Biology human cells. Medical search. Frequent questions

The function of the nucleus is to regulate gene expression, including controlling which proteins the cell makes. (pressbooks.pub)
Every cell consists of cytoplasm enclosed within a membrane, and contains many macromolecules such as proteins, DNA and RNA, as well as many small molecules of nutrients and metabolites. (wikipedia.org)
Study biologically important molecules including DNA, RNA and proteins, as well as the molecular events that govern cell function. (manchester.ac.uk)
Silencing Rab21 resulted in significantly increased expression of apoptosis-related proteins (caspase7, Bim and Bax) in glioma cells. (biomedcentral.com)
And you instruct the cells to make the protein or proteins that you need. (medscape.com)
Cancer stem cell-associated proteins revealed by proteomics. (medscape.com)
The investigation of cell proteome highlighted how simulated microgravity affects a relatively low number of proteins compared to time and/or osteogenic factors and has allowed us to reconstruct a hypothetical pipeline for cell response to simulated microgravity. (lu.se)

Present address: Department of Cell and Developmental Biology, Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, 08003 Barcelona, Spain. (biologists.com)
The study of cells and how they work has led to many other studies in related areas of biology, including: discovery of DNA, cancer systems biology, aging and developmental biology. (wikipedia.org)
In A. H. Brivanlou (Ed.), Current Topics in Developmental Biology (pp. 25-65). (elsevierpure.com)
In Brivanlou AH, editor, Current Topics in Developmental Biology. (elsevierpure.com)

Human granulosa cells (GCs) derived from women undergoing in vitro fertilization (IVF) are an adequate model for endocrine cells of the follicle and the corpus luteum and were therefore employed in an attempt to decipher their DA receptor repertoire and functionality. (biomedcentral.com)
Ectopic expression of ERBB2/ERBB3 mutants upregulated PD-L1 expression in GBC cells, effectively suppressed normal T-cell-mediated cytotoxicity in vitro through activation of the PI3K/Akt signalling pathway and contributed to the growth and progression of GBC in vivo . (bioxcell.com)
While early human embryos are inaccessible for research, in vitro model systems using pluripotent stem cells have provided critical insights into human PGC specification, which differs from that in mice. (elsevierpure.com)
Understanding of the pathogenesis of human noroviruses has been limited by our inability to propagate these viruses in vitro ( 12 ). (cdc.gov)
Recently, the first in vitro norovirus cell culture model was reported for a virus that infects mice ( 18 , 19 ). (cdc.gov)
The present study investigated the effects of in vitro DSWCNT exposure of human lung fibroblasts on proliferation and collagen production using cell multiplication (MTT), and Western blot techniques. (cdc.gov)
In this study, we investigated the effect of BNT162b2 on the human liver cell line Huh7 in vitro. (lu.se)

Here, we present a new study on induction of autophagy in human lung epithelial cells by the APD HO53. (researchgate.net)
Studies of viral attachment to cultured gastrointestinal epithelial cells (Caco-2) using recombinant virus-like particles or infectious noroviruses indicate that specific histo-blood group antigens play a key role in the attachment of the virus to the host cells ( 13 - 17 ). (cdc.gov)
From these studies, it was hypothesized that DSWCNT, due to their exceptionally small size, can quickly penetrate the alveolar epithelial wall, enter the underlying tissue, and induce a "direct" fibrotic effect by interacting with cells at the site of particle accumulation to induce collagen deposition. (cdc.gov)
Other particles may be engulfed by epithelial cells, primarily in the vicinity of the bronchial-alveolar duct junctions, and retained for much longer periods, with gradual removal to lymph nodes. (cdc.gov)
[ 2 ] The arachnoid cells have several proposed functions, including acting as a structural barrier with cellular wrapping/ensheathing, acting as a conduit for cerebrospinal fluid (CSF) drainage/absorption into dural sinuses/veins (arachnoid villi), epithelial-like/secretory functions, monocytelike functions, trophic support and byproduct detoxification for glial and neuronal cells, and participation in reactive/reparative processes. (medscape.com)
Both non-neoplastic meningothelial cells and meningiomas possess mixed features of epithelial and mesenchymal cells. (medscape.com)

Data from sequencing-based genomics assays is now available from hundreds of human cellular conditions, including varying tissues, individuals, disease states, and drug perturbations. (biomedcentral.com)
Its pharmacology and cell biology are largely unknown, and no known natural cell lines or tissues possess sufficient numbers of fBB 4 -R's to allow either of these to be determined. (acs.org)
Molecular Biology is the investigation at the molecular level of all aspects of cells and tissues from simple systems in bacteria to more complex systems in plants and mammals. (abdn.ac.uk)
Cells grown on porous collage-coated beads under fluid shear conditions in rotating wall vessel bioreactors differentiate into 3-D architectures resembling both the morphologic and physiologic function of in vivo tissues. (cdc.gov)
Normal proliferative tissues contain multipotent stem cells (SCs) that drive tissue turnover. (medscape.com)
According to the cancer stem cell (CSC) concept, the cellular hierarchy in normal tissues is preserved in a number of hematological and solid malignancies. (medscape.com)

