Cell SurvivalSurvival RateBiologySystems BiologyDisease-Free SurvivalApoptosisSurvivalSurvival AnalysisSignal TransductionGraft SurvivalMolecular BiologyDevelopmental BiologyCell Line, TumorTime FactorsTreatment OutcomeSynthetic BiologyCell ProliferationCells, CulturedComputational BiologyCell DeathKaplan-Meier EstimateModels, BiologicalProto-Oncogene Proteins c-aktPhosphorylationCell LineRetrospective StudiesAntineoplastic AgentsProto-Oncogene ProteinsPhosphatidylinositol 3-KinasesProtein-Serine-Threonine KinasesNeoplasm StagingRNA, Small InterferingNeoplasmsMice, Inbred C57BLBlotting, WesternImmunohistochemistryMice, KnockoutProportional Hazards ModelsMutationBreast NeoplasmsGene Expression Regulation, NeoplasticFollow-Up StudiesCell Differentiationbcl-X ProteinProto-Oncogene Proteins c-bcl-2Antineoplastic Combined Chemotherapy ProtocolsLung NeoplasmsEnzyme Activationbcl-Associated Death ProteinPrognosisCombined Modality TherapyGene Expression ProfilingReverse Transcriptase Polymerase Chain ReactionGene Expression RegulationCell DivisionCaspase 3RNA, MessengerTransfectionAutophagyMice, TransgenicRNA InterferenceTumor Cells, CulturedMolecular Sequence DataNF-kappa BCaspasesTumor Markers, BiologicalNeoplasm MetastasisEnzyme InhibitorsUp-RegulationAdenocarcinomaDisease Models, AnimalTumor Suppressor Protein p53DNA-Binding ProteinsApoptosis Regulatory ProteinsCell CycleDose-Response Relationship, DrugTranscription FactorsGene ExpressionNeoplasm Recurrence, LocalDisease ProgressionGene Knockdown TechniquesIn Situ Nick-End LabelingMultivariate AnalysisBrain NeoplasmsDown-RegulationCisplatinMembrane ProteinsPhenotypeDrug Resistance, NeoplasmRadiation ToleranceDNA DamageNeuronsStem CellsOligonucleotide Array Sequence AnalysisCell HypoxiaProtein BindingCell MovementOxidative StressCytoprotectionChromones