InflammationDysfunctionAngiogenesisPotential biomarkersSerumVEGFVascular endothelial cellsImpaired endothelial functionOxidative stressCellsInflammatory biomarkersMarkers of endothelialMetabolicInformative biomarkersNitric oxide syProteinFunctionCytokineSubstancesLungDisturbancesStudies have investigatedType 2 diabetCorrelationsElucidateTherapeutic targetCellPhysiologicalChemokinesCognitive impairmentActivationPhysiologyPrognosis
Inflammation8
- Plasma biomarkers of inflammation, oxidative stress, endothelial function and damage were examined in 16 individuals with chronic NFCI (NFCI) and matched controls with (COLD, n = 17) or without (CON, n = 14) previous cold exposure. (port.ac.uk)
- Consumption of trans fatty acids is related to plasma biomarkers of inflammation and endothelial dysfunction. (bioseek.eu)
- We examined whether trans fatty acid intake could also affect biomarkers of inflammation and endothelial dysfunction including C-reactive protein (CRP), interleukin-6 (IL-6), soluble tumor necrosis factor receptor 2 (sTNFR-2), E-selectin, and soluble cell adhesion molecules (sICAM-1 and sVCAM-1). (bioseek.eu)
- This MWCNT-induced lung-derived bioactivity caused pathological consequences of endothelial inflammation and barrier disruption. (cdc.gov)
- Previous data from more than 20,000 patients provide evidence, that high blood levels of bio-ADM(R) reflect impaired endothelial function independently from inflammation and other co-morbidities. (healthtechnologynet.com)
- We conducted a secondary analysis of 27 plasma biomarkers representing glucose metabolism, inflammation, adipokines, endothelial dysfunction, IGF axis, and iron store plus age and BMI at blood collection from an existing case-control study nested in the Nurses' Health Study (NHS), including 1,303 incident diabetes case subjects and 1,627 healthy women. (diabetesjournals.org)
- C-reactive protein, an indicator of acute inflammation, is the subject of considerable controversy as an important biomarker of cardiovascular health. (ift.org)
- Suboc TM, Dharmashankar K, Wang J, et al: Moderate obesity and endothelial dysfunction in humans: Influence of gender and systemic inflammation. (msdmanuals.com)
Dysfunction12
- SARS-CoV-2 infection primarily affects the pulmonary system, but accumulating evidence suggests that it also affects the pan-vasculature in the extrapulmonary systems by directly (via virus infection) or indirectly (via cytokine storm), causing endothelial dysfunction (endotheliitis, endothelialitis and endotheliopathy) and multi-organ injury. (nature.com)
- The purpose of this review is to provide a latest summary of biomarkers associated with endothelial cell activation in COVID-19 and offer mechanistic insights into the molecular basis of endothelial activation/dysfunction in macro- and micro-vasculature of COVID-19 patients. (nature.com)
- We envisage further development of cellular models and suitable animal models mimicking endothelial dysfunction aspect of COVID-19 being able to accelerate the discovery of new drugs targeting endothelial dysfunction in pan-vasculature from COVID-19 patients. (nature.com)
- A number of viral species, such as dengue, ebola and cytomegalovirus can infect endothelial cells (ECs) and cause endothelial dysfunction [ 5 ]. (nature.com)
- Taken together, the concerted actions of above factors lead to dysfunctional status of the vascular endothelium (endothelial dysfunction) (Fig. 1 ) [ 14 ]. (nature.com)
- Fig. 1: SARS-CoV-2 induced endothelial dysfunction. (nature.com)
- SARS-CoV-2 infection alters the balance of endothelial protective molecules and endothelial damaging molecules, leading to endothelial dysfunction. (nature.com)
- These alterations can influence endothelial dysfunction, excessive vasoconstriction, and abnormal cell proliferation of the vascular wall. (ajmc.com)
- Endothelial dysfunction, in particular, can encourage the expression of endothelin-1 (ET-1), a known vasoconstrictor. (ajmc.com)
- Tanner MJ, Wang J, Ying R, Suboc TB, et al: Dynamin-related protein 1 mediates low glucose-induced endothelial dysfunction in human arterioles. (msdmanuals.com)
- ABSTRACT This study assessed changes in serum levels of cytokines IFN and IL-10 (biomarkers of in ammatory changes) and soluble biomarkers sICAM-1 and sE-selectin (biomarkers of endothe- lial dysfunction) in diabetic patients with and without nephropathy. (who.int)
- However, the biomarkers sICAM-1 and sE-selectin (as mechanism of this immune dysregulation markers of endothelial dysfunction) in dia- is still unclear. (who.int)
Angiogenesis4
- The vascular endothelial growth factor (VEGF) is a key factor involved in angiogenesis. (hindawi.com)
- The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family and is active in angiogenesis, lymphangiogenesis, and endothelial cell growth. (nih.gov)
