Biology stem cells can differentiate. Medical search. Frequent questions

Over the last decades, mesenchymal stem cells (MSCs) have attracted extensive attention in the field of bone regeneration [ 4 - 7 ]. (hindawi.com)
Recently, mesenchymal stem cells (MSCs) have been suggested for use in the cell-based treatment of cartilage lesions. (researchgate.net)
The efficacy and safety profile of mesenchymal stem cells (MSCs) augmentation in chondral procedures are controversial. (springer.com)
Characterization of embryonic stem cell-differentiated fibroblasts as mesenchymal stem cells with robust expansion capacity and attenuated innate immunity. (usm.edu)
Because human mesenchymal stem cells are known to be sensitive to their mechanical environments, we investigated the mechanotransductive potential of Descemet membrane-like microtopography (DLT) to differentiate human mesenchymal stem cells into CEC-like cells. (lww.com)
Master molds with inverted DLT were produced by 2-photon lithography (2-PL). To measure the mechanotransductive potential of DLT, mesenchymal stem cells were cultivated on silicone or collagen imprints with DLT. (lww.com)
Mesenchymal Stem Cells (MSCs) are a heterogeneous subset of stromal stem cells that originate from the mesoderm layer of the fetus. (tocris.com)
Tocris offers the following scientific literature for Mesenchymal Stem Cells to showcase our products. (tocris.com)
Human mesenchymal stem cells (hMSCs) have emerged as a leading candidate in cellular therapies due to their unique properties. (selectscience.net)
Keywords: biliary tract tumor stem TCS PIM-1 1 cells exosomes gene appearance RNA genes paracrine signalling Bone tissue marrow-derived mesenchymal stem cells (MSCs) certainly are a potential way to obtain tissue replacement for TCS PIM-1 1 their regenerative capability and multipotent capacity. (sciencepop.org)
This innovative study by first-author Dr. Ani Grigoryan involved engineering mesenchymal stem cells and guiding them through a process mimicking how bones develop naturally in the human body. (lu.se)

Induced pluripotent stem cells, iPSCs, are mature, differentiated cells, such as skin cells, that are reprogrammed in the laboratory to be similar to undifferentiated embryonic stem cells. (jove.com)
The transcription factors then turn on genes that are expressed by embryonic stem cells. (jove.com)
These cells are also pluripotent like embryonic stem cells-able to produce all cell types-and are therefore called induced pluripotent stem cells (iPSCs). (jove.com)
The transcription factors then turn on many other genes that are expressed by embryonic stem cells, returning the cells to an undifferentiated, proliferative, and pluripotent state. (jove.com)
It is still being studied whether iPSCs are truly equivalent to embryonic stem cells, but they appear to be similar and can produce cells from all three germ layers of the body. (jove.com)
His current research projects utilize mouse embryonic stem cells as a model system to investigate the molecular mechanisms that control stem cell differentiation and the development of innate immunity. (usm.edu)
The Molecular Basis for the Lack of Inflammatory Responses in Mouse Embryonic Stem Cells and Their Differentiated Cells. (usm.edu)
Development of Antiviral Innate Immunity During In Vitro Differentiation of Mouse Embryonic Stem Cells. (usm.edu)
Attenuated Innate Immunity in Embryonic Stem Cells and Its Implications in Developmental Biology and Regenerative Medicine. (usm.edu)
Mouse embryonic stem cells are deficient in type I interferon expression in response to viral infections and double-stranded RNA. (usm.edu)
skin cells of the mouse into cells strikingly similar to embryonic stem cells, capable of development into a mouse. (brandeis.edu)
Depending on the source, stem cells can be classified into two broad categories i.e. embryonic stem cells that are derived from embryos and non-embryonic stem cells that are derived from adult and fetal tissues. (benthamscience.com)
The non-embryonic stem cells like adult stem cells are in clinical use for many years and embryonic stem cells are now emerging as an alternative source for the same purpose with huge potentials in drug discovery and toxicological studies. (benthamscience.com)
Embryonic stem cells (ESCs) can grow infinitely and give rise to all types of cells in human body, thus of tremendous therapeutic potentials for a variety of diseases, such as Parkinson's disease, spinal cord injury, and diabetes. (benthamscience.com)
Mouse nuclear transfer embryonic stem cells (NT-ESCs) were first established in 2000, and then proved to be able to differentiate either in vivo or in vitro, and give rise to individual tissues through germ line transmission or tetraploid complementation. (benthamscience.com)
An international collaboration has found for the first time that two new epigenetic regulators, TAF5L and TAF6L, maintain self-renewal of embryonic stem cells. (longdom.com)
Discoveries in fundamental basic research have revealed how human embryonic stem cells regulate gene expression to maintain pluripotency, how induced pluripotent stem cells retain a "memory" of their origin, and how adult stem cells differentiate in response to their environmental milieu. (ca.gov)
Embryonic stem cells (ESC) have the capacity to self-renew and remain pluripotent, while continuously providing a source of a variety of differentiated cell types. (lu.se)
More recently, she made a seminal discovery of a novel mechanism that controls cellular lifespan and telomere maintenance in mouse embryonic stem cells. (umaryland.edu)
We provide detailed protocols for lentiviral transduction, neural differentiation, and subsequent analysis of human embryonic stem cells. (lu.se)
Given this, human pluripotent stem cells, such as human embryonic stem cells (hESCs) and induced pluripo- tent stem cells (hiPSCs), have become a unique cell source for study- ing early human brain development. (lu.se)
Unlike earlier transcriptomics analyses using single-cell technologies, we observe that cells derived from human embryonic stem cells (hESCs) in the grafts adopt mature dopaminergic signatures. (lu.se)