In a study published in Cell , Surani and colleagues at Cambridge University (UK), jointly with Hanna and colleagues at the Weizmann Institute (Israel), report the development of a robust method for the specification of human PGC-like cells from ESCs and induced pluripotent stem cells (iPSCs). (nature.com)
1 Introduction to Pluripotent Stem Cells: Biology and Applications ( Maria Borowski and Gary S. Stein ). (ecampus.com)
They turned blood cells into "induced pluripotent stem cells" (iPS). (biologyonline.com)
Previously, nephron progenitors have primarily been studied in animal models or through the use of induced pluripotent stem cells (iPCs). (biologynews.net)

He is Executive Editor of Journal of Cellular Biochemistry , Journal of Cellular Physiology , Critical Reviews in Eukaryotic Gene expression , and Molecular Biology Reports , and has served on numerous Editorial Boards. (ecampus.com)
In this paper, we use the term "cell type" to refer to any such cellular condition that admits genomics assays. (biomedcentral.com)
This unit will cover how key signalling pathways in cells transduce extracellular signals to regulate gene expression and cellular processes such as growth and apoptosis. (manchester.ac.uk)
This degree programme will provide you with a broad base of knowledge regarding molecular biology at the molecular, cellular and organismal levels. (abdn.ac.uk)
It will determine how the cells may, under certain circumstances, contribute to inflammation, and will measure substances in the blood plasma (the liquid, non-cellular part of the blood) that might stimulate white blood cells, in order to understand how the blood responds to possible disease-related conditions. (nih.gov)
of cellular nomenclature that describes an accurate genotype and phenotype of the cells at specific stages in the process. (biospraysehatalami.com)
Introduction to the cellular and molecular biology of cancer / edited by L. M. Franks and N. M. Teich. (who.int)
Using single cell RNA sequencing, we aim to identify which cellular processes are affected by type 2 diabetes and in which islet and small intestinal cell type this occurs. (lu.se)

In contrast, a concatenated approach applied to these data can use at most 570 data sets, which is achieved by annotating 114 cell types with a panel of five assay types each. (biomedcentral.com)
Effects of DA on cell viability and cell volume were studied by using an ATP assay and an electronic cell counter system. (biomedcentral.com)
Experiments using the MTT assay, cell cycle analysis, apoptosis assay, real-time PCR and western blot were performed to establish the expression levels of related genes. (biomedcentral.com)
Human Rab21siRNA were transfected into T98G ( a ) and U87 ( b ) cells, followed by cell proliferation determination using the CCK-8 assay. (biomedcentral.com)

Downregulation of CDCA5 Can Inhibit Cell Proliferation, Migration, and Invasion, and Induce Apoptosis of Prostate Cancer Cells. (nih.gov)
We inferred that Rab21 silencing can induce apoptosis and inhibit proliferation in human glioma cells, indicating that Rab21 might act as an oncogene and serve as a novel target for glioma therapy. (biomedcentral.com)
Rab23 is implicated as a metastatic or tumorigenic biomarker as it shows differential expression in tumor cells and has been demonstrated to mediate proliferation and invasiveness in tumor cells [ 12 ]. (biomedcentral.com)
Rab21knockdown inhibits glioma cell proliferation. (biomedcentral.com)

To characterize these induced PGC-like cells and confirm their germ cell identity, the authors performed gene expression profile analyses, comparing the induced cells to human PGCs from 7-week-old male embryos and to a human seminoma originating from the germline in vivo . (nature.com)
Reads were aligned to the human reference genome hg19 and mapped to known genomic features at the gene level using the Rsubread package (version 1.16.1) (Liao et al. (refine.bio)
refine.bio: a resource of uniformly processed publicly available gene expression datasets. (refine.bio)
The protein encoded by this gene belongs to the immunoglobulin superfamily and is expressed selectively at the early stages of B cell development, namely, in proB and early preB cells. (nih.gov)
This gene encodes the iota polypeptide chain that is associated with the Ig-mu chain to form a molecular complex which is expressed on the surface of pre-B cells. (nih.gov)
The complex is thought to regulate Ig gene rearrangements in the early steps of B-cell differentiation. (nih.gov)
Mutational Analysis of the VPREB1 Gene of Pre-BCR Complex in a Cohort of Sporadic Pediatric Patients With B-Cell Acute Lymphoblastic Leukemia. (nih.gov)
CRISPR/Cas9 mediated knock-out of VPREB1 gene induces a cytotoxic effect in myeloma cells. (nih.gov)
Each data point is one gene-cell pair and is colored by its classification to the localization classes I to V ( Methods ) of Figure 2 . (biomedcentral.com)
The disease-relevant mutation is engineered into bit.bio's human ioWild Type cells using CRISPR/Cas9 gene editing. (businesswire.com)
We detected high levels of BNT162b2 in Huh7 cells and changes in gene expression of long interspersed nuclear element-1 (LINE-1), which is an endogenous reverse transcriptase. (lu.se)
2. Nuclear transfer is a technique used to duplicate genetic material by creating an embryo through the transfer and fusion of a diploid cell in an enucleated female oocyte.2 Cloning has a broader meaning than nuclear transfer as it also involves gene replication and natural or induced embryo splitting (see Annex 1). (who.int)