- Secondary objectives were to determine toxicity, enumerate circulating endothelial cells as an angiogenesis biomarker and analyze the effect of treatment on CYP3A4-metabolized steroids. (medscape.com)
- These cells can be differentiated into mature endothelial cells, which are involved in processes of angiogenesis and vessel regeneration. (intechopen.com)
Potential biomarkers2
- Liu C, Pan Y, Li Q, Zhang Y. Bioinformatics analysis identified shared differentially expressed genes as potential biomarkers for Hashimoto's thyroiditis-related papillary thyroid cancer. (medsci.org)
- STARD12 and STARD14 were expected to be potential biomarkers for LUAD, which were associated with epigenetic regulation, immune infiltration and ferroptosis. (medsci.org)
Serum9
- We used a series of multiplex assays to measure the concentrations of 55 serum analytes in specimens from patients from that outbreak to identify biomarkers specific to pediatric disease. (cdc.gov)
- Recently, we analyzed serum biomarkers by using samples from the Gulu outbreak and identified associations between cytokines/chemokines, acute-phase reactants, makers of coagulopathy, and markers of endothelial function and patient death, hemorrhage, and viremia ( 10 ). (cdc.gov)
- In this study, we used a series of multiplex assays to measure the concentrations of 55 serum analytes in specimens from patients from the Gulu outbreak to identify biomarkers that had age-specific associations with survival, hemorrhagic manifestations, or both. (cdc.gov)
- MWCNT-induced serum-borne bioactivity appears to dysregulate systemic endothelial cell function. (cdc.gov)
- In the present study, we utilize a broad-spectrum MMP inhibitor, Marimastat, along with a previously described oropharyngeal aspiration model of MWCNT administration to investigate the role of MMPs in MWCNT-derived serum peptide generation and endothelial bioactivity. (cdc.gov)
- The serum, in turn, exhibited differential potency in terms of inflammatory bioactivity when incubated with primary murine cerebrovascular endothelial cells. (cdc.gov)
- Serum from MWCNT-treated mice led to inflammatory responses in endothelial cells that were significantly blunted with serum from Marimastat-treated mice. (cdc.gov)
- Therefore, we investigated the cross-sectional association of cardiorespiratory fitness with serum nuclear magnetic resonance derived metabolic biomarkers in children. (frontiersin.org)
- Vectra measures 12 immune, endothelial, bone, cartilage, and metabolic biomarkers in serum to provide a picture of the underlying biology of RA. (genomeweb.com)
VEGF3
- We have previously demonstrated that a failure of pulmonary endothelial cell survival induced by vascular endothelial growth factor (VEGF) receptor blockade results in lung alveolar septal cell apoptosis and emphysema. (nih.gov)
- Using human colon adenocarcinoma tissues (hereinafter referred to as colon cancer) and their corresponding non-diseased colon from 114 patients' biopsies, the expression of SPARC and vascular endothelial growth factor (VEGF) were investigated by immunohistochemistry staining to assessment the relationship between SPARC and VEGF, as well as their prognostic significance in patients. (nih.gov)
- To measure intravitreal low-density lipoprotein receptor-related protein 6 (LRP6) and vascular endothelial growth factor (VEGF) levels in the eyes of patients with proliferative diabetic retinopathy (PDR) and to observe their correlation with PDR activity. (molvis.org)
Vascular endothelial cells3
- However, few studies have investigated LPS-induced apoptosis of vascular endothelial cells. (spandidos-publications.com)
- Furthermore, periodontitis has been shown to be associated with systemic cardiovascular disease ( 5 - 7 ), which suggests its close association with vascular endothelial cells. (spandidos-publications.com)
- CRP is produced by the liver and vascular endothelial cells, such those that line the arterial walls of major blood vessels of the heart and other vital organs. (ift.org)
Impaired endothelial function2
- According to principal investigator Prof. Alexandre Mebazaa (Hôpital Lariboisière, Paris, France), the results demonstrate that bio-ADM(R) is not only a biomarker indicating impaired endothelial function in patients with septic shock as previously shown 2 , but also identifies further ICU patients who require rapid therapeutic intervention at admission due to distortion in endothelial function, which is independently associated with malperfusion of organs. (healthtechnologynet.com)
- We hypothesize that increased sedentary time and more frequent bouts of uninterrupted sitting are associated with increased hemoglobin A1c, increased blood pressure, and impaired endothelial function. (cdc.gov)
Oxidative stress1
- Astragaloside IV might suppress autophagy initiation directly or indirectly through suppressing the oxidative stress and inflammatory response, which further enhances the cell viability and tight junction and reduces apoptosis in LPS-stimulated pulmonary endothelial ARDS cell model, thus exerting its therapeutic function in ARDS. (karger.com)
