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  • fibrosis
  • Nordic Bioscience has over 25 years' experience in biomarker development and clinical trials with extensive expertise in rheumatology and fibrosis. (bms.com)
  • The company has more than 25 years' experience in biomarker development and clinical trials and has acquired extensive expertise in rheumatology and fibrosis. (bms.com)
  • Fibrosis can be described as the excess deposition of extracellular matrix (ECM) components, such as collagens and proteoglycans. (springer.com)
  • Fibrosis may be described as extensive scar formation, observed as increased deposition and abnormal distribution of extracellular matrix (ECM) components, such as collagen and proteoglycans. (springer.com)
  • However, the problem of the development of biomarkers capable of non-invasive staging of fibrosis in the liver is difficult due to the fact that the process of fibrogenesis is a component of the normal healing response to injury, invasion by pathogens, and many other etiologic factors. (biomedcentral.com)
  • This review provides a systematic overview of these techniques, as well as both direct and indirect biomarkers based approaches used to stage fibrosis and covers recent developments in this rapidly advancing area. (biomedcentral.com)
  • OSCC
  • To identify potential biomarkers for the early detection of invasive OSCC, we compared the gene expressions of incident primary OSCC, oral dysplasia, and clinically normal oral tissue from surgical patients without head and neck cancer or preneoplastic oral lesions (controls), using Affymetrix U133 2.0 Plus arrays. (aacrjournals.org)
  • Subsequent modeling without these two markers showed that COL1A1 , encoding collagen, type I α1 chain, and PADI1 , encoding peptidyl arginine deiminase, type 1, could also distinguish OSCC from controls. (aacrjournals.org)
  • Differentially methylated oral squamous cell carcinoma (OSCC) biomarkers, identified in vitro and validated in well-characterized surgical specimens, have shown poor clinical correlation in cohorts with different risk profiles. (aacrjournals.org)
  • This phase I Biomarker Development Trial identified a panel of differentially methylated genes in normal and OSCC clinical samples from patients with heterogeneous risk profiles. (aacrjournals.org)
  • PATHOLOGY
  • However, previous efforts at identifying epigenomic biomarkers in HNSCC have been limited by candidate gene or cell culture-based discovery approaches and validation technologies on well-characterized pathology specimens from homogeneous cohorts, all of which have limited the clinical relevance of the results ( 11-13 ). (aacrjournals.org)
  • serum
  • LF markers including serum hyaluronic acid (HA), laminin (LN), procollagen type III (PC-III), type IV collagen (IV-C), matrix metalloproteinase (MMP), and tissue inhibitors of metalloproteinase (TIMP) were measured as primary outcomes. (biomedcentral.com)
  • diagnosis
  • NEW YORK & HERLEV, Denmark--( BUSINESS WIRE )-- Bristol-Myers Squibb Company (NYSE:BMY) and Nordic Bioscience , a Danish company specializing in biomarker technologies, today announced a collaboration agreement to develop biomarker technology to potentially aid in the diagnosis and monitoring of fibrotic diseases including Non-alcoholic steatohepatitis (NASH). (bms.com)
  • Thus, we suggest a combination of minimally-invasive diagnosis tools for human DCM recognition based on imaging techniques and measurements of related plasma biomarkers. (biomedcentral.com)
  • urinary
  • Recently, we have identified mesencephalic astrocyte-derived neurotrophic factor (MANF) and cysteine-rich with EGF-like domains 2 (CRELD2) as urinary ER stress biomarkers in ER stress-mediated kidney diseases. (springer.com)
  • identifies
  • The company invented C-terminal telopeptide (CTX), a biomarker that non-invasively identifies osteoporosis patients with a high rate of bone loss and can be used to assess response to osteoporosis therapy. (bms.com)
  • Our study identifies some novel corneal biomarkers that may help in screening patients prone to develop corneal haze prior to surgery. (arvojournals.org)
  • diagnostic
  • There is a big unmet need in medical and drug development for simple non-invasive diagnostic, early proof of efficacy of intervention and prognostic biomarkers in the NASH field. (bms.com)
