• The objectives of the Biomarkers of Acute Cardiovascular Diseases (BACD) Division involve furthering the clinical, analytical and fundamental science of established, developing and novel biomarkers for the diagnosis, risk assessment, monitoring and management of patients with acute cardiovascular diseases including, but not limited to, acute myocardial infarction, heart failure, ischemic and hemorrhagic stroke, and acute thromboembolic disease. (aacc.org)
  • Establish an international forum with a focus on laboratory medicine for laboratory professionals, physicians, individuals in industry, regulatory agencies and other stakeholders with an interest in biomarkers of acute cardiovascular diseases. (aacc.org)
  • The ST2 gene (also known as IL1RL1 ) is a potential biomarker of poor prognosis in cardiovascular diseases. (origene.com)
  • Cardiovascular and metabolic diseases (CVMDs) are a leading cause of death worldwide and imposes a huge socioeconomic burden on individuals and healthcare systems, underscoring the urgent need to develop new drug therapies. (authorea.com)
  • [ 1 ] Clinically, biomarkers can be used to screen for, diagnose, or monitor the activity of diseases as well as guide molecularly targeted therapy or assess therapeutic response. (medscape.com)
  • In the cardiovascular system, miRNAs regulate basic functions in almost all cell types including cardiac muscle, endothelial cells, smooth muscle, inflammatory cells, and fibroblasts and, therefore, play a pivotal role in the pathogenesis of several cardiovascular diseases (CVDs). (hindawi.com)
  • Intermittent fasting in rodents has been shown to reduce or prevent cellular dysfunction and degeneration in age-related neurological and cardiovascular diseases. (edu.au)
  • This week in BMC Medicine: Statins, personalized medicine and biomarkers for cardiovascular diseases. (biomedcentral.com)
  • Cholesterol-lowering drugs such as statins are the first line of treatment for hypercholesterolemia in the prevention of cardiovascular diseases but their side effects are associated with depression . (biomedcentral.com)
  • Together, the latest evidence provides hope that patients with cardiovascular diseases can be selected and treated based on their genetic makeup, serum protein and risk-factor profiles to provide a more personalized approach to their therapy and care. (biomedcentral.com)
  • Biomarkers in Cardiovascular Diseases. (wikipedia.org)
  • Both cTnI and NT-proBNP have been linked to increased cardiovascular risk in the general population, but little work has been done in the context of rheumatologic diseases. (medscape.com)
  • Circulating microRNAs (miRNAs) have been proposed as diagnostic biomarkers for various cardiovascular diseases. (biomedcentral.com)
  • Controversy persists on the association between dairy products, especially milk, and cardiovascular diseases (CVD). (uky.edu)
  • Type 2 diabetes mellitus is one of the most common diseases in occidental society and it is associated with a high cardiovascular risk, not only due to the classical factors but also to a chronic low-grade inflammation [ 1 ]. (biomedcentral.com)
  • Cardiovascular diseases are the leading cause of death worldwide except Africa. (wikipedia.org)
  • There are many cardiovascular diseases involving the blood vessels. (wikipedia.org)
  • There are also many cardiovascular diseases that involve the heart. (wikipedia.org)
  • Death attributed to cardiovascular and coronary heart diseases showed strong and consistent reductions with increasing nut/peanut butter consumption. (cambridge.org)
  • 7 In the 2000s, growing scientific attention turned to non-skeletal chronic diseases as vitamin D deficiency was linked to cancer, 8 cardiovascular diseases, 9 10 metabolic disorders, 11 infectious diseases, 12 and autoimmune diseases, 13 14 15 as well as mortality. (bmj.com)
  • [ 5 , 7 ] Although the underlying mechanisms are complex, the chronic inflammatory state and microbial burden in people with periodontal disease may predispose them to cardiovascular diseases in ways proposed for other infections. (medscape.com)
  • Is cholesterol the forgotten biomarker in managing cardiovascular risk in children with type 1 diabetes? (uk.com)
  • To determine in healthy individuals new circulating protein biomarkers, whose systemic levels may be associated with the risk of future development of CVD incidents and death. (redheracles.net)
