broad interest in structural, functional and molecular imaging, and in physiology. (wustl.edu)

Ultrasound molecular imaging with targeted microbubble contrast agents. (stanford.edu)

Molecular biomarkers were assessed using microarray analysis. (unav.edu)

Exogenous contrast agents may be given to the person to make the image clearer. (wikipedia.org)
The availability of real-time imaging of mice anatomy allows performing aspiration procedures under ultrasound guidance as well as the microinjection of cells, viruses, or other agents into precise locations. (hindawi.com)
38 - 43 ] Multispectral optoacoustic tomography (MSOT) is an optoacoustic imaging technique which can distinguish ultrasound signals generated by different agents. (thno.org)
Spherical core@shell (multi-Fe3O4@C) magnetic beads (MBs) (DMB~100 nm) composed of several single cores of magnetite nanoparticles (Dsingle-core~15 nm) surrounded by a wide carbon shell (δ~20 nm), have been used as cell labelling nanoprobes and efficient MRI contrast agents. (nanomag.es)

To rapidly collect the vast amount of biological information from intact systems, a pressing need for large-scale studies, we set our sights on the next leap forward in imaging throughput. (ren-lab.org)
In conclusion, molecular imaging of drug resistance is suitable and may provide biological information that can improve the efficacy of individual-tailored therapeutic strategies. (cnr.it)
After the fundamentals of photon transport in biological tissues are established, various optical imaging techniques for biological tissues are covered. (lu.se)

However, there are no validated methods for predicting which patients will respond to bevacizumab, although some have investigated whether a response can be predicted by using scanning (imaging) techniques that study tumour blood vessels or by using the levels of VEGF markers before treatment. (unav.edu)
In this study, we used a combination of imaging techniques and VEGF marker levels to show that bevacizumab caused structural and functional changes in the blood vessels of breast tumours and substantially slowed tumour growth. (unav.edu)
Ideally, a clinician could identify a tumour biomarker from a simple blood test. (ddw-online.com)

While MRI is most prominently used in diagnostic medicine and biomedical research, it also may be used to form images of non-living objects, such as mummies. (wikipedia.org)
Changes in exosomal miRNAs have been reported in patients diagnosed with Alzheimer's disease (AD), and miRNAs have been shown to provide diagnostic biomarkers [ 26 ]. (biomedcentral.com)

Quantify relative perfusion and study biomarker expression with ease. (visualsonics.com)

Diffusion MRI and functional MRI extend the utility of MRI to capture neuronal tracts and blood flow respectively in the nervous system, in addition to detailed spatial images. (wikipedia.org)
This article discusses the practical aspects of integrating functional imaging into head-and-neck radiation therapy planning and reviews the potential of molecular imaging biomarkers for response assessment and therapy adaptation. (rsna.org)
The purpose of this work was to evaluate the potential of functional imaging with 18 F-FDG PET, 18 F-fluoromisonidazole PET, diffusion-weighted MRI, and dynamic contrast-enhanced MRI to provide an appropriate and reliable biologic target for dose painting in radiotherapy for head and neck squamous cell carcinoma (HNSCC). (snmjournals.org)
Mostajeran M, Wetterling F, W Blixt F, Edvinsson L, Ansar S. Acute mitogen-activated protein kinase 1/2 inhibition improves functional recovery and vascular changes after ischaemic stroke in rat-monitored by 9.4 T magnetic resonance imaging. (lu.se)

In contrast, normoxic tissues will not have the activated form of prodrug providing a "therapeutic window" for radiosensitization. (utsouthwestern.edu)

This paper will describe some basic principles of high-resolution imaging equipment, and the most important applications in molecular and preclinical imaging in small animal research. (hindawi.com)

Dr. Zhou has made substantial contributions to the growing biomedical research field of Molecular Imaging. (stanford.edu)

Additional molecular subgroups within these major groups are anticipated (please see Molecular/Genetics ). (medscape.com)
[ 2 ] (See Molecular/Genetics . (medscape.com)

Microbubbles are visualized and quantified using Non-linear Contrast Mode. (visualsonics.com)
Within this imaging mode, the nonlinear response of the microbubbles to the ultrasound pulses is utilized. (visualsonics.com)

The contrast provided between grey and white matter makes it the best choice for many conditions of the central nervous system , including demyelinating diseases , dementia , cerebrovascular disease , infectious diseases and epilepsy . (alchetron.com)
16 , 17 , 25 , 44 - 46 ] More importantly, via rendering stacks of cross-sectional (tomographic) images as the maximum intensity projection images, the orthogonal-view three-dimensional (3D) MSOT images can be obtained, which enable us to precisely locate the disease focus through detecting biomarkers. (thno.org)
Changes of miRNAs in exosome have been reported in different disease diagnosis and provided as potential biomarkers. (biomedcentral.com)
Coronal, T1-weighted magnetic resonance imaging (MRI) scan in a patient with moderate Alzheimer disease. (medscape.com)
By contrast, public health, which is what we do collectively as a society to improve population health, focuses on populations as the units of intervention, with a focus on promoting health and disease control and prevention. (cdc.gov)