A project funded by the U.K.'s Technology Strategy Board investigates the production of pluripotent and differentiated stem cells in microplate formats, for applications such as compound library screening for drug discovery. (genengnews.com)
That is, they divide and are pluripotent, able to produce any cell type in the body. (jove.com)
Reprogramming" of adult differentiated cells into pluripotent stem cells is an exciting method in biology that holds enormous promise for rejuvenation biotechnology. (sens.org)
By adding three genes, they converted those cells into induced pluripotent stem cells (iPSCs), which have the capability to differentiate into any cell types in the body. (scienceblog.com)
For the study, the research team, led by INBT alum Quinton Smith and postdoctoral fellow Nash Rochman, placed human induced pluripotent stem cells, called hiSPCs, in patterns shaped like stars, circles, triangles, and hearts. (jhu.edu)
Drs. John B. Gurdon, Irving L. Weissman, and Shinya Yamanaka have been pioneers in studying stem cells and the reprogramming of highly differentiated adult cells into pluripotent cells capable of directing differentiation from a single cell to an adult animal. (brandeis.edu)
The awards will be given March 26 in a private reception, following a free public symposium entitled "Generation of Pluripotent Stem Cells. (brandeis.edu)
Kuldip S. Sidhu , " Frontiers in Pluripotent Stem Cells Research and Therapeutic Potentials Bench-to-Bedside ", Bentham Science Publishers (2012). (benthamscience.com)
Induced pluripotent stem cells, another types of pluripotent stem cells derived from any tissue by reprogramming and are the homologous source of stem cells. (benthamscience.com)
Bhatia's team spent more than six years delving down to the cellular level to examine what they say are previously overlooked cells that form on the edges of pluripotent stem cell colonies. (longdom.com)
Generation of Pluripotent Stem Cells and their Developmental Potential" by Brock J. Conley, Mark Denham et al. (edu.au)
More recently, advances in medical biology have shown that the genomic state of a somatic cell can be altered or 'reprogrammed' to become pluripotent. (edu.au)
This is a significant leap forward for obtaining patient-specific pluripotent stem cells that can then be differentiated to the cell type of interest. (edu.au)
Generation of reprogrammed somatic cells, known as induced pluripotent stem (iPS) cells, was initially performed by ectopic expression of four transcription factors, however, now this process is becoming more streamlined by improved methods. (edu.au)
The various ways in which pluripotent stem cells are generated, particularly in relation to induced pluripotency, are also discussed. (edu.au)
Finally an outline of disease-specific pluripotent stem cells is reviewed within the context of their capacity to generate the cell type of interest. (edu.au)
We apply our method to study differences between human pluripotent stem cells and several cell types including their parental cell line and differentiated progeny. (nature.com)
To get a new insight into pluripotency, we employed a plurifaceted experimental design combining expression proteomics with the proteome-wide integral solubility alteration (PISA) assay 7 to compare pluripotent cells with their isogenic progenies and parental cells as well as with allogeneic cells. (nature.com)
Learn how advances in human induced pluripotent stem cell (iPSC) technology enable early detection and avoidance of neuro-, cardio-, and hepatotoxicity during drug development. (norecopa.no)
Written by Rebecca Quelch and Stefan Przyborski from Durham University (UK), this poster describes the isolation of pluripotent stem cells, their maintenance in culture, differentiation, and the generation and potential uses of organoids. (tocris.com)
This laboratory is one of the pioneers in establishing disease models and cell therapies using the human induced pluripotent stem cell (iPSC) platform and has published extensively in this area. (postdocjobs.com)
Ongoing and future applications include 100-port valves and systems for optimizing the differentiation of induced pluripotent stem cells, a 10,000 channel yeast MicroChemostat, and a MicroDialysis imager, all with direct injection into a mass spectrometer. (selectbiosciences.com)
To model these polygenic disorders, we generate pluripotent stem cell cultures from a sample of the patient's skin cells. (libd.org)
Normal histiocytes originate from pluripotent stem cells, which can be found in bone marrow. (medscape.com)
Chad and I have both been principal investigators on the induced pluripotent stem cell (IPSC) grant. (medscape.com)
I fell in love with the idea of human pluripotent stem cells and started surveying the United States and even Europe for who was playing in that area. (medscape.com)
Many existing protocols for neuronal differentiation of human pluripotent cells result in heterogeneous cell populations and unsynchronized differentiation, necessitating the development of methods for labeling specific cell populations. (lu.se)
This strategy provides a useful tool for visualization and identification of neural progeny derived from human pluripotent stem cells. (lu.se)
However, current protocols for deriving neurons from human pluripotent stem cells give rise to heterogeneous cell populations both in regard to the temporal aspects and the cellular composition. (lu.se)
These strat- egies provide a robust way to visualize and isolate specific cell pop- ulations of differentiated pluripotent stem cells. (lu.se)
Pluripotent stem cells can also be committed to produce dendritic cells. (medscape.com)
Sozzi E, Nilsson F, Kajtez J, Parmar M, Fiorenzano A. Generation of Human Ventral Midbrain Organoids Derived from Pluripotent Stem Cells . (lu.se)

In this study, we verified that exosomes derived from osteogenically differentiated ADSCs can promote osteogenic differentiation of ADSCs. (hindawi.com)
The results of these analyses revealed that the differentially expressed exosomal miRNAs participate in multiple biological processes, such as gene expression, synthesis of biomolecules, cell development, differentiation, and signal transduction, among others. (hindawi.com)
Most of these paracrine secretions include soluble factors and exosomes, which regulate the repair and regeneration processes at sites of damage by affecting cell proliferation, migration, and differentiation [ 22 , 23 ]. (hindawi.com)
High variability and low consistency are major problems in manual stem cell culture processes, for both growth of stem cells and their differentiation into pre-defined cell types. (genengnews.com)
This minimizes fluctuations in environmental conditions that have been shown to impact on both cell growth over multiple passages and on the ultimate differentiation into specific cell types. (genengnews.com)
As with other types of stem cells, scientists are learning how to promote the differentiation of specific cell types from iPSCs efficiently, so that the needed cell types can be produced in adequate quantities. (jove.com)
Stem cells are not specialized and the process of their specialization is called differentiation. (benthamscience.com)
Advances in bioengineering have addressed problems of how to control growth and differentiation of stem cells using novel biomaterials, how to sort and purify specific stem cell products, and how to deliver and sustain stem cell grafts in vivo. (ca.gov)
Huang and Chang then looked at the proteins GATA1 and PU.1, transcription factors that normally favor differentiation into red and white blood cells, respectively. (sciencedaily.com)
Written by Kirsty E. Clarke, Victoria B. Christie, Andy Whiting and Stefan A. Przyborski, this review provides an overview of the use of small molecules in the control of stem cell growth and differentiation. (tocris.com)
This poster summarizes some key protocols demonstrating the use of small molecules across the stem cell workflow, from reprogramming, through self-renewal, storage and differentiation to verification. (tocris.com)
Our Stem Cells review gives an overview of the use of small molecules in the control of stem cell growth & differentiation and somatic cell reprogramming. (tocris.com)
BioTek's Cytation™ 5 Cell Imaging Multi-Mode Reader was used to monitor spheroids in the inserts during the differentiation process using the brightfield channel, as well as to capture fluorescent images to verify protein marker expression and chondrocyte differentiation. (selectscience.net)
To conclude tumour cell-derived EVs can donate to the era of tumour stroma through fibroblastic differentiation of MSCs and will also selectively modulate the mobile discharge of soluble elements such as for example IL-6 by MSCs that may subsequently alter tumour cell proliferation. (sciencepop.org)
In stratified epithelia proliferative basal cells adherent to the underlying basement membrane undergo cell cycle arrest then outward migration and terminal differentiation. (stanford.edu)
This process is mediated by 2 mutually exclusive programs of gene expression: 1) an undifferentiated program supporting proliferation by stem cells within the basal layer and 2) a differentiation program instructing growth arrest and differentiation-associated programmed cell death in suprabasal layers. (stanford.edu)
We are currently pursuing studies of the dominant signaling and gene regulatory networks that control this process, including the Ras/MAPK cascade, which is required for stem cell-mediated self-renewal and the p53 transcription factor family member, p63, which is required for epidermal differentiation. (stanford.edu)
The function of histone modifying epigenetic regulators and noncoding RNA as central mediators of epithelial stem cell renewal and differentiation represent major emerging areas of study in the lab. (stanford.edu)
At these sites, which are a compound of stromal cells, extracellular matrix and soluble factors, complex molecular interactions that maintain the essential properties of stem cells occur, such as self-renewal and differentiation into multiple lineages, according to the organism's needs. (bvsalud.org)
Despite increasing refinement of differentiation protocols and standardization of the transplanted neural precursors, the transcriptomic analysis of cells in the transplant after its full maturation in vivo has not been thoroughly investigated. (lu.se)

