• microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. (cancerindex.org)
  • miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. (cancerindex.org)
  • miRNAs are themselves matured from their long RNA precursors by ribonucleic proteins as part of a 2 step biogenesis mechanism involving RNA polymerase 2. (wikipedia.org)
  • The purpose of having a variety of miRNAs in a single piece of RNA processing machinery is to act as complementary strands to the recognition elements of a variety of target RNA molecules. (wikipedia.org)
  • miRNAs show potential as biomarkers and can even be found circulating in the serum. (wikipedia.org)
  • MicroRNAs (miRNAs) are small noncoding endogenous RNAs containing 19 to 25 nucleotides that promote posttranscriptional control in regulating the expression of target gene by binding to the 3′-UTR sequences of its mRNA [ 5 ]. (hindawi.com)
  • Most reports found that multiple miRNAs that include miR-548a, miR-1246, miR-632, and miR-5692a played pivotal roles in HCC [ 7 - 10 ]. (hindawi.com)
  • MicroRNAs (miRNAs) are single-stranded, endogenously expressed, short, noncoding RNAs with a length of 18-25 nucleotides. (nature.com)
  • Utilizing microRNAs (miRNAs) as a potential biomarker to differentiate BRCA will allow for specialized treatment regimens and increased clinical care. (biogenex.com)
  • miRNAs are small, evolutionarily conserved, noncoding RNAs that negatively regulate gene expression and have fundamental roles in cancer growth and metastasis. (biogenex.com)
  • Owing to their stability in biological fluids and resistance to various storage conditions, miRNAs are considered as useful biomarkers for cancer diagnosis, prognosis, and prediction of treatment efficacy. (biogenex.com)
  • Recent studies have tested miRNAs as predictive biomarkers for determining BRCA mutated patient's prognosis. (biogenex.com)
  • MicroRNAs (miRNAs) are an abundant class of small single-stranded non-coding RNA molecules ranging from 18 to 24 nucleotides. (pasteur.fr)
  • In addition, miRNAs involvement in osteoarticular diseases has been proved and some of them were identified as suitable biomarkers for pathological conditions. (pasteur.fr)
  • Non-coding RNAs (ncRNAs), mainly including microRNAs (miRNAs), long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs), can function as important regulators in gene expression. (biomedcentral.com)
  • MicroRNAs (miRNAs) are important non-coding, single-stranded RNAs possessing cru-cial regulating roles in human body. (nottingham.edu.cn)
  • Furthermore, the exceptional stability of miRNAs has presented them as biomarker with high specificity and sensitivity. (nottingham.edu.cn)
  • MicroRNAs (miRNAs) serve a role in gene expression, primarily by interacting with messenger RNAs, and may be potential biomarkers for detecting cancer. (spandidos-publications.com)
  • Further analysis of the expression of these circulating miRNAs and their association with prognosis in patients with TNBC treated with immunotherapy should be assessed to evaluate their possible use as non‑invasive predictive biomarkers. (spandidos-publications.com)
  • Micro-RNAs (miRNAs) are small RNA molecules that regulate the downstream genes [ 4 ]. (biomedres.info)
  • Previous studies demonstrated that aberrant miRNAs levels may be introduced as new biomarkers for early diagnosis and prognosis in bladder cancer [ 8 ]. (biomedres.info)
  • It has been suggested that abnormal expression of microRNAs (miRNAs) is associated with carcinogenesis. (spandidos-publications.com)
  • Mature microRNAs (miRNAs) are a class of small, well-conserved, non-coding RNA molecules that silence gene expression usually by interfering with mRNA stability or protein translation ( 6 , 7 ). (spandidos-publications.com)
  • Up to 30% of human protein-coding genes may be regulated by miRNAs ( 8 , 9 ). (spandidos-publications.com)
  • miRNAs are involved in biological and pathological processes including cell differentiation, proliferation, apoptosis and metabolism, and they are emerging as highly tissue-specific biomarkers with potential clinical application for defining cancer types and origins. (spandidos-publications.com)
  • Taking into account the important regulatory roles that miRNAs have in cancer development, by acting either as oncogenes or as tumor-suppressor genes, they represent potential biomarkers in ovarian cancer [ 5 ]. (biomedcentral.com)