  • We validated a set of established protein biomarkers for the prediction of trajectories of estimated glomerular filtration rate (eGFR) in people with moderately advanced chronic kidney disease and diabetes mellitus. (lu.se)
  • METHODS: We used Bayesian linear mixed models with weakly informative and shrinkage priors for clinical predictors (n = 12) and protein biomarkers (n = 19) to model eGFR trajectories in a retrospective cohort study of people with diabetes mellitus (n = 838) from the nationwide German Chronic Kidney Disease study. (lu.se)
  • CONCLUSIONS: Protein biomarkers only modestly improve predictive accuracy compared to clinical predictors alone. (lu.se)
  • We identified eight protein biomarkers, four of which are novel, for risk of MACE in community residents with type 2 diabetes, and found improved risk prediction by combining multiplex proteomics with an established risk model. (springer.com)
  • Multiplex protein arrays that rely on common methods such as PCR, require small sample volumes and are available at a fraction of the cost of large-scale platforms may provide a clinically applicable method for individualised treatment based on biomarker profiles. (springer.com)
  • Novel biomarkers of risk, such as apolipoprotein (Apo) A1 and ApoB (2), and the inflammatory markers C-reactive protein (CRP), fibrinogen, and homocysteine (3-5), have been proposed. (cdc.gov)
  • Research by William A LaFramboise and colleagues on serum protein biomarkers shows that some biomarkers can discriminate between patients without significant coronary artery disease from those with the disease and requiring angiography. (biomedcentral.com)
  • Biomarkers of inflammation (high- sensitivity C-reactive protein ), oxidative stress ( superoxide dismutase , F2-isoprostanes ), and endothelial dysfunction (soluble intercellular adhesion molecule 1 , soluble P-selectin ) were assessed at year 15. (bvsalud.org)
  • Interestingly, we characterised a set of biomarkers showing plasma and brain consistent protein profiles and opposite trends in APOE2 and APOE4 AD cases that could constitute screening tools for a disease that lacks specific blood biomarkers. (ox.ac.uk)
  • Patients with T2D were classified according to their LDL subfraction phenotype and inflammatory biomarkers (C-reactive protein, Interleukin-6, Interleukin-8, Transforming growth factor β 1 , Monocyte chemotactic protein 1, Leptin, Adiponectin) were evaluated according to the degree of glycemic control, LDL phenotype and other clinical characteristics. (biomedcentral.com)
  • We hypothesize that occupational exposure to Mn will be associated with detectable changes in cardiovascular autonomic control as assessed by 24-hr heart rate variability (HRV) as well as changes in inflammatory markers as assessed by C - reactive protein and fibrinogen. (cdc.gov)
  • Children and young people with type 1 diabetes (T1D) are faced with an increased risk of developing cardiovascular disease (CVD). (uk.com)
  • Current research approaches aim to determine genetic variants, biomarkers and prediction models for improved management and individualized treatment of patients with cardiac conditions. (biomedcentral.com)
  • Herein we investigated the hypothesis that some of these AGEs (fluorescence to be reported elsewhere) correlate with long-term subclinical cardiovascular disease (CVD) measurements, i.e. coronary artery calcium score (CAC) at EDIC year 7-9 (n = 187), change of carotid intima-media thickness (IMT) from EDIC year 1 to year 6 and 12 (n = 127), and cardiac MRI outcomes at EDIC year 15-16 (n = 142). (sens.org)
  • The risk of cardiovascular events in patients with psoriatic disease rises with higher levels of two cardiac biomarkers in a manner independent of risk calculated by the Framingham Risk Score (FRS), a longitudinal cohort study has shown. (medscape.com)
  • But researchers who conducted the study note that neither of the two biomarkers identified in the study ― cardiac troponin I (cTnI) and N-terminal pro-brain-type natriuretic peptide (NT-proBNP) ― led to an improvement in predictive performance when combined with the FRS, despite their association with carotid plaque burden. (medscape.com)
  • Plasma miR-222 appears to be a promising novel biomarker reflecting structural - but not functional - cardiac alterations in MD patients. (biomedcentral.com)
  • The introduction of biomarkers of myocardial injury such as high-sensitivity cardiac troponins made rule-out of AMI even more precise. (herts.ac.uk)
  • Numerous cardiac biomarker assays are currently available for the diagnosis of myocardial cell necrosis. (medscape.com)