The successful candidate will normally teach five lecture courses over three terms per year, these courses may include genetics, cell biology, molecular biology and human anatomy and physiology. (medjouel.com)
NIEHS research uses state-of-the-art science and technology to investigate the interplay between environmental exposures, human biology, genetics, and common diseases to help prevent disease and improve human health. (nih.gov)

13 Characterization of Human Embryonic Stem Cells by Immunofluorescence Microscopy ( Shirwin M. Pockwinse and Prachi N. Ghule ). (ecampus.com)

These algorithms take as input a collection of genomics data sets from a particular cell type. (biomedcentral.com)
The wide availability of genomics data sets necessitates the development of SAGA strategies that can be applied to many cell types. (biomedcentral.com)
Using this approach, we were able to annotate 164 human cell types using a total of 1615 genomics data sets. (biomedcentral.com)
The Program for Mathematical Genomics, Dept. Systems Biology,Columbia University invites outstanding candidates to apply for tenure track/tenured. (nature.com)
from ancient civilizations to the modern day science of genomics and synthetic biology. (abdn.ac.uk)

The study involved downregulation of Rab21 in two glioma cell lines (T98G and U87) through transfection with specific-siRNA. (biomedcentral.com)
We found that a significant increase occurred in Rab21 expression in T98G and U87 glioma cell lines and that downregulation of Rab21 using specific-siRNA transfected with two glioma cell lines (T98G and U87) significantly inhibits cell growth and remarkably induces cell apoptosis. (biomedcentral.com)
Human glioma cell lines U251, T98G, SHG44, U87 and U373 were obtained from the Cell Bank of Chinese Academy of Sciences. (biomedcentral.com)

Nevertheless, human PGC-like cells can be generated, albeit at very low frequency, by spontaneous differentiation of human embryonic stem cells (ESCs). (nature.com)
The cells were then transferred to a culture medium containing BMP2 or BMP4, leukaemia inhibitory factor (LIF), stem cell factor (SCF), epidermal growth factor (EGF) and RHO-kinase (ROCK) inhibitor, which induced PGC-like cells. (nature.com)
We can now take any embryonic stem cell line and once we have them in the proper conditions, we can make these primordial cells in five to six days" ( The Guardian , 24 Dec 2014). (nature.com)
Human Stem Cell Technology & Biology: A Research Guide and Laboratory Manual integrates readily accessible text, electronic and video components with the aim of effectively communicating the critical information needed to understand and culture human embryonic stem cells. (ecampus.com)
The volume will be a valuable reference resource for both experienced investigators pursuing stem cell and induced pluripotent stem cell research as well as those new to this field. (ecampus.com)
2 Researching and Obtaining Established Stem Cell Lines ( Mai X. Luong, Kelly P. Smith, and Gary S. Stein ). (ecampus.com)
4 The Stem Cell Laboratory ( Alicia Allaire, Mai X. Luong, and Kelly P. Smith ). (ecampus.com)
6 Preparation of Mouse Embryonic Fibroblasts for Culture of Human Embryonic Stem Cells ( Meng-Jiao Shi, Maria Borowski, and Kimberly Stencel ). (ecampus.com)
8 Thawing, Seeding, and Changing the Medium of Human Embryonic Stem Cells ( Meng-Jiao Shi, Kimberly Stencel, and Maria Borowski ). (ecampus.com)
9 Passaging of Human Embryonic Stem Cells on Inactivated Mouse Embryonic Fibroblast Plates ( Meng-Jiao Shi, Kimberly Stencel, and Maria Borowski ). (ecampus.com)
10 Harvesting Human Embryonic Stem Cells for Cryopreservation ( Meng-Jiao Shi, Kimberly Stencel, and Maria Borowski ). (ecampus.com)
11 Human Embryonic Stem Cell Culture on BD Matrigel™with mTeSR®1 Medium ( Meng-Jiao Shi, Kimberly Stencel, and Maria Borowski ). (ecampus.com)
A pluripotent stem cell is a cell capable of giving rise to various precursors that eventually will acquire specific identity and physiological function via a process called differentiation . (biologyonline.com)
What Can Stem Cell Models Tell Us About Human Germ Cell Biology? (elsevierpure.com)
Their results, published online in the journal Stem Cell Translational Medicine , will help scientists understand how these progenitor cells become renal cells in the developing fetus, and possibly offer a future way to foster renal regeneration after chronic kidney failure or acute injury. (biologynews.net)
Robust strategies for developing patient-specific human induced pluripotent stem cell (iPSC)-based therapies of the brain require an ability to derive large numbers of highly defined neural cells. (biospraysehatalami.com)
This offering allows scientists to commission their disease-relevant mutation of interest in bit.bio's human induced pluripotent stem cell (iPSC)-derived cells powered by opti-ox technology. (businesswire.com)
5. In 2001, France and Germany requested the United Nations General Assembly to develop international conventions on human reproductive cloning, therapeutic cloning and research on stem cells. (who.int)
Recent ChIP experiments of human and mouse embryonic stem cells have elucidated the architecture of the transcriptional regulatory circuitry responsible for cell determination, which involves the transcription factors OCT4, SOX2 and NANOG. (lu.se)
In addition to regulating each other through feedback loops, these genes also regulate downstream target genes involved in the maintenance and differentiation of embryonic stem cells. (lu.se)
Hence, the stem cell can be manipulated to be self-renewing without the requirement of input signals. (lu.se)
Normal multipotent tissue stem cells (SCs) are the driving force behind tissue turnover and repair. (medscape.com)
The cancer stem cell theory holds that tumors also contain stem-like cells that drive tumor growth and metastasis formation. (medscape.com)
Blood stem cells, in particular, lose some of their functionality over time, contributing to various blood disorders and dis. (lu.se)
At Lund Stem Cell Center, researchers are using innovative approach. (lu.se)
Each year, the Lund Stem Cell Center recognizes notable scientific achievements made by our members in the fields of stem cell biology and regenerative medicine through our Article. (lu.se)
Lund Stem Cell Center's Research School in Stem Cell Biology has a new Executive Coordinator, Mattias Magnusson. (lu.se)