  • MicroRNAs (miRNAs) are a kind of small noncoding RNAs that regulate the expression of protein through targeting the 3′UTR of messenger RNA (mRNA), resulting in mRNA degradation or suppression of translation [ 5 ]. (degruyter.com)
  • MicroRNAs (miRNAs) are non-coding small RNAs that regulate gene expression and that are frequently dysregulated in tumorigenesis. (biomedcentral.com)
  • MicroRNAs (miRNAs) are involved in the prognosis of nasopharyngeal carcinoma (NPC). (biomedcentral.com)
  • We identified 160 differentially expressed miRNAs using RNA-Seq data from the GEO database. (biomedcentral.com)
  • MicroRNAs (miRNAs) are a class of short, endogenous primed non-coding RNAs (18-25 nucleotides) that regulate gene expression through pairing with 3′-untranslated region (3′-UTR) bases to mediate translation inhibition or degradation of homologous mRNAs [ 7 ]. (biomedcentral.com)
  • It is confirmed that large variety of miRNAs in exosomes play important roles in tumor metastasis and invasion. (dovepress.com)
  • Thus, it would be of interest to identify molecular biomarkers which indicate predisposition to the development of HD, and as microRNAs (miRNAs) circulate in bio-fluids they would be particularly useful biomarkers. (fortuneonline.org)
  • MicroRNAs (miRNAs), short non-coding RNA molecules that play a key role in post-transcriptional gene regulation, have been found to be associated with different hallmarks of MM. Previous studies have indicated that abnormally functioning miRNA-mediated gene regulation followed by oncogene activation and tumor suppressor gene silencing results in drastic alterations in cell proliferation, apoptosis, growth, and metabolism. (helsinki.fi)
  • These changes in cellular functions have been indicated to be associated with the pathogenesis, progression, and formation of drug resistance in MM. Therefore, the role and potential of miRNAs to act as biomarkers to predict MM progression and drug sensitivity should be further investigated to ultimately improve the survival rates of patients. (helsinki.fi)
  • In addition, the specific gene targets of miRNAs involved in the regulation of drug responses and MM progression were predicted by identifying statistically significant, negatively correlated interactions between the miRNA and RNA sequencing data of 45 MM patients in pairwise comparative correlation analysis. (helsinki.fi)
  • In addition, the RT-qPCR validation demonstrated that the disease progression and drug sensitivity associated mir-92b, mir-363 and mir-221, would potentially regulate the expression of FGF2, MFF, and TMEM248, respectively, providing novel insights into the functional roles of miRNAs in MM pathways. (helsinki.fi)
  • Approximately 30-60 % of the human genome, regulated by miRNAs. (ukessays.com)
  • the micrornas (mirnas or mirs), a type of small non-coding rna , have emerged as molecular regulators that can have key roles as tumor suppressors or oncogenes in pathogenesis and progression of different malignancies, including breast cancer. (icbcongress.com)
  • Emerging evidence indicates that Long non-coding RNAs (LncRNAs) and microRNAs (miRNAs) play crucial roles in tumor progression, including hepatocellular carcinoma (HCC). (biomedcentral.com)
  • A series of studies indicate that lncRNAs serve as competing endogenous RNAs (ceRNA) by sponging miRNAs, and modulate the targets of miRNAs [ 15 , 16 ]. (biomedcentral.com)
  • In the search for molecular biomarkers that could reveal pre-clinical phases of the disease, scientists have focused much of their attention on microRNAs (miRNAs), the best characterised family of small non-coding RNAs. (biomedcentral.com)
  • MicroRNAs (miRNAs) are small RNA molecules that regulate gene expression at a post-transcriptional level. (microbiologyresearch.org)
  • miRNA-based diagnostic biomarkers for toxocariasis are emerging, but there is limited information about the role of many miRNAs and a more detailed diagnostic evaluation of miRNA expression patterns is needed to understand their immunobiological function. (microbiologyresearch.org)
  • Our study revealed that miRNAs 21 and 103a might play fundamental roles as biomarkers and diagnostic tools for toxocariasis. (microbiologyresearch.org)
  • However, the changes in expression of these miRNAs were not adequate to be used as biomarkers in diagnosis. (microbiologyresearch.org)