  • In addition, biomarkers alone or as part of accelerated diagnostic protocols (ADP) may reduce the number of patients with a missed diagnosis of NSTEMI who are at increased risk for major adverse cardiac events. (medscape.com)
  • Cardiac biomarkers Acute coronary syndromes result from acute obstruction of a coronary artery. (msdmanuals.com)
  • Conventional biomarkers for kidney function include serum creatinine (SCr), urine output (changes in which may precede biochemical changes), and urine microscopy. (medscape.com)
  • Given the limitations of serum creatinine as a biomarker of kidney function, different urinary and serum proteins, molecules, and, most recently, microRNAs have been rigorously investigated over the past decade as possible biomarkers for kidney disease. (medscape.com)
  • Validation of biomarkers of CVD risk from dried blood spots in community-based research: methodologies and study-specific serum equivalencies. (cdc.gov)
  • We determined the validity of DBS-derived biomarkers of CVD risk versus gold-standard assessments, and study-specific, serum-equivalency values for clinical relevance of DBS-derived values. (cdc.gov)
  • The majority of epigenetic drift observed in blood is independent of variations in blood cell composition, addressing concerns affecting traditional blood-based biomarker efficacy. (elsevierpure.com)
  • We identified 10 plasma miRs that were downregulated in male rheumatoid arthritis patients and in patients with acute myocardial infarction compared to controls suggesting that these microRNAs could be epigenetic biomarkers for cardiovascular disease in rheumatoid arthritis patients. (urv.cat)
  • We provide evidence of a possible role of microRNA-425-5p and microRNA-451 as useful epigenetic biomarkers to assess cardiovascular disease risk in patients with rheumatoid arthritis. (urv.cat)
  • The researchers reviewed more than 9000 studies published between 1990 and 2021 to identify the most promising biomarker candidates for prediction of cardiovascular disease among people with diabetes. (lu.se)
  • They found an increased risk for neurodegeneration on MRI, with a number of cardiovascular and metabolic conditions. (medscape.com)
  • Newer glucose-lowering drugs such as sodium-glucose co-transporter 2 inhibitors, and cholesterol-modifying agents such as proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors, in addition to standard treatment reduce cardiovascular risk in high-risk individuals [ 8 , 9 ]. (springer.com)
  • We are examining if short- and long-term ET receptor blockade will reduce cardiovascular risk in optimally managed patients with AAV. (ed.ac.uk)
  • It could well be that if you have a biomarker that accurately predicts a coming cataclysm, that it will lead you to redouble your efforts to do whatever it takes to reduce cardiovascular risk," he said. (medscape.com)
  • However, the relationship between 25(OH)D and individual biomarkers of cardiometabolic disease has not been explored in the Canadian population, and whether it differs by sex is unknown. (cdc.gov)
  • This includes the role of the vascular endothelium in the recruitment of inflammatory leucocytes where they contribute to tissue damage and cytokine release, which are key drivers of acute respiratory distress syndrome (ARDS), in disseminated intravascular coagulation, and cardiovascular complications in COVID-19. (scilifelab.se)
  • Up to 40% of the US population will develop type 2 diabetes during their lifetime, and type 2 diabetes is an important contributor to major adverse cardiovascular events (MACE) such as myocardial infarction and stroke-the leading causes of morbidity and mortality in Western countries [ 2 ]. (springer.com)
  • Clinical use of LS7 and further exploration of its relationships with coronary artery disease may enhance efforts to reduce cardiovascular morbidity and mortality in PWH. (reprievetrial.org)
  • Psoriasis and psoriatic arthritis are both associated with greater risk of cardiovascular morbidity and mortality, partly because of systemic inflammation that leads to atherogenesis. (medscape.com)
  • Endothelial dysfunction in COVID-19: a position paper of the ESC Working Group for Atherosclerosis and Vascular Biology, and the ESC Council of Basic Cardiovascular Science. (scilifelab.se)
  • We propose that endothelial biomarkers and tests of function (e.g. flow-mediated dilatation) should be evaluated for their usefulness in the risk stratification of COVID-19 patients. (scilifelab.se)