Blau is known for her support of women in science and success in mentoring numerous young scientists who comprise the next generation of academic leaders in muscle biology and regenerative medicine. (wikipedia.org)
Her discoveries fostered the development of the field of stem cell biology and regenerative medicine. (wikipedia.org)
She showed that stem cells lose their regenerative potential when grown in traditional plastic dishes and overcame this limitation by fabricating bioengineered microenvironments that mimic crucial stem cell niche and tissue properties. (wikipedia.org)
By transiently alleviating these brakes on the cell cycle, post-mitotic cells are induced to divide, reconstituting a regenerative cell source. (wikipedia.org)
Non-invasive bioluminescence imaging enables highly sensitive temporal and spatial resolution of muscle stem cell regenerative function in vivo. (wikipedia.org)
Therefore, understanding how tissue-specific stem cells can accurately renew tissues is an important aim of regenerative medicine. (nih.gov)
The regenerative medicine bioprocessing program within the UCL department of biochemical engineering focuses on two areas: regenerative medicine translation and bioprocess engineering of stem cells. (genengnews.com)
This form of cellular research is essential to the study of regenerative medicine, which focuses on replacing or repairing damaged tissue, often through the use of stem cells, a special population of cells that can give rise to all tissues in the body. (jhu.edu)
Bioengineers face the central question of regenerative medicine: what causes stem cells to grow, organize, and mature from a small population of cells to complex organs? (jhu.edu)
The study advances one of the primary goals of regenerative medicine researchers to one day repair damaged tissues using a patient's own cells. (jhu.edu)
Dr. Irving L. Weissman is professor of pathology and developmental biology at the Stanford University School of Medicine , where he is director of the Institute of Stem Cell Biology and Regenerative Medicine. (brandeis.edu)
Stem cells are emerging as an important source of material for diseases in regenerative medicine. (benthamscience.com)
The study of biology of stem cells is the hallmark of the recent emerging field of regenerative medicine and medical biotechnology. (benthamscience.com)
While analyzing the revenue growth of Stem Cell Research and Regenerative Medicine functions, it highly developed from $150 billion USD to $250 billion USD since from 2010-2015. (longdom.com)
Research carried out in the facility has made significant, high impact contributions in three areas of stem cell research: Molecular Mechanisms/Basic Science, Translational Bioengineering, and Regenerative Medicine. (ca.gov)
Detailed characterization of cell type transitions is essential for cell biology in general and particularly for the development of stem cell-based therapies in regenerative medicine. (nature.com)
Assistant Professor of Biology Luis Villa-Diaz, Ph.D. was awarded a $550,178 National Science Foundation grant to advance his research on the potential for stem cells to change their identity and become specialized, differentiated cells - a process that has significant implications for regenerative medicine. (oakland.edu)
Understanding what governs these properties at the molecular level is crucial for stem cell biology and its application to regenerative medicine. (lu.se)
Dr. Yanhong Shi's lab is looking for highly motivated and productive postdoctoral fellows for stem cell research projects within the Department of Stem Cell Biology and Regenerative Medicine (Shi laboratory) at Beckman Research Institute of City of Hope located in the county of Los Angeles, California. (postdocjobs.com)
They may also serve as an unlimited source of therapeutically active cells for regenerative medi- cine. (lu.se)
Each year, the Lund Stem Cell Center recognizes notable scientific achievements made by our members in the fields of stem cell biology and regenerative medicine through our Article of the Year Award. (lu.se)
This recognition highlights the outstanding contributions made by our members in advancing the fields of stem cell biology and regenerative medicine. (lu.se)

To create iPSCs, mature cells, like skin fibroblasts, are taken from a patient and put into culture. (jove.com)
To create iPSCs, mature cells such as skin fibroblasts or blood cells from a person are grown in culture. (jove.com)
Xu and his team, which includes researchers from Penn's departments of Dermatology and Biology, as well as the New Jersey Institute of Technology, started with human skin cells called dermal fibroblasts. (scienceblog.com)
Peritoneal cavity is rich in number of cells like mesothelial cells, fibroblasts, endothelial cells, adipocytes and immune cells like macrophages, T cells, B cells, mast cells. (ukessays.com)
Inside the tumour microenvironment MSCs can differentiate into myofibroblasts cancer-associated fibroblasts fibrocytes or pericytes and thus represent a potential way to obtain tumour stroma and desmoplasia (4-6). (sciencepop.org)
This development occurs under the influence of macrophage colony-stimulating factor (M-CSF), which is secreted by various cell types (eg, endothelial cells, fibroblasts). (msdmanuals.com)
Pertoft H. and Fries E. (1995) Inter-a-inhibitor is required for the formation of the hyaluronan-containing coat on fibroblasts and mesothelial cells. (lu.se)

Our findings reveal ErbB activation as a strong inductive signal for stem-cell proliferation. (nature.com)
The fourteen high school students at the recent BIO International Convention in Chicago were more interested in how to differentiate stem cells into pancreatic endoderm, which factors inhibit cell proliferation in glioblastomas, and why an antioxidant has anti-angiogenic effects on epithelial ovarian cancer. (the-scientist.com)
Tumour cells can connect to other cellular components within the neighborhood microenvironment by cell-cell connections and paracrine systems through the creation and discharge of a number of development elements chemokines and matrix-degrading enzymes that may improve the proliferation and invasion of tumour (21). (sciencepop.org)
Each category of histiocytosis can be traced to reactive or neoplastic proliferation in one of these cell lineages. (medscape.com)
Chronic myelogenous leukemia (CML), also known as chronic myeloid leukemia, is a myeloproliferative disorder characterized by increased proliferation of the granulocytic cell line without the loss of their capacity to differentiate. (medscape.com)

Recently, a number of studies have confirmed that ADSCs possess the ability to differentiate into adipocytes, osteoblasts, and chondrocytes [ 16 - 18 ], suggesting that a broader source of stem cells is available for application in tissue engineering. (hindawi.com)
They can differentiate into cells of the mesodermal lineage, such as adipocytes, and osteocytes. (tocris.com)
Under the suitable environment these cells could be induced to differentiate into osteocytes adipocytes chondrocytes and myocytes (1-3). (sciencepop.org)

MSCs are a population of nonhematopoietic adult stem cells that have the property of self-renewal and can differentiate into multiple lineages [ 8 - 10 ]. (hindawi.com)
The findings also help explain why the process of differentiating stem cells into specific lineages in the laboratory has been highly inefficient. (sciencedaily.com)