  • CircRNAs exert their biological effects by 4 different mechanisms: serving as sponges of microRNAs (miRNAs), serving as sponges of RNA binding proteins (RBPs), modulating parental gene transcription, and encoding functional proteins. (techscience.com)
  • In addition, we also discovered some differentially regulated miRNAs in follicular variant of papillary thyroid carcinoma as compared to follicular thyroid carcinoma (miR-486-5p and miR-31). (openaccesspub.org)
  • Micro-RNAs (miRNAs) are small non-coding RNAs of approximately 21-25 nucleotides that negatively regulate gene expression 1 , 2 , 3 . (openaccesspub.org)
  • DEFB1 expression after transfection with two micro RNAs (miRNAs), hsa-miR-186-5p and hsa-miR-340-5p, provided evidence that DEFB1 expression could be modulated by these miRNAs and hsa-miR-186-5p had a higher binding efficiency with DEFB1. (cdc.gov)
  • Simple Summary: This study identified a set of 73 microRNAs (miRNAs) that can accurately detect lung cancer tumors from normal lung tissues. (cdc.gov)
  • This study identified a set of 73 microRNAs (miRNAs) that classified lung cancer tumors from normal lung tissues with an overall accuracy of 96.3% in the training patient cohort (n = 109) and 91.7% in unsupervised classification and 92.3% in supervised classification in the validation set (n = 375). (cdc.gov)
  • Experimentally confirmed target genes were identified for the 73 diagnostic miRNAs, from which proliferation genes were selected from CRISPR-Cas9/RNA interference (RNAi) screening assays. (cdc.gov)
  • They negatively regulate gene expression at the post-transcriptional level and play key roles in many biological processes, including skeletal development and cartilage maturation. (pasteur.fr)
  • Many ncRNAs have critical roles in tumorigenesis, and some ncRNAs function as competing endogenous RNAs (ceRNAs) to perturb gene expression. (biomedcentral.com)
  • MicroRNA (miRNA) is a short and endogenous RNA molecule that regulates posttranscriptional gene expression. (edu.hk)
  • MicroRNAs are small noncoding RNAs that function to control gene expression. (biomedcentral.com)
  • Gene expression changes indicate that HTT has roles as a transcriptomic regulator. (fortuneonline.org)
  • Evolutionarily conserved, these 17-22 nucleotide long molecules regulate gene expression at post-transcriptional level generally by repressing translation or increasing degradation of messenger RNAs (mRNAs). (biomedcentral.com)
  • MicroRNA (miR) is a small, non-coding RNA that negatively regulates gene expression mainly via translational repression. (biomedcentral.com)
  • MicroRNAs (miRs) are small, non-coding RNAs that negatively regulate gene expression via translational repression or messenger RNA degradation. (biomedcentral.com)
  • MicroRNA (miRNA) is a kind of small non-coding RNAs with the function of modulating gene expression, which is involved in diverse pathological processes, e.g., cancers (Acunzo et al. (springeropen.com)
  • How Reliable Are Gene Expression-Based and Immunohistochemical Biomarkers Assessed on a Core-Needle Biopsy? (lu.se)
  • MicroRNAs are endogenous triggers of the RNAi pathway which involves several ribonucleic proteins (RNPs) dedicated to repressing mRNA molecules via translation inhibition and/or induction of mRNA cleavage. (wikipedia.org)
  • We established that endogenous ZAPL and ZAPS localize to membrane compartments and cytosol, respectively, and that the differential localization correlates with their target-RNA specificity. (bvsalud.org)
  • Mechanistically, PTTG3P upregulated the expression of miR-383 targets Cyclin D1 (CCND1) and poly ADP-ribose polymerase 2 (PARP2) by sponging miR-383, acting as a competing endogenous RNA (ceRNA). (biomedcentral.com)
  • Recent studies indicate that long noncoding RNAs (lncRNAs) can act as competing endogenous RNAs (ceRNAs) to indirectly regulate mRNAs through shared microRNAs, which represents a novel layer of RNA crosstalk and plays critical roles in the development of tumor. (lncrnablog.com)
  • Identifying genomic biomarkers for breast cancer prognosis will lead to a better understanding of breast cancer genetics and a more accurate understanding of tumor behavior. (biogenex.com)
  • To achieve such a goal, it is very highly important to explore the biological and molecular mechanism of NPC and identify biomarkers related to the stratification of prognosis risk. (biomedcentral.com)
  • It is an important factor for tumorigenesis of colorectal cancer (CRC), and a potential biomarker for diagnosis, prognosis, and therapy of CRC. (edu.hk)
