FixationCartilageOsteoporosisWoundCallusInjuriesStress fracturesVivoHumerusResorptionFemoralRegenerationFemurProximalBonesInjuryWoundsAccelerateMurineInflammationBiomedicalTraumaTissueTaxonomySurgeonsTherapiesUlnaRadiologicalOrthopaedicCytokinesRepairAnatomyProcessMiceTherapeuticClassificationComplicationsBiologicalSystemicMethodsSevereTreatmentPatientsMolecularAdequate
Fixation9
- Surgical methods have included excision of the fracture fragments, replacement, and internal fixation (see Treatment ). (medscape.com)
- Problems with proximal radial migration, especially with excision but also with replacement, and problems with the replacement implants have led to the belief that anatomic reduction and internal fixation is currently the treatment of choice for unstable and displaced radial head and neck fractures and dislocations. (medscape.com)
- Pathological fractures in the proximal part of the femur are treated by Zickel-nail fixation. (sarose.com.np)
- The adjunctive use of methylmethacrylate in fixation of pathological fractures. (sarose.com.np)
- Intramedullary fixation of pathological fractures and lesions of the subtrochanteric region of the femur. (sarose.com.np)
- Current concepts of external fixation of fractures. (sarose.com.np)
- Compression plate fixation and the effect of different types of internal fixation on fracture healing. (sarose.com.np)
- Fracture healing: a harmony of optimal biology and optimal fixation? (deepdyve.com)
- [ 4-6 ] A series of decisions must be made before proceeding with definitive diaphyseal femur fracture fixation, including patient positioning, surgical approach, and implant type. (medscape.com)
Cartilage9
- The concomitant decrease in cartilage fraction supports our prior work showing that β-NGF promotes endochondral conversion of cartilage to bone to accelerate healing. (frontiersin.org)
- Vascular and cellular invasion into the cartilage is a critical step in the fracture healing. (elsevierpure.com)
- Repair of the fracture in MMP-13 deficient (MMP-13 -/- ) mice was significantly delayed and characterized by a retarded cartilage resorption in the fracture callus. (elsevierpure.com)
- These results suggest that MMP-13 is crucial to the process of angiogenesis during healing of fracture, especially in the cartilage resorption process. (elsevierpure.com)
- Currently, specifically in the field of sports medication and orthopedics, PRP has displayed the regenerative capability to restore damaged tissues, inclusive of tendons, ligaments, and cartilage, all of which have a reduced intrinsic healing possibility. (industryarc.com)
- Effects of an articular cartilage lubrication with a viscosupplement in vitro and in vivo following osteochondral fractures in horses. (ucsd.edu)
- ORGANIC INDIA Osteoseal - Bone Support Herbal Calcium & Minerals ORGANIC INDIA Osteoseal Ayurvedic Capsules increases bone mineral density, enhances healing of fractured bones, callus formation and improves cartilage regeneration & strenthens teeth.It provides bio available organic calcium, phosphorus, vitamins and amino acids to promote healthy bone growth and strong teeth. (healthyram.com)
- The typical pathologic manifestations of vitamin C deficiency, including poor wound healing, are noted in collagen-containing tissues and in organs and tissues such as skin, cartilage, dentine, osteoid, and capillary blood vessels. (medscape.com)
- Preexisting bone becomes brittle and undergoes resorption at a normal rate, resulting in microscopic fractures of the spicules between the shaft and calcified cartilage. (medscape.com)
Osteoporosis4
- Thus any process or systemic condition that alters this optimal inflammatory milieu, such as bone diseases like osteoporosis or severe trauma, steroid therapy, diabetes, or advanced age, can disrupt the normal fracture healing process, resulting in nonunions or delayed healing, pain, disfigurement, and loss of function. (hindawi.com)
- In the weightlessness of space, researchers are able to study novel and current bone healing therapies to translate new discoveries in bone regeneration for osteoporosis, fracture healing and other bone disorders. (iu.edu)
- This model reproduces the effects of several widely used osteoporosis treatments on key parameters used to quantify fracture risk. (sirop.org)
- Disruptions in these mechanisms, as seen in conditions like postmenopausal osteoporosis, lead to decreased bone density and increased fracture risk. (sirop.org)