Much of what is known about mammalian germ cell specification is based on studies in mice, in which PGCs are specified at embryonic day 6.5 (E6.5) by bone morphogenetic protein 4 (BMP4) and other signals. (nature.com)
Here, we discuss recent advances and experimental systems used to study mammalian germ cell development. (elsevierpure.com)

however, as Professor Azim Surani commented: "It's not impossible that we could take these cells on towards making gametes, but whether we could ever use them is another question for another time" ( The Guardian , 24 Dec 2014). (nature.com)

In most human cells, mitochondria contain 10 3 -10 4 copies of a circular genome of 16,569 base-pairs that encodes two ribosomal RNAs, 22 tRNAs, and 13 polypeptides that form parts of the respiratory-chain located in the inner mitochondrial membrane [ 9 , 10 ]. (biomedcentral.com)
Semi-automated genome annotation methods such as Segway take as input a set of genome-wide measurements such as of histone modification or DNA accessibility and output an annotation of genomic activity in the target cell type. (biomedcentral.com)
Inside the cell is the cytoplasmic region that contains the genome (DNA), ribosomes and various sorts of inclusions. (wikipedia.org)
It has revolutionised our understanding of biology over the last half-century, culminating in the determination of the complete human genome sequence. (abdn.ac.uk)
Recent innovations in molecular biology include the technology behind genome engineering, which will have broad and lasting impacts on biology and medicine. (abdn.ac.uk)
Furthermore, a recent study showed that SARS-CoV-2 RNA can be reverse-transcribed and in-tegrated into the genome of human cells. (lu.se)

Rab21 is a member of the Rab subfamily, which has been identified as required for tumor-associated fibroblasts to promote the invasion of squamous carcinoma cells. (biomedcentral.com)
Six-well plates had been covered with 0.1% gelatin for 24 BMS 345541 hr before plating MEFs in the same moderate used to tradition human being fibroblasts (discover above). (biospraysehatalami.com)
Direct fibrogenic effects of dispersed single walled carbon nanotube s on human lung fibroblasts. (cdc.gov)

We analyzed the organization and function of mitochondrial DNA in a stable human cell line (ECV304, which is also known as T-24) containing mitochondria tagged with the yellow fluorescent protein. (biomedcentral.com)
In living cells, foci have an apparent diffusion constant of 1.1 × 10 -3 μm 2 /s, and mitochondria always split next to a focus to distribute all DNA to one daughter. (biomedcentral.com)
Mitochondria are the centre of energy production in the cell. (biomedcentral.com)
We now examine the organization of mitochondrial genomes in a human cell line that contains mitochondria tagged with the yellow fluorescent protein (YFP). (biomedcentral.com)
This is why mitochondria are sometimes referred to as the "power plants of the cell. (pressbooks.pub)
The phrase lives of a cell refers to the independent yet interrelated parts of a human cell including mitochondria, centrioles, and basal bodies that once led independent lives. (cdc.gov)