  • Thus, it is urgent to understand the molecular mechanism of HCC tumorigenesis to explore novel biomarkers for HCC prognosis, which will promote the development of therapeutic strategy for HCC patients. (biomedcentral.com)
  • 2021 ). Recent researches implied the crucial roles of miRNA in regulating the proliferation and differentiation of osteosarcoma cells and hold the view that miRNA could be potentially applied for the diagnosis, prognosis and treatment of osteosarcoma (Sekar et al. (springeropen.com)
  • This Special Issue of "Genes" seeks reviews and original papers covering a wide range of topics related to microRNA biology, such as regulation of expression in various disorders (cancer, metabolism, autoimmunity to mention but a few), genetics of microRNAs and their target sites, functional analysis of microRNA function and studies of interactions between microRNAs and target genes. (mdpi.com)
  • Herein, to provide better understanding of the molecular events in GBC pathogenesis, we developed GBCdb ( http://tmliang.cn/gbc/ ), a user-friendly interface for the query and browsing of GBC-associated genes and RNA interaction networks using published multi-omics data, which also included experimentally supported data from different molecular levels. (biomedcentral.com)
  • The top up- and down-regulated genes were shown by the heatmap and volcano plot (Figure 1). (researchsquare.com)
  • Identification of miRNA-regulated targeting genes is important for understanding their specific biological functions [ 11 ]. (degruyter.com)
  • We performed Kyoto Encyclopedia of Genes and Genomes (KEGG) and hub target genes analysis to illuminate potential biomarkers and related pathways in arecoline-induced cancer. (biomedcentral.com)
  • To decipher the potential roles of lncRNAs during infection, we identified 365 protein-coding genes that were associated with 214 ISELs. (biomedcentral.com)
  • Analysis of the predicted functions of these associated genes suggested that lncRNAs regulate pathogenesis-related genes, including xylanases and effectors. (biomedcentral.com)
  • LncRNAs can also be classified as cis-acting lncRNAs, which regulate target genes at adjacent regions, and trans-acting lncRNAs, which function at independent chromosomal loci [ 8 ]. (biomedcentral.com)
  • It is one of the largest gene families accounting for approximately 1% of the genome and regulate approximately 1/3rd of all human genes 4 , 5 , 6 . (openaccesspub.org)
  • while analyzing the cancer specific ceRNA interactions reveal that lncRNAs synergistically regulated tumor driver genes of cancer hallmarks. (lncrnablog.com)
  • The non-specific lethal complex regulates genes and pathways genetically linked to Parkinson's disease. (medscape.com)
  • The miR-92 microRNAs are short single stranded non-protein coding RNA fragments initially discovered incorporated into an RNP complex with a proposed role of processing RNA molecules and further RNP assembly. (wikipedia.org)
  • In this study, we aim to identify the key molecules and signaling pathways by analyzing the RNA-seq data. (researchsquare.com)
  • The ceRNA related molecules have more conserved features in tumor networks and they play critical roles in both the normal and tumorigenesis processes. (lncrnablog.com)
  • They play crucial roles as molecular cargoes to provide gene regulating microRNAs and key proteins between cells and therefore, they have develop into a molecule of interest to numerous researchers as a circulating diagnostic and prognostic biomarker. (lrrk2inhibitor.com)
  • These studies have also addressed the various diagnostic and prognostic implications of micro-RNAs in thyroid carcinomas. (openaccesspub.org)
  • Current Long noncoding RNAs (lncRNAs) LINC00958 showed some benefit to this cancer, but the mechanism is unknown. (researchsquare.com)
  • Long noncoding RNAs (lncRNAs) regulate a number of physiological and pathological processes, including gene transcription and translation, chromatin modification, cell cycle progression, cell proliferation, and oncogenic and tumor-suppressive signals in cancer 6 . (researchsquare.com)
  • Long non-coding RNAs (lncRNAs) play essential roles in developmental processes and disease development at the transcriptional and post-transcriptional levels across diverse taxa. (biomedcentral.com)