Cells11
- Endothelial cells are sentinels lining the innermost layer of blood vessel that gatekeep micro- and macro-vascular health by sensing pathogen/danger signals and secreting vasoactive molecules. (nature.com)
- Circulating endothelial cells (CEC) were shown to be elevated in patients with active antineutrophil cytoplasmic antibody-associated vasculitis. (bmj.com)
- We investigated the activity of physiologically relevant anthocyanin metabolite signatures, derived from a previous pharmacokinetics study of 500 mg 13C5-cyanidin-3-glucoside in 8 healthy participants, on soluble vascular adhesion molecule-1 (VCAM-1) and interleukin-6 (IL-6) in human endothelial cells. (uea.ac.uk)
- Once produced in endothelial cells, NO diffuses across the vascular smooth muscle cell membranes and activates the enzyme soluble guanylate cyclase (sGC), which catalyzes the conversion of guanosine triphosphate into cyclic guanosine monophosphate (cGMP). (wikipedia.org)
- There is a strong link between neural stem/progenitor cells (NSPCs) and endothelial cells (ECs) [ 7 ]. (hindawi.com)
- Preliminary correlative analysis suggested that a decrease in circulating endothelial cells from baseline to 1 week after treatment appeared to predict a positive response. (medscape.com)
- However, the effects of NAC on LPS‑induced apoptosis of human umbilical vein endothelial cells (HUVECs) and the associated mechanisms are not well characterized. (spandidos-publications.com)
- The apoptosis of endothelial cells is a key event that may impair the integrity of the vessel wall and lead to the formation of atherosclerotic plaques ( 9 ). (spandidos-publications.com)
- Human endothelial progenitor cells (hEPCs) are adult stem cells, located in the bone marrow and peripheral blood. (intechopen.com)
- Different phenotypes and subtypes of endothelial progenitor cells (EPCs), such as early and late EPCs, have been described according to their functionality. (intechopen.com)
- Thus, it has been shown that early EPCs release cytokines that promote tissue regeneration and neovasculogenesis, whereas late EPC and endothelial colony forming cells (ECFCs) contribute to the formation of blood vessels and stimulate tube formation. (intechopen.com)
Inflammatory biomarkers2
- Forty-five chronic ( 1 week) randomised controlled trials assessing CVD risk factors including endothelial (dys)function, blood pressure (BP), blood lipids and inflammatory biomarkers were included. (cranberryinstitute.org)
- Malik M, Suboc TM, Tyagi S, et al: Lactobacillus plantarum 299v supplementation improves vascular endothelial function and reduces inflammatory biomarkers in men with stable coronary artery disease. (msdmanuals.com)
Markers of endothelial1
- Clinical findings, microvascular function, global hemodynamics assessed with echocardiography, and serological markers of endothelial activation were determined at 4 time points.A total of 165 patients were enrolled. (ox.ac.uk)
Metabolic1
- 2011]. Sleep duration and biomarkers of metabolic function among police officers . (cdc.gov)
Informative biomarkers1
- The most informative biomarkers for predicting major cardiovascular events were BNP and the urinary albumin-to-creatinine ratio. (medscape.com)
Nitric oxide sy2
- Endothelial NOS (eNOS), also known as nitric oxide synthase 3 (NOS3) or constitutive NOS (cNOS), is an enzyme that in humans is encoded by the NOS3 gene located in the 7q35-7q36 region of chromosome 7. (wikipedia.org)
- The expression of caspase‑3, Bax, Bcl‑2, phosphorylated (p)‑p38MAPK/total (t‑)p38MAPK and p‑endothelial e nitric oxide synthase (eNOS)/t‑eNOS proteins were determined by western blotting. (spandidos-publications.com)
Protein3
- Developmental endothelial locus-1 (DEL-1) is a secreted multifunctional domain protein that can bind to integrins and play an important role in the occurrence and development of various diseases. (authorea.com)
- This protein is structurally and functionally similar to vascular endothelial growth factor C. Read-through transcription has been observed between this locus and the upstream PIR (GeneID 8544) locus. (nih.gov)
- Is C-Reactive Protein a Valid Biomarker? (ift.org)
Function7
- In conclusion, this study suggests that higher intake of trans fatty acids could adversely affect endothelial function, which might partially explain why the positive relation between trans fat and cardiovascular risk is greater than one would predict based solely on its adverse effects on lipids. (bioseek.eu)
- Association of Microvascular Function and Endothelial Biomarkers With Clinical Outcome in Dengue: An Observational Study. (ox.ac.uk)
- Failure of endothelial function has been demonstrated to precede the life-threatening blood pressure drop that causes shock and multiorgan failure e.g. in patients with sepsis at ICUs and in emergency departments (EDs) 2-3 . (healthtechnologynet.com)