  • A better understanding of the effects of SARS-CoV-2 on endothelial biology in both the micro- and macrovasculature is required, and endothelial function testing should be considered in the follow-up of convalescent COVID-19 patients for early detection of long-term cardiovascular complications. (scilifelab.se)
  • Co-occurring depressive symptoms and smoking do not seem to synergistically convey risk for cardiovascular disease via processes of inflammation , oxidative stress , or endothelial dysfunction. (bvsalud.org)
  • Chronically elevated levels of these biomarkers promote insulinresistance in skeletal muscle and endothelial dysfunction, as well as liberation of CRP from the liver [ 8 ]. (biomedcentral.com)
  • Research into predicting mortality and cardiovascular events is also a topic that has been of much interest in recent years, and a study by Bob JH van Kempen and colleagues on the Rotterdam Ischemic Heart and Disease and Stroke Computer Simulation (RISC) model shows that these events can be reliably predicted during a period of 5 years and through an extended follow-up of 13 years. (biomedcentral.com)
  • However, milk intake was not associated with CVD biomarkers, CVD or mortality either generally or in sub-groups. (uky.edu)
  • Automated CT biomarkers for opportunistic prediction of future cardiovascular events and mortality in an asymptomatic screening population: a retrospective cohort study. (wisc.edu)
  • We evaluated whether participant-reported health status, as indexed by self-rated health, predicted cardiovascular disease, and all-cause mortality risk excess of 10-year atherosclerotic cardiovascular disease (ASCVD) risk scores and 5 nontraditional risk biomarkers. (nau.edu)
  • Barger, SD, Cribbet, MR & Muldoon, MF 2016, ' Participant-Reported Health Status Predicts Cardiovascular and All-Cause Mortality Independent of Established and Nontraditional Biomarkers: Evidence From a Representative US Sample ', Journal of the American Heart Association , vol. 5, no. 9, e003741. (nau.edu)
  • Wendy Frost, Advanced Dietitian in Paediatrics, reports on an audit amongst children with type 1 diabetes carried out with the aim of identifying those who are potentially more at risk of cardiovascular disease. (uk.com)
  • The National Institute of Clinical Excellence (NICE) guidelines 1 recommend considering statin treatment for the primary prevention of cardiovascular disease in all adults with type 1 diabetes, and offering statin treatment to adults with type 1 diabetes who are older than 40 years of age or who have had diabetes for more than 10 years. (uk.com)
  • BACKGROUND: Chronic kidney disease (CKD) is a common comorbidity in people with diabetes mellitus, and a key risk factor for further life-threatening conditions such as cardiovascular disease. (lu.se)
  • Out of the 195 biomarkers examined, 13 were significantly associated with cardiovascular risk in people with type 2 diabetes. (lu.se)
  • An international team of researchers has identified 13 biomarkers that significantly improve the ability to accurately predict cardiovascular disease risk in people with type 2 diabetes. (lu.se)
  • Although people with type 2 diabetes are two times more likely to develop cardiovascular disease than those without diabetes, it remains a challenge for clinicians to predict who among this population is most at risk. (lu.se)
  • With numbers that high, it's important to identify readily available ways to accurately classify patients so that those at higher risk of cardiovascular disease can receive the preventative care they need", says Maria F. Gomez, co-senior author of the study and professor of physiology at Lund University Diabetes Centre. (lu.se)
  • They analysed differences between people with type 2 diabetes who experienced cardiovascular disease and those who did not. (lu.se)
  • Our goal was to identify promising markers that could improve cardiovascular risk prediction in people with type 2 diabetes. (lu.se)
  • The team found that, across several studies, higher levels of NT-proBNP in the body correlated with a higher risk of cardiovascular disease in patients with type 2 diabetes. (lu.se)
  • If future studies confirm their value in predicting cardiovascular risk in patients with type 2 diabetes, we may be able to change standards of care", says co-senior author of the analysis Ronald Ma, professor of diabetes at the Chinese University of Hong Kong. (lu.se)
  • Multiplex proteomics could improve understanding and risk prediction of major adverse cardiovascular events (MACE) in type 2 diabetes. (springer.com)