  • Non-coding RNAs longer than 200 nucleotides are considered long non-coding RNAs (lncRNAs), in contrast to small non-coding RNAs, such as microRNAs and small interfering RNAs [ 4 , 5 ]. (biomedcentral.com)
  • Pseudogene, a subclass of long non-coding RNAs (lncRNAs), are considered as genomic loci that resemble real gene, but lost some functionality because they are lack of protein-coding ability because of disabling mutation, lack of transcription, or their inability to encode RNA [ 3 ]. (biomedcentral.com)
  • While long noncoding RNAs (lncRNAs) are important i. (researchgate.net)
  • While long noncoding RNAs (lncRNAs) are important in cardiac development and disease, their role in physiol. (researchgate.net)
  • Long noncoding-RNAs (lncRNAs) are critical regulators of cardiac development as well as pathological hypertrophy and heart failure (HF). (researchgate.net)
  • Here, we used RNAseq to identify a novel class of cardiac lncRNAs that are dynamically regulated by exercise. (researchgate.net)
  • Besides, lncRNAs in the pan-cancer ceRNA network may be potential biomarkers of tumor. (lncrnablog.com)
  • The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. (cancerindex.org)
  • Gene mutations and aberrant signaling pathways play key roles in GBC tumorigenesis. (biomedcentral.com)
  • The results support significant roles for miR-126 in regulating cardiac myocyte survival pathways and cell death during exposure to simulated ischemia and acidosis. (biomedres.us)
  • Importance Mortality is high among patients heart failure (HF) who are receiving treatment, and therefore identifying new pathways rooted in preclinical cardiac remodeling phenotypes may afford novel biomarkers and therapeutic avenues. (researchgate.net)
  • In addition, Ingenuity Pathway Analysis (IPA) integrated with PCR array data showed that the JAK1/STAT3 pathway was significantly altered in cells overexpressing DEFB1, suggesting this to be one of the pathways by which defensin regulates IAV replication in HBEpCs. (cdc.gov)
  • Transforming growth factor-β (TGF-β) signaling pathway is a multifunctional cytokine and plays important roles in regulating cell proliferation, cell cycle, differentiation, migration, and apoptosis in a broad spectrum of tissues [ 12 ]. (degruyter.com)
  • TRIM13 inhibited cell proliferation and induced cell apoptosis by regulating NF-κB pathway in non-small-cell lung carcinoma cells. (cancerindex.org)
  • These small RNAs have been shown to contribute to the control of cell growth, differentiation and apoptosis, important features related to cancer development and progression. (biomedcentral.com)
  • Here we investigated roles for miR-126 in stress kinase activation, induction of inflammatory cytokines and apoptosis caused by exposure of cultured cardiac myocytes to hypoxia/acidosis or acidosis alone. (biomedres.us)
  • Obligatory roles for acidosis in promoting apoptosis confirmed our previous reports that hypoxia alone does not confer a lethal signal. (biomedres.us)
  • Proton pumps and pH regulation are known to play important roles in apoptosis signaling [15,16]. (biomedres.us)
  • Micro-RNAs have been demonstrated to have multiple roles in regulating embryonic development, proliferation, apoptosis, etc. (openaccesspub.org)
  • Regarding the important role of microRNAs in breast cancer, investigating the molecular mechanisms of miRs and their impacts on breast cancer progression is critical. (nature.com)
  • The oncogenic roles of miR-126 have been well validated in bladder cancer, which could promote tumor growth and progression both in vitro and in vivo experiments [ 6 , 7 ]. (biomedres.info)
  • In addition, microRNAs have been associated with cancer progression. (biomedcentral.com)
  • 2 , 3 Tumor cell-derived exosomes carry particular molecular components originated from donor cells to mediate tumorigenesis and drive tumor progression by regulating tumor microenvironment. (dovepress.com)
  • The aim of our study was to evaluate if there is differential microRNA (miRNA) expression in various tumor subtypes during this progression. (openaccesspub.org)
  • The lncRNA TMPO-AS1 promotes cell proliferation, migration, invasion and epithelial-to-mesenchymal transition by regulating the miR-1179/E2F2 axis [ 13 ]. (biomedcentral.com)
  • MicroRNAs control the levels of numerous cell cycle regulators that controls cell proliferation. (ukessays.com)
  • MicroRNAs are a group of small noncoding functional RNAs that are approximately 22 nucleotides in length [ 1 ]. (biomedcentral.com)