  • This review will focus on the pathophysiologic, diagnostic, and therapeutic implications of biomarkers in ARDS and on their utility to ultimately improve patient care. (hindawi.com)
  • novel
  • Ongoing research aims at identifying and characterizing novel biomarkers, in order to highlight relevant mechanistic explorations of lung injury and repair, and to ultimately develop innovative therapeutic approaches for ARDS patients. (hindawi.com)
  • molecules
  • sort I collagen is likely one of the such a lot considerable molecules within the physique, taking part in crucial roles in several tissues, quite bone and pores and skin. (hoycomentamos.com)
  • van den Hooff had tentatively proposed that signal molecules emanating from the ECM, such as collagens and their peptides, could "contribute to at least one aspect of ultimate malignancy of neoplastic cells" [ 1 - 4 ]. (omicsonline.org)
  • development
  • We continue to invest in innovative approaches to develop more precise methods to diagnose disease and monitor progression and we are pleased to partner with Nordic Bioscience and leverage their vast experience in biomarker development. (bms.com)
  • Under the terms of the agreement, Bristol-Myers Squibb and Nordic Bioscience will collaborate in the development of translational biomarkers and diagnostics for the evaluation of NASH in pre-clinical models of fibrotic diseases and in clinical settings. (bms.com)
  • Nordic Bioscience is a Danish Biotech company dedicated to preclinical and clinical drug development, specializing in precision medicine using unique biomarker technologies. (bms.com)
  • Therefore, the development of non-invasive biomarkers of fibrogenesis may be important for the staging and monitoring of chronic liver disease, and may provide additional information on the pathogenesis. (springer.com)
  • Together with histology, podoplanin may serve as a powerful biomarker to predict the risk for oral cancer development in patients with OPL. (weirdprofile.info)
  • clinical
  • Biomarkers may help to identify patients at the highest risk of developing ARDS, assess response to therapy, predict outcome, and optimize enrollment in clinical trials. (hindawi.com)
  • Methods
  • A patent application entitled "Mesencephalic astrocyte-derived neurotrophic factor (MANF) as a urine biomarker for endoplasmic reticulum (ER) stress-related kidney disease, methods and uses therefore" has been filed by Y.M. Chen and Washington University Office of Technology Management (serial no. 14730465, filed on June 4, 2015). (springer.com)
  • Another patent application entitled "Methods of detecting biomarkers of endoplasmic reticulum (ER) stress-associated kidney diseases" has been filed by Y.M. Chen and Y. Kim and Washington University Office of Technology Management (serial no. 15664476, filed on July 31, 2017). (springer.com)
  • mice
  • Background Prokineticin 2 (PK2) manifestation is upregulated in mice with collagen-induced joint disease (CIA), an pet model of arthritis rheumatoid. (exposed-skin-care.net)
  • disease
  • A biomarker is a molecule that may be used to diagnose a disease, or predict disease progression and indicate response to therapy. (bms.com)
  • Glomerular crescent-related biomarkers in a murine model of chronic graft versus host disease," Nephrology Dialysis Transplantation , vol. 21, no. 2, pp. 288-298, 2006. (hindawi.com)
  • Additionally, this information could be completed with a quantification of specific plasma biomarkers related to related to initial stages of the disease. (biomedcentral.com)
  • Here, we review the recent advances in the identification of malarial biomarkers, focusing on those related to parasite exposure and disease susceptibility. (fiocruz.br)
  • biological
  • After a short description of ARDS pathobiology, here, we review the scientific evidence that supports the value of various ARDS biomarkers with regard to their major biological roles in ARDS-associated lung injury and/or repair. (hindawi.com)
  • help
  • As we discuss in this Personal Perspective, we believe that context and various changes in plasticity biomarkers can help identify at least three types of EMT and that using a collection of criteria for EMT increases the likelihood that everyone is studying the same phenomenon - namely, the transition of epithelial and endothelial cells to a motile phenotype. (jci.org)