Wound12
- Effects of sub-acute co-exposure to WIFI (2.45 GHz) and Pistacia lentiscus oil treatment on wound healing by primary intention in male rabbits [med. (emf-portal.org)
- Such low-gravity environments slow wound and fracture healing and accelerate bone loss, muscle loss and certain aspects of aging. (newswise.com)
- In recent lab experiments, she and her team observed diabetic wound healing in 14 days without intermediate scar or scab formation. (newswise.com)
- 1. Wound healing a) Inflammatory phase of wound healing - vascular response, cellular response, mediators of inflammation, factors modulating the inflammatory reaction (acetylsalicylic acid, steroids). (edu.pl)
- b) Proliferation phase of wound healing - generation of epithelium, deposition of collagen, generation of scar tissue. (edu.pl)
- d) Factors affecting wound healing - systemic factors and local factors. (edu.pl)
- Epimorphic regeneration can be thought of as occurring in two phases: wound healing and cell proliferation. (biomedcentral.com)
- Regeneration-competent wound healing of amphibian appendages is generally rapid and involves covering the wound surface with a specialised epidermis lacking a basement membrane and dermis [ 3 , 4 ]. (biomedcentral.com)
- Once the wound is healed, the cells of the stump must mobilise under the wound epidermis and begin the process of replacing lost tissues, by forming a proliferating blastema. (biomedcentral.com)
- We have used this line to show that BMP function is not only required for appendage regeneration but that it is specifically needed to generate a proliferating blastema while being dispensable for wound healing [ 12 ]. (biomedcentral.com)
- These activities facilitate wound and bone fracture healing and also contribute to inflammation in active sickle cell disease and atherosclerosis. (bio-techne.com)
- She was originally rehabbed by Gulf Specimen in Panacea, FL and presented with an old, healed wound to the mid-carapace on the left side and rear buoyancy in water. (cmaquarium.org)
Callus4
- In vivo studies using our murine tibia fracture model show that PEGDMA microrods injected at the site of fracture remained adjacent to the callus for over 7 days. (frontiersin.org)
- Importantly, a single injection of β-NGF loaded PEGDMA microrods resulted in improved fracture healing as indicated by a significant increase in the percent bone in the fracture callus, trabecular connective density, and bone mineral density relative to soluble β-NGF control indicating improved drug retention within the tissue. (frontiersin.org)
- Immunohistochemistry indicated severe defects in vascular penetration and chondroclast recruitment to the fracture callus in MMP-13 -/- mice. (elsevierpure.com)
- The forces and strains experienced by the bone during everyday activities influence the cellular responses, callus formation, bone deposition, remodelling, and, ultimately, the successful recovery of the fractured bone. (sirop.org)
Injuries5
- Fractures, wounds and soft tissue injuries don't heal quickly in low-gravity conditions, and the biomedical engineer is studying how to speed the process. (newswise.com)
- These spheres, called microspheres, might be applied to external wounds or injected to treat fractures and soft tissue injuries. (newswise.com)
- Radial head fractures and dislocations are traumatic injuries that require adequate treatment to prevent disability from stiffness, deformity, posttraumatic arthritis, nerve damage, or other serious complications. (medscape.com)
- The physician needs to be especially aware of the ulnar nerve proximally because it passes behind the medial epicondyle and the posterior interosseous nerve, wraps around the radial neck, and is most likely to be damaged with radial head fractures or dislocations or during surgery to correct these injuries. (medscape.com)
- Stress fractures are common injuries that affect many people of all ages and level of activity. (sportsmedres.org)
Stress fractures10
- Stress fractures of the fibula. (sarose.com.np)
- Stress fractures of the femoral neck. (sarose.com.np)
- Do NSAID's Delay Healing in Stress Fractures? (sportsmedres.org)
- There are studies that show negative effects of NSAIDs on complete fracture healing, but there is little data on the relationship of NSAIDs and stress fractures. (sportsmedres.org)