  • This study assessed 80 cardiovascular and inflammatory proteins for biomarker discovery and prediction of MACE in type 2 diabetes. (springer.com)
  • Multiprotein arrays could be useful in identifying individuals with type 2 diabetes who are at highest risk of a cardiovascular event. (springer.com)
  • Cardiovascular prevention is further complicated by increased rates of drug side effects in people with diabetes, including potential adverse glycaemic effects of lipid-modifying agents [ 6 , 7 ]. (springer.com)
  • Skin collagen advanced glycation endproducts (AGEs) and the long-term progression of sub-clinical cardiovascular disease in type 1 diabetes. (sens.org)
  • Type 2 diabetes mellitus (T2D) is associated with higher cardiovascular risk partly related to an increase in inflammatory parameters. (biomedcentral.com)
  • Methods Coronary computed tomography angiography, immune/inflammatory biomarkers, and characterization of LS7 were collected among a subset of ART-treated PWH enrolled in REPRIEVE, a primary prevention trial. (reprievetrial.org)
  • Abstract Background Night shift work is associated with cardiovascular disease, but its associations with cardiovascular disease biomarkers are unclear. (asstsas.com)
  • Background: Lead exposure has been associated with cardiovascular disease (CVD) in animal and human studies. (drcalapai.com)
  • At the World Congress of Cardiology in September 2006 the Advanced Chronic Heart Failure Clinical Assessment of Immune Modulation Therapy (ACCLAIM) a phase III randomized, double-blind, placebo-controlled clinical trial involving some 2408 patients in 7 countries with left ventricular ejection fraction of 30% or less, reported that only one subgroup - patients with a previous cardiovascular event - benefited from the treatment. (wikipedia.org)
  • Here we review the highlights of cardiovascular basic science in published in 2021 and early 2022 on behalf of the European Society of Cardiology Council for Basic Cardiovascular Science. (scilifelab.se)
  • Here, the Working Group on Atherosclerosis and Vascular Biology together with the Council of Basic Cardiovascular Science of the European Society of Cardiology provide a Position Statement on the importance of the endothelium in the underlying pathophysiology behind the clinical presentation in COVID-19 and identify key questions for future research to address. (scilifelab.se)
  • 14 Cardiovascular Prevention Unit, Adult Cardiology Department. (nih.gov)
  • The aim of this study was to determine the association of inflammatory biomarkers with low-density lipoprotein (LDL) subfraction phenotype and glycemic control in subjects with T2D and poor glycemic control. (biomedcentral.com)
  • Subjects with T2D, especially those with LDL phenotype B and obesity, have higher levels of inflammatory biomarkers. (biomedcentral.com)
  • The cardiovascular health of each worker was assessed by ambulatory electrocardiogram (ECG) and inflammatory markers. (cdc.gov)
  • Establish a mechanism for young clinical laboratory professionals to gain clinical, research and development, and interpretive experience in the area of biomarkers of acute cardiovascular disease. (aacc.org)
  • Despite medication and lifestyle changes, patients with cardiovascular disease can experience MACE due to undertreatment, poor adherence, or failure to recognize clinical or biochemical changes that presage MACE. (escholarship.org)
  • Clinical decision-making based on overall cardiovascular risk in addition to individual risk factors can improve outcomes, as demonstrated for antihypertensive treatment [ 12 ]. (springer.com)
  • We perform pre-clinical and experimental medicine studies as well as investigating cardiovascular risk at a population level. (ed.ac.uk)
  • We are now exploring the utility of these OCT measures as potential clinical biomarkers and as short- and medium-term endpoints in clinical trials. (ed.ac.uk)
  • These data highlight that if the biomarkers are used in a clinical setting a reduced number of patients will be exposed to ionization, which will also lower healthcare costs. (biomedcentral.com)
  • Such biomarkers could assist with patient counseling, according to Mease, who is director of rheumatology research at Swedish Medical Center/Providence St. Joseph Health and is a clinical professor at the University of Washington, both in Seattle. (medscape.com)