- As a marker of endothelial function, bioactive Adrenomedullin (bio-ADM(R)) enables both prediction of circulatory shock before blood pressure decline, e.g. in septic patients, and diagnosis of residual congestion in acute heart failure patients. (healthtechnologynet.com)
- Blood pressure was measured with an automated cuff, and vascular endothelial function was assessed in a subsample of participants (n = 56) using EndoPAT. (cdc.gov)
- Widlansky ME, Puppula V, Suboc TM, et al: Impact of DPP-4 inhibition on acute and chronic endothelial function in humans with type 2 diabetes on background metformin therapy. (msdmanuals.com)
- Mohandas A, Suboc TB, Wang J, et al: Mineralocorticoid exposure and receptor activity modulate microvascular endothelial function in African Americans with and without hypertension. (msdmanuals.com)
Cytokine1
- Longitudinal analysis of aqueous humour cytokine expression and OCT-based imaging biomarkers in retinal vein occlusions treated with anti-vascular endothelial growth factor therapy in the IMAGINE study. (medscape.com)
Substances1
- The emerging understanding of the atherosclerotic process and the development of atherosclerotic plaque that leads to endothelial injury and subsequent production of inflammatory substances contributed to the issuance of these guidelines. (ift.org)
Lung2
- Design and methodological considerations for biomarker discovery and validation in the Integrative Analysis of Lung Cancer Etiology and Risk (INTEGRAL) Program. (who.int)
- The guidelines give a strong recommendation for the use of vascular endothelial growth factor D testing to establish the diagnosis of LAM before considering lung biopsy in patients with cystic abnormalities on HRCT characteristic of LAM, but no other confirmatory clinical features. (medscape.com)
Disturbances1
- Diabetic group ( n = 17): patients with in patients with chronic renal failure and type 2 diabetes without renal involve- under HD, and disturbances in endothelial ment (normoalbuminuria). (who.int)
Studies have investigated1
- Numerous studies have investigated individual biomarkers in relation to risk of type 2 diabetes. (diabetesjournals.org)
Type 2 diabet1
- Diabetic nephropathy (DN) is a leading selectin), and soluble thrombomodulin--are cause of chronic renal failure and is a grow- providing further evidence of the relation- ing concern given the increasing incidence ship between endothelial cell activation and of type 2 diabetes. (who.int)
Correlations3
- Although pairwise biomarker correlations tended to have similar directions comparing diabetes case subjects to noncase subjects, most correlations were stronger in noncase than in case subjects, with the largest differences observed for the insulin/HbA 1c and leptin/adiponectin correlations. (diabetesjournals.org)
- Leptin and soluble leptin receptor were two hubs of the network, with large numbers of different correlations with other biomarkers in case versus noncase subjects. (diabetesjournals.org)
- Shared biological pathways and pharmacokinetic factors affecting different toxins might be an unrecognised factor reflected in biomarker correlations. (medrxiv.org)
Elucidate1
- Pathway-based biomarkers identification may help elucidate the cellular signature of breast cancer metastasis in bone, further characterizing the etiology and promoting new therapeutic approaches. (degruyter.com)
Therapeutic target2
- Collectively, DEL-1 is a promising biomarker and therapeutic target for CVMDs. (authorea.com)
- LRP6 may be a good diagnostic biomarker and a new therapeutic target for PDR. (molvis.org)
Cell3
- 001 for both), negatively correlated.Modest microcirculatory alterations occur in dengue, are associated with plasma leakage, and are correlate with molecules of endothelial activation, angiopoietin 2 and vascular cell adhesion molecule 1. (ox.ac.uk)
- Biomarkers of the transsulfuration pathway and risk of renal cell carcinoma in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. (who.int)
- found evidence and they did not require insulin therapy of endothelial cell injury in renal failure for glucose control. (who.int)
Physiological1
- The first branch included numerous physiological biomarkers and several exogenous biomarkers. (medrxiv.org)
Chemokines1
- Moreover, NO affects leukocyte adhesion to the vascular endothelium by inhibiting the nuclear factor kappa B (NF-κB), which induces vascular endothelial expression of chemokines and adhesion molecules. (wikipedia.org)
Cognitive impairment1
- PlGF was the only biomarker that was associated with WML independent of Aβ status and cognitive impairment. (lu.se)
Activation1
- This compensation can increase endothelial activation. (ajmc.com)
Physiology1
- Environmental adaptations of the oral microbiota and effects on the divers' physiology: analysis of the metagenome and salivary stress biomarkers. (ntnu.no)