Together, she and Anderson designed a sealed, self-contained cell incubation system that is mobile and eliminates many of the problems with cultivating tissues in the fragile environment of the petri dish. (al.com)
Interestingly, the patterns' edges became densely packed with cells that organized and matured differently than the cells in the center, and expressed precursor markers that give rise to tissues such as the heart, muscle, and blood vessels. (jhu.edu)
As cells congregated and became more crowded at the edges of the shapes, they experienced more tension than the cells in the interior of the pattern, which seemed to trigger self-organization and the expression of those precursors that give rise to tissues. (jhu.edu)
This research shows how satellite cells can maintain their populations within injured tissues," said Olwin. (phys.org)
Stem cells have potential as a source of cells and tissues for research and treatment of disease. (tocris.com)
Organ-on-chips are miniaturized devices that arrange living cells to simulate functional subunits of tissues and organs. (selectbiosciences.com)
Skin malignancies, including epidermal squamous cell carcinoma (SCC), alone account for nearly as many cancers as all other tissues combined. (stanford.edu)
Histiocytoses encompass a group of diverse proliferative disorders characterized by the accumulation and infiltration of variable numbers of monocytes, macrophages, and dendritic cells in the affected tissues. (medscape.com)
Dendritic cells display a large amount of MHC-peptide complexes at their surface and can increase the expression of costimulatory receptors and migrate to the lymph nodes, spleen, and other lymphoid tissues, where they activate specific T cells. (medscape.com)
We develop and analyse models of biological networks to improve our understanding of how living cells and tissues function. (lu.se)
Understanding how stem cells behave in the niche is extremely important in order to extract these cells from their natural habitat, expand them in vitro and transplant the stem cells back to the patient, to repair and/or regenerate tissues and organs, with no risks to the individual's integrity. (bvsalud.org)
Likewise, the knowledge of stem cell biology is crucial to the development of stem cell therapies, based on tissue engineering applied to dentistry, seeking the regeneration of dental tissues damaged or lost by caries, trauma or genetic diseases. (bvsalud.org)
Therapies based on the application of stem cells have great potential in the prevention and treatment of several diseases, such as cancer, diabetes, cardiovascular disease, spinal cord injuries, neurological diseases such as Parkinson's and Alzheimer's, and in the regeneration of various tissues and organs. (bvsalud.org)
Dendritic cells are present in the skin (as Langerhans cells), lymph nodes, and tissues throughout the body. (msdmanuals.com)
Macrophages are phagocytic cells present in tissues throughout the body. (msdmanuals.com)
The stem cells suits human needs, does not cause harm and can be obtained from both adult and fetal does not conflict with religious beliefs, it has tissues, umbilical cord and early embryos. (who.int)

Now, for the first time, Dr. Su-Chun Zhang and coworkers at the University of Wisconsin-Madison have successfully generated neurons from reprogrammed nonhuman primate cells, transplanted them back into the same animal's brain, and seen them successfully and cleanly integrate into the local tissue. (sens.org)
iCell GlutaNeurons are a population of excitatory neurons that bring previously inaccessible human biology to the lab bench for both discovery and toxicity (seizurogenic) investigations. (norecopa.no)
Our scientists then differentiate these patient-derived stem cells into neurons that represent 2D and 3D models of the human brain. (libd.org)
We provide detailed protocols for the generation of lentiviral vectors, the transduction of hES-cells, and their differentia- tion into neurons. (lu.se)
for example, we study how immune system cells decide to mature or how skin cells can be directly reprogrammed into neurons or stem cells. (lu.se)
Deconvolution shows dopamine neurons being the dominating cell type in many features beneath the graft area. (lu.se)

Critical to the hypothesis is the experimental fact that human endometrial-derived stem cells (hEnSCs) as multipotent accessible source of cells are known as useful cell candidates in the field of nerve tissue engineering. (scirp.org)
These novel differentiated cells in fibrin gel might open new opportunities for the management of cell survival and neurotrophic potential in tissue engineering approaches for nerve repair. (scirp.org)
Improper regulation of adult stem cells and tissue homeostasis can result in cancers and age-dependent decline. (nih.gov)
It will allow us, as researchers, to not live in the lab and control our tissue culture conditions, including the sensitive cultures including those like adult stem cells. (al.com)
Among these, adipose-derived stem cells (ADSCs) are a type of mesenchymal stem cell isolated from adipose tissue, which has the advantages of abundant storage in vivo , easy acquisition, and expansion [ 13 - 15 ]. (hindawi.com)
For example, retinal cells that could be used to replace damaged retinal tissue. (jove.com)
Cellulose nanofibers (CNF) hydrogel has great potential as a cell-encapsulation delivery carrier for sustained release of paracrine factors and for tissue regeneration, with unique versatility for injection, scaffolding, and 3D bioprinting. (longdom.com)
Peritoneum is defined as gliding membrane, composed of mesothelial cells maintained by basement membrane and thin layer of connective tissue. (ukessays.com)
A University of Colorado at Boulder research team has identified a type of skeletal muscle stem cell that contributes to the repair of damaged muscles in mice, which could have important implications in the treatment of injured, diseased or aging muscle tissue in humans, including the ravages of muscular dystrophy. (phys.org)
The newly identified stem cells are found within populations of satellite cells located between muscle fibers and the surrounding connective tissue that are responsible for the repair and maintenance of skeletal muscles, said Professor Bradley Olwin of CU-Boulder's molecular, cellular and developmental biology department. (phys.org)
The stem cell population identified by the CU team within the satellite cells -- dubbed "satellite-SP" cells -- were shown to renew the satellite cell population after injection into injured muscle cells, contributing to recovery of muscle tissue in the laboratory mice. (phys.org)
In healthy skeletal muscle tissue, the population of satellite cells is constantly maintained, leading the CU-Boulder team to believe that at least some of the satellite cell population in the mouse study included stem cells. (phys.org)
For the study, the researchers injected 2,500 satellite-SP cells into a population of satellite cells within injured mouse muscle tissue. (phys.org)
They found that 75 percent of the satellite cells that reproduced were derived from the previous satellite-SP cells injected into the tissue. (phys.org)
iCell Hepatocytes 2.0 maintain appropriate function longer than existing models and over extended culture periods, thus providing a relevant means for acute and sub-chronic toxicity testing in human tissue cells. (norecopa.no)
The Zalzman laboratory generated a stem cell bank from adult tissue sources such as, bone, tonsils and adipose tissue. (umaryland.edu)
Our experimental focus is on the mammalian setting using multiomics, informatics, mouse genetics, human genetics, single cell studies, and new human tissue platforms. (stanford.edu)
Niches are special microenvironments in tissue where stem cells are located. (bvsalud.org)
Likewise, these cells give rise to progenitor cells committed to a particular cell lineage, and play a crucial role in tissue repair and homeostasis. (bvsalud.org)
Here, we present spatial transcriptomics analysis of fully differentiated grafts in their host tissue. (lu.se)
One of the greatest controversies triggered tissue, a stem cell encoding for heart tissue by the rapid pace of evolution in biology, will eventually develop into heart tissue particularly in genomics and biotechnology, and so on. (who.int)