  • Their study compared the ability of automated CT-based body composition biomarkers derived from deep-learning and feature-based, image-processing algorithms (previously developed at the NIH Clinical Center) to predict major cardiovascular events and overall survival with routinely used clinical parameters: the Framingham risk score (FRS) and body-mass index (BMI). (wisc.edu)
  • We found that automated measures provided more accurate risk assessments than established clinical biomarkers," said Dr. Ronald M. Summers of the NIH Clinical Center and senior author of the study. (wisc.edu)
  • A genetic predisposition biomarker is associated with increased or, in certain cases, decreased chances of developing a health disorder in an individual who, from a clinical viewpoint, has not yet suffered from that medical condition. (researchandmarkets.com)
  • The identification of new lipid biomarkers could provide future targets for prevention and innovative therapeutic approaches. (nih.gov)
  • Results: Lead levels were associated with several CVD biomarkers, including levels of TNF-R2 and lipid markers. (drcalapai.com)
  • There is interest to analyse newer biomarkers to identify healthy individuals at risk to develop cardiovascular disease (CVD) incidents and death. (redheracles.net)
  • Advance knowledge in biomarkers of acute cardiovascular disease through research and education, including the preanalytical, analytical, and post-analytical phases of testing. (aacc.org)
  • α1-antitrypsin isotype 3 plasma levels were significantly higher while apolipoprotein J plasma levels were lower in participants that developed CVD incidents than those that did not develop acute cardiovascular episode. (redheracles.net)
  • European Heart Journal - Acute Cardiovascular Care , 10 (3), 343-355. (herts.ac.uk)
  • By the cardiovascular of the keyboard, you will offer exploited the psychological risk past to use these laws in thinking to doing in your international item, ago never as genetic investors of terminology Thanks in the quick Internet. (arturovallejo.com)
  • This largely includes the identification of genetic biomarkers that suggest an increased likelihood of developing cancer in a later stage of life. (researchandmarkets.com)
  • CONCLUSIONS - : NT-proBNP and hs-cTnT are independently associated with silent MRI-defined BI and WML, suggesting that cardiovascular biomarkers may be useful to identify individuals with subclinical cerebral injury. (johnshopkins.edu)
  • Using large datasets, we are investigating the role of high-sensitivity troponin I (and other cardiovascular biomarkers) as a measure of outcome in patients with CKD and those undergoing kidney transplantation. (ed.ac.uk)
  • Conclusions: In OSA patients, a low PWAD index reflecting poor autonomic and vascular reactivity was independently associated with a higher cardiovascular risk. (imtlucca.it)
  • In fact, the CT-based measure of aortic calcification alone significantly outperformed the multivariate FRS for major cardiovascular events and overall survival. (wisc.edu)
  • To validate in a cohort of 214 rheumatoid arthritis patients a panel of 10 plasmatic microRNAs, which we previously identified and that can facilitate earlier diagnosis of cardiovascular disease in rheumatoid arthritis patients. (urv.cat)
  • The combined measurement of markers of myocardial injury with biomarkers reflecting ongoing thrombus formation might be helpful for the fast and correct diagnosis of an atherothrombotic type 1 AMI. (herts.ac.uk)
  • This position paper gives an overview of the current knowledge and possible role of biomarkers of coagulation and fibrinolysis for the diagnosis of AMI, risk stratification, and individualized treatment strategies in patients with AMI. (herts.ac.uk)
  • Diagnosis is by electrocardiography (ECG) and the presence or absence of biomarkers. (msdmanuals.com)
  • The main objective of this study was to investigate the prevalence of T. gondii among adults in the United States and its association with cardiovascular health using data from the National Health and Nutrition Examination Survey (NHANES 2009-2010). (mdpi.com)
  • Considering the limitation of studies investigating the relationship between T. gondii and cardiovascular biomarkers, this study was focused on assessing the association of T. gondii to nine cardiovascular biomarkers. (mdpi.com)
  • The aim of the study was to assess cardiovascular biomarkers and echocardiographic measures at rest and during hypovolemia in women with and without a history of vasovagal syncope. (diva-portal.org)