- Stress fractures are a painful injury and patients often look for some type of medication for pain control, commonly an NSAID. (sportsmedres.org)
- Although human studies would be needed to make a definite recommendation against the daily use of NSAIDs in stress fractures, we should be cautious when we prescribe a daily dose of these pain medications to our patients. (sportsmedres.org)
- Have you noticed any changes in healing rates in your patients with stress fractures that use NSAIDs? (sportsmedres.org)
- How do you counsel patients and athletes for pain control with stress fractures? (sportsmedres.org)
- Stress fractures are ridiculously common among runners, but this post will specifically address the apparent rash of metatarsal stress fractures afflicting minimalist and VFF runners, including myself. (joemaller.com)
- The majority of stress fractures affecting minimalist runners are not impact-related, but rather result from overloading weak metatarsals with increased toe push-off. (joemaller.com)
Vivo5
- Finally, in vivo studies using our well-established murine tibia fracture model were performed and a single injection of the β-NGF loaded PEGDMA microrods, non-loaded PEGDMA microrods, or soluble β-NGF was administered to assess the extent of fracture healing using Micro-computed tomography (µCT) and histomorphometry. (frontiersin.org)
- In this paper, we review the current literature on both in vitro and in vivo studies on the role of the immune system in fracture repair, the use of MSCs in the enhancement of fracture healing, and interactions between MSCs and immune cells. (hindawi.com)
- The teaching aspect of this lab encompasses molecular and cellular bone biology techniques and/or in vivo fracture healing models. (iu.edu)
- Investigating compromised bone fracture healing in mouse models using time-lapsed in vivo CT imaging and histological analysis. (sirop.org)
- We combined expertise from bone biology and immunology to develop a platform including in vitro osteoclast (OC) and osteoblast (OB) assays and in vivo mouse models of bone repair, immunogenicity, and allergenicity. (bvsalud.org)
Humerus2
- Radial head fractures and dislocations may be isolated just to the radial head (and neck) and the lateral elbow (and proximal forearm), or they may be part of a combined complex fracture injury pattern involving the other structures of the elbow, distal humerus , or forearm and wrist. (medscape.com)
- Remodeling of the humerus after supracondylar fractures in childhood. (sarose.com.np)
Resorption4
- While some signals are mitogenic and proosteogenic, others function to inhibit osteogenesis and increase bone resorption, and it appears that a well-controlled, delicate balance of inflammatory factors is necessary for proper fracture repair [ 3 - 6 ]. (hindawi.com)
- They act by inhibiting the effects of cyclooxygenase (COX) enzymes, which play a role in bone biology, specifically bone resorption by COX-2. (sportsmedres.org)
- The authors found that ibuprofen significantly reduced bone resorption and cortical formation 6 weeks after loading and that the selective COX-2 inhibitor significantly reduced resorption along the fracture line at 2 weeks only. (sportsmedres.org)
- The authors were surprised that ibuprofen caused a greater reduction in bone healing than the COX-2 inhibitor because there have been many studies that showed COX-2 plays the greatest role in fracture repair and resorption through the production of a prostaglandin (PGE2). (sportsmedres.org)
Femoral4
- Intraoperative assessment for associated femoral neck fractures and postoperative clinical examination of the hip and knee are imperative to the successful management of diaphyseal femur fractures. (medscape.com)
- and the displacement of unrecognized fractures, including ipsilateral femoral neck fractures. (medscape.com)
- Finally, using a rat femoral defect model, we showed that an ultra-low dose (0.5 µg) of BMP-2/7 accelerated fracture healing and performed at a level comparable to 20-times higher BMP-2 dose. (lu.se)
- An ultra-low dose of BMP-2/7 delivered via a collagen-HA (CHA) scaffold leads to accelerated healing of a critical femoral defect in rats while a 20-times higher BMP-2 dose was required to achieve comparable results. (lu.se)
Regeneration1