This study reports the development of a robust method to induce human PGC-like cells. (nature.com)
A previous study showed D 2 in human GCs, which are linked to cAMP, and the present study reveals the full spectrum of DA receptors present in these endocrine cells, which also includes D 2 -like receptors, linked to calcium. (biomedcentral.com)
Cell biology is the study of cells, which were discovered by Robert Hooke in 1665, who named them for their resemblance to cells inhabited by Christian monks in a monastery. (wikipedia.org)
This discovery is largely attributed to Robert Hooke, and began the scientific study of cells, known as cell biology. (wikipedia.org)
The destruction of a single kind of insulin-producing cell in the pancreas can lead to diabetes - but a study suggests that other cells could be modified to take its place and help to control blood sugar levels. (nature.com)
It is an important tool that will allow scientists to study cell renewal and differentiation in human cells, perhaps offering clues to how to regulate such development," added first author Stefano Da Sacco. (biologynews.net)
A degree in Molecular Biology is taught via a selection of compulsory and optional courses to enhance your learning and prepare you for a future career or further study. (abdn.ac.uk)
The Innate Immunity Signal Transduction in Human Leukocytes is a research study to determine the response of immune cells from the bloodstream. (nih.gov)
This study will investigate the response of immune cells to various signals in the test tube to determine how they sense the signals in the body and what substances they produce in response to them. (nih.gov)
In this study, we characterized the roles of Rab21 (Rab GTPase 21), a member of Rab GTPase family, in glioma cells. (biomedcentral.com)
With this new offering, we can cater to the vast diversity of scientific research into human diseases, providing scientists with the models they need to study their specific interests. (businesswire.com)

Primordial germ cells (PGCs) are the precursors of sperm and eggs. (nature.com)
Within a few days, a large proportion of cells formed in embryoid bodies expressed NANOS3-mCherry as well as other key PGC genes, indicating that they were probably nascent germ cells. (nature.com)
In mammals, primordial germ cells (PGCs) originate from peri-gastrulation embryos. (elsevierpure.com)

In addition to defining the genetic profile of human NP, this system will facilitate studies of human kidney development, providing a novel tool for renal regeneration and bioengineering purposes," says principal investigator Laura Perin, PhD, co-director of CHLA's GOFARR Laboratory for Organ Regenerative Research and Cell Therapeutics in Urology. (biologynews.net)

These methods are "semi-automated" because a human performs a functional interpretation of the state labels after the annotation process. (biomedcentral.com)
The cell is the basic structural and functional unit of all forms of life. (wikipedia.org)
The somatic cells, in turn, are the cells in the body that have varying functions, such as nourishing the sex cells as well as keeping the body thriving and functional. (biologyonline.com)
Functional experiments were applied in GBC cell lines to explore the oncogenic roles of ERBB2/ERBB3 hotspot mutations, their correlation with PD-L1 expression and the underlying mechanisms. (bioxcell.com)

The human IgG1 isotype control antibody is purified from human myeloma serum and is of unknown specificity. (bioxcell.com)

We found members of the two DA receptor families (D 1 - and D 2 -like) associated with different signaling pathways in human GCs, namely D 1 (as expected) and D 5 (both are Gs coupled and linked to cAMP increase) and D 2 , D 4 (Gi/Gq coupled and linked to IP3/DAG). (biomedcentral.com)
It does not bind to IgE that is already bound by the high affinity IgE receptor (FcεRI) on the surface of mast cells, basophils, and antigen-presenting dendritic cells. (bioxcell.com)
fBB 4 -R expression in cells widely used for other Bn receptor subtypes was unsuccessful as was expression in two frog cell lines. (acs.org)
However, stable fBB 4 -R cell lines were obtained in CHO-K1 cells which were shown to faithfully demonstrate the correct pharmacology of the related Bn receptor, the GRP receptor, when expressed in these cells. (acs.org)

Among the DA receptors found in human GCs, D 2 expression was marked both at mRNA and protein levels and it was therefore further studied. (biomedcentral.com)
Cells can acquire specified function and carry out various tasks within the cell such as replication, DNA repair, protein synthesis, and motility. (wikipedia.org)
We used comparative protein-structure modelling to predict residues that interact with two amino acids known to be critical for hRFVT-2 function (the clinical mutants L123 and L339), site-directed mutagenesis, and truncation approach in the human-derived brain U87 cell model. (biomedcentral.com)
These investigations report on identification of residues/sequences in the hRFVT-2 protein that is important for its physiological function and cell biology. (biomedcentral.com)
Besides that, there is little known about structural features of the hRFVT-2 protein that are important for its function and cell biology. (biomedcentral.com)
Introduction to cell signalling: signalling networks, protein-protein interactions, protein phosphorylation/de-phosphorylation. (manchester.ac.uk)
Intracellular signalling pathways: covering the major pathways in cells (MAPK, PI3K-AKT, mTOR, JAK-STAT, SMAD, IKK-NF- k B, Wnt), their components and key roles of protein kinases and phosphatases. (manchester.ac.uk)
Protein validation for selected factors was performed by immunohistochemistry on paraffin sections from three human donor eyes. (nih.gov)
Immunohistochemistry using antibody binding to LINE-1 open reading frame-1 RNA-binding protein (ORFp1) on Huh7 cells treated with BNT162b2 indicated increased nucleus distribution of LINE-1. (lu.se)
Sera from residual specimens from NHANES 2001-2002 participants were tested for levels of IgG antibodies against cancer antigen (CA) 125, CA15.3 and human epididymal secretory protein 4 (HE4). (cdc.gov)