  • Using biosensor, biomarkers, and patient-reported outcomes in participants with stable ischemic heart disease, the PRE-MACE study is designed to measure cross-sectional correlations and establish the ability of remote monitoring to predict major adverse cardiovascular event (MACE) biomarkers and incident MACE at baseline and 12-month follow-up. (escholarship.org)
  • All participants will be followed up for MACE at 12 months.The PRE-MACE study will utilize remote monitoring with biosensors, biomarkers, and patient-reported outcomes to identify intermediate biomarkers of MACE in patients with stable ischemic heart disease. (escholarship.org)
  • We conducted linear regressions analyses (adjusted for sex, waist circumference, physical activity, hormone use, and season) to assess the relationship between 25-hydroxyvitamin D and biomarkers of dysglycemia, dyslipidemia, and inflammation in the study population. (cdc.gov)
  • Evaluating Longitudinal Associations Between Depressive Symptoms, Smoking, and Biomarkers of Cardiovascular Disease in the CARDIA Study. (bvsalud.org)
  • The aim of the study was to evaluate associations between 15-year trajectories of co-occurring depressive symptoms and smoking with biomarkers of cardiovascular disease at year 15. (bvsalud.org)
  • The study of the plasma lipidome may help to better characterize molecular mechanisms underlying cardiovascular disease. (nih.gov)
  • Measures of cardiovascular risk such as the FRS rely on traditional measures of cardiovascular risk and thus are likely to underestimate the cardiovascular event risk of people with psoriatic disease, according to the authors of the new study, published online in Arthritis and Rheumatology . (medscape.com)
  • This opportunistic use of additional CT-based biomarkers provides objective value to what doctors are already doing," said Dr. Perry J. Pickhardt, professor of radiology at the University of Wisconsin School of Medicine & Public Health, and lead and corresponding author of the study. (wisc.edu)
  • The study used five AI computer programs to accurately measure liver volume and steatosis, visceral fat volume, skeletal muscle volume, spine bone mineral density, and atherosclerotic plaque burden on abdominal CT examinations, and they found that the panel of automated CT-based tissue biomarkers compared favorably with the FRS and BMI for presymptomatic prediction of future cardiovascular events and death. (wisc.edu)
  • Genome-wide DNA methylation study identifies genes associated with the cardiovascular biomarker GDF-15. (ox.ac.uk)
  • The third study, published in Annals of Neurology , [ 4 ] looked at lifestyle factors and biomarkers for Alzheimer disease . (medscape.com)
  • Our aim was to discern which biomarkers associate with baseline eGFR or are important for the prediction of the future eGFR trajectory. (lu.se)
  • We begin with non-coding RNAs which have emerged as central regulators cardiovascular biology, and then discuss how technological developments in single-cell 'omics are providing new insights in cardiovascular development, inflammation and disease. (scilifelab.se)
  • Collectively, DEL-1 is a promising biomarker and therapeutic target for CVMDs. (authorea.com)
  • The National Institutes of Health (NIH) Biomarkers Definitions Working Group has defined a biomarker as, "a characteristic that is ob-jectively measured and evaluated as an indicator of normal biologic pro-cesses, pathogenic processes, or pharmacologic responses to a therapeutic intervention. (medscape.com)
  • Our data suggest that plasma levels of miRNA-23b and miRNA-143 could be useful as noninvasive biomarkers of ISR. (hindawi.com)
  • In population-based studies utilising high-fidelity linked healthcare data unique to Scotland, we are investigating temporal trends in the incidence and outcomes of cardiovascular disease, including rates of secondary prevention prescribing, in patients with kidney failure. (ed.ac.uk)
  • The Nobel Prize in Physiology or Medicine 2021 recognised the importance of the molecular basis of mechanosensing and here we review breakthroughs in cardiovascular sensing of mechanical force. (scilifelab.se)
  • MicroRNAs (miRNAs) can be released into circulation from injured tissues, enticing a potential role as noninvasive biomarkers. (hindawi.com)
  • Biomarker and cardiovascular health endpoints analysis is ongoing. (cdc.gov)
  • Although current treatments have improved the short-term prognosis of AAV, these patients remain at a significantly increased risk of cardiovascular disease. (ed.ac.uk)
  • Analyses adjusted for cardiovascular disease risk (ASCVD score). (reprievetrial.org)