NR-NH 2 shows a strong absorption band at around 680 nm and a strong fluorescence band at 710 nm, allowing for both multispectral optoacoustic tomography imaging (MSOT) and fluorescent imaging of tumor hypoxia in a tumor-bearing mouse model. (thno.org)

In the field of brain imaging in epilepsy, a wide spectrum of abnormalities have been described in patients who have undergone MRI in the peri-ictal seizure period. (tcd.ie)
Patients with treatment resistant temporal lobe epilepsy were recruited for pre- and post-surgical dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI). (tcd.ie)

The performance of the SPECT was evaluated for two collimators dedicated for mouse (UHS-M) and rat imaging (UHR-RM) in terms of sensitivity, energy resolution, uniformity and spatial resolution. (unav.edu)

Through techniques such as full-space reconstruction, image enhancement, and topological abstract, we offer new perspectives and the most biologically essential information for large-scale investigations. (ren-lab.org)

dubious - discuss] In most medical applications, hydrogen nuclei, which consist solely of a proton, that are in tissues create a signal that is processed to form an image of the body in terms of the density of those nuclei in a specific region. (wikipedia.org)
16 , 17 , 25 , 44 - 46 ] As a result, a specific photoabsorber can be separately visualized in MSOT images. (thno.org)
Specific biomarkers can also measure response to a treatment. (nih.gov)

He develops cutting-edge and clinically viable imaging technologies to improve the diagnosis and treatment of cerebrovascular diseases across the lifespan. (stanford.edu)
Radiomics relates imaging features to molecular characteristics in order to contribute to diagnosis, prognosis, and treatment decisions. (springer.com)
Practice parameters for diagnosis and evaluation of dementia, as published by the American Academy of Neurology (AAN), consider structural brain imaging to be optimal. (medscape.com)

In mice, simultaneous multi-isotope imaging provided the separate distribution of 3 tracers and image quality of the multi-mouse bone scan was adequate. (unav.edu)

The Future of Cardiac Molecular Imaging. (nih.gov)

MRI was originally called NMRI (nuclear magnetic resonance imaging), but "nuclear" was dropped to avoid negative associations. (wikipedia.org)
Pre- and post-bevacizumab vascular changes were evaluated using dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI). (unav.edu)
negligible heating by magnetic hyperthermia (MH) procedure and an enhanced Magnetic Resonance Imaging (MRI) response. (nanomag.es)
On magnetic resonance imaging (MRI) scans, chordomas show a signal heterogeneity, possibly due to a variety of components, including fluid and gelatinous mucoid substance (associated with recent and old hemorrhage) and necrotic areas within the tumor (see the following images). (medscape.com)
A $600,000 grant from the National Institutes of Health (NIH), with matching funding from Georgia State University, will bring a 7 Tesla (7T) magnetic resonance imaging (MRI) machine to Georgia State. (gsu.edu)
Axial, T2-weighted magnetic resonance imaging (MRI) scan reveals atrophic changes within bilateral temporal lobes with prominence of the sylvian fissures. (medscape.com)
Magnetic resonance imaging (MRI) typically reveals a solid fourth ventricular mass that is hypointense on the T1-weighted image, hyperintense on T2-weighted images, and brightly enhancing on T1-weighted images after contrast administration (see the images below). (medscape.com)

CAMEL develops molecular imaging methods that evaluate biomarkers of the tumor microenvironment, including extracellular acidosis, hypoxia, enzyme activity, and vascular perfusion. (mdanderson.org)
Accurately detecting and imaging tumor hypoxia with high spatial resolution would be conducive to formulating optimized treatment plan and thus achieving better patient outcome. (thno.org)
Liposome encapsulated with the activatable chromophore (NR-azo) for detecting/imaging tumor hypoxia and for tumor inhibition was demonstrated. (thno.org)
optoacoustic, imaging, hypoxia. (thno.org)

We have also developed and patented analysis methods that improve the evaluation of vascular perfusion using MRI and MSOT imaging methods, which can assess the potential of drug delivery to a solid tumor. (mdanderson.org)

To fully harness these massive imaging volumes, we develop approaches that use photons efficiently to boost imaging throughput, such as depth of focus (DOF) extension and full-space scattering potential reconstruction. (ren-lab.org)

The Group is already planning to integrate their line of research with molecular diagnostics already being studied within the context of pre-neoplastic lesions. (nanowerk.com)

Finally, Dr. Pagel supports the molecular imaging research community by organizing meetings and conferences, reviewing grant applications and manuscripts, and facilitating academia-industry relationships. (mdanderson.org)
Prior to this, most research within EDRN was focused on identifying and validating blood biomarkers, not investigating molecular imaging techniques. (nanowerk.com)
Interesting research perspectives are opened for both techniques, including multivoxel MRS and statistical strategies for classification of MR spectra as well as diffusion tensor imaging and intravoxel incoherent motion for DWI. (univr.it)

Tumor size and relative enhancement ratio of the tumor were measured on contrast-enhanced MRI at each time point. (springer.com)
This axial T2 magnetic resonance image shows a cerebellar vermian midline mass with contrast enhancement and obstruction of the fourth ventricle. (medscape.com)

Anatomy14

Diseases26

Chemicals and Drugs88

Analytical, Diagnostic and Therapeutic Techniques and Equipment81

Psychiatry and Psychology4

Phenomena and Processes30

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