Hence, in principle, these methods could annotate a cell type without any data (or very little data) in that cell type. (biomedcentral.com)
Methods - Cell Culture: Lung adenocarcinoma cell lines NCI-H1975 and HCC827 from a range of passages (2-4) were grown on 3 separate occasions in RPMI media (Gibco) supplemented with Glutamax and 10% fetal calf serum to a 70% confluence. (refine.bio)
Methods - RNA preparation: Total RNA was extracted from between half a million and million cells using Total RNA Purification Kit (Norgen Biotek) with on-column DNAse treatment accorting to the kit instructions. (refine.bio)
However, traditional methods of producing human cells have long, laborious, protocols that often result in heterogenous cell populations that can lead to significant data variability. (businesswire.com)

Silencing oncogene cell division cycle associated 5 induces apoptosis and G1 phase arrest of non-small cell lung cancer cells via p53-p21 signaling pathway. (nih.gov)

Moreover, PGC-like cells initiated DNA demethylation, consistent with a germline-specific epigenetic programme. (nature.com)
Moreover, as these cells erase their epigenetic marks by undergoing global demethylation, Surani suggested: "This could tell us how to erase [age-related] epigenetic mutations. (nature.com)
Accordingly, the "immortal" germline transmits genetic and epigenetic information to subsequent generations with consequences for human health and disease. (elsevierpure.com)
We also highlight key aspects of germ cell disorders, as well as mitochondrial and potentially epigenetic inheritance in humans. (elsevierpure.com)

Researchers can now order their mutation of choice in bit.bio's opti-ox TM powered human-iPSC derived cells, receiving consistent, defined, cryopreserved products that can be immediately incorporated into drug discovery workflows. (businesswire.com)
iPSC-derived cells from patients offer a human model for disease research, but sourcing them with the disease-specific mutation of interest can be a complex and time-consuming process. (businesswire.com)

Therefore, it can be concluded that CAP resistance is coded in the cytoplasm and not in the nucleus of 296-1 cells. (rupress.org)
The DNA of a prokaryotic cell consists of a single circular chromosome that is in direct contact with the cytoplasm. (wikipedia.org)
2011 Under these conditions the cells grow as compact colonies of cells with characteristic high nucleus-to-cytoplasm ratios tightly. (biospraysehatalami.com)

At fertilization, the sperm cell and the egg cell unite to form a diploid cell (called zygote). (biologyonline.com)

Most eukaryotic cells contain just a single nucleus, but some types of cells (such as red blood cells) contain no nucleus and a few other types of cells (such as muscle cells) contain multiple nuclei. (pressbooks.pub)
Cells are broadly categorized into two types: eukaryotic cells, which possesses a nucleus, and prokaryotic cells, which lack a nucleus but still has a nucleoid region. (wikipedia.org)
They are simpler and smaller than eukaryotic cells, and lack a nucleus, and other membrane-bound organelles. (wikipedia.org)
Some eukaryotic cells (plant cells and fungal cells) also have a cell wall. (wikipedia.org)

In essence, our body consists of two major types of cells - one group involved directly in reproducing sexually (called sex cells ) and another group that are not (called somatic cells ). (biologyonline.com)

Cytoplasmic transfer of chloramphenicol resistance in human tissue culture cells. (rupress.org)
This technique provides a 'how to' of human tissue during development," Perin says. (biologynews.net)
Neurodegeneration and neurodegenerative diseases (including the shared mechanisms of nerve cell death that contribute to many diseases), Vascular Cognitive Impairment and Dementia (VCID), NINDS tissue/cell resources, basic invertebrate neuromuscular junction (NMJ). (nih.gov)
Human hyalocytes represent a unique and distinct innate immune cell population specialized and adapted for the tissue-specific needs in the human vitreous. (nih.gov)
By contrast, transit amplifying cells and differentiated cells are incapable of self-renewal and tissue regeneration. (medscape.com)
Furthermore, pathways controlling the self-renewal capacity of normal tissue SCs are frequently deregulated in human cancer. (medscape.com)

Boxplots describing the distribution of the fraction of molecules localized to the nucleus (Y axis) for each validated lncRNA-cell pair (X axis, orange: HeLa, blue: hFF, purple: hLF). (biomedcentral.com)
median number of molecules per cell) and nuclear localization (Y axis, median fraction of nuclear spots across all expressing cells). (biomedcentral.com)