  • García-Bailo B, Da Costa LA, Arora P, Karmali M, El-Sohemy A, Badawi A. Plasma Vitamin D and Biomarkers of Cardiometabolic Disease Risk in Adult Canadians, 2007-2009. (cdc.gov)
  • Objective To investigate relationships between Life's Simple 7 (LS7), an assessment of cardiovascular health (CVH), and coronary plaque among people with HIV (PWH). (reprievetrial.org)
  • Objective: To investigate the value of pulse wave amplitude drops (PWAD), reflecting sympathetic activations and vasoreactivity, as a biomarker of cardiovascular risk in OSA. (imtlucca.it)
  • This includes those who have established nephropathy, or other cardiovascular risk factors. (uk.com)
  • Multivariable-adjusted Cox regression was used in a discovery/replication design to identify biomarkers for incident MACE. (springer.com)
  • Measuring circulating proteins with presumed roles in cardiovascular pathology by targeted proteomics is a promising approach for biomarker discovery [ 15 ]. (springer.com)
  • In PLSC and HypnoLaus, every 10 events/h increase in continuous PWAD index was independently associated with incident cardiovascular events exclusively in OSA patients (HR 0.85[0.73-0.99], p=0.031 and HR 0.91[0.86-0.96], p=<0.001 respectively). (imtlucca.it)
  • abstract = "Biomarkers encompass a wide range of different measurable indicators, representing a tangible link to physiological changes occurring within the body. (elsevierpure.com)
  • abstract = "BACKGROUND AND PURPOSE - : Cerebrovascular and cardiovascular disease share common risk factors. (johnshopkins.edu)
  • Moreover, apolipoprotein J plasma levels were found lower in participants that died by cardiovascular cause. (redheracles.net)
  • Conclusions We found suggestive evidence of adverse short-term and long-term effects of night shift work on select cardiovascular disease biomarkers. (asstsas.com)
  • Conclusions: Self-rated health provides prognostic information beyond that captured by traditional ASCVD risk assessments and by nontraditional CVD biomarkers. (nau.edu)
  • This article is the latest addition to our article collection on personalized medicine: genes, biomarkers and tailored treatment . (biomedcentral.com)
  • Rationale: It is currently unclear which patients with obstructive sleep apnea (OSA) are at increased cardiovascular risk. (imtlucca.it)
  • Six of those microRNAs were validated in independent plasma samples from 214 rheumatoid arthritis patients and levels of expression were associated with surrogate markers of cardiovascular disease (carotid intima-media thickness, plaque formation, pulse wave velocity and distensibility) and with prior cardiovascular disease. (urv.cat)
  • In addition, microRNA-425-5p increased the accuracy to discriminate male patients with prior cardiovascular disease by 3% (p=0.008). (urv.cat)
  • Some patients may struggle with advice to lose weight or adopt lifestyle measures to limit cardiovascular risk, and more accurate predictions of risk may serve as further motivation. (medscape.com)
  • All MD patients and controls underwent comprehensive cardiovascular magnetic resonance (CMR) studies as well as venous blood sampling on the same day. (biomedcentral.com)
  • This automated process requires no additional time, effort, or radiation exposure to patients, yet these prognostic measures could one day impact patient health through pre-symptomatic detection of elevated cardiovascular or other health risks. (wisc.edu)
  • GDF-15 is associated with cardiovascular dysfunction and over-expressed in the myocardium of patients with myocardial infarction (MI). (ox.ac.uk)
  • Cardiovascular and behavioral risk factors were observed more among patients with HAND compared to no-HAND. (who.int)
  • Biomarker discovery is complex and involves many phases. (medscape.com)
  • 7 Cicarrone Center for the Prevention of Cardiovascular Disease, Johns Hopkins University School of Medicine, Baltimore, MD, USA. (nih.gov)
  • Whether measurement of circulating biomarkers of coagulation and fibrinolysis could be useful for risk stratification in secondary prevention is currently not fully understood. (herts.ac.uk)
  • My group's research focuses on the cardiovascular risk associated with the spectrum of chronic kidney disease (CKD) from early in the disease trajectory through to kidney failure requiring either dialysis or kidney transplantation. (ed.ac.uk)
  • Cardiovascular disease is the commonest complication of kidney disease and cardiovascular risk is greatest in those with kidney failure. (ed.ac.uk)