Ciliary neurotMutationsReceptor2001Acute lymphobl2023CellsGene expressionFetalCytokineDifferentiationRNAiProteinTranscription factorsDevelopmentalCNTFCellularReproductiveGlycoproteinFunctionalImmunologyChronic lymphocyProteinsGrowthReproductionElongationBiologicalArrestSecondaryFrontiersExpressionMolecularPreviouslyOccurChildhoodGenetic
Ciliary neurot2
- Both LIFR and gp130 are members of a family of cytokine receptors that includes components of the receptors for the majority of hematopoietic cytokines and for cytokines that affect other systems, including the ciliary neurotrophic factor, growth hormone and prolactin. (wikipedia.org)
- We have compared the immunological, biochemical, and biological properties of three previously described cholinergic factors, cholinergic differentiation factor/Leukemia inhibitory factor (CDF/UF), ciliary neurotrophic factor (CNTF), and membrane-associatedneurotransmitter-inducing substance (MANS). (caltech.edu)
Mutations5
- Leukemia inhibitory factor gene mutations in the population of infertile women are not restricted to nulligravid patients. (cdc.gov)
- The minisymposium, organized by Victor D. Vacquier, included the following presentations: "An Hypothesis to Explain the Evolution of Species-Specific Fertilization" by Victor D. Vacquier, "Molecular Biology of the Zona Pellucida: Genetic Mutations and Fertility" by Jurrein Dean, and "Sperm-Egg Membrane Interactions During Fertilizations" by Janice P. Evans. (bioone.org)
- There is strong evidence that inherited genetic factors (mutations plus single nucleotide polymorphisms) can play a major role in breast cancer susceptibility [ 1 ]. (hindawi.com)
- Specifically, we focused on understanding the disease mechanisms and studied two of the most common chromosomal translocations, or genetic mutations, that lead to pediatric leukemia. (lu.se)
- Some of these mutations, such as (mixed-lineage leukemia) MLL fusions, are highly aggressive and can generate leukemia very quickly. (lu.se)
Receptor4
- LIFR also known as CD118 (Cluster of Differentiation 118), is a subunit of a receptor for leukemia inhibitory factor. (wikipedia.org)
- Leukemia inhibitory factor receptor has been shown to interact with glycoprotein 130. (wikipedia.org)
- In the context of relapsed and refractory childhood pre-B cell acute lymphoblastic leukemia (R/R B-ALL), CD19-targeting chimeric antigen receptor (CAR)-T cells often induce durable remissions, which requires the persistence of CAR-T cells. (nature.com)
- Kim and Morshead, 2003), and the fibroblast that SSEA4 associated with CD133 can be used for growth factor (FGF) receptor 4 (Cai et al. (lu.se)
20011
- Translocations between MLL (a human trithorax -related gene) and AF4 or AF5q31 are involved in acute lymphoblastic leukemia (Wittwer, 2001, Tang, 2001 and Su, 2001). (sdbonline.org)
Acute lymphobl1
- B-lineage acute lymphoblastic leukemia (B-ALL) is the most common type of childhood cancer and mostly derives from immature B cells that carry the cell surface antigen CD19 (ref. 1 ). (nature.com)
20231
- American Journal Of Respiratory Cell And Molecular Biology 2023, 68: 75-89. (yalemedicine.org)
Cells20
- The leukemia inhibitory factor (LIF) is a polyfunctional cytokine that affects the differentiation, survival, and proliferation of a wide variety of cells in the adult and the embryo. (wikipedia.org)
- Deletion of HP1β, but not HP1α, in ESCs provokes a loss of the morphological and proliferative characteristics of embryonic pluripotent cells, reduces expression of pluripotency factors and causes aberrant differentiation. (biomedcentral.com)
- NBC involves molecular biology approaches and techniques involving mouse embryonic stem cells and mouse embryos that fall within the technical repertoire of laboratories addressing neurobiological and developmental questions. (researchsquare.com)
- While LIF induces the differentiation of several myeloid leukemia cells and inhibits their growth, it also promotes tumor progression, metastasis and chemoresistance in many solid tumors. (oncotarget.com)
- Leukemia inhibitory factor (LIF), a member of the interleukin-6 cytokine superfamily, is a pleiotropic protein expressed in multiple types of tissues and cells which regulates an array of important biological functions. (oncotarget.com)
- For example, LIF maintains the pluripotency of embryonic stem cells, while induces the differentiation of several myeloid leukemia cells and inhibits their growth [ 1 , 2 ]. (oncotarget.com)