Japanese researchers have, for the first time, successfully converted a somatic cell into a sex cell precursor. (biologyonline.com)
The researchers transformed human blood cells into oogonia ( plural of oogonium ). (biologyonline.com)
The researchers have yet to induce them to become mature, fully differentiated egg cells. (biologyonline.com)
Biology Stack Exchange is a question and answer site for biology researchers, academics, and students. (stackexchange.com)
In a first-of-its-kind look at human kidney development, researchers at The Saban Research Institute of Children's Hospital Los Angeles have isolated human nephron progenitor (NP) cells. (biologynews.net)

Cell Sciences, Inc. manufactures & supplies immunochemicals for life science research. (biosciregister.com)
Alpha Diagnostic International (ADI) develops & delivers ELISA reagents & kits for animal and human research. (biosciregister.com)
The Department, while among the smallest in the nation, is ranked 14th for extramural research funding among Cell Biology and Anatomy Departments. (ucdavis.edu)
If, in the future, research on the conversion of a somatic cell into a sex cell pushes through to completion, it could lead to significant resolves to infertility issues. (biologyonline.com)
The Position As a Postdoctoral Fellow in the Department of Cancer Cell Targeted Therapies (CCTT), you will focus on exploratory research projects o. (nature.com)
Our active work toward reconciliation takes place across our campuses through research, learning, teaching, and community building, and is centralized within our Indigenous Initiatives Office ( https://uwaterloo.ca/human-rights-equity-inclusion/indigenousinitiatives ). (medjouel.com)
Techniques used to research cell signalling. (manchester.ac.uk)
Additionally, you will gain an in depth understanding of selected aspects of Molecular Biology which will reflect the research expertise and strengths within the School, and you will be instructed in the many applications of this subject. (abdn.ac.uk)
Our custom disease cell model offering aligns with bit.bio's mission to democratise access to human cells for research and drug discovery. (businesswire.com)
bit.bio has partnered with leading contract research organisation Charles River Laboratories to provide disease models in their early drug discovery programmes. (businesswire.com)
Human cells are key to disease research, drug discovery, and clinical translation. (businesswire.com)
The purpose of our research is to understand how each islet cell type and each enteroendocrine cell type in the gut is affected in type 2 diabetes. (lu.se)

Transcriptome profiling of human lung cancer cell lines. (refine.bio)
2014). Overall design: Total RNA was extracted from lung adenocarcinoma cell lines NCI-H1975 and HCC827 (3 independent samples for each cell line) and mixed in known ratios. (refine.bio)
For these short fibers, which can be fully engulfed by lung cells and do not dissolve in airway fluids in less than a few weeks, their clearance will be similar to other mineral and vitreous particles. (cdc.gov)

Extended incubation of PDGF-treated cells in the presence of IL-1 revealed that the stimulation by IL-1 occurred predominantly during the subsequent cycle of DNA replication, wherein DNA synthesis reached three- to fivefold higher than the untreated cultures. (rupress.org)
These comprise basic cell culture technology, e.g. cell cultivation and expanding cell cultures, but also authentication and contamination tests. (dsmz.de)
Our results demonstrate that the highly differentiated 3-D cell culture model can support the natural growth of human noroviruses, whereas previous attempts that used differentiated monolayer cultures failed. (cdc.gov)
Reporting Guidelines for Whole-Body Vibration Studies in Humans, Animals and Cell Cultures: A Consensus Statement from an International Group of Experts. (bvsalud.org)
Leads from these studies are tested experimentally in cell models, primary cultures as well as in small and large animals. (lu.se)

Loss of cell division cycle‑associated 5 promotes cell apoptosis by activating DNA damage response in clear cell renal cell carcinoma. (nih.gov)
The results show that downregulation of Rab21 can significantly inhibit cell growth and remarkably induce cell apoptosis in T98G and U87 cell lines. (biomedcentral.com)

We aim to identify type 2 diabetes-induced, cell type-specific alterations in islet and intestinal cells that explain why the disease develops. (lu.se)

Histograms on top and right are the distribution of all lncRNAs- (black) and mRNA- (yellow) cell pairs. (biomedcentral.com)

However, there are only a few of these cells for each antibody. (stackexchange.com)

Importantly, the authors could also obtain PGC-like cells from iPSCs, which widens the range of potential applications, such as disease modelling from patient-derived iPSCs. (nature.com)
Once a particular disease is recognized by these few specific B cells, the B cells turn into plasma cells, clone themselves and start pumping out antibodies. (stackexchange.com)
However, while it is being eliminated, other B cells for the disease clone themselves but do not generate antibodies. (stackexchange.com)
This second set of B cells remains in your body for years, so if the disease reappears your body is able to eliminate it immediately before it can do anything to you. (stackexchange.com)
Molecular Biology is central to current investigations to understand the genetic basis of human disease and pathology, as well as to the development of improved crops. (abdn.ac.uk)
The disease model cells will support scientists in the generation of data in a human context with improved translatability in early stage drug discovery. (businesswire.com)
As disease model cells come from an identical human genetic background to ioWild Type cells, any experimental differences observed between the wild type and the disease model can be confidently attributed to the effects caused by the disease-specific mutations. (businesswire.com)
These cells also often lack standardisation and optimised, fast protocols, making it difficult to generate consistent data and scalable disease models. (businesswire.com)
IndiCell, short for Individualized Cell Therapy, is a national initiative in Sweden to speed up the development of advanced therapies that can help treat or cure a range of disease. (lu.se)