- In this study, the authors investigated a novel alternative approach to bone repair based on peptide amphiphile nanofiber gels that are engineered to control the release of vascular endothelial growth factor (VEGF) to recruit circulating stem cells to a site of bone regeneration and facilitate bone healing by bone morphogenetic protein-2 (BMP-2). (bvsalud.org)
Femur6
- Complete fractures of the femur in Paget's disease of bone. (sarose.com.np)
- To fully prepare for successful surgical management of diaphyseal femur fractures, surgeons must consider appropriate patient positioning and necessary tools, including surgical tables, traction devices, and instruments. (medscape.com)
- Reduction of diaphyseal femur fractures should be attained in the least invasive manner, via percutaneous reduction techniques, if possible, to preserve fracture biology and promote successful fracture healing. (medscape.com)
- Other reference modalities and clinical examinations are required in patients with bilateral diaphyseal femur fractures. (medscape.com)
- Diaphyseal femur fractures, which commonly result from a high-energy mechanism of injury, may be isolated or associated with multisystem trauma. (medscape.com)
- Given that 1.1 to 2.9 million diaphyseal femur fractures occur each year, an emphasis has been placed on the efficient and effective management of diaphyseal femur fractures to maximize good patient outcomes. (medscape.com)
Proximal2
- The intra-articular position also means that soft-tissue attachments to the most proximal portion of the bone are limited, and thus, fractured fragments frequently lose their blood supply, resulting in avascular necrosis and potential nonunion. (medscape.com)
- Proximal stress fracture of the second metatarsal after running much faster than usual in VFFs. (joemaller.com)
Bones4
- If successful, this new drug therapy introduced through the RR-IV mission may help expedite the healing process for patients with severely damaged or injured bones. (iu.edu)
- The biology of fracture healing in long bones. (sarose.com.np)
- Definitely agree with the theory of the muscles getting stronger before the bones do, and that the fractures are not due to impact, but rather the muscles pulling too hard on the bones, before the bones have enough time to get stronger. (joemaller.com)
- With these fractures, the periosteum becomes loosened, resulting in the classic subperiosteal hemorrhage at the ends of the long bones. (medscape.com)
Injury3
- Bone Injury and Fracture Healing Biology[J]. Biomedical and Environmental Sciences, 2015, 28(1): 57-71. (besjournal.com)
- The normal process of fracture repair begins with an immediate inflammatory response as the innate immune system (macrophages, monocytes, neutrophils, and NK cells) responds with a variety of cytokines that recruit and activate several cell types, including osteoprogenitor mesenchymal stem cells (MSCs), to the site of injury [ 1 , 2 ]. (hindawi.com)
- The initial examination showed that he had an old healed injury to the left side of his carapace (shell). (cmaquarium.org)
Wounds8
- Tissue-engineered skin grafts are available now on Earth, but non-healing wounds remain troublesome for burn victims, diabetics and the elderly. (newswise.com)
- Olabisi's goal is to develop injectable microscopic biomaterials, topical lotions, and large biomaterials that can speed healing of skin wounds, bone fractures and degenerating retinas. (newswise.com)
- Normally, such wounds would take 35 days to heal, Olabisi said. (newswise.com)
- What is the healing process of mouth wounds? (stackexchange.com)
- Our mouths are supposed to be the among the most contaminated parts of the human body, so why do mouth wounds heal in just about a week and don't get infected? (stackexchange.com)
- What is the healing mechanism found in the mouth tissue, because I figure it is completely different from the processes in wounds occurring in the external skin. (stackexchange.com)
- As to why oral wounds heal quickly and don't get infected that much? (stackexchange.com)
- One is that the head and neck has an excellent blood supply- just think of scalp wounds where you bleed like crazy but then they heal very well. (stackexchange.com)
Accelerate2
- Currently, there are no non-surgical FDA-approved biological approaches to accelerate fracture repair. (frontiersin.org)
- This device will allow physicians and surgeons to accelerate bone healing for various fractures and procedures across multiple disciplines of medicine. (wustl.edu)
Murine1