  • Most recently, the advent of next generation sequencing technologies allows for the measurement of the absolute abundance as well as the discovery of novel microRNAs. (biomedcentral.com)
  • 2University of California, Riverside, CA, USAIntroduction: The exosome-derived analytes which includes RNA, DNA, proteins, metabolites and lipids might mirror the altered state on the cell of origin. (lrrk2inhibitor.com)
  • Exosomes have gradually become the focus of research, exosomes are rich in nucleic acids and proteins, including a large amount of microRNAs. (imrpress.com)
  • Network dynamic analysis highlights the critical roles of ceRNA regulation in tumorigenesis. (lncrnablog.com)
  • Therefore, this article reviews the role of microRNAs from different cells or tissue sources in the occurrence and development of PH. (imrpress.com)
  • When applied to obesity prevention and management, each omics type could potentially help to detect specific biomarkers in people with risk profiles and guide healthcare professionals and decision makers in developing individualized treatment plans according to the needs of the individual before the onset of obesity. (springermedizin.at)
  • however, these goals are difficult to achieve because of the lack of sensitive and specific biomarkers for early detection and disease monitoring. (icbcongress.com)
  • Because they have identical sequences in their mature form it is not always possible to establish which is prominent in a sample simply by sequencing the small RNA content. (wikipedia.org)
  • Synovial fluid represents a potential source of disease-specific small non-coding RNAs (sncRNAs) that could aid in the understanding of the pathogenesis of osteoarthritis. (biomedcentral.com)
  • Small RNA sequencing was performed using synovial fluid from the metacarpophalangeal joints of both control and early osteoarthritic horses. (biomedcentral.com)
  • Extracellular small non-coding RNAs (exRNAs) have been associated with cardiac inflammation and fibrosis and we hypothesized that they are associated with post-MI LVRm phenotypes. (researchgate.net)
  • LncRNA RZE1 regulates zinc finger transcription factor ZNF2 and affects the yeast-to-hypha transition in the human pathogenic fungus Cryptococcus neoformans [ 22 ]. (biomedcentral.com)
  • Luciferase reporter assay and RNA pull-down assay were carried out to detect the interaction between miR-383 and LncRNA PTTG3P. (biomedcentral.com)
  • High risk of metastasis and recurrence of NPC will increase the complexity of and difficulty of treatment, and currently there is an urgent need to improve the treatment effect with effective biomarkers and treatment strategies. (biomedcentral.com)
  • 1999 ). Therefore, it is of great significance to develop reliable and effective biomarkers for early diagnosis of osteosarcoma, and providing valuable information for the long-term postoperative management. (springeropen.com)
  • Synovial fluid sncRNAs may be used as molecular biomarkers for early disease in equine osteoarthritic joints. (biomedcentral.com)
  • Human ZAP inhibits many viruses, including HIV and coronaviruses, by binding to viral RNAs to promote their degradation and/or translation suppression. (bvsalud.org)
  • Thus, it is necessary to investigate the biomarkers for the treatment and the pathogenesis of HCC. (hindawi.com)
  • We hypothesised that early stages of osteoarthritis would alter the expression of sncRNAs, facilitating the understanding of the underlying pathogenesis and potentially provide early biomarkers. (biomedcentral.com)
  • The biological processes they regulate may play an important role in understanding early osteoarthritis pathogenesis. (biomedcentral.com)
  • This review summarizes the physiological and pathological roles of alpha-synuclein and its implication in Parkinson's disease pathogenesis. (medscape.com)
  • Exosomes contain different functional bimolecular characteristics related to physiological or pathological processes and are now recognized as new biomarkers in different human cancers. (mdpi.com)
  • A promising approach is measuring the presence of biomarkers to detect tumors at various stages and determine their specific characteristics, thus allowing for more personalized treatment. (spandidos-publications.com)
  • The data revealed that the expression of mir-494 was up-regulated in breast cancer tumors compared with normal breast tissues thus identified as onco- mirna in human breast cancer. (icbcongress.com)