Second, this annotation strategy is very sensitive to artifactual differences between data from different cell types, resulting in bias for or against each label. (biomedcentral.com)
What they discovered were significant differences between the two types of cells. (wikipedia.org)
Some DNA differences result from the blunders during the DNA replication necessary for cell division. (cdc.gov)

Figure 4.6.2 This closeup of a cell nucleus shows that it is surrounded by a structure called the nuclear envelope, which contains tiny perforations, or pores. (pressbooks.pub)

It has roles in cell division, membrane trafficking, and cell migration. (biologists.com)
page needed] A prokaryotic cell has three regions: Enclosing the cell is the cell envelope, generally consisting of a plasma membrane covered by a cell wall which, for some bacteria, may be further covered by a third layer called a capsule. (wikipedia.org)
Though most prokaryotes have both a cell membrane and a cell wall, there are exceptions such as Mycoplasma (bacteria) and Thermoplasma (archaea) which only possess the cell membrane layer. (wikipedia.org)
This Omalizumab biosimilar reacts with free human IgE in blood and interstitial fluid and to membrane-bound IgE on the surface of IgE-expressing B cells. (bioxcell.com)

Molecular and cell biology of sexually transmitted diseases / edited by David Wright and Leonard Archard. (who.int)

Scientists create immature Human Eggs Out of Blood Cells For the First Time. (biologyonline.com)
The Center for Evolutionary & Organismal Biology invites applications from evolutionary scientists for All ranks. (nature.com)
The CHLA scientists utilized an efficient protocol for direct isolation of human NP using RNA-labeling probes to obtain NP-expressing SIX2 and CITED1 - the master genes regulating renal development. (biologynews.net)
Scientists receive defined, consistent, ready-to-use cells, empowering them to investigate the impact of their mutation in a human context. (businesswire.com)
Due to a lack of standardised, easy to use and readily accessible human cell models, scientists have relied on animal models and cell lines that differ considerably from human biology. (businesswire.com)
Scientists can now request their mutations in bit.bio's ioGlutamatergic Neurons, ioGABAergic Neurons, ioMicroglia and ioSkeletal Myocytes by contacting [email protected] . (businesswire.com)

Results of search for 'su:{Molecular biology. (who.int)

These studies represent the first genetic evidence of cytoplasmic inheritance in human cells. (rupress.org)
And the way we do it is to start with the genetic information of your cancer cell. (medscape.com)

Previous studies reported that several members of Rab GTPase family are involved in the development of glioma, and abnormal expression of Rab small GTPases is known to cause aberrant tumor cell behavior. (biomedcentral.com)
In human malignancies, including glioma, abnormal expression of Rabsled to aberrant tumor cell behavior. (biomedcentral.com)

Trained immunity of natural killer (NK) cells has shown great potential in the treatment of cancers by eliciting enhanced effector responses to restimulation by cytokines or cancer cells for long time periods after preactivation. (cancerbiomed.org)
And then we make a product just for you to educate your immune system, your T cells, to recognize the mutation of a cancer cell that they have missed so far, so that your immune system can go to work and get rid of your cancer. (medscape.com)
I'm fascinated by liquid biopsy - the ability to find pieces of DNA of cancer cells in blood. (medscape.com)
Here, the authors review the novel insights that these studies have provided and present a comprehensive strategy for the use of proteomics in studying cancer SC biology. (medscape.com)
The CSC is defined as a cancer cell with self-renewing capacity that can regenerate the original tumor in all its differentiated heterogeneity. (medscape.com)
Powering Down Cancer Cells - A New Way to Beat Leukemia? (lu.se)
Cancer cells are the ultimate sugar addicts, gobbling up glucose to fuel their growth and spread. (lu.se)

Anatomy27

Organisms15

Diseases6

Chemicals and Drugs64

Analytical, Diagnostic and Therapeutic Techniques and Equipment40

Phenomena and Processes89

Disciplines and Occupations15

Technology, Industry, Agriculture4

Humanities3

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Health Care2

Proteins7

Developmental Biology4

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Epithelial6

Tissues6

PLURIPOTENT STEM4

Cellular8

Assay4

Proliferation4

Gene12

Genetics2

Characterization1

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Glioma cell3

Stem27

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Professor1

Genome6

Fibroblasts3

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Study11

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Principal Investigator1

Functional4

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Receptor4

Protein10

Methods4

Induces1

Epigenetic4

IPSC2

Cytoplasm3

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Involved directly1

Tissue6

Molecules2

Researchers5

Research12

Lung3

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