The bioprocess engineering aspect of this work deals with the critical challenge of developing reliable processes for the preparation of homogenous populations of stem cells and their progeny. (genengnews.com)
The findings, published in the May 22 issue of Nature, give a glimpse into how that collective behavior works, and show that cell populations maintain a built-in variability that nature can harness for change under the right conditions. (sciencedaily.com)
They began by examining populations of seemingly identical blood stem cells, and found that a cell marker of "stemness," a protein called Sca-1, was actually present in highly variable amounts from cell to cell -- in fact, they found a 1,000-fold range. (sciencedaily.com)
Here we describe how microRNA-regulated lentiviral vectors can be used to visualize specific cell populations by exploiting endogenous microRNA expression patterns. (lu.se)
To track differentiating cell populations, reporter cell lines generated by homologous recombination (knock-in) or via BAC transgenes have been widely used in mouse cells (5-8 ). (lu.se)
Such systems biology models can, for example, describe how whole populations interact with their environment, how individual cells choose to differentiate into different cell types, or how multicellular systems form patterns and grow new organs in two or three dimensions. (lu.se)
But when it comes to studying diverse populations of cells, this approach can fall short and an extra dimension is needed. (lu.se)

Molecular Systems Biology. (tudelft.nl)
Euro Stem Cells 2019 aims in proclaim knowledge and share new ideas amongst the professionals, industrialists and students from research area of ' Stem Cell Research and Molecular Biology ' to share their research experiences and indulge in interactive discussions at the event. (longdom.com)
Stem Cell Research and Molecular Biology is the latest trending research in many fields especially in Organ cancer: breast, oral, head and neck Cancer Myeloid, lymphoid leukaemia's, cancer treatments etc. (longdom.com)
In such case more Stem Cells research institutes were newly introduced within market which obviously shows the market growth of Stem Cell Research and Molecular Biology. (longdom.com)
This major molecular response that the scientists investigated implies that, within the limits of our technical means, we can no longer detect the biomarkers indicating the presence of the residual nidus of leukemic cells. (cea.fr)
Using our integrative proteomics approach and the web-based tool, we uncover a molecular basis for the uncoupling of robust transcription from parsimonious translation in stem cells and propose a method for maintaining pluripotency in vitro. (nature.com)
Understanding transitions from one cell type or state to another is in the focus of modern molecular biology. (nature.com)
Of particular relevance is to elucidate those molecular interactions which govern the reprogramming of somatic cells into ESC. (lu.se)
A Ph.D., M.D. & Ph.D., or equivalent in biomedical research, with experience in cell culture and basic molecular biology. (postdocjobs.com)
Strong molecular biology background is preferred. (postdocjobs.com)
Dr. Zalzman is a molecular cell biologist and a stem-cells expert who made significant discoveries related to telomere biology and cellular lifespan. (umaryland.edu)
Androgen or antagonist's cellular treatments and knockdown experiments were used to detect changes in cell morphology, molecular markers, migration properties and in vivo tumour growth. (bvsalud.org)
He has over 21 years of experience in molecular biology and biochemistry of enteroviruses. (cdc.gov)
Through his leadership, his team developed molecular assays to detect, differentiate and identify picornaviruses. (cdc.gov)

Her landmark papers showed that nuclear reprogramming and the activation of novel programs of gene expression were possible, overturning the prevailing view that the differentiated state was fixed and irreversible. (wikipedia.org)
Using single cell lineage tracking and the Baxter algorithms her lab developed, cell morphology, movement, cell-cell interactions, division behavior and gene expression can be dynamically monitored, resolving the cellular basis for population changes, in response to pharmacologic interventions. (wikipedia.org)
Comparison of the gene expression patterns of the human iPSC-derived epithelial stem cells with epithelial stem cells obtained from human hair follicles showed that the team had succeeded in producing the cells they set out to make in the first place. (scienceblog.com)
Epigenetic control of gene expression lasts through multiple cell divisions without alterations in primary DNA sequence and can occur via mechanisms that include histone modification and DNA methylation. (stanford.edu)

Blau's ongoing research focuses on cellular reprogramming, therapeutic interventions to enhance stem cell function in muscle regeneration, and cell rejuvenation strategies. (wikipedia.org)
He was the first to appreciate the therapeutic potential of stem cell therapy and has pioneered its development. (brandeis.edu)
The work also suggests a much more efficient way of differentiating stem cells for therapeutic purposes. (sciencedaily.com)
Although ES cells may be ideal in terms of their pluripotency, from a therapeutic point of view, their great disadvantage is that they are not patient derived. (edu.au)
The François-Jacob Biology Institute, in collaboration with the Department of Hematology and Oncology at the Mignot Hospital in Versailles, France, has developed a therapeutic strategy to treat the residual disease of chronic myeloid leukemia (LMC). (cea.fr)
The Shi laboratory has established protocols for differentiating human iPSCs into a variety of cell types, including brain cells, blood cells, and organoids, and has developed cellular models and cell therapeutic candidates for diseases including Alzheimer's disease, Canavan disease, and glioblastoma. (postdocjobs.com)
Research scientists are using cell and animal models to understand the basic mechanisms that cause neurodevelopmental disorders in order to identify therapeutic targets. (libd.org)
Understanding the efforts of MSCs to tumour biology is certainly worth focusing on because they could result in brand-new therapeutic or precautionary paradigms. (sciencepop.org)
This cell then has therapeutic cloning: the global the capacity to divide and grow into an exact replica of the original from whom the debate somatic cell was taken. (who.int)

2 Despite having high metabolic activity, human CECs (hCECs) do not proliferate in vivo because these cells arrest in the G1 phase of the cell cycle. (lww.com)

Exploiting a rare combination of samples and technical platforms, we are carrying out a large-scale association study with high phenotyping resolution and including both differentiated cells and stem- and progenitor cells. (lu.se)
The project will provide a first high-resolution analysis of how genetic variation influences blood cell formation, including at the stem- and progenitor levels, potentially exposing novel regulatory mechanisms that could be utilized to modulate blood cell formation for clinical benefit. (lu.se)

The Cellular Dynamics line of iCell® products are fully differentiated human cells derived from iPSCs. (norecopa.no)

Researchers have devised a novel biosensor that can isolate and target leukemic stem cells. (longdom.com)
Outside of the tumor mass is a subpopulation of leukemic stem cells that form the original source of cancer cells and are not completely eliminated by conventional therapy. (cea.fr)
The persistence of these resistant leukemic stem cells could explain the relapse observed in 50 to 60% of the patients when the treatments are stopped. (cea.fr)
After a series of studies originally focusing on HIV ( see here ), the team from the François-Jacob Institute has developed a therapy that combines the traditional treatment for LMC that targets differentiated cancer cells (imatibinib) with pioglitazone, which targets leukemic stem cells. (cea.fr)

Key signaling pathways are highlighted, and the regulation of ES cell self-renewal and somatic cell reprogramming is discussed. (tocris.com)