- Therefore we investigated the possible involvement of MMP-13 in a murine model of stabilized bone fracture healing. (elsevierpure.com)
Inflammation2
- however, prolonged inflammation is inhibitory for fracture repair. (hindawi.com)
- Fracture healing is a complex process that involves inflammation, angiogenesis, and bone remodeling. (sirop.org)
Biomedical1
- If healing people faster on Earth is going to be helpful, then it's really going to be helpful in space," said Olabisi, an assistant professor in Rutgers' Department of Biomedical Engineering . (newswise.com)
Trauma1
- Except for congenital radial head dislocations, which by definition are not acquired, radial head fractures and dislocations are the result of trauma, usually from a fall on the outstretched arm with the force of impact transmitted up the hand through the wrist and forearm to the radial head, which is forced into the capitellum. (medscape.com)
Tissue3
- Tissue engineering could repair hip fractures, saving lives. (newswise.com)
- Healing of a transverse root fracture by calcified tissue was demonstrated histologically by Howe in 1926, while Boulger in 1928 showed the two other patterns of root fracture healing, namely the interposition of fibrous connective tissue and the interposition of bone and periodontal ligament around both fractured segments. (edu.au)
- Accompanying the historical review are two case reports with histology of root fracture healing by (a) calcified tissue and (b) dense fibrous connective tissue. (edu.au)
Taxonomy1
- Taxonomy is the branch of biology that deals with the naming and classifying of organisms. (proprofs.com)
Surgeons1
- We propose that surgeons with a subspecialist interest in non-union surgery use this system in reporting results, and that non-specialist surgeons use it to inform their decision to treat the fracture themselves, or refer to a subspecialist. (deepdyve.com)
Therapies1
- Injectable therapies designed to stimulate bone healing represent an exciting alternative to surgically implanted biologics, however, the translation of effective osteoinductive therapies remains challenging due to the need for safe and effective drug delivery. (frontiersin.org)
Ulna2
- Kidd et al, set out to determine the effects of three different NSAIDs on stress fracture healing and woven bone consolidation in an animal model using the rat ulna. (sportsmedres.org)
- Cocoa also had a variety of issues including a broken ulna in his right front flipper, a semi-healed fractured radius in his left front flipper, a ruptured right eye, and severed edges of the maxilla that would need to be surgically rejoined. (cmaquarium.org)
Radiological2
- Radiological diagnosis of fractures. (sarose.com.np)
- A consecutive cohort underwent radiological review to determine whether the osteotomy healed and the correction was maintained. (openorthopaedicsjournal.com)
Orthopaedic2
- Could you tell us more about the magnesium-based orthopaedic implants and how they are able to be reabsorbed by the body after a fractured bone has healed? (opnews.com)
- The overall aim of this US-Ireland R&D centre-to-centre partnership collaboration is to develop bioresorbable orthopaedic implants made from novel high-strength, high-ductility magnesium and magnesium alloy systems that can replace the permanent metals/metal alloys usually used in applications ranging from thin wires to thicker pins, rods and elastic stable intramedullary nails (ESINs), as well as meshes for the treatment of complex bone fractures. (opnews.com)
Cytokines2
- The precise spatial and temporal impact of immune cells and their cytokines on fracture healing remains obscure. (hindawi.com)
- Some cytokines are reported to be proosteogenic while others inhibit bone healing. (hindawi.com)
Repair6
- Here, we describe poly (ethylene glycol) dimethacrylate (PEGDMA)-based microparticles, in the shape of microrods, loaded with beta nerve growth factor (β-NGF) for the purpose of promoting fracture repair. (frontiersin.org)
- We demonstrate a novel and translational method wherein β-NGF can be encapsulated within PEGDMA microrods for local delivery and that β-NGF bioactivity is maintained resulting in improved bone fracture repair. (frontiersin.org)
- Cell-based therapy utilizing mesenchymal stromal cells (MSCs) is an attractive option for augmenting the fracture repair process. (hindawi.com)