  • miR-494 and miR-125a-5p were found to be differentially regulated in tumors with an anaplastic component and even the well-differentiated component (FTC) of these tumors were found to be aligned with the anaplastic profile. (openaccesspub.org)
  • Recently, Nikiforva et al showed that miR-187 was the most up-regulated miRNA in tumors harboring RET/PTC rearrangements and RAS mutations, however it's expression is much lower in tumors with BRAF mutation 10 . (openaccesspub.org)
  • BC-related differentially expressed microRNAs (DE-miRs) were recognized and assessed in the present study. (nature.com)
  • Bioinformatic analysis was performed in order to identify putative targets of the differentially expressed microRNAs and to explore potential associations with specific biological processes. (biomedcentral.com)
  • Our results have laid down a solid foundation in exploration of novel CRC mechanisms, and identification of miRNA roles as oncomirs or tumor suppressor mirs in CRC. (edu.hk)
  • RAB18 was upregulated in HCC tissues and cell lines, and the expression of RAB18 was regulated by miR-455. (hindawi.com)
  • All the fresh tissues were snap-frozen in liquid nitrogen and stored at −80°C until RNA extraction. (hindawi.com)
  • It has been proven that the miR-183 expression is up-regulated in tumor tissues and patient serum in BC, which indicates its possibly an oncogenic role 15 , 16 . (nature.com)
  • in the present study total rna of breast cancer tissues was extracted with trizol solution referring to manufacture's protocols. (icbcongress.com)
  • In this study, we found that PTTG3P was up-regulated in HCC tissues and cells. (biomedcentral.com)
  • Therefore, early diagnosis of GBC is essential, and the identification of specific and sensitive biomarkers is critical to improve patient outcome. (biomedcentral.com)
  • In this study, we examined the feasibility and efficacy of urine miR-126 detection in the diagnosis of bladder cancer, which could help identify a new diagnostic biomarker for such deadly disease. (biomedres.info)
  • Sensitive quantification of microRNA (miRNA) plays a crucial role in early diagnosis and precise therapy of osteosarcoma. (springeropen.com)
  • 2014 ). The lack of reliable biomarkers for the early diagnosis of osteosarcoma leads to a high distant metastasis rate (approximate 80%) and low 5-year survival rate of 10-20% (Kaste et al. (springeropen.com)
  • As compared with wild type breast cancer, expression of miR-17 and miR-21 was downregulated in BRCA mutated breast cancer, suggesting that the miRNA expression pattern may serve as a potential biomarker in predicting BRCA mutation status in invasive breast cancer. (biogenex.com)
  • GBCdb will help to elucidate the potential biological roles of different RNAs and allow for the exploration of RNA interactions in GBC. (biomedcentral.com)
  • Moreover, the potential application of microRNAs in clinical settings will also be highlighted. (biomedcentral.com)
  • Therefore, we aimed to determine the potential of monomeric CRP in serum as a biomarker of disease severity in COVID-19 patients (admission to intensive care unit [ICU] and/or in-hospital mortality). (bvsalud.org)
  • Overall, this study demonstrates that the competition between splicing and IPA is a potential target for the modulation of the ZAPL/S balance, and reports new cellular transcripts and processes regulated by the ZAP isoforms. (bvsalud.org)
  • This study aimed to investigate the potential effects of quercetin nanoemulsion (QN) on regulating the microRNA (miR)-33/34a pathway involved in cholesterol efflux in the liver of mice fed with a high-cholesterol (HC) diet. (pnfs.or.kr)
  • In conclusion, the reduction in IAV copy number in DEFB1 overexpressing cells suggests that beta-defensin-1 plays a key role in regulating IAV survival through STAT3 and is a potential target for antiviral drug development. (cdc.gov)
  • Based on our identified miRNA-regulated molecular machinery, an inhibitor of PDK1/Akt BX-912, an anthracycline antibiotic daunorubicin, and a multi-targeted protein kinase inhibitor midostaurin were discovered as potential repositioning drugs for treating lung cancer. (cdc.gov)
  • MicroRNAs constitute a pervasive post-transcriptional filter on protein or mRNA expression levels that are likely to control developmental timing, cellular differentiation, stress responses, metabolism and proliferation. (mdpi.com)