To overcome this obstacle, researchers in the department of biochemical engineering at University College London (UCL) recently developed an automated stem cell culture system in a microplate format, offering higher consistency and reproducibility, better protection of cells from contamination, and improved operator safety. (genengnews.com)
Still, he notes that stem-cell researchers are developing more workarounds, including strategies using only chemical agents. (scienceblog.com)
But recreating this niche environment is incredibly complex in a controlled setting, because researchers are still learning all the factors that influence cell behavior and growth. (jhu.edu)
In a new study, researchers have learned how a specific genetic mutation affects the maturation of blood cells in mouse models. (longdom.com)
Past and current users of the Laboratory for Stem Cell Biology and Engineering include 52 researchers from 18 research groups, representing collaborations with 12 companies and 17 different universities and research institutes. (ca.gov)
Past and current users of the Laboratory for Stem Cell Biology and Engineering include 58 researchers (6 new researchers in the past year) from 18 research groups, representing collaborations with 12 companies and 17 different universities and research institutes. (ca.gov)
Led by Sui Huang, MD, PhD, a Visiting Associate Professor in the Children's Hospital Boston Vascular Biology Program (now also on the faculty of the University of Calgary), and Hannah Chang, an MD/PhD student in Children's Vascular Biology Program, the researchers examined how blood stem cells "decide" to become white blood cell progenitors or red blood cell progenitors. (sciencedaily.com)
This interdisciplinary research is conducted in close collaboration with researchers in medicine and biology. (lu.se)
In today's world of science, single-cell sequencing technologies allow researchers to examine the genetic details of individual cells, creating a treasure trove of data. (lu.se)

Helen Margaret Blau is an American biologist and the Donald E. and Delia B. Baxter Foundation Professor and Director of the Baxter Laboratory for Stem Cell Biology at Stanford University School of Medicine. (wikipedia.org)
She was awarded an endowed chair in 1999 and named Director of the Baxter Laboratory for Stem Cell Biology in 2002. (wikipedia.org)
As reported in a Penn news release , Xiaowei "George" Xu, MD, PhD, associate professor of Pathology and Laboratory Medicine and Dermatology at the Perelman School of Medicine, University of Pennsylvania, and colleagues published in Nature Communications a method for converting adult cells into epithelial stem cells (EpSCs), the first time anyone has achieved this in either humans or mice. (scienceblog.com)
His laboratory has also identified human stem cells including human leukemia stem cells that have helped to form the concept of cancer stem cells. (brandeis.edu)
We have developed and renovated a 1400 sq. ft. shared-use stem cell laboratory called the Laboratory for Stem Cell Biology and Engineering. (ca.gov)
The overall mission of this laboratory is to facilitate and promote stem cell research by investigators at UCSB, as well as those at neighboring universities, research institutes, and biotechnology companies on the California central coast. (ca.gov)
The Shi laboratory has been well known for stem cell research, including stem cell-based disease modeling and cell therapy development. (postdocjobs.com)
The technology developed in the laboratory allows for the culture of adult stem cells in combination with 3D printing technology, which can be translated to novel therapies for bone regeneration and reconstruction. (umaryland.edu)
Our group also has connections to plant biology through the Sainsbury Laboratory at the University of Cambridge. (lu.se)

First, a hair follicle contains epithelial cells - a cell type that lines the body's vessels and cavities - as well as a specific kind of adult stem cell called dermal papillae. (scienceblog.com)
Some adult stem cell niches have already been described, but the majority of them remain unclear, including the dental pulp stem cell niches. (bvsalud.org)

Further, the team develops a novel stem cell therapy for the treatment of Parkinson's disease. (umaryland.edu)

The cells terminally differentiate as they migrate from the basal layer of the epidermis to the surface. (dictionary.com)
The stem cells within the basal layer, which contact the basement membrane, continually divide during the lifetime of the organism, providing a source of cells which progressively migrate upwards through the epidermis, differentiating and stratifying to form the barrier layer of the skin [ 11 , 14 ]. (springer.com)
[ 12 ] These cells can capture antigen and migrate to lymphoid organs, where they present the antigens to naive T cells. (medscape.com)

Morrison, S. J. & Spradling, A. C. Stem cells and niches: mechanisms that promote stem cell maintenance throughout life. (nature.com)
It is now a widely used model system to decipher regulatory mechanisms of stem cell biology. (nih.gov)

She is known for establishing the reversibility of the mammalian differentiated state. (wikipedia.org)
In the 1980s Dr. Blau's findings challenged the prevalent view that the mammalian differentiated state is fixed and irreversible. (wikipedia.org)

Hence malignant cells can "educate" MSCs to induce regional microenvironmental adjustments that enhance tumour cell development. (sciencepop.org)
A contribution of interactions between MSCs within tumour stroma and malignancy cells to tumour progression and metastases has been recognized (7-9). (sciencepop.org)
MSCs may contribute to tumour propagation or dissemination by preventing recognition of the tumour cells by the immune system or by promoting tumour cell invasiveness (10 11 However MSCs could also suppress tumour growth (12-15). (sciencepop.org)
Thus while MSCs may interact with tumour cells the consequences of these interactions and impact on tumour behaviour warrant definition and likely depend on other factors. (sciencepop.org)

Both academic and commercial collaborations are essential in this research, which addresses the complete stem cell process from donor or patient biopsy through to clinical implantation into the patient. (genengnews.com)
We need all these interdisciplinary approaches, which includes biology, engineering, and computational modeling, to ensure stem cells are stable, functional, and efficiently differentiate before using a hiPSCs source in a clinical setting," Smith said. (jhu.edu)
In a phase 2 clinical trial, scientists showed the efficiency of targeting cancer stem cells-an approach imagined and developed at the CEA François-Jacob Institute for the treatment of leukemia, chronic myeloid leukemia in particular. (cea.fr)
METHODS: Differential expression analyses using Genome Expression Omnibus (GEO) database, clinical samples and cell lines were performed. (bvsalud.org)
Cell therapy for Parkinson's disease has experienced substantial growth in the past decades with several ongoing clinical trials. (lu.se)

Here, we review recent findings on how adult intestinal stem cells differentiate, interact with their environment, and change during aging. (nih.gov)

However, scientists have found a way to reprogram these mature cells so that they "de-differentiate" and return to an unspecialized, proliferative state. (jove.com)
Scientists wanting to read the cell's history can either measure its GFP output, which will stay on continuously, or if the cell has died, they can retrieve the memory by sequencing its DNA. (sciencedaily.com)
The con- is removed and replaced by a nucleus of cept of human cloning has long been in the another cell type, the stem cell will then imagination of many scientists, scholars and be reprogrammed to produce the product fiction writers [ 1 ]. (who.int)

His demonstration that the expression of four master regulatory genes was sufficient to cause the reprogramming of adult cells has opened up many possibilities for human stem cell therapies. (brandeis.edu)
This full potentiality makes them particularly suitable for developing cell replacement therapies or establishing cellular model systems. (edu.au)
However, the worldwide shortages of corneal donor material generate a strong demand for personalized stem cell-based alternative therapies. (lww.com)
However, further studies are required to gain complete understanding of stem cell biology, which is fundamental for the development of successful cell-based therapies 1-3 . (bvsalud.org)

iPSCs are potentially valuable in medicine, because a patient who needs a particular cell type-for instance, someone with a damaged retina due to macular degeneration-could receive a transplant of the required cells, generated from another cell type in their own body. (jove.com)
Starting with procedures other research teams had previously worked out to convert iPSCs into keratinocytes, Xu's team demonstrated that by carefully controlling the timing of the growth factors the cells received, they could force the iPSCs to generate large numbers of epithelial stem cells. (scienceblog.com)
In the Xu study, the team's protocol succeeded in turning over 25% of the iPSCs into epithelial stem cells in 18 days. (scienceblog.com)
What's more, the process Xu used to create iPSCs involves genetic modification of human cells with genes encoding oncogenic proteins and so needs more refinement. (scienceblog.com)