- Differences in gene expression between wild type and Hoxa1 knockout embryonic stem cells after retinoic acid treatment or leukemia inhibitory factor (LIF) removal. (igbmc.fr)
- They are also found in transforming growth factor beta regulator 1 (TBRG1), a growth inhibitory protein induced in cells undergoing arrest in response to DNA damage and transforming growth factor (TGF)-beta1. (embl.de)
- Conclusion: For the protection of stem cells against apoptosis, different pathways, namely Phosphoinositide 3-Kinase (PI3K/AKT), Hypoxia-Inducible Factor (HIF1), Mitogen-Activated Protein Kinases (MAPK) and Hippo, are discussed. (benthamscience.com)
- Discussion: Activation of the PI3K/AKT pathway decreases the concentration of apoptotic factors, while the HIF pathway protects stem cells against the micro-environment of tissue (hypoxia). (benthamscience.com)
- An exception was long-lived CAR-T cells in two adult individuals with a different cancer-chronic lymphocytic leukemia (CLL)-in whom anti-CD19 CAR-T cells have persisted for almost a decade thus far 7 . (nature.com)
- To generate EBs, ES cells were dissociated into a suspension of single cells using trypsin and then diluted to 10,000 cells/ml in 6-well petri dishs (Corning) in ES medium (see growth conditions for ES cells) lacking leukemia inhibitory factor (LIF). (nih.gov)
- Chronic myeloid leukemia (CML) results from BCR-ABL oncogene, which blocks CML cells differentiation and protects these cells from apoptosis. (jcancer.org)
- Chronic myeloid leukemia (CML) is a clonal expansion of the progenitor hematopoietic stem cells arising from the existence of the fusion BCR-ABL oncogene, that represents 15%-20% of the newly diagnosed cases of leukemia patients [ 1 - 2 ]. (jcancer.org)
- Embryonic stem (ES) cells are naturally derived from early stage embryos and induced pluripotent stem (iPS) cells are reprogrammed from somatic cells with overexpression of four reprogramming factors, Oct4, Sox2, Klf4 and c-Myc. (biomedcentral.com)
- Both ES cells and iPS cells are pluripotent stem cells with capabilities of indefinite self-renewal and can be differentiated into almost all cell types of the body, which make them valuable for studying early developmental biology, for modeling and as therapy for human diseases. (biomedcentral.com)
- Mouse ES cells have been widely utilized as an in vitro model to study cardiogenesis, as cardiomyocytes were found to spontaneously differentiate from ES cells after withdrawal of LIF (leukemia inhibitory factor), which functions to maintain the pluripotency of undifferentiated mouse ES cells [ 2 - 4 ]. (biomedcentral.com)
- Leukemia is characterized by the abnormal and uncontrolled expansion of malfunctioning blood cells that crowd out normal cells. (lu.se)
- Development: For advances in developmental biology and stem cells. (lu.se)
- The hemostatic system consists of platelets, coagulation factors, and the endothelial cells lining the blood vessels. (medscape.com)
Gene expression1
- Both of these enzymes play a key role in the epigenetic regulation of gene expression during development, and the gene coding for MLL is frequently rearranged in infant and secondary therapy-related acute leukemias. (embl.de)
Fetal1
- We recently described the expression of leukemia inhibitory factor (LIF) in human fetal and murine corticotrophs. (manchester.ac.uk)
Cytokine1
- Leukemia inhibitory factor (LIF), a multi-functional cytokine, has a complex role in cancer. (oncotarget.com)
Differentiation4
- We have investigated the possible role of CDF (cholinergic differentiation factor from skeletal muscle), CDF/LIF CNTF, and MANS in mediating the target directed noradrenergic to cholinergic switch that characterizes sweat gland innervation. (caltech.edu)
- Expression of the differentiation activity in footpads occurs at a time period appropriate for a role for this factor(s) in vivo. (caltech.edu)
- Comparison with other differentiation molecules suggests that it is distinct from MANS, CDF and the heparin binding cholinergic factor. (caltech.edu)
- The possible relationship between CNTF, LlF and sweat gland cholinergic differentiation factor(s) is discussed. (caltech.edu)
RNAi1
- Expression profiles following lilliputian and Suppressor of Triplolethal RNAi were nearly identical raising the possibility that they are obligatory co-factors. (sdbonline.org)
Protein4
- They are particularly common in histone H3K4 methyltransferases most notably in a family of proteins that includes human mixed lineage leukemia (MLL) and the Drosophila melanogaster protein trithorax. (embl.de)