  • However, the role of microRNA in mammalian tissue development and differentiation is still quite uncharacterized. (mdpi.com)
  • Molecular profiling, the global analysis of gene and protein expression profiles, is an emerging promising tool for new biomarker identification in RCC. (biomedcentral.com)
  • yet, a global view of bcr activation-regulated protein ubiquitination is lacking when ebv is actively replicating. (liverpool.ac.uk)
  • One of the microRNA strands of the duplex is loaded onto the RNA-induced silencing complex (RISC) where it is then able to either cleave RNA targets or repress protein translation dependent upon its complementarity to the target mRNA. (biomedcentral.com)
  • Many HEAT binding motifs are found on HTT implying it has roles as a scaffolding protein and is involved in many protein interactions [8]. (fortuneonline.org)
  • Here, we summarize the different types of epigenetic enzymes which target corresponding protein domains, emphasize DNA methylation , histone modifications, and microRNA-mediated cooperation with epigenetic modification, and highlight recent achievements in developing targets for epigenetic inhibitor therapy. (frontiersin.org)
  • equal amount of total rna was then transcribed into the first-strand cdna using bonmir kit. (icbcongress.com)
  • Total RNA was extracted from ESCC cell lines, OE21 and TE10, and a non-malignant human esophageal squamous cell line, Het-1A, and subjected to microarray analysis. (biomedcentral.com)
  • Based on our identified miRNA-regulated network, we discovered three drugsBX-912, daunorubicin, and midostaurinthat can be repositioned to treat lung cancer, which was not known before. (cdc.gov)
  • 2021 ). For example, Hu reported that serum miRNA-21 was up-expressed as the T-stage osteosarcoma increased and demonstrated that miRNA-21 could inhibit the proliferation of osteosarcoma through targeting PTEN and regulating the TGF-1 signaling pathway (Hu et al. (springeropen.com)
  • Studies have shown that exosomes microRNAs from different cells or tissue sources play an important role in cardiovascular diseases including PH and is expected to become a new way to treat PH. (imrpress.com)
  • The binding sites of miR-128-3p and TGFBR2 were predicted by Targetscan online software and confirmed by dual-luciferase reporter assay and RNA immunoprecipitation (RIP) assay. (degruyter.com)
  • Thus, the pivotal roles of miR-455 in cell viability and metastasis in HCC still needed to be explored. (hindawi.com)
  • Circulating extracellular RNAs (ex-RNAs) are an emerging class of biomarkers with target-organ epigenetic effects. (researchgate.net)
  • These demonstrations of BBB dysfunction have been confirmed with biofluid biomarker data and observations of postmortem tissue analysis [ 6 , 12 - 17 ]. (hindawi.com)
  • Tumor tissue samples were collected at the operating-room into tubes containing Tissue Tek ® , snap frozen in liquid nitrogen and stored at − 80 °C. 10 × 10 μm sections of the samples were cut using a Leica CM3050S cryostat (Leica Microsystems GmbH, Wetzlar, Germany) and RNA was collected with TRI Reagent ® (Molecular Research Center Inc. Cincinnati, OH, USA) according to the manufacturer's protocol. (biomedcentral.com)
  • This is due to the finding that microRNAs display altered expression profiles in cancers versus normal tissue. (biomedcentral.com)
  • Although various microRNAs have been detected from tissue sources, these methods require invasive techniques to collect the starting material. (biomedcentral.com)
  • The early detection rate was still very low due to the lack of effective diagnostic biomarkers. (biomedres.info)
  • Our findings supported that the detection of urine miR-126 could serve as a diagnostic biomarker for bladder cancer. (biomedres.info)
  • Thus, the identification of early diagnostic biomarkers for bladder cancer is of special significance. (biomedres.info)
  • One explanation for the lack of progress is that lifestyle intervention programs are traditionally implemented without a comprehensive evaluation of an individual's diagnostic biomarkers. (springermedizin.at)
  • Important roles of inflammatory mediators in cardiac cell death by ischemia with or without reperfusion are well established [12-14]. (biomedres.us)
  • One of the most predominant methods in the literature is microRNA microarrays. (biomedcentral.com)