My thesis project investigated the role of the immune system's microglia cells in Alzheimer's disease pathogenesis," Ran says. (harvard.edu)
In 1988 he first identified and isolated the blood-forming stem cells from mice and went on to define the stages of development between the stem cells and differentiated cells of the immune system. (brandeis.edu)
What is more, by deriving NT-ESCs from patient cells, the problem of immune rejection may be avoided. (benthamscience.com)
These studies have led to several findings, for example that certain cytokines are generated by beta cells themselves, sometimes under stress, and also that there are probably key factors that render beta cells susceptible to immune attacks. (selectbiosciences.com)
Mechanistically, the importance and meaning of these observations needs to be addressed in a suitable and easily manipulable in vitro system consisting of human islets and immune cells. (selectbiosciences.com)
The latter encompass human skin regenerated on immune deficient mice as well as organotypic constructs with epithelial and stromal cells embedded within architecturally faithful mesenchyma in vitro. (stanford.edu)
Effective induction of antigen-specific T-cell responses requires interaction between the dendritic cells and T lymphocytes to prime the latter cells for expansion and subsequent immune responses. (medscape.com)
Overview of the Immune System The immune system distinguishes self from nonself and eliminates potentially harmful nonself molecules and cells from the body. (msdmanuals.com)
Although some antigens (Ags) can stimulate the immune response directly, T cell-dependent acquired immune responses typically require antigen-presenting cells (APCs) to present antigen-derived peptides within major histocompatibility complex (MHC) molecules. (msdmanuals.com)
they have receptors for the crystallizable fragment (Fc) region of immunoglobulin (Ig) G and for complement, which enable them to bind with immune complexes and present the complex to B cells in germinal centers of secondary lymphoid organs. (msdmanuals.com)

Jain spent two and a half years working on her research with Matthias Falk, a cell biologist at Lehigh University, after contacting him during her freshman year of high school and asking to him to "give [her] a try" in his lab. (the-scientist.com)
Traditional methods for manual cultivation of stem cells often lead to high variability and low consistency, making development of robust experimental protocols for stem cell research extremely difficult. (genengnews.com)
Dr. Guo was employed as a Research Assistant Professor in the Sol Sherry Thrombosis Research Center at Temple University School of Medicine from 1999 to 2004 where he studied vascular biology and the process of angiogenesis. (usm.edu)
The 2009 Rosenstiel Award for Distinguished Work in Basic Medical Science will be awarded to three pioneers in stem cell research. (brandeis.edu)
The University of California at Santa Barbara (UCSB) is well positioned to make significant contributions by leveraging fundamental stem cell-based biomedical research efforts with enabling technologies in materials, microfluidics and bioengineering. (ca.gov)
Most importantly, examples of how iPSC-derived cell types can accelerate your research. (norecopa.no)
Our guide highlights the use of small molecules in stem cell research and cell therapy and lists relevant products. (tocris.com)
Materials and strategies Cell lines and lifestyle For these research we utilized TCS PIM-1 1 KMBC and HuCCT1 individual cholangiocarcinoma cells and H69 individual nonmalignant cholangiocyte cells. (sciencepop.org)
At International Society for Stem Cell Research-the big stem cell meeting-Yamanaka revealed one more factor. (medscape.com)
Among this years winners are studies that represent some of the ways in which we perceive and engage with stem cell research are being reshaped. (lu.se)
This paper outlines the debates prompted through a reproduction mechanism involv- by progress in cloning research, with special ing male and female germ cells. (who.int)
Johan Jakobsson, a professor at Lund University and research group leader at MultiPark and Lund Stem Cell Center, explains, "LINE-1 retrotransposons are a rich source of genetic sequences that we suspect have shaped the evolution of the human brain, and we now have the tools to explore their role in brain development. (lu.se)

Our idea is based on the fact that in LMC, as in many other types of cancer, the diseased cells are heterogeneous,' said CEA researcher Stéphane Prost. (cea.fr)

How deformable cells are, and thus how stiff or squishy they are, plays an important role in retaining blood-forming stem cells in their marrow niches and thus preserving their long-term repopulation capabilities. (longdom.com)

The new cells could then be transplanted back into the patient to treat damage or disease with minimal risk of rejection, because they originated from the patient's own cells. (jove.com)
What if doctors had a remote control that they could use to steer a patient's own cells to a wound to speed up the healing process? (longdom.com)

She has applied this approach to identify molecules that rejuvenate the function of the aged stem cell population and enhance muscle regeneration. (wikipedia.org)
Schwann cells (SCs) have important roles in development, myelination and regeneration in the peripheral nervous system. (scirp.org)
The Drosophila midgut harbors multipotent adult stem cells that are essential to renew the gut in homeostatic conditions and upon stress-induced regeneration. (nih.gov)
The epithelial stem cells, when implanted into immunocompromised mice, regenerated the different cell types of human skin and hair follicles, and even produced structurally recognizable hair shaft, raising the possibility that they may eventually enable hair regeneration in people. (scienceblog.com)

Loss of corneal endothelial cells (CECs) bears disastrous consequences for the patient, including corneal clouding and blindness. (lww.com)
1 If the number of corneal endothelial cells (CECs) falls below a certain threshold because of traumatic injury, disease, or normal aging processes, functionality of the CE is decreased, and the cornea swells and becomes milky, leading to eventual vision loss. (lww.com)

They then converted the iPS cells into epithelial stem cells, normally found at the bulge of hair follicles. (scienceblog.com)
This is the first time anyone has made scalable amounts of epithelial stem cells that are capable of generating the epithelial component of hair follicles," Xu says. (scienceblog.com)
That said, iPSC-derived epithelial stem cells are not yet ready for use in human subjects, Xu adds. (scienceblog.com)
The control of this transition from epithelial stem cell to differentiated corneocyte, which is abnormal in epidermal cancers, is not well understood. (stanford.edu)

We're thrilled to have Chad Cowan, an associate professor at Harvard University who is at the Harvard Stem Cell Institute. (medscape.com)

Developmental biology is the study of how living organisms develop from their earliest stages and grow to maturity. (encyclopedia.com)
Comparing them has led to many important advances in developmental biology. (encyclopedia.com)
At its core, developmental biology seeks to understand how an organism grows from a simple, undifferentiated form to a complex, specialized living thing. (encyclopedia.com)
The origins of developmental biology lie in the search to understand the phenomenon of evolution. (encyclopedia.com)
Thus modern developmental biology views development as the expression of a preformed genetic program which controls the epigenetic development of an undifferentiated egg into a morphologically complex adult. (encyclopedia.com)
Developmental Cell. (lu.se)