- Complement Factor H (FH): This is a soluble protein that is essential for regulating the alternative complement pathway (4). (promegaconnections.com)
- Glycoprotein pigment epithelium-derived factor (PEDF): This secreted protein has roles in neuroprotection, angiogenesis, and inflammation (5). (promegaconnections.com)
- Therefore, we hypothesized that there may be a protein that acts as a tumor inhibitor during these early stages of life, preventing the development of leukemia. (lu.se)
Transcription factors4
- Evidence of domain swapping within the jumonji family of transcription factors. (embl.de)
- KH domains are found in a wide variety of proteins including ribosomal proteins, transcription factors, and mRNA processing proteins. (novusbio.com)
- Biochemical studies suggest that in one case this transcription factors to implement particular genetic programs. (lu.se)
- In occurs through the inhibition of DNA binding of cognate cis- hematopoiesis there exist several lineage branch points with regulatory motif while in the other case DNA binding is unaffected identified key transcription factors and external signals [3-5]. (lu.se)
Developmental1
- Frontiers in Cell and Developmental Biology. (monash.edu)
CNTF1
- Thus, at least two distinct factors, CNTF and CDF/LlF, exist and have distinct but overlapping functions. (caltech.edu)
Cellular2
- In this review, we summarize the current knowledge on the role of CDK9 in transcriptional regulation, epigenetic regulation, and different cellular factor interactions, focusing on new advances. (bvsalud.org)
- Predicted to act upstream of or within cellular response to leukemia inhibitory factor. (nih.gov)
Reproductive1
Glycoprotein1
- Platelets play a primary role in this process, interacting with subendothelium-bound von Willebrand factor (vWf) via the membrane glycoprotein (GP) Ib complex. (medscape.com)
Functional1
- Our in vivo brain organogenesis approach is efficient, allowing functional and systematic analysis of genes (or other factors) in as little as three months in the context of a whole organism. (researchsquare.com)
Immunology1
- She is a member of the Cancer Biology, Biophysics, and Immunology graduate programs. (stanford.edu)
Chronic lymphocy1
- This persistence signature was also detected in two adult patients with chronic lymphocytic leukemia with decade-long remissions who received a different CD19 CAR-T cell product. (nature.com)
Proteins1
- The alpha granules contain hemostatic proteins such as fibrinogen, vWf, and growth factors (eg, platelet-derived growth factor and transforming growth factors). (medscape.com)
Growth1
Reproduction3
- Biology of Reproduction. (wikipedia.org)
- EDITOR'S PREFACE: The first paper in this issue of Biology of Reproduction is a minireview entitled "Getting Sperm and Egg Together: Things Conserved and Things Diverged," by Janice P. Evans. (bioone.org)
- This minireview was submitted to the Editorial Office of Biology of Reproduction and then subjected to same standards of peer review as all manuscripts published in the journal. (bioone.org)
Elongation2
- Cyclin-dependent kinase (CDK) 9 associates mainly with cyclin T1 and forms the positive transcription elongation factor b (p-TEFb) complex responsible for transcriptional regulation. (bvsalud.org)
- Following relatively long initiation and promoter clearance, RNA polymerase II can pause and then rapidly elongate following recruitment of positive elongation factors. (sdbonline.org)
Biological2
Arrest1
- p90Rsk is not involved in cytostatic factor arrest in mouse oocytes. (igbmc.fr)
Secondary1
- Platelet disorders lead to defects in primary hemostasis and produce signs and symptoms different from coagulation factor deficiencies (disorders of secondary hemostasis). (medscape.com)
Frontiers1
- Alzheimer's disease (AD) is the most common form of degenerative dementia, Bio Med Frontiers whose symptoms usually appear in the pre-senile age. (1elisakits.com)
Expression1
Molecular1
- If regular time pounding the pavement does improve brain function, what is the underlying molecular biology of exercise-induced neuroprotection? (promegaconnections.com)
Previously1
- Previously, this lab showed that leukemia inhibitory factor (LIF) promoted recovery after stroke through antioxidant enzyme upregulation. (uky.edu)
Occur1
- Most childhood leukemias are thought to originate in the womb and occur due to a genetic error or a mutation. (lu.se)
Childhood1
Genetic1
- Furthermore, modification of genetic susceptibility by environmental factors, both endogenous and exogenous, may alter the degree of penetrance. (hindawi.com)