- Insight into this paradigm can provide valuable clues in identifying cellular and noncellular targets that can potentially be modulated to enhance both natural bone healing and bone repair augmented by the exogenous addition of MSCs. (hindawi.com)
- the molecular mechanisms underlying bone repair and fracture healing. (iu.edu)
- We also tested a ß-TCP/Collagen (ß-TCP/C) foam which is a commercially available material used clinically for bone repair in a critical-sized calvarial bone defect mouse model to determine the effects on the early phase of bone healing. (bvsalud.org)
Anatomy2
- Lisa Greenhead, UK - Human Biology 1a (Anatomy and Physiology) course. (acseduonline.com)
- Bone Anatomy and the Biologic Healing Process of a Fracture. (dr.tr)
Process5
- The adaptive immune response, primarily comprised of T and B lymphocytes, has important implications in the fracture healing process as well [ 3 , 4 ]. (hindawi.com)
- As people age, the healing process is impeded and people who break their hips are more likely to die in the hospital than those who don't, said Olabisi, who joined Rutgers in 2012. (newswise.com)
- The healing mechanism involves the inflammatory process, which is the same in almost the entire body. (stackexchange.com)
- It's surprising because most athletes are told to take these NSAIDS to help reduce pain however this could be causing further problems in the healing process. (sportsmedres.org)
- The prevalence and severity of periodontal disease in diabetics has been shown to be greater than that of the population as a whole 3-4 , where the effects of periodontal disease in these individuals are aggravated by metabolic and histopathological changes, characteristics of diabetes, as well as vascular changes, defective immunological responses and a delayed process of healing 1,5-7 . (bvsalud.org)
Mice1
- For example, mice genetically deficient for adaptive immunity displayed accelerated bone healing. (hindawi.com)
Therapeutic1
- It is estimated that, of the 7.9 million fractures sustained in the United States each year, 5% to 20% result in delayed or impaired healing requiring therapeutic intervention. (hindawi.com)
Classification1
- Jens Andreasen and Erik Hjörting-Hansen's landmark paper in 1967 included new histological reports and a classification of healing responses following transverse root fractures. (edu.au)
Complications1
- Although auto- and allogeneic bone grafts are excellent for healing such lesions, there are potential complications with their use. (bvsalud.org)
Biological1
- The aim of the review was to highlight those earlier histological reports and studies that have contributed to the current understanding of the biological processes involved in the healing of transverse root fractures. (edu.au)
Systemic1
- Vaccine antigens bio-encapsulated in plant cells upon oral delivery after priming, conferred both mucosal and systemic immunity and protection against bacterial, viral or protozoan pathogens or toxin challenge. (upenn.edu)
Methods1
- Radial head and neck fractures and dislocations have been treated by closed and open methods. (medscape.com)
Severe1
- A severe bone fracture often requires surgery using metal pins, rods or plates to ensure it heals in the correct position. (opnews.com)
Treatment3
- Under the direction of Melissa Kacena, PhD , the Kacena Lab is exploring the interaction of the bone and hematopoietic systems, thereby potentially improving the treatment of metabolic bone disease, hematopoietic disorders and fracture healing. (iu.edu)
- Consequently, treatment has evolved so that only patients with fractures stable enough to allow early motion undergo closed treatment, while essentially all other patients are treated with a form of surgical treatment. (medscape.com)
- The closed treatment of common fractures. (sarose.com.np)
Patients1
- Ulster University has established a collaboration with leading universities in the USA and Ireland on a £1.5 million research project to revolutionise bone fracture healing in patients across the globe. (opnews.com)
Molecular2
- Nature Reviews Molecular Cell Biology 2012;13(2):127-33. (scielo.br)
- BTE aims to combine the cellular ( osteogenic cells), extracellular ( osteoconductive scaffolds) and/or molecular elements ( osteoinductive growth factors) required for bone healing [ 2 ]. (biomedcentral.com)
Adequate1
- Achieving and maintaining adequate fracture reduction is critical to prevent nonunion and malunion, which result in substantial disability-adjusted life-year burden. (medscape.com)