The importance of dendritic cells in presenting antigens to T and B lymphocytes is increasingly recognized. (medscape.com)
Dendritic cells appear to develop in several pathways. (medscape.com)
[ 11 ] Immature dendritic cells respond to GM-CSF (not to macrophage colony-stimulating factor [M-CSF]) and become committed to generating dendritic cells, which are "professional" antigen-presenting cells (APCs). (medscape.com)
[ 13 ] Dendritic cells are also efficient stimulators of B-cell lymphocytes. (medscape.com)
Dendritic cells in the skin act as sentinel APCs, taking up antigen, then traveling to local lymph nodes where they can activate T cells. (msdmanuals.com)
Follicular dendritic cells are a distinct lineage (a different cell type than conventional dendritic cells), do not express class II MHC molecules, and therefore do not present antigen to Th cells. (msdmanuals.com)

When they mixed those cells with mouse follicular inductive dermal cells and grafted them onto the skin of immunodeficient mice, they produced functional human epidermis (the outermost layers of skin cells) and follicles structurally similar to human hair follicles. (scienceblog.com)

HYPOTHESIS: Do LRIG Proteins Regulate Stem Cell Quiescence by Promoting BMP Signaling? (nature.com)
The conventional view of how stem cells differentiate assumes that cells are "instructed" to progress along prescribed signaling pathways. (sciencedaily.com)
A new study suggests that the conventional view, which assumes that cells are "instructed" to progress along prescribed signaling pathways, is too simplistic. (sciencedaily.com)

Xu and his team mixed iPSC-derived EpSCs and mouse dermal cells to generate hair follicles to achieve the growth of the follicles. (scienceblog.com)
Procedures for implementing iPSC-derived cell types in your lab. (norecopa.no)

Conversely, when stem cells were exposed to granulocyte--macrophage colony-stimulating factor, which stimulates white blood cell formation, those that were highest in Sca-1 were the most likely to become white cells. (sciencedaily.com)

Some study the cell growth, or how specialized cell types differentiate from stem cells. (encyclopedia.com)
Stem cells are undifferentiated cells that divide and produce different types of cells. (jove.com)
When a person loses hair, they lose both types of cells. (scienceblog.com)
The circuits, described in the Feb. 10 online edition of Nature Biotechnology , could be used as long-term environmental sensors, efficient controls for biomanufacturing, or to program stem cells to differentiate into other cell types. (sciencedaily.com)
Using stem cells to biologically augment the reconstruction of the tears might have a great potential since these cells can differentiate into various cell types that are integral for healing. (wellnessresources.com)
a Cells of different types in were grown simultaneously ( n = 3 biologically independent samples per cell type). (nature.com)
Stem cells are distinguished by their ability to renew themselves through cell division and differentiate into specialized cell types. (phys.org)

A computational approach can be used as a framework to explore the dynamics of a simplified network of the ESC with the aim to understand how stem cells differentiate and also how they can be reprogrammed from somatic cells. (lu.se)
Furthermore, the model (iv) provides a framework for reprogramming from somatic cells and conveys an understanding of reprogramming efficiency as a function of OCT4 over-expression. (lu.se)

Her discoveries opened the door for cellular reprogramming and its application to stem cell biology. (wikipedia.org)
It is strongly recommended that when using a reagent for the first time, users compare the spillover on cells and BD CompBeads to ensure that BD® CompBeads are appropriate for your specific cellular application. (bdbiosciences.com)
We detect alterations of protein properties in numerous cellular pathways and components including ribosome biogenesis and demonstrate that modulation of ribosome maturation through SBDS protein can be helpful for manipulating cell stemness in vitro. (nature.com)
An alternative solution mechanism where tumour cells can connect to the neighborhood microenvironment consists of inter-cellular communication relating to the discharge of extracellular vesicles (EVs) such as for example exosomes (22). (sciencepop.org)

The award's namesake, MCB faculty John Dowling , was impressed by Ran's investigation into the role of microglial cells' "engulfment" behavior in Alzheimer's risk. (harvard.edu)
When there is no cell tension, self-organization won't happen, indicating that mechanical confinement plays an important role in cell growth and behavior. (jhu.edu)
Instead, it supports the idea that cells differentiate through the collective behavior of multiple genes in a network that ultimately leads to just a few endpoints -- just as a marble on a hilltop can travel a nearly infinite number of downward paths, only to arrive in the same valley. (sciencedaily.com)
by discharge of EVs that may modulate receiver cell behavior (25). (sciencepop.org)

Along with cells, they contain cytokines and growth factors, like interleukin-1 (IL-1), Transforming growth factor-Î²1 (TGF-Î²1), Fibroblast growth factor (FGF), and Hepatocyte growth factor (HGF). (ukessays.com)
At infection sites, activated T cells secrete cytokines (eg, interferon-gamma [IFN-gamma]) that induce production of macrophage migration inhibitory factor, preventing macrophages from leaving. (msdmanuals.com)

Since endometrial stromal cells are easy to isolate, and expand rapidly from patients without leading to major ethical and technical problems. (scirp.org)

This body of work showed that the differentiated state requires continuous regulation and that a shift in the stoichiometry of trans-acting regulators induces nuclear reprogramming to another differentiated state. (wikipedia.org)
As ErbB-family ligands and receptors are highly expressed within the stem-cell niche 7 , we hypothesize that strong endogenous regulators must control the pathway in the stem-cell compartment. (nature.com)
It accounts for (i) the observed heterogeneity of key regulators, (ii) characterizes the ESC under certain external stimuli conditions and (iii) describes the occurrence of transitions from the ESC to the differentiated state. (lu.se)
In this project we explore an innovative, population-genetic approach to find regulators of blood cell formation. (lu.se)

Anatomy57

Organisms15

Diseases10

Chemicals and Drugs56

Analytical, Diagnostic and Therapeutic Techniques and Equipment55

Phenomena and Processes56

Disciplines and Occupations10

Technology, Industry, Agriculture4

Information Science3

Named Groups1

Health Care1

Mesenchymal stem11

Embryonic stem22

Pluripotent32

Differentiation20

Regenerative22

Fibroblasts7

Proliferation5

Adipocytes3

Lineages2

Tissues16

Neurons6

Tissue21

Populations7

Molecular14

Gene expression4

Therapeutic9

Vivo1

Progenitor2

Fully differentiated1

Leukemic stem cells4

Self-renewal1

Researchers9

Laboratory9

Adult stem2

Treatment of Parkinson's disease1

Migrate3

Mechanisms2

Mammalian2

MSCs4

Clinical5

Interact with their environment1

Scientists3

Therapies4

IPSCs4

Immune10

Research12

Heterogeneous1

Blood-forming st1

Patient's2

Regeneration4

Endothelial cells2

Epithelial stem4

Harvard Stem Cell Institute1

Developmental6

Dendritic cells6

Epidermis1

Signaling3

IPSC2

Granulocyte--macro1

Types7

Somatic2

Cellular4

Behavior4

Cytokines2

Stromal cells1

Regulators4